Changes in Body Adiposity in Women Undergoing Breast Cancer Treatment: A Scoping Review

References

• Heer E, Harper A, Escandor N, Sung H, McCormack V, Fidler-Benaoudia MM. Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study. Lancet Glob Health. 2020;8(8):e1027–37–e1037. doi:10.1016/S2214-109X(20)30215-1
   Web of Science ®Google Scholar
• World Cancer Research Fund/American Institute for Cancer Research. Breast cancer statistics. https://www.wcrf.org/dietandcancer/cancer-trends/breast-cancer-statistics. Accessed 6 Nov 2020.
   Google Scholar
• World Cancer Research Fund/American Institute for Cancer Research. Diet, nutrition, physical activity and breast cancer survivors 2014 – Revised 2018. Continuous Update Project Expert Report; 2020. https://www.wcrf.org/sites/default/files/Breast-cancer-survivors-report.pdf. Accessed 6 Nov 2020.
   Google Scholar
• Instituto Nacional de Câncer José Alencar Gomes da Silva. Tipos de câncer: câncer de mama. https://www.inca.gov.br/tipos-de-cancer/cancer-de-mama. Accessed 6 Nov 2020.
   Google Scholar
• Waks AG, Winer EP. Breast cancer treatment: a review. JAMA. 2019;321(3):288–300. doi:10.1001/jama.2018.19323
   PubMed Web of Science ®Google Scholar
• Prado CMM, Heymsfield SB. Lean tissue imaging: a new era for nutritional assessment and intervention. JPEN J Parent Enteral Nutr. 2014;38(8):940–53. doi:10.1177/0148607114550189
   PubMed Web of Science ®Google Scholar
• Prado CMM, Siervo M, Mire E, Heymsfield SB, Stephan BCM, Broyles S, Smith SR, Wells JCK, Katzmarzyk PT. A population-based approach to define body-composition phenotypes. Am J Clin Nutr. 2014;99(6):1369–77. doi:10.3945/ajcn.113.078576
   PubMed Web of Science ®Google Scholar
• Thibault R, Genton L, Pichard C. Body composition: why, when and for who? Clin Nutr. 2012;31(4):435–47. doi:10.1016/j.clnu.2011.12.011
   PubMed Web of Science ®Google Scholar
• Piché M-E, Poirier P, Lemieux I, Després J-P. Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: an update. Prog Cardiovasc Dis. 2018;61(2):103–13. doi:10.1016/j.pcad.2018.06.004
   PubMed Web of Science ®Google Scholar
• Blake T, Gullick NJ, Hutchinson CE, Barber TM. Psoriatic disease and body composition: a systematic review and narrative synthesis. PLoS One. 2020;15(8):e0237598. doi:10.1371/journal.pone.0237598
   PubMed Web of Science ®Google Scholar
• Ebadi M, Bhanji RA, Tandon P, Mazurak V, Baracos VE, Montano-Loza AJ. Review article: prognostic significance of body composition abnormalities in patients with cirrhosis. Aliment Pharmacol Ther. 2020;52(4):600–18. doi:10.1111/apt.15927
   PubMed Web of Science ®Google Scholar
• Pielkenrood B, Van Urk P, Van der Velden J, Kasperts N, Verhoeff J, Bol G, Verkooijen L, Verlaan J. Impact of body morphology on survival in patients with bone metastases: a prospective cohort study. Radiother Oncol. 2019;133:S876–S7. doi:10.1016/S0167-8140(19)32047-X
   Web of Science ®Google Scholar
• Guven HE, Dogan L, Gulçelik MA, Gulcelik NE, Department of General Surgery, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey. Adiponectin: a predictor for breast cancer survival? Eur J Breast Health. 2019;15(1):13–7. doi:10.5152/ejbh.2018.4349
