Pro-Oxidant and Cytotoxic Effects of Tucum-Do-Cerrado (Bactris setosa Mart.) Extracts in Colorectal Adenocarcinoma Caco-2 Cells

References

• WHO. 2018. Cancer. [accessed 2021 Jun 1]. https://www.who.int/news-room/fact-sheets/detail/cancer.
   Google Scholar
• Negri E, La Vecchia C, Franceschi S, D’Avanzo B, Talamini R, Parpinel M, Ferraroni M, Filiberti R, Montella M, Falcini F, et al. Intake of selected micronutrients and the risk of breast cancer. Int. J. Cancer. 1996;65(2):140–144. doi:10.1002/(SICI)1097-0215(19960117)65:2 < 140::AID-IJC3 > 3.0.CO;2-Z
   PubMed Web of Science ®Google Scholar
• Corrêa Lima MP, Gomes-Da-Silva MHG. Colorectal cancer: lifestyle and dietary factors. Nutr Hosp. 2005;20(4):235–241.
   PubMedGoogle Scholar
• Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology. 2010;138(6):2029–2043.e10. doi:10.1053/j.gastro.2010.01.057
   PubMed Web of Science ®Google Scholar
• Cho YA, Lee J, Oh JH, Chang HJ, Sohn DK, Shin A, Kim J. Genetic risk score, combined lifestyle factors and risk of colorectal cancer. Cancer Res Treat. 2019;51(3):1033–1040. doi:10.4143/crt.2018.447
   PubMed Web of Science ®Google Scholar
• Duthie GG, Duthie SJ, Kyle JAM. Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants. Nutr Res Rev. 2000;13(1):79–106. doi:10.1079/095442200108729016
   PubMed Web of Science ®Google Scholar
• Mileo AM, Miccadei S. Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies. Oxid Med Cell Longev. 2016;2016:6475624. doi:10.1155/2016/6475624
   PubMed Web of Science ®Google Scholar
• León-González AJ, Auger C, Schini-Kerth VB. Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy. Biochem Pharmacol. 2015;98(3):371–380. doi:10.1016/j.bcp.2015.07.017
   PubMed Web of Science ®Google Scholar
• Bhat SH, Azmi AS, Hadi SM. Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties. Toxicol Appl Pharmacol. 2007;218(3):249–255. doi:10.1016/j.taap.2006.11.022
   PubMed Web of Science ®Google Scholar
• Jiricny J, Marra G. DNA repair defects in colon cancer. Curr Opin Genet Dev. 2003;13(1):61–69. doi:10.1016/S0959-437X(03)00004-2
   PubMed Web of Science ®Google Scholar
• Fang MZ, Wang Y, Ai N, Hou Z, Sun Y, Lu H, Welsh W, Yang CS. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res. 2003;63(22):7563–7570.
