288
Views
0
CrossRef citations to date
0
Altmetric
Articles

Proton Pump Inhibitor Use and Obesity-Associated Cancer in the Women’s Health Initiative

, , , , , , , , , , , , & show all
Pages 265-275 | Received 06 May 2022, Accepted 28 Jul 2022, Published online: 13 Aug 2022

References

  • Sung H, Siegel RL, Torre LA, Pearson-Stuttard J, Islami F, Fedewa SA, Goding Sauer A, Shuval K, Gapstur SM, Jacobs EJ, et al. Global patterns in excess body weight and the associated cancer burden. CA Cancer J Clin. 2019;69(2):88–112.
  • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348(17):1625–38. doi:10.1056/NEJMoa021423
  • Kwan ML, Chen WY, Kroenke CH, Weltzien EK, Beasley JM, Nechuta SJ, Poole EM, Lu W, Holmes MD, Quesenberry CP, Jr., et al. Pre-diagnosis body mass index and survival after breast cancer in the After Breast Cancer Pooling Project. Breast Cancer Res Treat. 2012;132(2):729–39. doi:10.1007/s10549-011-1914-3
  • Schmitz KH, Neuhouser ML, Agurs-Collins T, Zanetti KA, Cadmus-Bertram L, Dean LT, Drake BF. Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity. J Natl Cancer Inst. 2013;105(18):1344–54. doi:10.1093/jnci/djt223
  • Prizment AE, Flood A, Anderson KE, Folsom AR. Survival of women with colon cancer in relation to precancer anthropometric characteristics: the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2010;19(9):2229–37. doi:10.1158/1055-9965.EPI-10-0522
  • McTiernan A, Friedenreich CM, Katzmarzyk PT, Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B, Tennant B, Vaux-Bjerke A, 2018 Physical Activity Guidelines Advisory Committee*, et al. Physical activity in cancer prevention and survival: a systematic review. Med Sci Sports Exerc. 2019;51(6):1252–61. doi:10.1249/MSS.0000000000001937
  • Liu H, Liu JY, Wu X, Zhang JT. Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker. Int J Biochem Mol Biol. 2010;1(1):69–89.
  • Lenhard JM. Lipogenic enzymes as therapeutic targets for obesity and diabetes. Curr Pharm Des. 2011;17(4):325–31.
  • Boizard M, Le Liepvre X, Lemarchand P, Foufelle F, Ferre P, Dugail I. Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. J Biol Chem. 1998;273(44):29164–71. doi:10.1074/jbc.273.44.29164
  • Kusunoki J, Kanatani A, Moller DE. Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. ENDO. 2006;29(1):91–100. doi:10.1385/ENDO:29:1:91
  • Kusakabe T, Maeda M, Hoshi N, Sugino T, Watanabe K, Fukuda T, Suzuki T. Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells. J Histochem Cytochem. 2000;48(5):613–22. doi:10.1177/002215540004800505
  • Montesdeoca N, Lopez M, Ariza X, Herrero L, Makowski K. Inhibitors of lipogenic enzymes as a potential therapy against cancer. Faseb J. 2020;34(9):11355–81. doi:10.1096/fj.202000705R
  • Chajes V, Cambot M, Moreau K, Lenoir GM, Joulin V. Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Cancer Res. 2006;66(10):5287–94. doi:10.1158/0008-5472.CAN-05-1489
  • Liu H, Liu Y, Zhang JT. A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction. Mol Cancer Ther. 2008;7(2):263–70. doi:10.1158/1535-7163.MCT-07-0445
  • Fhu CW, Ali A. Fatty acid synthase: An emerging target in cancer. Molecules. 2020;25(17):3935. doi:10.3390/molecules25173935
  • Porta R, Blancafort A, Casoliva G, Casas M, Dorca J, Buxo M, Vinas G, Oliveras G, Puig T. Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients. Menopause. 2014;21(2):188–91. doi:10.1097/GME.0b013e31829d17dc
  • Kuhajda FP, Piantadosi S, Pasternack GR. Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease. N Engl J Med. 1989;321(10):636–41. doi:10.1056/NEJM198909073211003
  • Alo PL, Visca P, Marci A, Mangoni A, Botti C, Di Tondo U. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer. 1996;77(3):474–82. doi:10.1002/(SICI)1097-0142(19960201)77:3<474::AID-CNCR8>3.0.CO;2-K
