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Articles

Elevated Serum and Hair Levels of Cadmium as a Risk Factor for Liver Carcinoma: A Meta-Analysis

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Pages 1438-1447 | Received 22 Dec 2022, Accepted 14 Mar 2023, Published online: 19 May 2023

References

  • Gao S, Jiang X, Wang L, Jiang S, Luo H, Chen Y, Peng C. The pathogenesis of liver cancer and the therapeutic potential of bioactive substances. Front Pharmacol. 2022;13:1029601. doi: 10.3389/fphar.2022.1029601.
  • Barsouk A, Thandra KC, Saginala K, Rawla P, Barsouk A. Chemical risk factors of primary liver cancer: an update. Hepat Med. 2020;12:179–88. doi: 10.2147/HMER.S278070.
  • Yang Y, McDonald AC, Wang X, Pan Y, Wang M. Arsenic exposures and prostate cancer risk: a multilevel meta-analysis. J Trace Elem Med Biol. 2022;72:126992. doi: 10.1016/j.jtemb.2022.126992.
  • Zhang L, Shao J, Tan SW, Ye HP, Shan XY. Association between serum copper/zinc ratio and lung cancer: a systematic review with meta-analysis. J Trace Elem Med Biol. 2022;74:127061. doi: 10.1016/j.jtemb.2022.127061.
  • Liu L, Chen J, Liu C, Luo Y, Chen J, Fu Y, Xu Y, Wu H, Li X, Wang H. Relationships between biological heavy metals and breast cancer: a systematic review and meta-analysis. Front Nutr. 2022;9:838762. doi: 10.3389/fnut.2022.838762.
  • Wu L, Yue W, Wu J, Cao C, Liu H, Teng Y. Metal-mining-induced sediment pollution presents a potential ecological risk and threat to human health across China: a meta-analysis. J Environ Manage. 2023;329:117058. doi: 10.1016/j.jenvman.2022.117058.
  • Branca JJV, Morucci G, Pacini A. Cadmium-induced neurotoxicity: still much ado. Neural Regen Res. 2018;13(11):1879–82. doi: 10.4103/1673-5374.239434.
  • Gu J, Kong A, Guo C, Liu J, Li K, Ren Z, Zhou Y, Tang M, Shi H. Cadmium perturbed lipid profile and induced liver dysfunction in mice through phosphatidylcholine remodeling and promoting arachidonic acid synthesis and metabolism. Ecotoxicol Environ Saf. 2022;247:114254. doi: 10.1016/j.ecoenv.2022.114254.
  • Yan J, Zhang H, Niu J, Luo B, Wang H, Tian M, Li X. Effects of lead and cadmium co-exposure on liver function in residents near a mining and smelting area in northwestern China. Environ Geochem Health. 2022;44(11):4173–89. doi: 10.1007/s10653-021-01177-6.
  • Kang MY, Cho SH, Lim YH, Seo JC, Hong YC. Effects of environmental cadmium exposure on liver function in adults. Occup Environ Med. 2013;70(4):268–73. doi: 10.1136/oemed-2012-101063.
  • Renu K, Chakraborty R, Myakala H, Koti R, Famurewa AC, Madhyastha H, Vellingiri B, George A, Valsala Gopalakrishnan A. Molecular mechanism of heavy metals (lead, chromium, arsenic, mercury, nickel and cadmium) – induced hepatotoxicity – a review. Chemosphere. 2021;271:129735. doi: 10.1016/j.chemosphere.2021.129735.
  • Souza-Arroyo V, Fabián JJ, Bucio-Ortiz L, Miranda-Labra RU, Gomez-Quiroz LE, Gutiérrez-Ruiz MC. The mechanism of the cadmium-induced toxicity and cellular response in the liver. Toxicology. 2022;480:153339. doi: 10.1016/j.tox.2022.153339.
  • Chen XX, Xu YM, Lau ATY. Metabolic effects of long-term cadmium exposure: an overview. Environ Sci Pollut Res Int. 2022;29(60):89874–88. doi: 10.1007/s11356-022-23620-6.
  • Zhang L, Zhu Y, Hao R, Shao M, Luo Y. Cadmium levels in tissue and plasma as a risk factor for prostate carcinoma: a meta-analysis. Biol Trace Elem Res. 2016;172(1):86–92. doi: 10.1007/s12011-015-0576-0.
  • Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5. doi: 10.1007/s10654-010-9491-z.
  • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.
  • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–88. 10.1016/0197-2456(86)90046-2
  • Munafo MR, Clark TG, Flint J. Assessing publication bias in genetic association studies: evidence from a recent meta-analysis. Psychiatry Res. 2004;129(1):39–44. doi: 10.1016/j.psychres.2004.06.011.
  • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34. 10.1136/bmj.315.7109.629
  • Waalkes MP. Cadmium carcinogenesis in review. J Inorg Biochem. 2000;79(1–4):241–4. 10.1016/s0162-0134(00)00009-x
