AFAP1-AS1/Hsa-miR-15a-5p/Bcl-2 Axis is a Potential Regulator of Cancer Cell Proliferation and Apoptosis in Gallbladder Carcinoma

References

• Schmidt MA, Marcano-Bonilla L, Roberts LR. Gallbladder cancer: epidemiology and genetic risk associations. Chin Clin Oncol. 2019;8(4):31.
   PubMedGoogle Scholar
• Rai A, Mohapatra SC, Shukla HS. A review of association of dietary factors in gallbladder cancer. Indian J Cancer. 2004;41(4):147–51.
   PubMedGoogle Scholar
• Deng Y, Pang Q, Bi JB, Zhang X, Zhang LQ, Zhou YY, Miao RC, Chen W, Qu K, Liu CA. A promising prediction model for survival in gallbladder carcinoma patients: pretreatment prognostic nutrient index. Tumour Biol. 2016. doi:10.1007/s13277-016-5396-0
   Google Scholar
• Costa J, Lima N, Santos C. An overview on possible links between aflatoxin B1 exposure and gallbladder cancer. Mycotoxin Res. 2021;37(3):205–14.
   PubMedGoogle Scholar
• Wolpin BM, Mayer RJ. A step forward in the treatment of advanced biliary tract cancer. N Engl J Med. 2010;362(14):1335–7. doi:10.1056/NEJMe1001183
   PubMed Web of Science ®Google Scholar
• Li M, Zhang Z, Li X, Ye J, Wu X, Tan Z, Liu C, Shen B, Wang XA, Wu W, et al. Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway. Nat Genet. 2014;46(8):872–6. doi:10.1038/ng.3030
   PubMed Web of Science ®Google Scholar
• Ma F, Zhang M, Gong W, Weng M, Quan Z. MiR-138 suppresses cell proliferation by targeting bag-1 in gallbladder carcinoma. PLoS One. 2015;10(5):e0126499.
   PubMedGoogle Scholar
• Bergmann JH, Spector DL. Long non-coding RNAs: modulators of nuclear structure and function. Curr Opin Cell Biol. 2014;26(:10–8.
   PubMed Web of Science ®Google Scholar
• Huarte M. The emerging role of lncRNAs in cancer. Nat Med. 2015;21(11):1253–61.
   PubMed Web of Science ®Google Scholar
• Abdul S, Majid A, Wang J, Liu Q, Sun MZ, Liu S. Bidirectional interaction of lncRNA AFAP1-AS1 and CRKL accelerates the proliferative and metastatic abilities of hepatocarcinoma cells. J Adv Res. 2020;24(:121–30.
   PubMedGoogle Scholar
• Huang N, Guo W, Ren K, Li W, Jiang Y, Sun J, Dai W, Zhao W. LncRNA AFAP1-AS1 supresses miR-139-5p and promotes cell proliferation and chemotherapy resistance of non-small cell lung cancer by competitively upregulating RRM2. Front Oncol. 2019;9:1103.
   PubMed Web of Science ®Google Scholar
• Zhou J, Liu M, Chen Y, Xu S, Guo Y, Zhao L. Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR-146b-5p and lncRNA-AFAP1-AS1. J Cell Physiol. 2019;234(4):4655–67. doi:10.1002/jcp.27264
   PubMedGoogle Scholar
• Zhong Y, Wu X, Li Q, Ge X, Wang F, Wu P, Deng X, Miao L. Long noncoding RNAs as potential biomarkers and therapeutic targets in gallbladder cancer: a systematic review and meta-analysis. Cancer Cell Int. 2019;19(1):169. (doi:10.1186/s12935-019-0891-1
   PubMedGoogle Scholar
• Kondo Y, Shinjo K, Katsushima K. Long non-coding RNAs as an epigenetic regulator in human cancers. Cancer Sci. 2017;108(10):1927–33.
   PubMed Web of Science ®Google Scholar
• Ma HW, Xi DY, Ma JZ, Guo M, Ma L, Ma DH, Li PW, Guo CA. Long noncoding RNA AFAP1-AS1 promotes cell proliferation and metastasis via the miR-155-5p/FGF7 axis and predicts poor prognosis in gastric cancer. Dis Markers. 2020;2020:1–10. doi:10.1155/2020/8140989
   Google Scholar
• Wang K, Sun H, Sun T, Qu H, Xie Q, Lv H, Hu B. Long non-coding RNA AFAP1-AS1 promotes proliferation and invasion in prostate cancer via targeting miR-512-3p. Gene. 2020;726:144169. doi:10.1016/j.gene.2019.144169
   PubMedGoogle Scholar
• Geng ZM, Zhang M, Pan XT, Wang L. Bcl-2 gene silencing by RNA interference inhibits the growth of the human gallbladder carcinoma cell line GBC-SD in vitro and in vivo. Oncol Rep. 2013;30(2):793–800.
