All-Trans Retinoic Acid Prevents the Progression of Gastric Precancerous Lesions by Regulating Disordered Retinoic Acid Metabolism

References

• Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019;14(1):26–38. doi:10.5114/pg.2018.80001
   PubMed Web of Science ®Google Scholar
• Correa P. Human gastric carcinogenesis: a multistep and multifactorial process–First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992;52(24):6735–40. https://aacrjournals.org/cancerres/article/52/24/6735/498347/Human-Gastric-Carcinogenesis-AMultistep-and?searchresult=1
   PubMed Web of Science ®Google Scholar
• Mera RM, Bravo LE, Camargo MC, Bravo JC, Delgado AG, Romero-Gallo J, Yepez MC, Realpe JL, Schneider BG, Morgan DR, et al. Dynamics of infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut. 2018;67(7):1239–46. doi:10.1136/gutjnl-2016-311685
   PubMed Web of Science ®Google Scholar
• Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol. 2006;12(1):17–20. doi:10.3748/wjg.v12.i1.17.
   PubMed Web of Science ®Google Scholar
• Hu A, Li L, Hu C, Zhang D, Wang C, Jiang Y, Zhang M, Liang C, Chen W, Bo Q, et al. Serum concentrations of 15 elements among Helicobacter pylori-infected residents from Lujiang county with high gastric cancer risk in Eastern China. Biol Trace Elem Res. 2018;186(1):21–30. doi:10.1007/s12011-018-1283-4
   PubMed Web of Science ®Google Scholar
• Wu H, Wang C, Wang G, Zhao Q, Li L, et al. Relationships between the intake of salt and salted food and the infection of Helicobacter pylori in 40-69 years old local residents in a county with high gastric cancer risk in Anhui Province. Chin J Dis Control Prev. 2020;24:164–9. doi:10.16462/j.cnki.zhjbkz.2020.02.009
   Google Scholar
• Kang H, Kim H. Astaxanthin and β-carotene in Helicobacter pylori-induced gastric inflammation: a mini-review on action mechanisms. J Cancer Prev. 2017;22(2):57–61. doi:10.15430/JCP.2017.22.2.57
   PubMed Web of Science ®Google Scholar
• Lahner E, Persechino S, Annibale B. Micronutrients (other than iron) and Helicobacter pylori infection: a systematic review. Helicobacter. 2012;17(1):1–15. doi: 10.1111/j.23-5378.2011.00892.x.
   PubMed Web of Science ®Google Scholar
• Ventura U, Ceriani T, Montini E, Romano M, Ricci V. Vitamin A deficiency alters the bioelectric parameters and RNA content of rat gastric mucosa in vitro. J Physiol Pharmacol. 2003;54:523–32. https://www.jpp.krakow.pl/journal/archive/12_03/pdf/523_12_03_article.pdf
   PubMed Web of Science ®Google Scholar
• Swain S, Roe MM, Sebrell TA, Sidar B, Dankoff J, VanAusdol R, Smythies LE, Smith PD, Bimczok D. CD103 (αE integrin) undergoes endosomal trafficking in human dendritic cells, but does not mediate epithelial adhesion. Front Immunol. 2018;9:2989. doi:10.3389/fimmu.2018.02989
   PubMed Web of Science ®Google Scholar
• Carazo A, Macáková K, Matoušová K, Krčmová LK, Protti M, Mladěnka P. Vitamin a update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity. Nutrients. 2021;13(5):1703. doi:10.3390/nu1305
   PubMed Web of Science ®Google Scholar
• Zhong M, Kawaguchi R, Costabile B, Tang Y, Hu J, Cheng G, Kassai M, Ribalet B, Mancia F, Bok D, et al. Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport. Proc Natl Acad Sci USA. 2020;117(18):9857–64. doi:10.1073/pnas.1918540117
   PubMed Web of Science ®Google Scholar
• Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007;315(5813):820–5. doi:10.1126/science.1136244.
