Diallyl Trisulfide Suppresses the Renal Cancer Stem-like Cell Properties via Nanog

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30.
   PubMed Web of Science ®Google Scholar
• Bussolati B, Bruno S, Grange C, Ferrando U, Camussi G. Identification of a tumor-initiating stem cell population in human renal carcinomas. Faseb J. 2008;22(10):3696–3705.
   PubMed Web of Science ®Google Scholar
• Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med. 2006;355(12):1253–1261.
   PubMed Web of Science ®Google Scholar
• Collins AT, Berry PA, Hyde C, Stower MJ, Maitland NJ. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 2005;65(23):10946–10951.
   PubMed Web of Science ®Google Scholar
• Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003;100(7):3983–3988.
   PubMed Web of Science ®Google Scholar
• Peitzsch C, Tyutyunnykova A, Pantel K, Dubrovska A. Cancer stem cells: the root of tumor recurrence and metastases. Semin Cancer Biol. 2017;44:10–24.
   PubMed Web of Science ®Google Scholar
• Dawood S, Austin L, Cristofanilli M. Cancer stem cells: implications for cancer therapy. Oncology. 2014;28(12):1101–1107.
   PubMed Web of Science ®Google Scholar
• Song K-H, Choi CH, Lee H-J, Oh SJ, Woo SR, Hong S-O, Noh KH, Cho H, Chung EJ, Kim J-H, et al. HDAC1 upregulation by NANOG promotes multidrug resistance and a stem-like phenotype in immune edited tumor cells. Cancer Res. 2017;77(18):5039–5053.
   PubMed Web of Science ®Google Scholar
• Yong X, Tang B, Xiao YF, Xie R, Qin Y, Luo G, Hu CJ, Dong H, Yang SM. Helicobacter pylori upregulates Nanog and Oct4 via Wnt/beta-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer. Cancer Lett. 2016;374(2):292–303.
   PubMed Web of Science ®Google Scholar
• Yu B, Cai H, Xu Z, Xu T, Zou Q, Gu M. Expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma tissues and clinical significance. Artif Cells Nanomed Biotechnol. 2016;44(8):1818–1823.
   PubMed Web of Science ®Google Scholar
• Zhao X, Wang F, Hou M. Expression of stem cell markers Nanog and PSCA in gastric cancer and its significance. Oncol Lett. 2016;11(1):442–448.
   PubMed Web of Science ®Google Scholar
• Samy A, Shah D, Shahagadkar P, Shah H, Munirathinam G. Can diallyl trisulfide, a dietary garlic-derived compound, activate ferroptosis to overcome therapy resistance in prostate cancer? Nutr Health. 2022;28(2):207–212.
   PubMedGoogle Scholar
• Liu Y, Fu R, Tu S, Qu D, Liu C, Li X, Zhao Y, Ma C, Chen Y, Tao L. Extracellular microparticles encapsulated with diallyl trisulfide interfere with the inflammatory tumor microenvironment and Lung metastasis of invasive melanoma. Mol Pharm. 2021;18(3):822–835.
   PubMedGoogle Scholar
• Liu Y, Zhao Y, Wei Z, Tao L, Sheng X, Wang S, Chen J, Ruan J, Liu Z, Cao Y, et al. Targeting thioredoxin system with an organosulfur compound, diallyl trisulfide (DATS), attenuates progression and metastasis of triple-negative breast cancer (TNBC). Cell Physiol Biochem. 2018;50(5):1945–1963.
   PubMedGoogle Scholar
• Jiang X, Zhu X, Huang W, Xu H, Zhao Z, Li S, Li S, Cai J, Cao J. Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice. Int Immunopharmacol. 2017;48:135–145.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Li X-T, Chen Y, Chen J-Q, Zhu J-Y, Meng Y, Wang X-Q, Li Y, Geng S-S, Xie C-F, et al. Wnt/beta-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells. Cancer Chemother Pharmacol. 2018;81(6):969–977.
   PubMed Web of Science ®Google Scholar
• Qian W, Kong X, Zhang T, Wang D, Song J, Li Y, Li X, Geng H, Min J, Kong Q, et al. Cigarette smoke stimulates the stemness of renal cancer stem cells via Sonic Hedgehog pathway. Oncogenesis. 2018;7(3):24.
   PubMedGoogle Scholar
• Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, et al. Apatinib suppresses gastric cancer stem cells properties by inhibiting the sonic hedgehog pathway. Front Cell Dev Biol. 2021;9:679806.
   PubMed Web of Science ®Google Scholar
• Zhu J-Y, Yang X, Chen Y, Jiang Y, Wang S-J, Li Y, Wang X-Q, Meng Y, Zhu M-M, Ma X, et al. Curcumin suppresses lung cancer stem cells via inhibiting Wnt/beta-catenin and Sonic Hedgehog pathways. Phytother Res. 2017;31(4):680–688.
   PubMed Web of Science ®Google Scholar
• Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C. Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway. Biochem Biophys Res Commun. 2017;493(1):521–527.
   PubMed Web of Science ®Google Scholar
• Chen Y, Wang X-Q, Zhang Q, Zhu J-Y, Li Y, Xie C-F, Li X-T, Wu J-S, Geng S-S, Zhong C-Y, et al. (-)-Epigallocatechin-3-gallate inhibits colorectal cancer stem cells by suppressing Wnt/beta-catenin pathway. Nutrients. 2017;9(6):572.
