Effect of Diets Varying in Iron and Saturated Fat on the Gut Microbiota and Intestinal Inflammation: A Crossover Feeding Study among Older Females with Obesity

References

• Cancer facts & figures 2021. 2021. Atlanta, GA: American Cancer Society.
   Google Scholar
• Frezza EE, Wachtel MS, Chiriva-Internati M. Influence of obesity on the risk of developing colon cancer. Gut. 2006;55(2):285–91. doi: 10.1136/gut.2005.073163
   PubMed Web of Science ®Google Scholar
• Ma Y, Yang Y, Wang F, Zhang P, Shi C, Zou Y, Qin H. Obesity and risk of colorectal cancer: A systematic review of prospective studies. PLoS One. 2013;8(1):e53916. doi: 10.1371/journal.pone.0053916
   PubMed Web of Science ®Google Scholar
• Sánchez-Alcoholado L, Ramos-Molina B, Otero A, Laborda-Illanes A, Ordóñez R, Medina JA, Gómez-Millán J, Queipo-Ortuño MI. The role of the gut microbiome in colorectal cancer development and therapy response. Cancers (Basel. 2020;12(6):1406. doi: 10.3390/cancers12061406
   PubMed Web of Science ®Google Scholar
• Song M, Garrett WS, Chan AT. Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015;148(6):1244–60.e16. e1216. doi: 10.1053/j.gastro.2014.12.035
   PubMed Web of Science ®Google Scholar
• Cronin SJF, Woolf CJ, Weiss G, Penninger JM. The role of iron regulation in immunometabolism and immune-related disease. Front Mol Biosci. 2019;6:116–doi: 10.3389/fmolb.2019.00116
   PubMed Web of Science ®Google Scholar
• Rusu IG, Suharoschi R, Vodnar DC, Pop CR, Socaci SA, Vulturar R, Istrati M, Moroșan I, Fărcaș AC, Kerezsi AD, et al. Iron supplementation influence on the gut microbiota and probiotic intake effect in iron deficiency-a literature-based review. Nutrients. 2020;12(7):1993. doi: 10.3390/nu12071993
   PubMed Web of Science ®Google Scholar
• Lund EK, Wharf SG, Fairweather-Tait SJ, Johnson IT. Oral ferrous sulfate supplements increase the free radical–generating capacity of feces from healthy volunteers. Am J Clin Nutr. 1999;69(2):250–5. doi: 10.1093/ajcn/69.2.250
   PubMed Web of Science ®Google Scholar
• Karl JP, Hatch AM, Arcidiacono SM, Pearce SC, Pantoja-Feliciano IG, Doherty LA, Soares JW. Effects of psychological, environmental and physical stressors on the gut microbiota. Front Microbiol. 2018;9:2013–
   PubMed Web of Science ®Google Scholar
• Paganini D, Uyoga MA, Zimmermann MB. Iron fortification of foods for infants and children in low-income countries: Effects on the gut microbiome, gut inflammation, and diarrhea. Nutrients. 2016;8(8):494. doi: 10.3390/nu8080494
   PubMed Web of Science ®Google Scholar
• van der Logt EM, Blokzijl T, van der Meer R, Faber KN, Dijkstra G. Westernized high-fat diet accelerates weight loss in dextran sulfate sodium-induced colitis in mice, which is further aggravated by supplementation of heme. J Nutr Biochem. 2013;24(6):1159–65. doi: 10.1016/j.jnutbio.2012.09.001
   PubMed Web of Science ®Google Scholar
• Uritski R, Barshack I, Bilkis I, Ghebremeskel K, Reifen R. Dietary iron affects inflammatory status in a rat model of colitis. J Nutr. 2004;134(9):2251–5. doi: 10.1093/jn/134.9.2251
   PubMed Web of Science ®Google Scholar
• Werner T, Wagner SJ, Martínez I, Walter J, Chang JS, Clavel T, Kisling S, Schuemann K, Haller D. Depletion of luminal iron alters the gut microbiota and prevents crohn’s disease-like ileitis. Gut. 2011;60(3):325–33. doi: 10.1136/gut.2010.216929
   PubMed Web of Science ®Google Scholar
• Barollo M, D’Incà R, Scarpa M, Medici V, Cardin R, Fries W, Angriman I, Sturniolo GC. Effects of iron deprivation or chelation on DNA damage in experimental colitis. Int J Colorectal Dis. 2004;19(5):461–6. doi: 10.1007/s00384-004-0588-2