   PubMed Web of Science ®Google Scholar
• Belyaeva OV, Adams MK, Popov KM, Kedishvili NY. Generation of retinaldehyde for retinoic acid biosynthesis. Biomolecules. 2019;10(1):5. doi:10.3390/biom1001000
   Web of Science ®Google Scholar
• Kedishvili NY. Enzymology of retinoic acid biosynthesis and degradation. J Lipid Res. 2013;54(7):1744–60. doi:10.1194/jlr.R037028
   PubMed Web of Science ®Google Scholar
• Ghyselinck NB, Duester G. Retinoic acid signaling pathways. Development. 2019;146(13):dev167502. doi:10.1242/dev.167502
   PubMed Web of Science ®Google Scholar
• Stevison F, Jing J, Tripathy S, Isoherranen N. Role of retinoic acid-metabolizing cytochrome P450s, CYP26, in inflammation and cancer. Adv Pharmacol. 2015;74:373–412. doi:10.1016/bs.apha.2015.04.006
   PubMedGoogle Scholar
• Pennimpede T, Cameron DA, MacLean GA, Li H, Abu-Abed S, Petkovich M. The role of CYP26 enzymes in defining appropriate retinoic acid exposure during embryogenesis. Birth Defects Res A Clin Mol Teratol. 2010;88(10):883–94. doi:10.1002/bdra.20709
   PubMedGoogle Scholar
• Kim YS, Oh DK. Biotransformation of carotenoids to retinal by carotenoid 15,15’-oxygenase. Appl Microbiol Biotechnol. 2010;88(4):807–16. doi:10.1007/s00253-010-2823-9
   PubMed Web of Science ®Google Scholar
• Wang C, Zhao D, Wang K, Gao L, He Y, Wu H, Ruan L, Chen W, Zhang D, Xia T, et al. All-trans retinoic acid rescues the tumor suppressive role of RAR-β by inhibiting LncHOXA10 expression in gastric tumorigenesis. Nutr Cancer. 2021;73(10):2065–77. doi:10.1080/01635581.2020.1823006
   PubMed Web of Science ®Google Scholar
• Gao L, He Y, Wang K, Wang C, Wu H, Hu A, Ruan L, Bo Q, Chen W, Hu C, et al. All-trans retinoic acid suppressed GES-1 cell proliferation induced by exosomes from patients with precancerous lesions by arresting the cell cycle in S-phase. Eur J Cancer Prev. 2021;30(1):113–9. doi:10.1097/CEJ.0000000000000571
   PubMed Web of Science ®Google Scholar
• Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu LJ, Wang ZY. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood. 1988;72(2):567–72. doi:10.1182/blood-2016-11-750182
   PubMed Web of Science ®Google Scholar
• Costantini L, Molinari R, Farinon B, Merendino N. Retinoic acids in the treatment of most lethal solid cancers. J Clin Med. 2020;9(2):360. doi:10.3390/jcm9020
   Web of Science ®Google Scholar
• Hu A, Yang Y, Zhang S, Zhou Q, Wei W, Wang Y. 4-Amino-2-trifluoromethyl-phenyl retinate inhibits the migration of BGC-823 human gastric cancer cells by downregulating the phosphorylation level of MLC II. Oncol Rep. 2014;32(4):1473–80. doi:10.3892/or.2014.3343
   PubMed Web of Science ®Google Scholar
• Sanada Y, Oue N, Mitani Y, Yoshida K, Nakayama H, Yasui W. Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype. J Pathol. 2006;208(5):633–42. doi:10.1002/path.1922.
   PubMed Web of Science ®Google Scholar
• Narmcheshm S, Sasanfar B, Hadji M, Zendehdel K, Toorang F, Azadbakht L. Patterns of nutrient intake in relation to gastric cancer: a case control study. Nutr Cancer. 2021;1–10. doi:10.1080/01635581.2021.1931697
   Web of Science ®Google Scholar
• Epplein M, Signorello LB, Zheng W, Cai Q, Hargreaves MK, Michel A, Pawlita M, Fowke JH, Correa P, Blot WJ, et al. Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population. Cancer Prev Res (Phila). 2011;4(6):871–8. doi:10.1158/1940-6207.CAPR-10-0398
   PubMed Web of Science ®Google Scholar
• Assaad S, Chaaban R, Tannous F, Costanian C. Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital. BMC Gastroenterol. 2018;18(1):48. doi:10.1186/s12876-018-0775-1
   PubMedGoogle Scholar
• Stevison F, Hogarth C, Tripathy S, Kent T, Isoherranen N. Inhibition of the all-trans retinoic acid (atRA) hydroxylases CYP26A1 and CYP26B1 results in dynamic, tissue-specific changes in endogenous atRA signaling. Drug Metab Dispos. 2017;45(7):846–54. doi:10.1124/dmd.117.075341
   PubMed Web of Science ®Google Scholar
• Arnold SLM, Kent T, Hogarth CA, Griswold MD, Amory JK, Isoherranen N. Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner. Biochem Pharmacol. 2015;95(3):177–92. doi:10.1016/j.bcp.2015.03.001
   PubMed Web of Science ®Google Scholar
• Draut H, Liebenstein T, Begemann G. New insights into the control of cell fate choices and differentiation by retinoic acid in cranial, axial and caudal structures. Biomolecules. 2019;9(12):860. doi:10.3390/biom9120
   Web of Science ®Google Scholar
• Dubey A, Rose RE, Jones DR, Saint-Jeannet JP. Generating retinoic acid gradients by local degradation during craniofacial development: one cell’s cue is another cell’s poison. Genesis. 2018;56(2):e23091. doi:10.1002/dvg.23091
   Web of Science ®Google Scholar
• Matsumoto M, Yokoyama H, Suzuki H, Shiraishi-Yokoyama H, Hibi T. Retinoic acid formation from retinol in the human gastric mucosa: role of class IV alcohol dehydrogenase and its relevance to morphological changes. Am J Physiol Gastrointest Liver Physiol. 2005;289(3):G429–G433. doi:10.1152/ajpgi.00502.2004.