   PubMed Web of Science ®Google Scholar
• Sheean PM, Hoskins K, Stolley M. Body composition changes in females treated for breast cancer: a review of the evidence. Breast Cancer Res Treat. 2012;135(3):663–80. doi:10.1007/s10549-012-2200-8
   PubMed Web of Science ®Google Scholar
• Trestini I, Carbognin L, Monteverdi S, Zanelli S, De Toma A, Bonaiuto C, Nortilli R, Fiorio E, Pilotto S, Di Maio M, et al. Clinical implication of changes in body composition and weight in patients with early-stage and metastatic breast cancer. Crit Rev Oncol Hematol. 2018;129:54–66. doi:10.1016/j.critrevonc.2018.06.011
   PubMed Web of Science ®Google Scholar
• Lee K, Kruper L, Dieli-Conwright CM, Mortimer JE. The impact of obesity on breast cancer diagnosis and treatment. Curr Oncol Rep. 2019;21(5):41. doi:10.1007/s11912-019-0787-1
   PubMed Web of Science ®Google Scholar
• Iwase T, Sangai T, Nagashima T, Sakakibara M, Sakakibara J, Hayama S, Ishigami E, Masuda T, Miyazaki M. Impact of body fat distribution on neoadjuvant chemotherapy outcomes in advanced breast cancer patients. Cancer Med. 2016;5(1):41–8. doi:10.1002/cam4.571
   PubMed Web of Science ®Google Scholar
• Wong AL, Seng KY, Ong EM, Wang LZ, Oscar H, Cordero MT, Copones R, Fan L, Tan SH, Goh BC, et al. Body fat composition impacts the hematologic toxicities and pharmacokinetics of doxorubicin in Asian breast cancer patients. Breast Cancer Res Treat. 2014;144(1):143–52. doi:10.1007/s10549-014-2843-8
   PubMed Web of Science ®Google Scholar
• Lee K, Shin Y, Huh J, Sung YS, Lee IS, Yoon KH, Kim KW. Recent issues on body composition imaging for sarcopenia evaluation. Kor J Radiol. 2019;20(2):205–17. doi:10.3348/kjr.2018.0479
   PubMed Web of Science ®Google Scholar
• Thiebaud RS, Abe T, Loenneke JP, Fujita E, Akamine T. Body fat percentage assessment by ultrasound subcutaneous fat thickness measurements in middle-aged and older adults. Clin Nutr. 2019;38(6):2659–67. doi:10.1016/j.clnu.2018.11.017
   PubMed Web of Science ®Google Scholar
• Achamrah N, Colange G, Delay J, Rimbert A, Folope V, Petit A, Grigioni S, Déchelotte P, Coëffier M. Comparison of body composition assessment by DXA and BIA according to the body mass index: a retrospective study on 3655 measures. PLoS ONE. 2018;13(7):e0200465. doi:10.1371/journal.pone.0200465
   PubMed Web of Science ®Google Scholar
• Borga M, West J, Bell JD, Harvey NC, Romu T, Heymsfield SB, Dahlqvist Leinhard O. Advanced body composition assessment: from body mass index to body composition profiling. J Investig Med. 2018;66(5):1–9. doi:10.1136/jim-2018-000722
   PubMed Web of Science ®Google Scholar
• Guerri S, Mercatelli D, Aparisi Gómez MP, Napoli A, Battista G, Guglielmi G, Bazzocchi A. Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia. Quant Imaging Med Surg. 2018;8(1):60–85. doi:10.21037/qims.2018.01.05
   PubMed Web of Science ®Google Scholar
• Andreoli A, Garaci F, Cafarelli FP, Guglielmi G. Body composition in clinical practice. Eur J Radiol. 2016;85(8):1461–8. doi:10.1016/j.ejrad.2016.02.005
   PubMed Web of Science ®Google Scholar
• Erlandson MC, Lorbergs AL, Mathur S, Cheung AM. Muscle analysis using pQCT, DXA and MRI. Eur J Radiol. 2016;85(8):1505–11. doi:10.1016/j.ejrad.2016.03.001
