Dietary vitamin E, hepatic aryl hydrocarbon hydroxylase and the metabolic activation of procarcinogens to mutagens

References and notes

• Ames , BN , McCan , J and Yamasaki , E . 1975 . “Methods for Detecting Carcinogens and Mutagens with the Salmonella/Mammalian Microsome Mutagenicity Test” . Mutat Res , 31 : 347 – 364 .
   PubMed Web of Science ®Google Scholar
• Arrhenius , E . 1974 . “Comparative Metabolism of Aromatic Amines” . In Chemical Carcinogenesis Essays , Edited by: Montesano , R and Tomatis , L . Lyon : IARC . IARC Publ. No. 10
   Google Scholar
• Becking , GC . 1976 . “Hepatic Drug Metabolism in Iron, Magnesium, and Potassium‐Deficient Rats” . Fed Proc , 35 : 2480 – 2485 .
   PubMedGoogle Scholar
• Borgen , A , Darvey , H Castagnoli , N . 1973 . “Metabolic Conversion of Benzo (a) pyrene by Syrian Hamster Liver Microsomes and Binding of Metabolites to Deoxyribonucleic Acid” . J Med Chem , 16 : 502 – 506 .
   PubMed Web of Science ®Google Scholar
• Campbell , TC and Hayes , JR . 1976 . “The Effect of Quantity and Quality of Dietary Protein on Drug Metabolism” . Fed Proc , 35 : 2470 – 2474 .
   PubMedGoogle Scholar
• Carpenter , MP . 1972 . “Vitamin E and Microsomal Drug Hydroxyla‐tions” . Ann NY Acad Sci , 203 : 81 – 92 .
   PubMed Web of Science ®Google Scholar
• Chow , CK , Csallany , AS and Draper , HH . 1971 . “Relative Turnover Rates of the Tocochromanols in Rabbit Plasma” . Nutr Rep Int , 4 : 45 – 48 .
   Google Scholar
• Conney , AH , Miller , EC and Miller , JA . 1957 . “Induced Synthesis and Other Properties of Benzo (a) pyrene Hydroxylase in Rat Liver” . J Biol Chem , 228 : 753 – 761 .
   PubMed Web of Science ®Google Scholar
• Conney , AH , Pantuck , EJ Hsiao , KC . 1977 . “Regulation of Drug Metabolism in Man by Environmental Chemicals and Diet” . Fed Proc , 36 : 1647 – 1652 .
   PubMedGoogle Scholar
• Draper , HH and Csallany , AS . 1969 . “A Simplified Hemolysis Test for Vitamin E Deficiency” . J Nutr , 98 : 390 – 394 .
   PubMed Web of Science ®Google Scholar
• Gelboin , HV , Wiebel , FJ and Kinoshita , N . 1974 . “Aryl Hydrocarbon Hydroxylase: Regulation and Role in Polycyclic Hydrocarbon Action” . In Chemical Carcinogenesis , Edited by: Tso Paul , OP and DiPaolo , JA . 309 – 349 . New York : Marcel Dekker, Inc. .
   Google Scholar
• Haber , SL and Wissler , RW . 1962 . “Effect of Vitamin E on Carcin‐ogenicity of Methylcholanthrene” . Proc Soc Exp Biol Med , 111 : 774 – 775 .
   Web of Science ®Google Scholar
• Hauswirth , JW and Nair , PP . 1975 . “Effect of Dietary Vitamin E Basal Diets on Hepatic Catalase and Microsomal Cytochromes P‐450 and b5 in Rats” . Am J Clin Nutr , 28 : 1087 – 1096 .
   PubMedGoogle Scholar
• Heidelberger , C . 1975 . “Chemical Carcinogenesis” . Ann Rev Bio‐chem , 44 : 79 – 121 .
   PubMed Web of Science ®Google Scholar
• Horn , LR , Machlin , LJ Barker , MO . 1976 . “Drug Metabolism and Hepatic Heme Proteins in the Vitamin E Deficient Rat” . Arch Biochem Biophys , 172 : 270 – 277 .
   PubMed Web of Science ®Google Scholar
• Kitto , GB . 1969 . “Intra‐ and Extra‐Mitochondrial Malate Dehy‐drogenase from Chicken and Tuna Heart” . Methods Enzymol , 13 : 106 – 116 .
   Google Scholar
• Kotake , AN , Deloria , LB Abbott , VS . 1975 . “Reversal of the Inhibiting Effect of Lipid Peroxides on the Hepatic Cytochrome P‐450 Monooxygenase System by Soluble Factor from Liver and a Commercial Isocitric Dehydrogenase Preparation from Hog Heart” . Biochem Biophys Res Commun , 63 : 209 – 216 .