   PubMed Web of Science ®Google Scholar
• Gao K, Henning SM, Niu Y, Youssefian AA, Seeram NP, Xu A, Heber D. The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells. J Nutr Biochem. 2006;17(2):89–95. doi:10.1016/j.jnutbio.2005.05.009
   PubMed Web of Science ®Google Scholar
• Siqueira EMdA, Rosa FR, Fustinoni AM, de Sant’Ana LP, Arruda SF. Brazilian savanna fruits contain higher bioactive compounds content and higher antioxidant activity relative to the conventional red delicious apple. PLoS One. 2013;8(8):e72826–8. doi:10.1371/journal.pone.0072826
   PubMed Web of Science ®Google Scholar
• Boeing JS, Ribeiro D, Chisté RC, Visentainer JV, Costa VM, Freitas M, Fernandes E. Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress. Food Chem. 2017;220:427–437. doi:10.1016/j.foodchem.2016.09.188
   PubMed Web of Science ®Google Scholar
• Rosa FR, Arruda AF, Siqueira EMA, Arruda SF . Phytochemical compounds and antioxidant capacity of tucum-do-cerrado (Bactris setosa mart), Brazil’s Native Fruit. Nutrients. 2016;8(3):110. doi:10.3390/nu8030110
   PubMed Web of Science ®Google Scholar
• Fustinoni-Reis AM, Arruda SF, Dourado LPS, da Cunha MSB, Siqueira EMA. Tucum-do-cerrado (Bactris setosa mart.) consumption modulates iron homeostasis and prevents iron-induced oxidative stress in the Rat Liver. Nutrients. 2016;8(2):38. doi:10.3390/nu8020038
   PubMed Web of Science ®Google Scholar
• Heibel AB, da Cunha MdS, Ferraz CTS, Arruda SF. Tucum-do-cerrado (Bactris setosa Mart.) may enhance hepatic glucose response by suppressing gluconeogenesis and upregulating Slc2a2 via AMPK pathway, even in a moderate iron supplementation condition. Food Res Int. 2018;113:433–442. doi:10.1016/j.foodres.2018.07.032
   PubMed Web of Science ®Google Scholar
• da Cunha M, Arruda S. Tucum-do-cerrado (Bactris setosa Mart.) may promote anti-aging effect by upregulating SIRT1-Nrf2 pathway and attenuating oxidative stress and inflammation. Nutrients. 2017;9(11):1243. doi:10.3390/nu9111243
   Web of Science ®Google Scholar
• Sambuy Y, De Angelis I, Ranaldi G, Scarino ML, Stammati A, Zucco F . The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol Toxicol. 2005;21(1):1–26. doi:10.1007/s10565-005-0085-6
   PubMed Web of Science ®Google Scholar
• Gonçalves AC, Rodrigues M, Santos AO, Alves G, Silva LR. Antioxidant status, antidiabetic properties and effects on Caco-2 cells of colored and non-colored enriched extracts of sweet cherry fruits. Nutrients. 2018;10(11):1688. doi:10.3390/nu10111688
   Web of Science ®Google Scholar
• Matusiewicz M, Bączek KB, Kosieradzka I, Niemiec T, Grodzik M, Szczepaniak J, Orlińska S, Węglarz Z. Effect of juice and extracts from Saposhnikovia divaricata root on the colon cancer cells Caco-2. IJMS. 2019;20(18):4526. doi:10.3390/ijms20184526
   Google Scholar
• Boulaaba M, Mkadmini K, Tsolmon S, Han J, Smaoui A, Kawada K, Ksouri R, Isoda H, Abdelly C. In vitro antiproliferative effect of arthrocnemum indicum extracts on CACO-2 cancer cells through cell cycle control and related phenol LC-TOF-MS identification. Evid Based Complement Alternat Med. 2013;2013:529375. doi:10.1155/2013/529375
   PubMed Web of Science ®Google Scholar
• Engelbrecht A-M, Mattheyse M, Ellis B, Loos B, Thomas M, Smith R, Peters S, Smith C, Myburgh K. Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett. 2007;258(1):144–153. doi:10.1016/j.canlet.2007.08.020
   PubMed Web of Science ®Google Scholar
• Atsumi T, Fujisawa S, Tonosaki K. A comparative study of the antioxidant/prooxidant activities of eugenol and isoeugenol with various concentrations and oxidation conditions. Toxicol in Vitro. 2005;19(8):1025–1033. doi:10.1016/j.tiv.2005.04.012