   PubMed Web of Science ®Google Scholar
• Johnson Stoklossa CA, Forhan M, Padwal RS, Gonzalez MC, Prado CM. Practical considerations for body composition assessment of adults with class II/III obesity using bioelectrical impedance analysis or dual-energy X-ray absorptiometry. Curr Obes Rep. 2016;5(4):389–96. doi:10.1007/s13679-016-0228-5
   PubMed Web of Science ®Google Scholar
• Fosbøl MØ, Zerahn B. Contemporary methods of body composition measurement. Clin Physiol Funct Imaging. 2015;35(2):81–97. doi:10.1111/cpf.12152
   PubMed Web of Science ®Google Scholar
• Khalil S, Mohktar M, Ibrahim F. The theory and fundamentals of bioimpedance analysis in clinical status monitoring and diagnosis of diseases. Sensors (Basel). 2014;14(6):10895–928. doi:10.3390/s140610895
   PubMed Web of Science ®Google Scholar
• Wagner DR. Ultrasound as a tool to assess body fat. J Obes. 2013;2013:280713. doi:10.1155/2013/280713
   PubMedGoogle Scholar
• Stahn A, Terbalanche E, Gunga HC. Use of bioelectrical impedance: general principles and overview. In: Preedy VR, editor. Handbook of anthropometry: physical measures of human form in health and disease. New York: Springer; 2012.
   Google Scholar
• Lenz M, Arts ICW, Peeters RLM, de Kok TM, Ertaylan G. Adipose tissue in health and disease through the lens of its building blocks. Sci Rep. 2020;10(1):10433. doi:10.1038/s41598-020-67177-1
   PubMed Web of Science ®Google Scholar
• Kapoor ND, Twining PK, Groot OQ, Pielkenrood BJ, Bongers MER, Newman ET, Verlaan JJ, Schwab JH. Adipose tissue density on CT as a prognostic factor in patients with cancer: a systematic review. Acta Oncol. 2020;59(12):1488–95. doi:10.1080/0284186X.2020.1800087
   PubMed Web of Science ®Google Scholar
• Rosenquist KJ, Massaro JM, Pedley A, Long MT, Kreger BE, Vasan RS, Murabito JM, Hoffmann U, Fox CS. Fat quality and incident cardiovascular disease, all-cause mortality, and cancer mortality. J Clin Endocrinol Metab. 2015;100(1):227–34. doi:10.1210/jc.2013-4296
   PubMed Web of Science ®Google Scholar
• Franzoi MA, Vandeputte C, Eiger D, Caparica R, Brandão M, De Angelis C, Hendlisz A, Awada A, Piccart M, de Azambuja E, et al. Computed tomography-based analyses of baseline body composition parameters and changes in breast cancer patients under treatment with CDK 4/6 inhibitors. Breast Cancer Res Treat. 2020;181(1):199–209. doi:10.1007/s10549-020-05617-2
   PubMed Web of Science ®Google Scholar
• Goossens GH. The metabolic phenotype in obesity: fat mass, body fat distribution, and adipose tissue function. Obes Facts. 2017;10(3):207–15. doi:10.1159/000471488
   PubMed Web of Science ®Google Scholar
• Samuelson I, Vidal-Puig A. Studying brown adipose tissue in a human in vitro context. Front Endocrinol. 2020;11:629. doi:10.3389/fendo.2020.00629
   PubMed Web of Science ®Google Scholar
• Waters DL. Intermuscular adipose tissue: a brief review of etiology, association with physical function and weight loss in older adults. Ann Geriatr Med Res. 2019;23(1):3–8. doi:10.4235/agmr.19.0001
   PubMed Web of Science ®Google Scholar