  • Waalkes MP. Cadmium carcinogenesis. Mutat Res. 2003;533(1–2):107–20. 10.1016/j.mrfmmm.2003.07.011
  • Satarug S. Long-term exposure to cadmium in food and cigarette smoke, liver effects and hepatocellular carcinoma. Curr Drug Metab. 2012;13(3):257–71. 10.2174/138920012799320446
  • Gerhardsson L, Brune D, Nordberg GF, Wester PO. Distribution of cadmium, lead and zinc in lung, liver and kidney in long-term exposed smelter workers. Sci Total Environ. 1986;50:65–85. 10.1016/0048-9697(86)90352-9
  • Oldereid NB, Thomassen Y, Attramadal A, Olaisen B, Purvis K. Concentrations of lead, cadmium and zinc in the tissues of reproductive organs of men. J Reprod Fertil. 1993;99(2):421–5. 10.1530/jrf.0.0990421
  • Schopfer J, Drasch G, Schrauzer GN. Selenium and cadmium levels and ratios in prostates, livers, and kidneys of nonsmokers and smokers. Biol Trace Elem Res. 2010;134(2):180–7. doi: 10.1007/s12011-010-8636-y.
  • Onosaka S, Min KS, Fukuhara C, Tanaka K, Tashiro S, Shimizu I, Furuta M, Yasutomi T, Kobashi K, Yamamoto K, et al. Concentrations of metallothionein and metals in malignant and non-malignant tissues in human liver. Toxicology. 1986;38(3):261–8.
  • Tao W, Peng Q, Wu C, Zheng W, Li C, Gong Z. Association between Mn, Cu, Zn, Fe, and Cd concentrations and etiology of liver cancer. J Clin Exp Pathol. 1991;7:19–22.
  • Tashiro H, Kawamoto T, Okubo T, Koide O. Variation in the distribution of trace elements in hepatoma. Biol Trace Elem Res. 2003;95(1):49–63. doi: 10.1385/BTER:95:1:49.
  • Hyder O, Chung M, Cosgrove D, Herman JM, Li Z, Firoozmand A, Gurakar A, Koteish A, Pawlik TM. Cadmium exposure and liver disease among US adults. J Gastrointest Surg. 2013;17(7):1265–73. doi: 10.1007/s11605-013-2210-9.
  • Hammer DI, Calocci AV, Hasselblad V, Williams ME, Pinkerson C. Pinkerson C: cadmium and lead in autopsy tissues. J Occup Med. 1973;15(12):956–63.
  • Iwao S, Kodama Y, Tsuchiya K. Associations of cadmium with zinc and copper in cancer cases and controls. Biol Trace Elem Res. 1983;5(4–5):383–8. doi: 10.1007/BF02987222.
  • Li Z, Liang Y, Sheng S, Li G, Lin R. Concentrations of hair trace elements in patients with liver cancer and healthy individuals in Shunde of Guangdong province. Guangzhou Med J. 1985;(01):42–45+47.
  • Shi X, Shen T. The changes and clinical significance of serum Zn, Se, Cd and Ni in liver and bile duct diseases. Pract J Clin Med. 1989;15:25–7.
  • Jiang H, Han G, Lv M, Liu X, Cui X, et al. Serum trace elements in patients with hepatic cirrhosis and liver cancer. Chin J Clin Oncol. 1990;17:348–50.
  • Yin DZ. Comparison of serum trace element spectrum of liver cancer patients and healthy adults. Chin J Oncol. 1990;12:200–2.
  • Ma Y, Jia Q, Zhong S, Lu W. A primary study of monitoring hair cadmium of the patients with liver cancer by catalytic oscillopolarography. Acta Univ Med Tangji. 1992;21:46–8.
  • Li Y, Zhang J, Tian M, Gong G. Analysis of serum copper, zinc, manganese, cadmium and nickel levels in patients with hepatocellular carcinoma. J Henan Oncol. 1993;6:170.
  • Gong Q, Wang Q, Qian J. Detection of level of four microelements and activities of enzymes in sera of patients with hepatocarcinoma and cholangiocarcinoma. Med J Natl Defend Forces Southwest China. 1999;9:272–4.
  • Kazi TG, Kolachi NF, Afridi HI, Kazi NG, Sirajuddin, Naeemullah, Arain SS. Effects of mineral supplementation on liver cirrhotic/cancer male patients. Biol Trace Elem Res. 2012;150(1–3):81–90. doi: 10.1007/s12011-012-9501-y.
  • Kolachi NF, Kazi TG, Afridi HI, Kazi NG, Khan S. Investigation of essential trace and toxic elements in biological samples (blood, serum and scalp hair) of liver cirrhotic/cancer female patients before and after mineral supplementation. Clin Nutr. 2012;31(6):967–73. doi: 10.1016/j.clnu.2012.04.015.
  • Larsson SC, Wolk A. Urinary cadmium and mortality from all causes, cancer and cardiovascular disease in the general population: systematic review and meta-analysis of cohort studies. Int J Epidemiol. 2016;45(3):782–91. doi: 10.1093/ije/dyv086.
