Effects of dietary carbohydrate on the incidence of mammary tumors induced in rats by 7, 12‐dimethylbenz[α] anthracene

References and notes

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• Sources of dietary ingredients were as follows: Casein (high test, purified), rice starch, salt mixture and vitamins were obtained from ICN Life Sciences Group, Nutritional Biochemicals Division, Cleveland, OH; dextrose monohydrate from Teklad Test Diets, ARS/Sprague‐Dawley Division of the Mogul Corporation, Madison, Wl; wheat starch from Industrial Grain Products, Toronto, Ont; potato starch from Stein‐Hall, Ltd., Toronto, Ont; cooked potato starch (Redisol 78, from Staley Canada, Ltd., Toronto, Ont) and celluflour from Chicago Dietetic Supply House, Inc., La Grange, IL. Sucrose and sunflower seed oil ("Safflo”, Gardenland Packers, Ltd., Altona, MN) were obtained from local stores and the lard was a gift of Canada Packers, Ltd., Toronto, Ont. The mixture of lard and sunflower seed oil was designed to give fatty acid composition similar to that of the fat in Purina Chow. The salt mixture formulated by Bernhardt and Tomarelli2 and the vitamin mixtures described by Greenfield et al8 were used in these diets. The salt mixture provided 6.00 g calcium, 1.80 g potassium, 0.50 g sodium, 0.40 g magnesium, 5.00 g phosphorus, 0.50 g chlorine, 0.33 g sulfur, 0.025 g iron, 0.012 g zinc, 0.05 g manganese, 0.005 g copper and 150 pg iodine per kg of diet. Water‐soluble vitamins were mixed with the celluflour to provide 10 mg thiamine hydrochloride, 10 mg ri‐boflavin, 60 mg nicotinic acid, 10 mg pyridoxine hydro‐chloride, 40 mg calcium pantothenate, 1 mg biotin, 5 mg folic acid, 0.05 mg vitamin B12, 1800 mg choline bitartrate and 75 mg ascorbic acid per kg of diet. Fat‐soluble vitamins were added to the dietary fat to provide 65 mg (13,000 IU) vitamin A ester concentrate, 3 mg (1,220 IU) vitamin D3, 75 mg dl‐a‐tocopherol acetate and 1 mg vitamin K3 (2‐methyl‐naphtho‐quinone) per kg of diet.
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• We thank R Rasmussen for technical assistance and GJ Hopkins for statistical analysis of the results. Susan Hoehn's present address is: Department of Biochemistry, University of Manitoba, Winnipeg, Manitoba, R3E 0W3.
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• Address correspondence to: Dr. KK Carroll, Department of Biochemistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1.
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• This work was supported by grants from the National Cancer Institute of Canada and the Medical Research Council of Canada.
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