• Mittal B. Subcutaneous adipose tissue and visceral adipose tissue. Indian J Med Res. 2019;149(5):571–3. doi:10.4103/ijmr.IJMR_1910_18
   PubMed Web of Science ®Google Scholar
• Nattenmüller J, Böhm J, Bagdassarjan A, Kulu Y, Gigic B, Schneider M, Kauczor H-U, Ulrich CM, Ulrich A. CT-quantified adipose tissue distribution: risk or protective factor for complications after rectal cancer surgery? Obes Facts. 2019;12(3):259–71. doi:10.1159/000499320
   PubMed Web of Science ®Google Scholar
• Ulbrich EJ, Nanz D, Leinhard OD, Marcon M, Fischer MA. Whole-body adipose tissue and lean muscle volumes and their distribution across gender and age: MR-derived normative values in a normal-weight Swiss population. Magn Reson Med. 2018;79(1):449–58. doi:10.1002/mrm.26676
   PubMed Web of Science ®Google Scholar
• Pedersen B, Delmar C, Lörincz T, Falkmer U, Grønkjaer M. Investigating changes in weight and body composition among women in adjuvant treatment for breast cancer: a scoping review. Cancer Nurs. 2019;42(2):91–105. doi:10.1097/NCC.0000000000000590
   PubMed Web of Science ®Google Scholar
• Peters MDJ, Godfrey C, McInerney P, et al. Chapter 11: Scoping Reviews (2020 Version). JBI Manual for Evidence Synthesis. Aromataris E, Munn Z; 2020. https://wiki.jbi.global/display/MANUAL/Chapter+11%3A+Scoping+reviews
   Google Scholar
• Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsley T, Weeks L, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73. doi:10.7326/M18-0850
   PubMed Web of Science ®Google Scholar
• Ginzac A, Barres B, Chanchou M, Gadéa E, Molnar I, Merlin C, Coudert B, Thivat E, Durando X. A decrease in brown adipose tissue activity is associated with weight gain during chemotherapy in early breast cancer patients. BMC Cancer. 2020;20(1):96. doi:10.1186/s12885-020-6591-3
   PubMed Web of Science ®Google Scholar
• Jung GH, Kim JH, Chung MS. Changes in weight, body composition, and physical activity among patients with breast cancer under adjuvant chemotherapy. Eur J Oncol Nurs. 2020;44:101680. doi:10.1016/j.ejon.2019.101680
   PubMed Web of Science ®Google Scholar
• van den Berg MMGA, Kok DE, Visser M, de Vries JHM, de Kruif JTCM, de Vries Y, Posthuma L, Sommeijer DW, Timmer-Bonte A, Los M, et al. Changes in body composition during and after adjuvant or neo-adjuvant chemotherapy in women with breast cancer stage I–IIIB compared with changes over a similar timeframe in women without cancer. Support Care Cancer. 2020;28(4):1685–93. doi:10.1007/s00520-019-04951-6
   PubMed Web of Science ®Google Scholar
• Artese AL, Simonavice E, Madzima TA, Kim J-S, Arjmandi BH, Ilich JZ, Panton LB. Body composition and bone mineral density in breast cancer survivors and non-cancer controls: a 12- to 15-month follow-up. Eur J Cancer Care (Engl). 2018;27(2):e12824. doi:10.1111/ecc.12824
   PubMed Web of Science ®Google Scholar
• Gadéa E, Thivat E, Dubray-Longeras P, Arbre M, Van-Praagh I, Mouret-Reynier M-A, Herviou P, Dohou J, Ginzac A, Duclos M, et al. Prospective study on body composition, energy balance and biological factors changes in post-menopausal women with breast cancer receiving adjuvant chemotherapy including taxanes. Nutr Cancer. 2018;70(7):997–1006. doi:10.1080/01635581.2018.1502330
