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Articles

Ultra-Processed Food Intake and Risk of Colorectal Cancer: A Matched Case-Control Study

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Pages 532-541 | Received 13 Jun 2022, Accepted 14 Sep 2022, Published online: 03 Oct 2022

References

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin. 2021;71(3):209–49. doi:10.3322/caac.21660
  • Thanikachalam K, Khan G. Colorectal cancer and nutrition. Nutrients. 2019;11(1):164. doi:10.3390/nu11010164
  • Safiri S, Sepanlou SG, Ikuta KS, Bisignano C, Salimzadeh H, Delavari A, Ansari R, Roshandel G, Merat S, Fitzmaurice C, et al. The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2019;4(12):913–33.
  • Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, Jemal A. Colorectal cancer statistics, 2017. CA: a Cancer Journal for Clinicians. 2017;67(3):177–93. doi:10.3322/caac.21395
  • Bailey CE, Hu C-Y, You YN, Bednarski BK, Rodriguez-Bigas MA, Skibber JM, Cantor SB, Chang GJ. Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975–2010. JAMA Surg. 2015;150(1):17–22. doi:10.1001/jamasurg.2014.1756
  • Center MM, Jemal A, Smith RA, Ward E. Worldwide variations in colorectal cancer. CA Cancer J Clin. 2009;59(6):366–78. doi:10.3322/caac.20038
  • La Vecchia C, Bosetti C, Lucchini F, Bertuccio P, Negri E, Boyle P, Levi F. Cancer mortality in Europe, 2000–2004, and an overview of trends since 1975. Ann Oncol. 2010;21(6):1323–60. doi:10.1093/annonc/mdp530
  • Mentella MC, Scaldaferri F, Ricci C, Gasbarrini A, Miggiano GAD. Cancer and Mediterranean diet: a review. Nutrients. 2019;11(9):2059. doi:10.3390/nu11092059
  • Clinton SK, Giovannucci EL, Hursting SD. The world cancer research fund/American institute for cancer research third expert report on diet, nutrition, physical activity, and cancer: impact and future directions. J Nutr. 2020;150(4):663–71. doi:10.1093/jn/nxz268
  • Centers for Disease Control and Prevention. National health and nutrition examination survey (nhanes): anthropometry procedures manual. Centers for Disease Control and Prevention; 2004. Available from: https://www.cdc.gov/nchs/data/nhanes/nhanes_03_04/bm.pdf.
  • Gibney MJ, Forde CG. Nutrition research challenges for processed food and health. Nat Food. 2022;3(2):104–9. doi:10.1038/s43016-021-00457-9
  • Zhang Y, Giovannucci EL. Ultra-processed foods and health: a comprehensive review. Crit Rev Food Sci Nutr. 2022;6:1–13. doi:10.1080/10408398.2022.2084359
  • Monteiro CA, Cannon G, Moubarac J-C, Levy RB, Louzada MLC, Jaime PC. The UN decade of nutrition, the NOVA food classification and the trouble with ultra-processing. Public Health Nutr. 2018;21(1):5–17. doi:10.1017/S1368980017000234
  • Monteiro CA, Cannon G, Levy RB, Moubarac J-C, Louzada ML, Rauber F, Khandpur N, Cediel G, Neri D, Martinez-Steele E, et al. Ultra-processed foods: what they are and how to identify them. Public Health Nutr. 2019;22(5):936–41. doi:10.1017/S1368980018003762
  • Poti JM, Braga B, Qin B. Ultra-processed food intake and obesity: what really matters for health—processing or nutrient content? Curr Obes Rep. 2017;6(4):420–31. doi:10.1007/s13679-017-0285-4
  • da Costa Louzada ML, Ricardo CZ, Steele EM, Levy RB, Cannon G, Monteiro CA. The share of ultra-processed foods determines the overall nutritional quality of diets in Brazil. Public Health Nutr. 2018;21(1):94–102. doi:10.1017/S1368980017001434
  • Scrinis G, Monteiro CA. Ultra-processed foods and the limits of product reformulation. Public Health Nutr. 2018;21(1):247–52. doi:10.1017/S1368980017001392
  • Martínez Steele E, Popkin BM, Swinburn B, Monteiro CA. The share of ultra-processed foods and the overall nutritional quality of diets in the US: evidence from a nationally representative cross-sectional study. Popul Health Metr. 2017;15(1):6–11. doi:10.1186/s12963-017-0119-3
