2,090
Views
0
CrossRef citations to date
0
Altmetric
Article

Suppression of HCT116 Human Colon Cancer Cell Motility by Polymethoxyflavones is Associated with Inhibition of Wnt/β-Catenin Signaling

, , &
Pages 3662-3669 | Received 20 Aug 2021, Accepted 26 May 2022, Published online: 06 Jun 2022

References

  • Novellasdemunt L, Antas P, Li VS. Targeting Wnt signaling in colorectal cancer: a review in the theme: cell signaling: proteins, pathways and mechanisms. Am J Physiol Cell Physiol 2015;309(8):C511–C521. doi:10.1152/ajpcell.00117.2015
  • Zhang L, Shay JW. Multiple roles of APC and its therapeutic implications in colorectal cancer. J Natl Cancer Inst 2017;109:djw332. doi:10.1093/jnci/djw332
  • Yang X, Zhong J, Zhang Q, Feng L, Zheng Z, Zhang J, Lu S. Advances and insights of APC-Asef inhibitors for metastatic colorectal cancer therapy. Front Mol Biosci 2021;8:662579. doi:10.3389/fmolb.2021.662579
  • Zhang Y, Wang X. Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol 2020;13(1):165. doi:10.1186/s13045-020-00990-3
  • Lecarpentier Y, Schussler O, Hébert JL, Vallée A. Multiple targets of the canonical Wnt/β-catenin signaling in cancers. Front Oncol 2019;9:1248. doi:10.3389/fonc.2019.01248
  • Lazarova DL, Bordonaro M. Vimentin, colon cancer progression and resistance to butyrate and other HDACis. J Cell Mol Med 2016;20(6):989–93. doi:10.1111/jcmm.12850
  • Strouhalova K, Přechová M, Gandalovičová A, Brábek J, Gregor M, Rosel D. Vimentin intermediate filaments as potential target for cancer treatment. Cancers 2020;12(1):184. doi:10.3390/cancers12010184
  • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434(7035):843–50. doi:10.1038/nature03319
  • Humphries A, Wright NA. Colonic crypt organization and tumorigenesis. Nat Rev Cancer 2008;8(6):415–24. doi:10.1038/nrc2392
  • Scholer-Dahirel A, Schlabach MR, Loo A, Bagdasarian L, Meyer R, Guo R, Woolfenden S, Yu KK, Markovits J, Killary K, et al. Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling . Proc Natl Acad Sci U S A 2011;108(41):17135–40. doi:10.1073/pnas.1104182108
  • Cheriyamundath S, Ben ZA. Wnt/β-catenin target genes in colon cancer metastasis: the special case of L1CAM. Cancers 2020;12(11):3444. doi:10.3390/cancers12113444
  • Kundu JK, Surh YJ. Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals. Mutat Res 2005;591(1-2):123–46. doi:10.1016/j.mrfmmm.2005.04.019
  • Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal 2008;10(3):475–510. doi:10.1089/ars.2007.1740
  • Rodríguez-García C, Sánchez-Quesada C, Gaforio JJ. Dietary flavonoids as cancer chemopreventive agents: an updated review of human studies. Antioxidants 2019;8(5):137. doi:10.3390/antiox8050137
  • Amado NG, Fonseca BF, Cerqueira DM, Neto VM, Abreu JG. Flavonoids: potential Wnt/beta-catenin signaling modulators in cancer. Life Sci 2011;89(15-16):545–54. doi:10.1016/j.lfs.2011.05.003
  • Kawabata K, Murakami A, Ohigashi H. Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells. Biosci Biotechnol Biochem 2005;69(2):307–14. doi:10.1271/bbb.69.307
  • Lai C-S, Li S, Chai C-Y, Lo C-Y, Dushenkov S, Ho C-T, Pan M-H, Wang Y-J. Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3’,4’-didemethylnobiletin, derived from nobiletin. Carcinogenesis 2008;29(12):2415–24. doi:10.1093/carcin/bgn222
  • Li N, Zhang Z, Jiang G, Sun H, Yu D. Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K/Akt/MTOR pathway. Front Biosci (Landmark Ed) 2019;24(2):303–12. doi:10.2741/4719
  • Arnold A, Tronser M, Sers C, Ahadova A, Endris V, Mamlouk S, Horst D, Möbs M, Bischoff P, Kloor M, et al. The majority of β-catenin mutations in colorectal cancer is homozygous. BMC Cancer 2020;20(1):1038. doi:10.1186/s12885-020-07537-2
  • Hino S-I, Tanji C, Nakayama K-I, Kikuchi A. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination . Mol Cell Biol 2005;25(20):9063–72. doi:10.1128/MCB.25.20.9063-9072.2005
  • Lu B, Green BA, Farr JM, Lopes FC, Van Raay TJ. Wnt drug discovery: weaving through the screens, patents and clinical trials. Cancers 2016;8(9):82. doi:10.3390/cancers8090082
  • Yamada Y, Mori H. Multistep carcinogenesis of the colon in Apc(Min/+) mouse. Cancer Sci 2007;98(1):6–10. doi:10.1111/j.1349-7006.2006.00348.x
  • Vermeulen L, De Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 2010;12(5):468–76. doi:10.1038/ncb2048
  • Park CH, Chang JY, Hahm ER, Park S, Kim H-K, Yang CH. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun 2005;328(1):227–34. doi:10.1016/j.bbrc.2004.12.151
  • Shan BE, Wang MX, Li RQ. Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway . Cancer Invest 2009;27(6):604–12. doi:10.1080/07357900802337191