   PubMed Web of Science ®Google Scholar
• Pedersen B, Delmar C, Bendtsen MD, Bosaeus I, Carus A, Falkmer U, Groenkjaer M. Changes in weight and body composition among women with breast cancer during and after adjuvant treatment: a prospective follow-up study. Cancer Nurs. 2017;40(5):369–76. doi:10.1097/NCC.0000000000000426
   PubMed Web of Science ®Google Scholar
• Rier HN, Jager A, Sleijfer S, van Rosmalen J, Kock MCJM, Levin M-D. Changes in body composition and muscle attenuation during taxane-based chemotherapy in patients with metastatic breast cancer. Breast Cancer Res Treat. 2018;168(1):95–105. doi:10.1007/s10549-017-4574-0
   PubMed Web of Science ®Google Scholar
• Battisti S, Guida FM, Coppa F, Vaccaro DM, Santini D, Tonini G, Zobel BB, Semelka RC. Modification of abdominal fat distribution after aromatase inhibitor therapy in breast cancer patients visualized using 3-D computed tomography volumetry. Clin Breast Cancer. 2014;14(5):365–70. doi:10.1016/j.clbc.2014.02.003
   PubMed Web of Science ®Google Scholar
• Hojan K, Milecki P, Molińska-Glura M, et al. Effect of physical activity on bone strength and body composition in breast cancer premenopausal women during endocrine therapy. Eur J Phys Rehabil Med. 2013;49:331–9.
   PubMed Web of Science ®Google Scholar
• van Londen GJ, Perera S, Vujevich K, Rastogi P, Lembersky B, Brufsky A, Vogel V, Greenspan SL. The impact of an aromatase inhibitor on body composition and gonadal hormone levels in women with breast cancer. Breast Cancer Res Treat. 2011;125(2):441–6. doi:10.1007/s10549-010-1223-2
   PubMed Web of Science ®Google Scholar
• Irwin ML, Alvarez-Reeves M, Cadmus L, Mierzejewski E, Mayne ST, Yu H, Chung GG, Jones B, Knobf MT, DiPietro L, et al. Exercise improves body fat, lean mass, and bone mass in breast cancer survivors. Obesity. 2009;17(8):1534–41. doi:10.1038/oby.2009.18
   PubMed Web of Science ®Google Scholar
• Francini G, Petrioli R, Montagnani A, Cadirni A, Campagna S, Francini E, Gonnelli S. Exemestane after tamoxifen as adjuvant hormonal therapy in postmenopausal women with breast cancer: effects on body composition and lipids. Br J Cancer. 2006;95(2):153–8. doi:10.1038/sj.bjc.6603258
   PubMed Web of Science ®Google Scholar
• Freedman RJ, Aziz N, Albanes D, Hartman T, Danforth D, Hill S, Sebring N, Reynolds JC, Yanovski JA. Weight and body composition changes during and after adjuvant chemotherapy in women with breast cancer. J Clin Endocrinol Metab. 2004;89(5):2248–53. doi:10.1210/jc.2003-031874
   PubMed Web of Science ®Google Scholar
• Demark-Wahnefried W, Peterson BL, Winer EP, Marks L, Aziz N, Marcom PK, Blackwell K, Rimer BK. Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol. 2001;19(9):2381–9. doi:10.1200/JCO.2001.19.9.2381
   PubMed Web of Science ®Google Scholar
• Kutynec CL, McCargar L, Barr SI, Hislop TG. Energy balance in women with breast cancer during adjuvant treatment. J Am Diet Assoc. 1999;99(10):1222–7. doi:10.1016/S0002-8223(99)00301-6
   PubMed Web of Science ®Google Scholar
• Cheney CL, Mahloch J, Freeny P. Computerized tomography assessment of women with weight changes associated with adjuvant treatment for breast cancer. Am J Clin Nutr. 1997;66(1):141–6. doi:10.1093/ajcn/66.1.141