   PubMed Web of Science ®Google Scholar
• Sani HA, Rahmat A, Ismail M, Rosli R, Endrini S. Potential anticancer effect of red spinach (Amaranthus gangeticus) extract. Asia Pac J Clin Nutr. 2004;13:396–400. doi:10.1111/(ISSN)1440-6047/
   PubMed Web of Science ®Google Scholar
• Silva AM, Martins-Gomes C, Fangueiro JF, Andreani T, Souto EB. Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines. Pharm Dev Technol. 2019;24(10):1243–1249. doi:10.1080/10837450.2019.1658774
   PubMed Web of Science ®Google Scholar
• Yu Y, Deng Y, Lu BM, Liu YX, Li J, Bao JK. Green tea catechins: a fresh flavor to anticancer therapy. Apoptosis. 2014;19(1):1–18. doi:10.1007/s10495-013-0908-5
   PubMed Web of Science ®Google Scholar
• Shih PH, Yeh CT, Yen GC. Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. Food Chem Toxicol. 2005;43(10):1557–1566. doi:10.1016/j.fct.2005.05.001
   PubMed Web of Science ®Google Scholar
• Zhang Y, Vareed SK, Nair MG. Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sci. 2005;76(13):1465–1472. doi:10.1016/j.lfs.2004.08.025
   PubMed Web of Science ®Google Scholar
• Moore J, Yousef M, Tsiani E. Anticancer effects of rosemary (Rosmarinus officinalis L.) extract and rosemary extract polyphenols. Nutrients. 2016;8(11):731. doi:10.3390/nu8110731
   PubMed Web of Science ®Google Scholar
• Stevens JF, Revel JS, Maier CS. Mitochondria-centric review of polyphenol bioactivity in cancer models. Antioxid Redox Signal. 2018;29(16):1589–1611. doi:10.1089/ars.2017.7404
   PubMed Web of Science ®Google Scholar
• Hornik P, Milde D, Trenz Z, Vysloužil K, Stužka V. Colon tissue concentrations of copper, iron, selenium, and zinc in colorectal carcinoma patients. Chem Pap. 2006;60:297–301. doi:10.2478/s11696-006-0052-6
   Web of Science ®Google Scholar
• Sutton HC, Winterbourn CC. On the participation of higher oxidation states of iron and copper in fenton reactions. Free Radic Biol Med. 1989;6(1):53–60. doi:10.1016/0891-5849(89)90160-3
   PubMed Web of Science ®Google Scholar
• Ahmad A, Syed FA, Singh S, Hadi SM. Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid DNA. Toxicol Lett. 2005;159(1):1–12. doi:10.1016/j.toxlet.2005.04.001
   PubMed Web of Science ®Google Scholar
• Lambert JD, E RJ. The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys. 2010;501(1):65–72. doi:10.1016/j.abb.2010.06.013
   PubMed Web of Science ®Google Scholar
• Elbling L, Weiss R-M, Teufelhofer O, Uhl M, Knasmueller S, Schulte-Hermann R, Berger W, Micksche M. Green tea extract and (−)‐epigallocatechin‐3‐gallate, the major tea catechin, exert oxidant but lack antioxidant activities. FASEB J. 2005;19(7):1–26. doi:10.1096/fj.04-2915fje
   PubMedGoogle Scholar
• Forester SC, Lambert JD . The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Mol Nutr Food Res. 2011;55(6):844–854. doi:10.1002/mnfr.201000641
   PubMed Web of Science ®Google Scholar
• Oikawa S, Furukawa A, Asada H, Hirakawa K, Kawanishi S. Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species. Free Radic Res. 2003;37(8):881–890. doi:10.1080/1071576031000150751
   PubMed Web of Science ®Google Scholar
• Mármol I, Jiménez-Moreno N, Ancín-Azpilicueta C, Osada J, Cerrada E, Rodríguez-Yoldi MJ. A combination of Rosa canina extracts and gold complex favors apoptosis of caco-2 cells by increasing oxidative stress and mitochondrial dysfunction. Antioxidants. 2019;9(1):17–2. doi:10.3390/antiox9010017
   Web of Science ®Google Scholar
• Jiménez S, Gascón S, Luquin A, Laguna M, Ancin-Azpilicueta C, Rodríguez-Yoldi MJ. Rosa canina extracts have antiproliferative and antioxidant effects on Caco-2 human colon cancer. PLoS One. 2016;11(7):e0159136–14. doi:10.1371/journal.pone.0159136