   PubMed Web of Science ®Google Scholar
• Bimczok D, Kao JY, Zhang M, Cochrun S, Mannon P, Peter S, Wilcox CM, Mönkemüller KE, Harris PR, Grams JM, et al. Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells. Mucosal Immunol. 2015;8(3):533–44. doi:10.1038/mi.2014.86
   PubMed Web of Science ®Google Scholar
• Kropotova ES, Zinov’eva OL, Zyrianova AF, Choĭnzonov EL, Afanas’ev SG, Cherdyntseva NV, Beresten’ SF, Oparina NI, Mashkova TD. Expression of genes involved in retinoic acid biosynthesis in human gastric cancer. Mol Biol (Mosk). 2013;47(2):317–30. doi:10.7868/s0026898413020079.
   PubMed Web of Science ®Google Scholar
• Chang J, Zhong R, Tian J, Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, et al. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet. 2018;50(3):338–43. doi:10.1038/s41588-018-0045-8
   PubMed Web of Science ®Google Scholar
• Brown GT, Cash BG, Blihoghe D, Johansson P, Alnabulsi A, Murray GI. The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer. PloS One. 2014;9(3):e90776. doi:10.1371/journal.pone.0090776
   PubMed Web of Science ®Google Scholar
• Wu Q, Chen ZM, Su WJ. Anticancer effect of retinoic acid via AP-1 activity repression is mediated by retinoic acid receptor alpha and beta in gastric cancer cells. Int J Biochem Cell Biol. 2002;34(9):1102–14. doi:10.1016/s1357-2725(02)00030-4
   PubMed Web of Science ®Google Scholar
• Grace VMB, Saranya S, Wilson DD. Protective role of All Trans Retinoic Acid on B16F10 melanoma cell line metastasis in C57BL/6 mice by enhancing RAR- β protein and homeostasis maintenance. J Histotechnol. 2021;44(3):127–38. doi:10.1080/01478885.2021.1896291
   PubMed Web of Science ®Google Scholar
• Bessone MID, Berardi DE, Cirigliano SM, Delbart DI, Peters MG, Todaro LB, Urtreger AJ. Protein Kinase C Alpha (PKCα) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RARβ) activation in mammary cancer cells. J Cancer Res Clin Oncol. 2020;146(12):3241–53. doi:10.1007/s00432-020-03368-7
   PubMed Web of Science ®Google Scholar
• Hayashi K, Yokozaki H, Naka K, Yasui W, Lotan R, Tahara E. Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines. Jpn J Cancer Res. 2001;92(1):42–50. doi:10.1111/j.1349-7006.2001.tb01046.x
   PubMedGoogle Scholar
• Li Y, Gao Y, Cui T, Yang T, Liu L, Li T, Chen J. Retinoic acid facilitates toll-like receptor 4 expression to improve intestinal barrier function through retinoic acid receptor beta. Cell Physiol Biochem. 2017;42(4):1390–406. doi:10.1159/000479203
   PubMedGoogle Scholar
• Serafin-Higuera N, Hernandez-Sanchez J, Ocadiz-Delgado R, Vazquez-Hernandez J, Albino-Sanchez ME, Hernandez-Pando R, Gariglio P. Retinoic acid receptor β deficiency reduces splenic dendritic cell population in a conditional mouse line. Immunol Lett. 2012;146(1–2):15–24. doi:10.1016/j.imlet.2012.04.006
   PubMed Web of Science ®Google Scholar
• Tsukita S, Tanaka H, Tamura A. The claudins: trom tight junctions to biological systems. Trends Biochem Sci. 2019;44(2):141–52. doi:10.1016/j.tibs.2018.09.008
   PubMed Web of Science ®Google Scholar
• Dejana E. Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol. 2004;5(4):261–70. doi:10.1038/nrm1357.
   PubMed Web of Science ®Google Scholar