   PubMed Web of Science ®Google Scholar
• González-Domínguez Á, Visiedo-García FM, Domínguez-Riscart J, González-Domínguez R, Mateos RM, Lechuga-Sancho AM. Iron metabolism in obesity and metabolic syndrome. IJMS. 2020;21(15):5529. doi: 10.3390/ijms21155529
   Google Scholar
• Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2009;122(2-3):78–86. doi: 10.1159/000243791
   PubMed Web of Science ®Google Scholar
• Mena NP, Esparza A, Tapia V, Valdés P, Núñez MT. Hepcidin inhibits apical iron uptake in intestinal cells. Am J Physiol Gastrointest Liver Physiol. 2008;294(1):G192–198. doi: 10.1152/ajpgi.00122.2007
   PubMed Web of Science ®Google Scholar
• Cepeda-Lopez AC, Melse-Boonstra A, Zimmermann MB, Herter-Aeberli I. In overweight and obese women, dietary iron absorption is reduced and the enhancement of iron absorption by ascorbic acid is one-half that in normal-weight women. Am J Clin Nutr. 2015;102(6):1389–97. doi: 10.3945/ajcn.114.099218
   PubMed Web of Science ®Google Scholar
• Ervin RB, Kennedy-Stephenson J. Mineral intakes of elderly adult supplement and non-supplement users in the third national health and nutrition examination survey. J Nutr. 2002;132(11):3422–7. doi: 10.1093/jn/132.11.3422
   PubMed Web of Science ®Google Scholar
• Galesloot TE, Vermeulen SH, Geurts-Moespot AJ, Klaver SM, Kroot JJ, van Tienoven D, Wetzels JF, Kiemeney LA, Sweep FC, den Heijer M, et al. Serum hepcidin: Reference ranges and biochemical correlates in the general population. Blood. 2011;117(25):e218-225–e225. doi: 10.1182/blood-2011-02-337907
   Web of Science ®Google Scholar
• Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, et al. Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the centers for disease control and prevention and the american heart association. Circulation. 2003;107(3):499–511. doi: 10.1161/01.CIR.0000052939.59093.45
   PubMed Web of Science ®Google Scholar
• Medicine. FaNBIo. 2001. Dietary reference intakes: Vitamin a, vitamin k, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: The National Academies Press. 101(3):p. 294–301.
   Google Scholar
• Pabón ML, Lönnerdal B. Effects of type of fat in the diet on iron bioavailability assessed in suckling and weanling rats. J Trace Elem Med Biol. 2001;15(1):18–23. doi: 10.1016/S0946-672X(01)80021-3
   PubMed Web of Science ®Google Scholar
• Block G, Woods M, Potosky A, Clifford C. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol. 1990;43(12):1327–35. doi: 10.1016/0895-4356(90)90099-b
   PubMed Web of Science ®Google Scholar
• Paffenbarger RS, Jr., Wing AL, Hyde RT. Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol. 1978;108(3):161–75. doi: 10.1093/oxfordjournals.aje.a112608
   PubMed Web of Science ®Google Scholar
• Baraldi E, Carraro S, Alinovi R, Pesci A, Ghiro L, Bodini A, Piacentini G, Zacchello F, Zanconato S. Cysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations. Thorax. 2003;58(6):505–9. doi: 10.1136/thorax.58.6.505
   PubMed Web of Science ®Google Scholar
• Bressler B, Panaccione R, Fedorak RN, Seidman EG. Clinicians’ guide to the use of fecal calprotectin to identify and monitor disease activity in inflammatory bowel disease. Can J Gastroenterol Hepatol. 2015;29(7):369–72. doi: 10.1155/2015/852723
   PubMed Web of Science ®Google Scholar
• Naqib A, Poggi S, Wang W, Hyde M, Kunstman K, Green SJ. 2018. Making and sequencing heavily multiplexed, high-throughput 16s ribosomal rna gene amplicon libraries using a flexible, two-stage pcr protocol. In Raghavachari N, Garcia-Reyero N, editors. Gene expression analysis: Methods and protocols. New York, NY: Springer New York. p. 149–169.