   Google Scholar
• Kouri , RE , Ratrie , H and Whitmire , CE . 1973 . “Evidence of a Genetic Relationship Between Susceptibility to 3‐Methylcholan‐threne‐lnduced Subcutaneous Tumors and Inducibility of Aryl Hydrocarbon Hydroxylase” . J Natl Cancer Inst , 51 : 197 – 200 .
   PubMedGoogle Scholar
• Kouri , RE , Salerno , RA and Whitmire , CE . 1973 . “Relationships Between Aryl Hydrocarbon Hydroxylase Inducibility and Sensitivity to Chemically Induced Subcutaneous Sarcomas in Various Strains of Mice” . J Natl Cancer Inst , 50 : 363 – 368 .
   PubMed Web of Science ®Google Scholar
• Levin , W , Wood , AW Chang , RL . 1977 . “Marked Differences in the Tumor‐Initiating Activity of Optically Pure (+) and (‐) trans‐7, 8‐Dihydrobenzo (a) pyrene on Mouse Skin” . Cancer Res , 37 : 2721 – 2725 .
   PubMed Web of Science ®Google Scholar
• McCay , PB , Poyer , JL Pfeifer , PM . 1971 . “A Function for α‐Tocopherol: Stabilization of the Microsomal Membrane from Radical Attack During TPNH‐Dependent Oxidation” . Lipids , 6 : 297 – 306 .
   Web of Science ®Google Scholar
• Miller , GL . 1959 . “Protein Determination for Large Numbers of Samples” . Anal Chem , 31 : 964
   Web of Science ®Google Scholar
• Schutt , HAJ , Wirth , PJ and Thorgeirsson , SS . 1978 . “Mutagenic Activation of N‐Hydroxyl‐2‐ Acetyl Aminofluorene in the Salmonella Test System: The Role of Deacetylation by Liver and Kidney Fractions from Mouse and Rat” . Mol Pharmacol , 14 : 682 – 692 .
   Google Scholar
• Shamberger , RJ , Corlett , CL Beaman , KD . 1979 . “Antiox‐idants Reduce the Mutagenic Effect of Malonaldehyde and β ‐Propio!actone IX Antioxidants and Cancer” . Mutat Res , 66 : 349 – 355 .
   PubMedGoogle Scholar
• Sims , P , Grover , PL Swaisland , A . 1974 . “Metabolic Activation of Benzo (a) pyrene Proceeds by a Diol‐Epoxide” . Nature , 252 : 326 – 328 .
   PubMed Web of Science ®Google Scholar
• Swartz , K and Fredga , A . 1969 . “Biological Potency of Organic Selenium Compounds“ . J Biol Chem , 244 : 2103 – 2110 .
   Google Scholar
• Thakker , DR , Yagi , H Akagi , H . 1977 . “Metabolism of Benzo (a) pyrene VI Stereoselective Metabolism of Benzo (a) pyrene and Benzo (a) pyrene 7, 8‐Dihydrodiol to Diol Epoxides” . Chem Biol Interaction , 16 : 281 – 300 .
   PubMed Web of Science ®Google Scholar
• Van Cantfort , J , Graeve , JD and Gielen , JE . 1977 . “Radioactive Assay for Aryl Hydrocarbon Hydroxylase, Improved Method and Biological Importance” . Biochem Biophys Res Commun , 79 : 505 – 512 .
   PubMed Web of Science ®Google Scholar
• Wade , AE and Norred , WP . 1976 . “Effect of Dietary Lipid on Drug Metabolizing Enzymes” . Fed Proc , 35 : 2475 – 2479 .
   PubMedGoogle Scholar
• Wattenberg , LW , Loub , WD Lam , LK . 1976 . “Dietary Constituents Altering the Responses to Chemical Carcinogens” . Fed Proc , 35 : 1327 – 1331 .
   PubMedGoogle Scholar
• Weisburger , EK . 1979 . “Mechanisms of Chemical Carcinogenesis” . Annu Rev Pharmocol Toxicol , 18 : 395 – 415 .
   Google Scholar
• Zannoni , VG and Sato , PH . 1976 . “The Effect of Certain Vitamin Deficiencies on Hepatic Drug Metabolism” . Fed Proc , 35 : 2464 – 2467 .
   Google Scholar
• We would like to thank Judy Glass and Richard Thacker for their technical assistance.
   Google Scholar