   PubMed Web of Science ®Google Scholar
• Cespedes Feliciano EM, Chen WY, Bradshaw PT, Prado CM, Alexeeff S, Albers KB, Castillo AL, Caan BJ. Adipose tissue distribution and cardiovascular disease risk among breast cancer survivors. J Clin Oncol. 2019;37(28):2528–36. doi:10.1200/JCO.19.00286
   PubMed Web of Science ®Google Scholar
• Del Fabbro E, Parsons H, Warneke CL, Pulivarthi K, Litton JK, Dev R, Palla SL, Brewster A, Bruera E. The relationship between body composition and response to neoadjuvant chemotherapy in women with operable breast cancer. Oncologist. 2012;17(10):1240–5. doi:10.1634/theoncologist.2012-0169
   PubMed Web of Science ®Google Scholar
• Bradshaw PT, Cespedes Feliciano EM, Prado CM, Alexeeff S, Albers KB, Chen WY, Caan BJ. Adipose tissue distribution and survival among women with nonmetastatic breast cancer. Obesity (Silver Spring). 2019;27(6):997–1004. doi:10.1002/oby.22458
   PubMed Web of Science ®Google Scholar
• Caan BJ, Cespedes Feliciano EM, Prado CM, Alexeeff S, Kroenke CH, Bradshaw P, Quesenberry CP, Weltzien EK, Castillo AL, Olobatuyi TA, et al. Association of muscle and adiposity measured by computed tomography with survival in patients with nonmetastatic breast cancer. JAMA Oncol. 2018;4(6):798–804. doi:10.1001/jamaoncol.2018.0137
   PubMed Web of Science ®Google Scholar
• Iwase T, Sangai T, Fujimoto H, Sawabe Y, Matsushita K, Nagashima K, Sato Y, Nakagawa A, Masuda T, Nagashima T, et al. Quality and quantity of visceral fat tissue are associated with insulin resistance and survival outcomes after chemotherapy in patients with breast cancer. Breast Cancer Res Treat. 2020;179(2):435–43. doi:10.1007/s10549-019-05467-7
   PubMed Web of Science ®Google Scholar
• Liu L-N, Lin Y-C, Miaskowski C, Chen S-C, Chen M-L. Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status. BMC Cancer. 2017;17(1):863. doi:10.1186/s12885-017-3869-1
   PubMedGoogle Scholar
• Barone I, Giordano C, Bonofiglio D, Andò S, Catalano S. The weight of obesity in breast cancer progression and metastasis: clinical and molecular perspectives. Semin Cancer Biol. 2020;60:274–84. doi:10.1016/j.semcancer.2019.09.001
   PubMed Web of Science ®Google Scholar
• Lima MTM, de Carvalho KP, Mazzutti FS, de Almeida Maia M, Canto PPL, Paiva CE, de Paiva Maia YC. Temporal influence of endocrine therapy with tamoxifen and chemotherapy on nutritional risk and obesity in breast cancer patients. BMC Cancer. 2017;17(1):578. doi:10.1186/s12885-017-3559-z
   PubMedGoogle Scholar
• Srinivasalu VK, George AS, Philip A, Kotne S, Bamroo S, DK V, Pillai R, K B, Jose WM, Pavithran K, et al. Effect of obesity on the toxicity profile of patients with breast cancer treated with adjuvant chemotherapy. JCO. 2017;35(15_suppl):e12033–e12033. doi:10.1200/JCO.2017.35.15_suppl.e12033
   Google Scholar
• Sparreboom A, Wolff AC, Mathijssen RH, Chatelut E, Rowinsky EK, Verweij J, Baker SD. Evaluation of alternate size descriptors for dose calculation of anticancer drugs in the obese. JCO. 2007;25(30):4707–13. doi:10.1200/JCO.2007.11.2938
   PubMed Web of Science ®Google Scholar