   Google Scholar
• Moonsamy PV, Williams T, Bonella P, Holcomb CL, Höglund BN, Hillman G, Goodridge D, Turenchalk GS, Blake LA, Daigle DA, et al. High throughput hla genotyping using 454 sequencing and the fluidigm access array™ system for simplified amplicon library preparation. Tissue Antigens. 2013;81(3):141–9. doi: 10.1111/tan.12071
   PubMedGoogle Scholar
• Searle LJ, Méric G, Porcelli I, Sheppard SK, Lucchini S. Variation in siderophore biosynthetic gene distribution and production across environmental and faecal populations of Escherichia coli. PLoS One. 2015;10(3):e0117906-e0117906. doi: 10.1371/journal.pone.0117906
   Web of Science ®Google Scholar
• Io M. 2005. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, DC: The National Academies Press.
   Google Scholar
• Sivaprakasam S, Ristic B, Mudaliar N, Hamood AN, Colmer-Hamood J, Wachtel MS, Nevels AG, Kottapalli KR, Ganapathy V. Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice. Biochem J. 2020;477(19):3867–83.
   PubMed Web of Science ®Google Scholar
• Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE. Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev. 2014;94(2):329–54. doi: 10.1152/physrev.00040.2012
   PubMed Web of Science ®Google Scholar
• Mahalhal A, Williams JM, Johnson S, Ellaby N, Duckworth CA, Burkitt MD, Liu X, Hold GL, Campbell BJ, Pritchard DM, et al. Oral iron exacerbates colitis and influences the intestinal microbiome. PLoS One. 2018;13(10):e0202460. doi: 10.1371/journal.pone.0202460
   PubMed Web of Science ®Google Scholar
• Diet, nutrition, physical activity and cancer: A global perspective. Continuous update project expert report. 2018. World Cancer Research Fund/American Institute for Cancer Research.
   Google Scholar
• Gibson RS. The role of diet- and host-related factors in nutrient bioavailability and thus in nutrient-based dietary requirement estimates. Food Nutr Bull. 2007;28(1 Suppl International):S77–S100. doi: 10.1177/15648265070281S108
   PubMed Web of Science ®Google Scholar
• Pereira DI, Aslam MF, Frazer DM, Schmidt A, Walton GE, McCartney AL, Gibson GR, Anderson GJ, Powell JJ. Dietary iron depletion at weaning imprints low microbiome diversity and this is not recovered with oral nano fe(iii). Microbiologyopen. 2015;4(1):12–27. doi: 10.1002/mbo3.213
   PubMed Web of Science ®Google Scholar
• Coe GL, Pinkham NV, Celis AI, Johnson C, DuBois JL, Walk ST. Dynamic gut microbiome changes in response to low-iron challenge. Appl Environ Microbiol. 2021;87(3):e02307-02320. doi: 10.1128/AEM.02307-20
   Web of Science ®Google Scholar
• Constante M, Fragoso G, Lupien-Meilleur J, Calvé A, Santos MM. Iron supplements modulate colon ­microbiota composition and potentiate the protective effects of probiotics in dextran sodium sulfate-induced colitis. Inflamm Bowel Dis. 2017;23(5):753–66. doi: 10.1097/MIB.0000000000001089
   PubMed Web of Science ®Google Scholar
• Cross AJ, Pollock JR, Bingham SA. Haem, not protein or inorganic iron, is responsible for endogenous intestinal n-nitrosation arising from red meat. Cancer Res. 2003;63(10):2358–60.