  • Giro-Perafita A, Sarrats A, Perez-Bueno F, Oliveras G, Buxo M, Brunet J, Vinas G, Miquel TP. Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer. Oncotarget. 2017;8(43):74391–405. doi:10.18632/oncotarget.20152
  • Ogino S, Nosho K, Meyerhardt JA, Kirkner GJ, Chan AT, Kawasaki T, Giovannucci EL, Loda M, Fuchs CS. Cohort study of fatty acid synthase expression and patient survival in colon cancer. JCO. 2008;26(35):5713–20. doi:10.1200/JCO.2008.18.2675
  • Wysham WZ, Roque DR, Han J, Zhang L, Guo H, Gehrig PA, Zhou C, Bae-Jump VL. Effects of fatty acid synthase inhibition by Orlistat on proliferation of endometrial cancer cell lines. Target Oncol. 2016;11(6):763–9. doi: 10.1007/s11523-016-0442-9. PMID: 27188391.
  • Fako VE, Wu X, Pflug B, Liu JY, Zhang JT. Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase. J Med Chem. 2015;58(2):778–84. doi:10.1021/jm501543u
  • Madka V, Kumar G, Pathuri G, Panneerselvam J, Zhang Y, Ganta V, Lightfoot S, Lubet R, Suen CS, Steele VE, et al. Proton pump inhibitor omeprazole suppresses carcinogen-induced colonic adenoma progression to adenocarcinoma in F344 rat. Cancer Prev Res (Phila). 2021;14(11):1009–20.
  • Halfdanarson OO, Fall K, Ogmundsdottir MH, Lund SH, Steingrimsson E, Ogmundsdottir HM, Zoega H. Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanoma: an Icelandic population-based case-control study. Pharmacoepidemiol Drug Saf. 2019;28(4):471–8. doi:10.1002/pds.4702
  • Song HJ, Jeon N, Squires P. The association between acid-suppressive agent use and the risk of cancer: a systematic review and meta-analysis. Eur J Clin Pharmacol. 2020;76(10):1437–56. doi:10.1007/s00228-020-02927-8
  • Hwang IC, Chang J, Park SM. Emerging hazard effects of proton pump inhibitor on the risk of colorectal cancer in low-risk populations: A Korean nationwide prospective cohort study. PLoS One. 2017;12(12):e0189114. doi:10.1371/journal.pone.0189114
  • Group TWsHIS Design of the women's health initiative clinical trial and observational study. The Women's Health Initiative Study Group. Control Clin Trials. 1998;19(1):61–109.
  • Anderson GL, Manson J, Wallace R, Lund B, Hall D, Davis S, Shumaker S, Wang CY, Stein E, Prentice RL. Implementation of the women's health initiative study design. Ann Epidemiol. 2003;13(9 Suppl):S5–S17. doi:10.1016/S1047-2797(03)00043-7
  • Sardesai SD, Thomas A, Gallagher C, Lynce F, Ottaviano YL, Ballinger TJ, Schneider BP, Storniolo AM, Bauchle A, Althouse SK, et al. Inhibiting fatty acid synthase with omeprazole to improve efficacy of neoadjuvant chemotherapy in patients with operable TNBC. Clin Cancer Res. 2021;27(21):5810–7. doi:10.1158/1078-0432.CCR-21-0493
  • Vargas AJ, Neuhouser ML, George SM, Thomson CA, Ho GY, Rohan TE, Kato I, Nassir R, Hou L, Manson JE. Diet quality and colorectal cancer risk in the women's health initiative observational study. Am J Epidemiol. 2016;184(1):23–32. doi:10.1093/aje/kwv304
  • Patlolla JM, Zhang Y, Li Q, Steele VE, Rao CV. Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats. Int J Oncol. 2012;40(1):170–5.
  • Janakiram NB, Mohammed A, Patlolla JMR, Zhang Y, Biddick L, Madka V, Qian L, Lightfoot S, Dunn B, Lubet R, et al. Abstract 5260: NGS Transcriptome analysis of colon adenocarcinomas treated with individual and combination of aspirin and omeprazole. Cancer Research. 2017;77(13_Supplement):5260– doi:10.1158/1538-7445.AM2017-5260
  • Mohammed A, P JMR, Zhang Y, Biddick L, Madka V, Li Q, Lightfoot S, Lubet R, Suen CS, Steele VE, et al. Omeprazole alone, or in combination with Aspirin inhibits azoxymethane-induced colon adenoma progression to adenocarcinoma and carcinoma invasion in F344 rat model. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18–22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015. 75(15 Suppl): Abstract no. 2820. doi:10.1158/1538-7445.AM2015-2820