• van den Berg MMGA, Kok DE, Posthuma L, Kamps L, Kelfkens CS, Buist N, Geenen M, Haringhuizen A, Heijns JB, van Lieshout RHMA, et al. Body composition is associated with risk of toxicity-induced modifications of treatment in women with stage I–IIIB breast cancer receiving chemotherapy. Breast Cancer Res Treat. 2019;173(2):475–81. doi:10.1007/s10549-018-5014-5
   PubMed Web of Science ®Google Scholar
• Friese CR, Harrison JM, Janz NK, Jagsi R, Morrow M, Li Y, Hamilton AS, Ward KC, Kurian AW, Katz SJ, et al. Treatment-associated toxicities reported by patients with early-stage invasive breast cancer. Cancer. 2017;123(11):1925–34. doi:10.1002/cncr.30547
   PubMed Web of Science ®Google Scholar
• Custódio IDD, Marinho EdC, Gontijo CA, Pereira TSS, Paiva CE, Maia YCdP. Impact of chemotherapy on diet and nutritional status of women with breast cancer: a prospective study. PLoS One. 2016;11(6):e0157113. doi:10.1371/journal.pone.0157113
   PubMed Web of Science ®Google Scholar
• Champ CE, Volek JS, Siglin J, Jin L, Simone NL. Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data? Int J Breast Cancer. 2012;2012:506868. doi:10.1155/2012/506868
   PubMedGoogle Scholar
• Huntington MO. Weight gain in patients receiving adjuvant chemotherapy for carcinoma of the breast. Cancer. 1985;56(3):472–4. ≤472::aid-cncr2820560310≥3.0.co;2-3. doi:10.1002/1097-0142(19850801)56:3
   PubMed Web of Science ®Google Scholar
• Barbat-Artigas S, Aubertin-Leheudre M. Menopausal transition and fat distribution. Menopause. 2013;20(4):370–1. doi:10.1097/GME.0b013e318286cfb3
   PubMed Web of Science ®Google Scholar
• Messier V, Rabasa-Lhoret R, Barbat-Artigas S, Elisha B, Karelis AD, Aubertin-Leheudre M. Menopause and sarcopenia: a potential role for sex hormones. Maturitas. 2011;68(4):331–6. doi:10.1016/j.maturitas.2011.01.014
   PubMed Web of Science ®Google Scholar
• Gibb FW, Dixon JM, Clarke C, Homer NZ, Faqehi AMM, Andrew R, Walker BR. Higher Insulin resistance and adiposity in postmenopausal women with breast cancer treated with aromatase inhibitors. J Clin Endocrinol Metab. 2019;104(9):3670–8. doi:10.1210/jc.2018-02339
   PubMed Web of Science ®Google Scholar
• Casson PR, Toth MJ, Johnson JV, Stanczyk FZ, Casey CL, Dixon ME. Correlation of serum androgens with anthropometric and metabolic indices in healthy, nonobese postmenopausal women. J Clin Endocrinol Metab. 2010;95(9):4276–82. doi:10.1210/jc.2009-2390
   PubMed Web of Science ®Google Scholar
• Akyol M, Demir L, Alacacioglu A, Ellidokuz H, Kucukzeybek Y, Yildiz Y, Gumus Z, Bayoglu V, Yildiz I, Salman T, et al. The effects of adjuvant endocrine treatment on serum leptin, serum adiponectin and body composition in patients with breast cancer: the Izmir Oncology Group (IZOG) study. Chemotherapy. 2016;61(2):57–64. doi:10.1159/000440944
   PubMed Web of Science ®Google Scholar
• Tenti S, Correale P, Cheleschi S, Fioravanti A, Pirtoli L. Aromatase inhibitors-induced musculoskeletal disorders: current knowledge on clinical and molecular aspects. IJMS. 2020;21(16):5625. doi:10.3390/ijms21165625
   Google Scholar