  • Monteiro CA, Moubarac JC, Cannon G, Ng SW, Popkin B. Ultra‐processed products are becoming dominant in the global food system. Obes Rev. 2013;14:21–8. doi:10.1111/obr.12107
  • Machado PP, Steele EM, Levy RB, Sui Z, Rangan A, Woods J, Gill T, Scrinis G, Monteiro CA. Ultra-processed foods and recommended intake levels of nutrients linked to non-communicable diseases in Australia: evidence from a nationally representative cross-sectional study. BMJ Open. 2019;9(8):e029544. doi:10.1136/bmjopen-2019-029544
  • Steele EM, Baraldi LG, da Costa Louzada ML, Moubarac J-C, Mozaffarian D, Monteiro CA. Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative cross-sectional study. BMJ Open. 2016;6(3):e009892. doi:10.1136/bmjopen-2015-009892
  • Cediel G, Reyes M, da Costa Louzada ML, Martinez Steele E, Monteiro CA, Corvalán C, Uauy R. Ultra-processed foods and added sugars in the Chilean diet. Public Health Nutr. 2018;21(1):125–33. 2018
  • Marrón-Ponce JA, Sánchez-Pimienta TG, da Costa Louzada ML, Batis C. Energy contribution of NOVA food groups and sociodemographic determinants of ultra-processed food consumption in the Mexican population. Public Health Nutr. 2018;21(1):87–93. doi:10.1017/S1368980017002129
  • Marrón-Ponce JA, Tolentino-Mayo L, Hernández-F M, Batis C. Trends in ultra-processed food purchases from 1984 to 2016 in Mexican households. Nutrients. 2018;11(1):45. doi:10.3390/nu11010045
  • Juul F, Hemmingsson E. Trends in consumption of ultra-processed foods and obesity in Sweden between 1960 and 2010. Public Health Nutr. 2015;18(17):3096–107. doi:10.1017/S1368980015000506
  • Martinez-Perez N, Arroyo-Izaga M. Availability, nutritional profile and processing level of food products sold in vending machines in a Spanish public university. Int J Environ Res Public Health. 2021;18(13):6842.
  • Canhada SL, Luft VC, Giatti L, Duncan BB, Chor D, Fonseca MdJMd, Matos SMA, Molina MdCB, Barreto SM, Levy RB, et al. Ultra-processed foods, incident overweight and obesity, and longitudinal changes in weight and waist circumference: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Public Health Nutr. 2020;23(6):1076–86. doi:10.1017/S1368980019002854
  • Nardocci M, Leclerc B-S, Louzada M-L, Monteiro CA, Batal M, Moubarac J-C. Consumption of ultra-processed foods and obesity in Canada. Can J Public Health. 2019;110(1):4–14. doi:10.17269/s41997-018-0130-x
  • Steele EM, Juul F, Neri D, Rauber F, Monteiro CA. Dietary share of ultra-processed foods and metabolic syndrome in the US adult population. Prev Med. 2019;125:40–8. doi:10.1016/j.ypmed.2019.05.004
  • Srour B, Fezeu LK, Kesse-Guyot E, Allès B, Debras C, Druesne-Pecollo N, Chazelas E, Deschasaux M, Hercberg S, Galan P, et al. Ultraprocessed food consumption and risk of type 2 diabetes among participants of the NutriNet-Santé prospective cohort. JAMA Intern Med. 2020;180(2):283–91. doi:10.1001/jamainternmed.2019.5942
  • Srour B, Fezeu LK, Kesse-Guyot E, Allès B, Méjean C, Andrianasolo RM, Chazelas E, Deschasaux M, Hercberg S, Galan P, et al. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé). BMJ. 2019;365:l1451. doi:10.1136/bmj.l1451
  • Rauber F, Campagnolo PDB, Hoffman DJ, Vitolo MR. Consumption of ultra-processed food products and its effects on children’s lipid profiles: a longitudinal study. Nutr Metab Cardiovasc Dis. 2015;25(1):116–22. doi:10.1016/j.numecd.2014.08.001
  • Mendonça R, Lopes ACS, Pimenta AM, Gea A, Martinez-Gonzalez MA, Bes-Rastrollo M. Ultra-processed food consumption and the incidence of hypertension in a Mediterranean cohort: the Seguimiento Universidad de Navarra Project. Am J Hypertens. 2017;30(4):358–66.