  • Brasky TM, Liu J, White E, Peters U, Potter JD, Walter RB, Baik CS, Lane DS, Manson JE, Vitolins MZ, et al. Non-steroidal anti-inflammatory drugs and cancer risk in women: results from the Women's Health Initiative. Int J Cancer. 2014;135(8):1869–83. doi:10.1002/ijc.28823
  • Zeng R, Cheng Y, Luo D, Wang J, Yang J, Jiang L, Zhuo Z, Guo K, Wu H, Leung FW, et al. Comprehensive analysis of proton pump inhibitors and risk of digestive tract cancers. Eur J Cancer. 2021;156:190–201. doi:10.1016/j.ejca.2021.07.030
  • Singh S, Karthikeyan C, Moorthy N. Recent advances in the development of fatty acid synthase inhibitors as anticancer agents. Mini Rev Med Chem. 2020;20(18):1820–37. doi:10.2174/1389557520666200811100845
  • Jin UH, Lee SO, Pfent C, Safe S. The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis. BMC Cancer. 2014;14:498. doi:10.1186/1471-2407-14-498
  • He J, Shi XY, Li ZM, Pan XH, Li ZL, Chen Y, Yan SJ, Xiao L. Proton pump inhibitors can reverse the YAP mediated paclitaxel resistance in epithelial ovarian cancer. BMC Mol Cell Biol. 2019;20(1):49.
  • Song T, Jeon HK, Hong JE, Choi JJ, Kim TJ, Choi CH, Bae DS, Kim BG, Lee JW. Proton pump inhibition enhances the cytotoxicity of paclitaxel in cervical cancer. Cancer Res Treat. 2017;49(3):595–606. doi:10.4143/crt.2016.034
  • Chen CH, Lee CZ, Lin YC, Kao LT, Lin HC. Negative association of proton pump inhibitors with subsequent development of breast cancer: A nationwide population-based study. J Clin Pharmacol. 2019;59(3):350–5. doi:10.1002/jcph.1329
  • Ding DC, Sung FC, Chen W, Wang JH, Lin SZ. Proton pump inhibitors reduce breast cancer risk in gastric ulcer patients: A population-based cohort study. Breast J. 2020;26(3):474–8. doi:10.1111/tbj.13519
  • Wang CJ, Li D, Danielson JA, Zhang EH, Dong Z, Miller KD, Li L, Zhang JT, Liu JY. Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting ­fatty acid synthase. Cancer Lett. 2021;509:1–12. doi:10.1016/j.canlet.2021.03.026
  • Goedert JJ, Jones G, Hua X, Xu X, Yu G, Flores R, Falk RT, Gail MH, Shi J, Ravel J, et al. Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study. J Natl Cancer Inst. 2015;107(8). doi:10.1093/jnci/djv147
  • Soto-Pantoja DR, Gaber M, Arnone AA, Bronson SM, Cruz-Diaz N, Wilson AS, Clear KYJ, Ramirez MU, Kucera GL, Levine EA, et al. Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis. Cancer Res. 2021;81(14):3890–904. doi:10.1158/0008-5472.CAN-20-2983
  • Dacha S, Razvi M, Massaad J, Cai Q, Wehbi M. Hypergastrinemia. Gastroenterol Rep (Oxf). 2015;3(3):201–8. doi:10.1093/gastro/gov004
  • Babic A, Zhang X, Morales-Oyarvide V, Yuan C, Khalaf N, Khalili H, Lochhead P, Chan AT, Ogino S, Wolpin BM, et al. Acid-suppressive medications and risk of colorectal cancer: results from three large prospective cohort studies. Br J Cancer. 2020;123(5):844–51. doi:10.1038/s41416-020-0939-y
  • Zuo Y, Jing Z, Bie M, Xu C, Hao X, Wang B. Association between Helicobacter pylori infection and the risk of colorectal cancer: a systematic review and meta-analysis. Medicine (Baltimore). ) 2020;99(37):e21832. doi:10.1097/MD.0000000000021832
  • Kantor ED, Rehm CD, Haas JS, Chan AT, Giovannucci EL. Trends in prescription drug use among adults in the United States from 1999-2012. JAMA. 2015;314(17):1818–31. doi:10.1001/jama.2015.13766
  • Menendez JA, Lupu R. Fatty acid synthase (FASN) as a therapeutic target in breast cancer. Expert Opin Ther Targets. 2017;21(11):1001–16. doi:10.1080/14728222.2017.1381087
  • Cuzick J, Thorat MA, Bosetti C, Brown PH, Burn J, Cook NR, Ford LG, Jacobs EJ, Jankowski JA, La Vecchia C, et al. Estimates of benefits and harms of prophylactic use of aspirin in the general population. Ann Oncol. 2015;26(1):47–57. doi:10.1093/annonc/mdu225

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.