• Nguyen MC, Stewart RB, Banerji MA, Gordon DH, Kral JG. Relationships between tamoxifen use, liver fat and body fat distribution in women with breast cancer. Int J Obes Relat Metab Disord. 2001;25(2):296–8. doi:10.1038/sj.ijo.0801488
   PubMed Web of Science ®Google Scholar
• Ali PA, Al-Ghorabie FH, Evans CJ, El-Sharkawi AM, Hancock DA. Body composition measurements using DXA and other techniques in tamoxifen-treated patients. Appl Radiat Isot. 1998;49(5–6):643–5. doi:10.1016/S0969-8043(97)00082-1
   PubMed Web of Science ®Google Scholar
• Tsai J-P. The association of serum leptin levels with metabolic diseases. Ci Ji Yi Xue Za Zhi. 2017;29(4):192–6. doi:10.4103/tcmj.tcmj_123_17
   Google Scholar
• Ozet A, Arpaci F, Yilmaz MI, Ayta H, Ozturk B, Komurcu S, Yavuz AA, Tezcan Y, Acikel C. Effects of tamoxifen on the serum leptin level in patients with breast cancer. Jpn J Clin Oncol. 2001;31(9):424–7. doi:10.1093/jjco/hye097
   PubMed Web of Science ®Google Scholar
• Marttunen MB, Andersson S, Hietanen P, Karonen SL, Koistinen HA, Koivisto VA, Tiitinen A, Ylikorkala O. Antiestrogenic tamoxifen and toremifene increase serum leptin levels in postmenopausal breast cancer patients. Maturitas. 2000;35(2):175–9. doi:10.1016/S0378-5122(00)00121-3
   PubMed Web of Science ®Google Scholar
• Xu B, Lovre D, Mauvais-Jarvis F. The effect of selective estrogen receptor modulators on type 2 diabetes onset in women: basic and clinical insights. J Diabet Complicat. 2017;31(4):773–9. doi:10.1016/j.jdiacomp.2016.12.010
   Google Scholar
• Lampert C, Arcego DM, Laureano DP, Diehl LA, da Costa Lima IF, Krolow R, Pettenuzzo LF, Dalmaz C, Vendite D. Effect of chronic administration of tamoxifen and/or estradiol on feeding behavior, palatable food and metabolic parameters in ovariectomized rats. Physiol Behav. 2013;119:17–24. doi:10.1016/j.physbeh.2013.05.026
   PubMed Web of Science ®Google Scholar
• Hozumi Y, Kawano M, Hakamata Y, Miyata M, Jordan VC. Tamoxifen inhibits lipoprotein activity: in vivo and in vitro studies. Horm Res Paediatr. 2000;53(1):36–9. doi:10.1159/000023511
   Google Scholar
• Liu L, Zou P, Zheng L, Linarelli LE, Amarell S, Passaro A, Liu D, Cheng Z. Tamoxifen reduces fat mass by boosting reactive oxygen species. Cell Death Dis. 2015;6(1):e1586–e1586. doi:10.1038/cddis.2014.553
   PubMedGoogle Scholar
• Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, et al. Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer. Ann Oncol. 2018;29(7):1541–7. doi:10.1093/annonc/mdy155
   PubMed Web of Science ®Google Scholar
• Rugo HS, Finn RS, Diéras V, Ettl J, Lipatov O, Joy AA, Harbeck N, Castrellon A, Iyer S, Lu DR, et al. Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up. Breast Cancer Res Treat. 2019;174(3):719–29. doi:10.1007/s10549-018-05125-4
   PubMed Web of Science ®Google Scholar
• Hou X, Zhang Y, Li W, Hu AJ, Luo C, Zhou W, Hu JK, Daniele SG, Wang J, Sheng J, et al. CDK6 inhibits white to beige fat transition by suppressing RUNX1. Nat Commun. 2018;9(1):1023. doi:10.1038/s41467-018-03451-1
   PubMedGoogle Scholar
• Iqbal NJ, Lu Z, Liu SM, Schwartz GJ, Chua S, Zhu L. Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity. JCI Insight. 2018;3(17):e123000. doi:10.1172/jci.insight.123000
   PubMed Web of Science ®Google Scholar