  • Aramjoo H, Arab-Zozani M, Feyzi A, Naghizadeh A, Aschner M, Naimabadi A, Farkhondeh T, Samarghandian S. The association between environmental cadmium exposure, blood pressure, and hypertension: a systematic review and meta-analysis. Environ Sci Pollut Res Int. 2022;29(24):35682–706. doi: 10.1007/s11356-021-17777-9.
  • Chowdhury R, Ramond A, O'Keeffe LM, Shahzad S, Kunutsor SK, Muka T, Gregson J, Willeit P, Warnakula S, Khan H, et al. Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis. BMJ. 2018;362:k3310. doi: 10.1136/bmj.k3310.
  • Xu L, Zhang W, Liu X, Zhang C, Wang P, Zhao X. Circulatory levels of toxic metals (aluminum, cadmium, mercury, lead) in patients with Alzheimer’s disease: a quantitative meta-analysis and systematic review. J Alzheimers Dis. 2018;62(1):361–72. doi: 10.3233/JAD-170811.
  • Lu L, Li Y, Chen C, Zhang Y, Guo W, Zhang S, Kahe K. Associations of cadmium exposure with risk of metabolic syndrome and its individual components: a meta-analysis. J Expo Sci Environ Epidemiol. 2022; Forthcoming. doi: 10.1038/s41370-022-00444-7.
  • Rezapour M, Rezapour HA, Chegeni M, Khanjani N. Exposure to cadmium and head and neck cancers: a meta-analysis of observational studies. Rev Environ Health. 2021;36(4):577–84. doi: 10.1515/reveh-2020-0109.
  • Nawrot TS, Martens DS, Hara A, Plusquin M, Vangronsveld J, Roels HA, Staessen JA. Association of total cancer and lung cancer with environmental exposure to cadmium: the meta-analytical evidence. Cancer Causes Control. 2015;26(9):1281–8. doi: 10.1007/s10552-015-0621-5.
  • Zhang L, Wang Y, Song M, Chang A, Zhuo W, Zhu Y. Fibronectin 1 as a key gene in the genesis and progression of cadmium-related bladder cancer. Biol Trace Elem Res. 2022; Forthcoming. doi: 10.1007/s12011-022-03510-1.
  • Hu W, Xia M, Zhang C, Song B, Xia Z, Guo C, Cui Y, Jiang W, Zhang S, Xu D, et al. Chronic cadmium exposure induces epithelial mesenchymal transition in prostate cancer cells through a TGF-beta-independent, endoplasmic reticulum stress induced pathway. Toxicol Lett. 2021;353:107–17. doi: 10.1016/j.toxlet.2021.10.007.
  • Lin HP, Wang Z, Yang C. LncRNA DUXAP10 upregulation and the Hedgehog pathway activation are critically involved in chronic cadmium exposure-induced cancer stem cell-like property. Toxicol Sci. 2021;184(1):33–45. doi: 10.1093/toxsci/kfab099.
  • Haase H, Ober-Blobaum JL, Engelhardt G, Hebel S, Rink L. Cadmium ions induce monocytic production of tumor necrosis factor-alpha by inhibiting mitogen activated protein kinase dephosphorylation. Toxicol Lett. 2010;198(2):152–8. doi: 10.1016/j.toxlet.2010.06.010.
  • Nordberg M, Nordberg GF. Metallothionein and cadmium toxicology – historical review and commentary. Biomolecules. 2022;12(3):360. doi: 10.3390/biom12030360.
  • Genchi G, Sinicropi MS, Lauria G, Carocci A, Catalano A. The effects of cadmium toxicity. Int J Environ Res Public Health. 2020;17(11):3782. doi: 10.3390/ijerph17113782.
  • Satarug S, Vesey DA, Gobe GC, Phelps KR. Estimation of health risks associated with dietary cadmium exposure. Arch Toxicol. 2023;97(2):329–58. doi: 10.1007/s00204-022-03432-w.
  • Schaefer HR, Dennis S, Fitzpatrick S. Cadmium: mitigation strategies to reduce dietary exposure. J Food Sci. 2020;85(2):260–7. doi: 10.1111/1750-3841.14997.
  • Peana M, Pelucelli A, Chasapis CT, Perlepes SP, Bekiari V, Medici S, Zoroddu MA. Biological effects of human exposure to environmental cadmium. Biomolecules. 2022;13(1):36. doi: 10.3390/biom13010036.
  • Ferrero ME. Neuron protection by EDTA may explain the successful outcomes of toxic metal chelation therapy in neurodegenerative diseases. Biomedicines. 2022;10(10):2476. doi: 10.3390/biomedicines10102476.
  • Famurewa AC, Renu K, Eladl MA, Chakraborty R, Myakala H, El-Sherbiny M, Elsherbini DMA, Vellingiri B, Madhyastha H, Ramesh Wanjari U, et al. Hesperidin and hesperetin against heavy metal toxicity: insight on the molecular mechanism of mitigation. Biomed Pharmacother. 2022;149:112914. doi: 10.1016/j.biopha.2022.112914.
  • Boateng ID. Potentialities of Ginkgo extract on toxicants, toxins, and radiation: a critical review. Food Funct. 2022;13(15):7960–83. doi: 10.1039/d2fo01298g.

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