   PubMed Web of Science ®Google Scholar
• Cheng Z, Li Y. What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: An update. Chem Rev. 2007;107(3):748–66.
   PubMed Web of Science ®Google Scholar
• Brito A, Hertrampf E, Olivares M. Iron status biomarkers and c-reactive protein in children aged 19 to 72 months in chile. Food Nutr Bull. 2013;34(1):14–20. doi: 10.1177/156482651303400103
   PubMed Web of Science ®Google Scholar
• Zimmermann MB, Chassard C, Rohner F, N’Goran EK, Nindjin C, Dostal A, Utzinger J, Ghattas H, Lacroix C, Hurrell RF. The effects of iron fortification on the gut microbiota in african children: A randomized controlled trial in cote d’ivoire. Am J Clin Nutr. 2010;92(6):1406–15. doi: 10.3945/ajcn.110.004564
   PubMed Web of Science ®Google Scholar
• Jaeggi T, Kortman GA, Moretti D, Chassard C, Holding P, Dostal A, Boekhorst J, Timmerman HM, Swinkels DW, Tjalsma H, et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in kenyan infants. Gut. 2015;64(5):731–42. doi: 10.1136/gutjnl-2014-307720
   PubMed Web of Science ®Google Scholar
• Seiwert N, Heylmann D, Hasselwander S, Fahrer J. Mechanism of colorectal carcinogenesis triggered by heme iron from red meat. Biochim Biophys Acta Rev Cancer. 2020;1873(1):188334. doi: 10.1016/j.bbcan.2019.188334
   PubMed Web of Science ®Google Scholar
• Knight LC, Wang M, Donovan SM, Dilger RN. Early-life iron deficiency and subsequent repletion alters development of the colonic microbiota in the pig. Front Nutr. 2019;6:1–16. doi: 10.3389/fnut.2019.00120
   PubMed Web of Science ®Google Scholar
• Seyoum Y, Baye K, Humblot C. Iron homeostasis in host and gut bacteria - a complex interrelationship. Gut Microbes. 2021;13(1):1–19. doi: 10.1080/19490976.2021.1874855
   PubMed Web of Science ®Google Scholar
• Lagkouvardos I, Lesker TR, Hitch TCA, Gálvez EJC, Smit N, Neuhaus K, Wang J, Baines JF, Abt B, Stecher B, et al. Sequence and cultivation study of muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family. Microbiome. 2019;7(1):28. doi: 10.1186/s40168-019-0637-2
   PubMed Web of Science ®Google Scholar
• World Cancer Research Fund, American Institute for Cancer Research. 2007. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington DC: AICR.
   Google Scholar
• Galaris D, Skiada V, Barbouti A. Redox signaling and cancer: The role of "labile" iron. Cancer Lett. 2008;266(1):21–9. doi: 10.1016/j.canlet.2008.02.038
   PubMed Web of Science ®Google Scholar
• Toyokuni S. Role of iron in carcinogenesis: Cancer as a ferrotoxic disease. Cancer Sci. 2009;100(1):9–16. doi: 10.1111/j.1349-7006.2008.01001.x
   PubMed Web of Science ®Google Scholar
• Skrypnik K, Bogdański P, Sobieska M, Schmidt M, Suliburska J. Influence of multistrain probiotic and iron supplementation on iron status in rats. J Trace Elem Med Biol. 2021;68:126849. doi: 10.1016/j.jtemb.2021.126849
   PubMed Web of Science ®Google Scholar