  • Fiolet T, Srour B, Sellem L, Kesse-Guyot E, Allès B, Méjean C, Deschasaux M, Fassier P, Latino-Martel P, Beslay M, et al. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. BMJ. 2018;360:k322. doi:10.1136/bmj.k322
  • Blanco-Rojo R, Sandoval-Insausti H, López-Garcia E, Graciani A, Ordovás JM, Banegas JR, Rodríguez-Artalejo F, Guallar-Castillón P. Consumption of ultra-processed foods and mortality: a national prospective cohort in Spain. Mayo Clin Proc. 2019;94(11):2178–88. doi:10.1016/j.mayocp.2019.03.035
  • Rico-Campà A, Martínez-González MA, Alvarez-Alvarez I, Mendonça RdD, de la Fuente-Arrillaga C, Gómez-Donoso C, Bes-Rastrollo M. Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study. BMJ. 2019;365:l1949. doi:10.1136/bmj.l1949
  • Marrón-Ponce JA, Flores M, Cediel G, Monteiro CA, Batis C. Associations between consumption of ultra-processed foods and intake of nutrients related to chronic non-communicable diseases in Mexico. J Acad Nutr Diet. 2019;119(11):1852–65. doi:10.1016/j.jand.2019.04.020
  • Romaguera D, Fernández-Barrés S, Gracia-Lavedán E, Vendrell E, Azpiri M, Ruiz-Moreno E, Martín V, Gómez-Acebo I, Obón M, Molinuevo A, et al. Consumption of ultra-processed foods and drinks and colorectal, breast, and prostate cancer. Clin Nutr. 2021;40(4):1537–45. doi:10.1016/j.clnu.2021.02.033
  • Fliss-Isakov N, Zelber-Sagi S, Ivancovsky-Wajcman D, Shibolet O, Kariv R. Ultra-processed food intake and smoking interact in relation with colorectal adenomas. Nutrients. 2020;12(11):3507. doi:10.3390/nu12113507
  • El Kinany K, Huybrechts I, Hatime Z, El Asri A, Boudouaya HA, Deoula MMS, Kampman E, El Rhazi K. Food processing groups and colorectal cancer risk in Morocco: evidence from a nationally representative case-control study. Eur J Nutr. 2022;61(5):2507–15. doi:10.1007/s00394-022-02820-3
  • Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr. 2010;13(05):654–62. doi:10.1017/S1368980009991698
  • Esfahani FH, Asghari G, Mirmiran P, Azizi F. Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the Tehran Lipid and Glucose Study. J Epidemiol. 2010;20(2):150–8. doi:10.2188/jea.je20090083
  • Ghaffarpour M, Houshiar-Rad A, Kianfar H. The manual for household measures, cooking yields factors and edible portion of foods. Tehran: Nashre Olume Keshavarzy. 1999;7(213):42–58.
  • Azar M, Sarkisian E. Food composition table of Iran: National Nutrition and food research institute. Tehran: Shaheed Beheshti University; 1980.
  • Lane KE, Davies IG, Darabi Z, Ghayour-Mobarhan M, Khayyatzadeh SS, Mazidi M. The association between ultra-processed foods, quality of life and insomnia among adolescent girls in Northeastern Iran. Int J Environ Res Public Health. 2022;19(10):6338. doi:10.3390/ijerph19106338
  • Safari A, Shariff ZM, Kandiah M, Rashidkhani B, Fereidooni F. Dietary patterns and risk of colorectal cancer in Tehran Province: a case-control study. BMC Public Health. 2013;13:222. doi:10.1186/1471-2458-13-222
  • Madden AM, Smith S. Body composition and morphological assessment of nutritional status in adults: a review of anthropometric variables. J Hum Nutr Diet. 2016;29(1):7–25. doi:10.1111/jhn.12278
  • Aadahl M, Jørgensen T. Validation of a new self-report instrument for measuring physical activity. Med Sci Sports Exerc. 2003;35(7):1196–202.