   PubMedGoogle Scholar
• Mikami T, Yanagisawa N, Baba H, Koike M, Okayasu I. Association of Bcl-2 protein expression with gallbladder carcinoma differentiation and progression and its relation to apoptosis. Cancer. 1999;85(2):318–25. doi:10.1002/(SICI)1097-0142(19990115)85:2<318::AID-CNCR8>3.0.CO;2-S
   PubMedGoogle Scholar
• Zheng C, Liu T, Liu H, Wang J. Role of BCL-2 family proteins in apoptosis and its regulation by nutrients. Curr Protein Pept Sci. 2020;21(8):799–806.
   PubMedGoogle Scholar
• Liz J, Esteller M. lncRNAs and microRNAs with a role in cancer development. Biochim Biophys Acta. 2016;1859(1):169–76. doi:10.1016/j.bbagrm.2015.06.015
   PubMed Web of Science ®Google Scholar
• Tekcham DS, Tiwari PK. Non-coding RNAs as emerging molecular targets of gallbladder cancer. Gene. 2016;588(1):79–85.
   PubMedGoogle Scholar
• Khandelwal A, Malhotra A, Jain M, Vasquez KM, Jain A. The emerging role of long non-coding RNA in gallbladder cancer pathogenesis. Biochimie. 2017;132(:152–60.
   PubMedGoogle Scholar
• Lian Y, Xiong F, Yang L, Bo H, Gong Z, Wang Y, Wei F, Tang Y, Li X, Liao Q, et al. Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway. J Exp Clin Cancer Res. 2018;37(1):253.
   PubMedGoogle Scholar
• Shi D, Wu F, Mu S, Hu B, Zhong B, Gao F, Qing X, Liu J, Zhang Z, Shao Z. LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway. J Exp Clin Cancer Res. 2019;38(1):375.
   PubMed Web of Science ®Google Scholar
• Ma F, Wang SH, Cai Q, Zhang MD, Yang Y, Ding J. Overexpression of LncRNA AFAP1-AS1 predicts poor prognosis and promotes cells proliferation and invasion in gallbladder cancer. Biomed Pharmacother. 2016;84(:1249–55.
   PubMedGoogle Scholar
• Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer. 2002;2(9):647–56.
   PubMed Web of Science ®Google Scholar
• Cousin F, Baldassini S, Bourchany D, Claudy A, Kanitakis J. Expression of the pro-apoptotic caspase 3/CPP32 in cutaneous basal and squamous cell carcinomas. J Cutan Pathol. 2000;27(5):235–41.
   PubMedGoogle Scholar
• Wang ZM, Wan XH, Sang GY, Zhao JD, Zhu QY, Wang DM. miR-15a-5p suppresses endometrial cancer cell growth via Wnt/beta-catenin signaling pathway by inhibiting WNT3A. Eur Rev Med Pharmacol Sci. 2017;21(21):4810–8.
   PubMed Web of Science ®Google Scholar
• Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the Rosetta stone of a hidden RNA language? Cell. 2011;146(3):353–8. doi:10.1016/j.cell.2011.07.014
   PubMed Web of Science ®Google Scholar
• Yang D, Zhan M, Chen T, Chen W, Zhang Y, Xu S, Yan J, Huang Q, Wang J. miR-125b-5p enhances chemotherapy sensitivity to cisplatin by down-regulating Bcl2 in gallbladder cancer. Sci Rep. 2017;7(:43109.
   PubMed Web of Science ®Google Scholar
• Wang X, Xie Y, Wang J. Overexpression of MicroRNA-34a-5p inhibits proliferation and promotes apoptosis of human cervical cancer cells by downregulation of Bcl-2. Oncol Res. 2018;26(6):977–85.
   PubMed Web of Science ®Google Scholar
• Pena-Blanco A, Garcia-Saez AJ. Bax, Bak and beyond - mitochondrial performance in apoptosis. Febs J. 2018;285(3):416–31.
   PubMed Web of Science ®Google Scholar
• Zhao H, Han L, Jian Y, Ma Y, Yan W, Chen X, Xu H, Li L. Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis. Onco Targets Ther. 2018;11(:8995–9006.
   PubMed Web of Science ®Google Scholar
• Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, et al. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res. 2017;27(3):329–51.
   PubMed Web of Science ®Google Scholar