   PubMed Web of Science ®Google Scholar
• Ho IYM, Abdul Aziz A, Mat Junit S. Evaluation of anti-proliferative effects of barringtonia racemosa and gallic acid on Caco-2 cells. Sci Rep. 2020;10(1):1–13. doi:10.1038/s41598-020-66913-x
   PubMed Web of Science ®Google Scholar
• Nallathambi R, Poulev A, Zuk JB, R I. Proanthocyanidin-rich grape seed extract reduces inflammation and oxidative stress and restores tight junction barrier function in Caco-2 colon cells. Nutrients. 2020;12(6):1623. doi:10.3390/nu12061623
   PubMed Web of Science ®Google Scholar
• Aherne SA, Kerry JP, O’Brien NM. Effects of plant extracts on antioxidant status and oxidant-induced stress in Caco-2 cells. Br J Nutr. 2007;97(2):321–328. doi:10.1017/S0007114507250469
   PubMed Web of Science ®Google Scholar
• Ma Q. Role of Nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 2013;53:401–426. doi:10.1146/annurev-pharmtox-011112-140320
   PubMed Web of Science ®Google Scholar
• Hayes JD, Dinkova-Kostova AT. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci. 2014;39(4):199–218. doi:10.1016/j.tibs.2014.02.002
   PubMed Web of Science ®Google Scholar
• Schmidt HHHW, Stocker R, Vollbracht C, Paulsen G, Riley D, Daiber A, Cuadrado A. Antioxidants in translational medicine. Antioxid Redox Signal. 2015;23(14):1130–1143. doi:10.1089/ars.2015.6393
   PubMed Web of Science ®Google Scholar
• Huang Y, Li W, Su Z y, Kong ANT. The complexity of the Nrf2 pathway: beyond the antioxidant response. J Nutr Biochem. 2015;26(12):1401–1413. doi:10.1016/j.jnutbio.2015.08.001
   PubMed Web of Science ®Google Scholar
• Chen G, Gharib TG, Huang C-C, Taylor JM, Misek DE, Kardia SL, Giordano TJ, Iannettoni MD, Orringer MB, Hanash SM, et al. Discordant protein and mRNA expression in lung adenocarcinomas. Mol Cell Proteomics. 2002;1(4):304–313. doi:10.1074/mcp.M200008-MCP200
   PubMed Web of Science ®Google Scholar
• Kweon MH, Adhami VM, Lee JS, Mukhtar H. Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate. J Biol Chem. 2006;281(44):33761–33772. doi:10.1074/jbc.M604748200
   PubMed Web of Science ®Google Scholar
• Ratcliffe PJ, O’Rourke JF, Maxwell PH, Pugh CW. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J Exp Biol. 1998;201(Pt 8):1153–1162. doi:10.1242/jeb.201.8.1153
   PubMed Web of Science ®Google Scholar
• Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A. 1998;95(20):11715–11720. doi:10.1073/pnas.95.20.11715
   PubMed Web of Science ®Google Scholar
• Chandel SN, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM. Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell. 2001;12:323–337. doi:10.1091/mbc.12.2.323
   PubMed Web of Science ®Google Scholar
• Chandel NS, McClintock DS, Feliciano CE, W TM, Melendez JA, Rodriguez AM, S PT . Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem. 2000;275(33):25130–25138. doi:10.1074/jbc.M001914200
   PubMed Web of Science ®Google Scholar
• Brunelle JK, Bell EL, Quesada NM, Vercauteren K, Tiranti V, Zeviani M, Scarpulla RC, Chandel NS. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab. 2005;1(6):409–414. doi:10.1016/j.cmet.2005.05.002
   PubMed Web of Science ®Google Scholar
• Pryor WA, Squadrito GL. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol. 1995;268(5 Pt 1):L699–L722. doi:10.1152/ajplung.1995.268.5.L699
   PubMedGoogle Scholar
• Xi X, Wang J, Qin Y, You Y, Huang W, Zhan J. The biphasic effect of flavonoids on oxidative stress and cellproliferation in breast cancer cells. Antioxidants. 2022;11(4):622. doi:10.3390/antiox11040622
   Web of Science ®Google Scholar