  • Luiten CM, Steenhuis IH, Eyles H, Ni Mhurchu C, Waterlander WE. Ultra-processed foods have the worst nutrient profile, yet they are the most available packaged products in a sample of New Zealand supermarkets–CORRIGENDUM. Public Health Nutr. 2016;19(3):539. doi:10.1017/S1368980015002840
  • Moubarac JC, Batal M, Louzada ML, Martinez Steele E, Monteiro CA. Consumption of ultra-processed foods predicts diet quality in Canada. Appetite. 2017;108:512–20. doi:10.1016/j.appet.2016.11.006
  • Poti JM, Mendez MA, Ng SW, Popkin BM. Is the degree of food processing and convenience linked with the nutritional quality of foods purchased by US households? Am J Clin Nutr. 2015;101(6):1251–62. doi:10.3945/ajcn.114.100925
  • Fardet A. Minimally processed foods are more satiating and less hyperglycemic than ultra-processed foods: a preliminary study with 98 ready-to-eat foods. Food Funct. 2016;7(5):2338–46. doi:10.1039/c6fo00107f
  • Mendonça RdD, Pimenta AM, Gea A, de la Fuente-Arrillaga C, Martinez-Gonzalez MA, Lopes ACS, Bes-Rastrollo M. Ultraprocessed food consumption and risk of overweight and obesity: the University of Navarra Follow-Up (SUN) cohort study. Am J Clin Nutr. 2016;104(5):1433–40. doi:10.3945/ajcn.116.135004
  • Louzada M, Martins APB, Canella DS, Baraldi LG, Levy RB, Claro RM, et al. Impact of ultra-processed foods on micronutrient content in the Brazilian diet. Rev Saude Publ. 2015;49:45.
  • Bingham SA, Hughes R, Cross AJ. Effect of white versus red meat on endogenous N-nitrosation in the human colon and further evidence of a dose response. J Nutr. 2002;132(11 Suppl):3522s–5S. doi:10.1093/jn/132.11.3522S
  • Joosen AM, Kuhnle GG, Aspinall SM, Barrow TM, Lecommandeur E, Azqueta A, Collins AR, Bingham SA. Effect of processed and red meat on endogenous nitrosation and DNA damage. Carcinogenesis. 2009;30(8):1402–7. doi:10.1093/carcin/bgp130
  • Sinha R, Rothman N, Brown ED, Mark SD, Hoover RN, Caporaso NE, et al. Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. Cancer Res. 1994;54(23):6154–9.
  • Carbon black, titanium dioxide, and talc. IARC Monogr Eval Carcinog Risks Hum. 2010;93:1–413.
  • Singh K, Ahluwalia P. Effect of monosodium glutamate on lipid peroxidation and certain antioxidant enzymes in cardiac tissue of alcoholic adult male mice. J Cardiovasc Dis Res. 2012;3(1):12–8. doi:10.4103/0975-3583.91595
  • Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L, Guha N, Mattock H, Straif K. Carcinogenicity of consumption of red and processed meat. Lancet Oncol. 2015;16(16):1599–600. doi:10.1016/S1470-2045(15)00444-1
  • Zhang Q, Bai Y, Yang Z, Tian J, Meng Z. The molecular mechanisms of sodium metabisulfite on the expression of K ATP and L-Ca2+ channels in rat hearts. Regul Toxicol Pharmacol. 2015;72(3):440–6. doi:10.1016/j.yrtph.2015.05.021
  • Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015;519(7541):92–6. doi:10.1038/nature14232
  • Martínez Leo EE, Segura Campos MR. Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases. Nutrition. 2020;71:110609. doi:10.1016/j.nut.2019.110609
  • Cuevas-Sierra A, Milagro FI, Aranaz P, Martínez JA, Riezu-Boj JI. Gut microbiota differences according to ultra-processed food consumption in a Spanish population. Nutrients. 2021;13(8):2710. doi:10.3390/nu13082710
  • Rastogi YR, Saini AK, Thakur VK, Saini RV. New insights into molecular links between microbiota and gastrointestinal cancers: a literature review. Int J Mol Sci. 2020;21(9):3212.
  • Chen J, Pitmon E, Wang K. Microbiome, inflammation and colorectal cancer. Semin Immunol. 2017;32:43–53. doi:10.1016/j.smim.2017.09.006
  • Marino M, Puppo F, Del Bo’ C, Vinelli V, Riso P, Porrini M, Martini D. A systematic review of worldwide consumption of ultra-processed foods: findings and criticisms. Nutrients. 2021;13(8):2778. doi:10.3390/nu13082778
  • Giovannucci E. Aspirin and delayed chemoprevention of colorectal cancer. Clin Chem. 2018;64(11):1668–9. doi:10.1373/clinchem.2018.290809
  • Zhang Y, Chan AT, Meyerhardt JA, Giovannucci EL. Timing of aspirin use in colorectal cancer chemoprevention: a prospective cohort study. J Natl Cancer Inst. 2021;113(7):841–51. doi:10.1093/jnci/djab009

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