Inhibitory effect of a fat‐free diet on mammary carcinogenesis in rats

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• Sources of dietary ingredients were as follows: Casein (high test, purified) and vitamins were obtained from ICN Life Sciences Group, Nutritional Biochemicals Division, Cleveland, OH; dextrose was obtained from Corn Products International, Englewood Cliffs’, NJ; celluflour was obtained from Chicago Dietetics, Le Grange, IL; salt mixture was obtained from Teklad Test Diets, Madison, WI; corn oil was obtained from local retailers, marketed by St. Lawrence Starch Company Ltd., Mississauga, Ont. The salt mixture formulated by Bernhart and Tomarelli [19] was used. It provides 8.9 g calcium, 2.7 g potassium, 0.7 g sodium, 0.6 g magnesium, 7.4 g phosphorus, 0.7 g chlorine, 0.49 g sulphur, 0.037 g iron, 0.018 g zinc, 0.07 g manganese, 0.007 g copper, and 222 g iodine per kg of diet. Water‐soluble vitamins were added to the diets to provide 7.5 mg thiamine hydrochloride, 7.5 mg pyridoxine hydrochloride, 0.3 mg biotin, 1500 mg cholinechloride, 150 mg inositol, 15 mg riboflavin, 75 mg nicotinic acid, 88.5 mg calcium pantothenate, and 0.75 mg folic acid per kg of diet. Fat‐soluble vitamins were added to the corn oil in the high‐fat diet, and to the dextrose in the fat‐free diet. They were added to provide 100 mg (20,000 IU) vitamin A ester, 110 mg DL‐α‐tocopherol acetate, and 30 mg menadione (vitamine K) per kg of diet.
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• This work was conducted at the Biochemistry Department, University of Western Ontario, London, Ontario, Canada.
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• This work was supported by the National Cancer Institute of Canada. Martha Davidson is the recipient of an Ontario Graduate fellowship, and Dr. K.K. Carroll is a Career Investigator of the Medical Research Council of Canada.
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• We thank M. Rotterman and D. Girard for technical assistance.
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• Address correspondence to: Dr. K.K. Carroll. Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1.
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