   PubMed Web of Science ®Google Scholar
• Zhong Y, Guan K, Guo S, Zhou C, Wang D, Ma W, Zhang Y, Li C, Zhang S. Spheres derived from the human SK-RC-42 renal cell carcinoma cell line are enriched in cancer stem cells. Cancer Lett. 2010;299(2):150–160.
   PubMed Web of Science ®Google Scholar
• Shaheen S, Ahmed M, Lorenzi F, Nateri AS. Spheroid-formation (colonosphere) assay for in vitro assessment and expansion of stem cells in colon cancer. Stem Cell Rev Rep. 2016;12(4):492–499.
   PubMed Web of Science ®Google Scholar
• Gassenmaier M, Chen D, Buchner A, Henkel L, Schiemann M, Mack B, Schendel DJ, Zimmermann W, Pohla H. CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis. Stem Cells. 2013;31(8):1467–1476.
   PubMed Web of Science ®Google Scholar
• Ueda K, Ogasawara S, Akiba J, Nakayama M, Todoroki K, Ueda K, Sanada S, Suekane S, Noguchi M, Matsuoka K, et al. Aldehyde dehydrogenase 1 identifies cells with cancer stem cell-like properties in a human renal cell carcinoma cell line. PLoS One. 2013;8(10):e75463.
   PubMed Web of Science ®Google Scholar
• Xun J, Wang D, Shen L, Gong J, Gao R, Du L, Chang A, Song X, Xiang R, Tan X. JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity. Oncotarget. 2017;8(13):21918–21929.
   PubMedGoogle Scholar
• Guo T, Kong J, Liu Y, Li Z, Xia J, Zhang Y, Zhao S, Li F, Li J, Gu C. Transcriptional activation of NANOG by YBX1 promotes lung cancer stem-like properties and metastasis. Biochem Biophys Res Commun. 2017;487(1):153–159.
   PubMed Web of Science ®Google Scholar
• Miltonprabu S, Sumedha NC, Senthilraja P. Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway. Int Immunopharmacol. 2017;50:107–120.
   PubMed Web of Science ®Google Scholar
• Lai Y, Liang X, Zhong F, Wu W, Zeng T, Huang J, Duan X, Li S, Zeng G, Wu W. Allicin attenuates calcium oxalate crystal deposition in the rat kidney by regulating gap junction function. J Cell Physiol. 2019;234(6):9640–9651.
   PubMed Web of Science ®Google Scholar
• Wang HC, Chu YL, Hsieh SC, Sheen LY. Diallyl trisulfide inhibits cell migration and invasion of human melanoma a375 cells via inhibiting integrin/facal adhesion kinase pathway. Environ Toxicol. 2017;32(11):2352–2359.
   PubMed Web of Science ®Google Scholar
• Liu H, Wu RP, Li XF, Cao KY, Li LJ, Zhang W. Study on the effects of allitride and its mechanisms on renal cell carcinoma in vitro. Urologia. 2011;78:116–122.
   PubMedGoogle Scholar
• Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, Geng S, Wu J, Zhong C, Li M. Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/beta-catenin pathway. J Cell Biochem. 2018;119(5):4134–4141.
   PubMed Web of Science ®Google Scholar
• Li X, Yue Y, Zhou Y, Fan Y, Fan C, Huang Y, Wu F, Liu Y. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: formulation and evaluation. Int J Pharm. 2011;407(1-2):158–166.
   PubMed Web of Science ®Google Scholar
• Loh Y-H, Wu Q, Chew J-L, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet. 2006;38(4):431–440.
   PubMed Web of Science ®Google Scholar
• Rasti A, Mehrazma M, Madjd Z, Abolhasani M, Saeednejad ZL, Asgari M. Co-expression of cancer stem cell markers OCT4 and NANOG predicts poor prognosis in renal cell carcinomas. Sci Rep. 2018;8(1):11739.
   PubMedGoogle Scholar
• Huang G, Zhang J, Wang X, Chen Y, Liu D, Guo S. Clinicopathological and prognostic significance of Nanog expression in non-small cell lung cancer: a meta-analysis. Onco Targets Ther. 2019;12:3609–3617.
   PubMed Web of Science ®Google Scholar
• Cai W, Wang Z, Wei C, Wu M, Zheng W, Zhang H, Liu C, Liu L. Prognostic evaluation of NANOG and OCT4 expression for posttransplantation hepatocellular carcinoma recurrence. J Cell Biochem. 2019;120(5):8419–8429.
   PubMed Web of Science ®Google Scholar
• Yao C, Su L, Shan J, Zhu C, Liu L, Liu C, Xu Y, Yang Z, Bian X, Shao J, et al. IGF/STAT3/NANOG/slug signaling axis simultaneously controls epithelial-mesenchymal transition and stemness maintenance in colorectal cancer. Stem Cells. 2016;34(4):820–831.
   PubMed Web of Science ®Google Scholar
• Kawamura N, Nimura K, Nagano H, Yamaguchi S, Nonomura N, Kaneda Y. CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells. Oncotarget. 2015;6(26):22361–22374.
   PubMedGoogle Scholar
• Chen T, Du J, Lu G. Cell growth arrest and apoptosis induced by Oct4 or Nanog knockdown in mouse embryonic stem cells: a possible role of Trp53. Mol Biol Rep. 2012;39(2):1855–1861.
   PubMed Web of Science ®Google Scholar
• Tamura S, Isobe T, Ariyama H, Nakano M, Kikushige Y, Takaishi S, Kusaba H, Takenaka K, Ueki T, Nakamura M, et al. Ecadherin regulates proliferation of colorectal cancer stem cells through NANOG. Oncol Rep. 2018;40(2):693–703.
   PubMed Web of Science ®Google Scholar