A hypothesis for dietary components as blocking agents of chemical carcinogenesis: Plant phenolics and pyrrole pigments

References

• Higginson , J . 1979 . “Environmental Carcinogenesis: A Global Perspective” . In Environmental Carcinogenesis: Occurrence, Risk Evaluation and Mechanisms , Edited by: Emelot , P and Kriek , E . 9 – 29 . New York : Elsevier/North Holland Biomedical Press .
   Google Scholar
• Wynder , EL and Gori , GB . 1977 . “Contribution of the Environment to Cancer Incidence: An Epidemiological Exercise” . JNCISS , : 825 – 832 .
   Google Scholar
• Ryser , HJ‐P . 1971 . “Chemical Carcinogenesis” . N Engl J Med , 285 : 721 – 734 .
   PubMedGoogle Scholar
• Farber , E . 1982 . “Chemical Carcinogenesis, a Biological Perspective” . Am J Pathol , 106 : 271 – 296 .
   PubMed Web of Science ®Google Scholar
• Correa , P . 1981 . “Epidemiological Correlations Between Diet and Cancer Frequency” . Cancer Res , 41 : 3685 – 3689 .
   PubMed Web of Science ®Google Scholar
• Eyssen, G: and Bright‐See, E: Personal communication, 1983.
   Google Scholar
• Watanabe , K , Reddy , BS , Weisburger , JH and Kritchevsky , D . 1979 . “Effect of Dietary Alfalfa, Pectin, and Wheat Bran on Azoxymethane‐ or Methylnitrosourea‐Induced Colon Carcinogenesis in F344 Rats” . JNCI , 63 : 141 – 145 .
   PubMedGoogle Scholar
• Wilson , RB , Hutcheson , DP and Wideman , L . 1977 . “Dimethylhydrazine‐Induced Colon Tumors in Rats Fed Diets Containing Beef Fat or Corn Oil With and Without Wheat Bran” . Am J Clin Nutr , 30 : 176 – 181 .
   PubMed Web of Science ®Google Scholar
• Fleiszer , DM , Murray , D , Richards , GK and Brown , RA . 1980 . “Effects of Diet on Chemically Induced Bowel Cancer” . CanJSurg , 23 : 67 – 73 .
   Google Scholar
• Wattenberg , LW . 1981 . “Inhibitors of Chemical Carcinogens” . In Cancer: Achievements, Challenges and Prospects for the 1980's , Edited by: Burchenal , JH and Dettgen , HF . Vol. I , 517 – 539 . New York : Grune & Stratton, Inc. .
   Google Scholar
• Arimoto , S , Okara , Y , Namba , T , Negishi , T and Hagatsu , H . 1980 . “Inhibition of the Mutagenicity of Amino Acid Pyrolysis Products by Hemin and Other Biological Pyrrole Pigments” . Biochem Biophys Res Commun , 92 : 662 – 668 .
   PubMed Web of Science ®Google Scholar
• Lai , C‐N . 1979 . “Chlorophyll: The Active Factor in Wheat Sprout Extract Inhibiting the Metabolic Activation of Carcinogens in Vitro” . Nutr Cancer , 1 (3) : 19 – 21 .
   Google Scholar
• Newmark , HL and Mergens , WJ . 1981 . “Alpha Tocopherol and Tumor Induction and Development” . In Inhibition of Tumor Induction and Development , Edited by: Zedeck , MS and Lipkin , M . 127 – 168 . New York : Plenum Publishing Corporation .
   Google Scholar
• Fiala , ES . 1981 . “Inhibition of Carcinogen Metabolism and Action by Disulfiram, Pyrazole, and Related Compounds” . In Inhibition of Tumor Induction and Development , Edited by: Zedeck , MS and Lipkin , M . 23 – 69 . New York : Plenum Publishing Corporation .
   Google Scholar
• Wattenberg , LW and Lam , LKT . 1981 . “Inhibition of Chemical Carcinogenesis by Phenols, Coumarins, Aromatic Isothiocyanates, Flavones, and Indoles” . In Inhibition of Tumor Induction and Development , Edited by: Zedeck , MS and Lipkin , M . 1 – 22 . New York : Plenum Publishing Corporation .
   Google Scholar
• Miller , EC and Miller , JA . 1976 . “The Metabolism of Chemical Carcinogens to Reactive Electrophiles and Their Possible Mechanisms of Action in Carcinogenesis” . In Chemical Carcinogenesis , Monograph 173 Edited by: Searle , CE . 737 – 762 . Washington, DC : American Chemical Society .
   Google Scholar
• Chasseaud , LF . 1976 . “Conjugation With Glutathione and Mercapturic Acid Excretion” . In Glutathione, Metabolism and Function , Edited by: Arias , IM and Jakoby , WB . 77 – 114 . New York : Raven Press .
   Google Scholar
• Lawley , PD and Thatcher , CJ . 1970 . “Methylation of Deoxyribonucleic Acid in Cultured Mammalian Cells by N‐Methyl‐N'‐nitro‐N‐nitrosoguanidine” . Biochem J , 116 : 693 – 707 .
   PubMed Web of Science ®Google Scholar
• Williamson , JM , Boettcher , B and Meister , A . 1982 . “Intracellular Cysteine Delivery System That Protects Against Toxicity by Promoting Glutathione Synthesis” . Proc Natl Acad Sci USA , 79 : 6246 – 6249 .
   PubMed Web of Science ®Google Scholar
• Lam , LK , Sparnins , VL and Wattenberg , LW . 1982 . “Isolation and Identification of Kahweol Palmitate and Cafestol Palmitate as Active Constituents of Green Coffee Beans That Enhance Glutathione S‐Transferase Activity in the Mouse” . Cancer Res , 42 : 1193 – 1198 .
   PubMed Web of Science ®Google Scholar
• Mitchell , JR , Hinson , JA and Nelson , SD . 1976 . “Glutathione and Drug‐Induced Tissue Lesions” . In Glutathione: Metabolism and Function , Edited by: Arias , IM and Jakoby , WB . 357 – 366 . New York : Raven Press .
   Google Scholar
• Van Doom , R , Leijdekkers , CM , Bos , RP , Brocins , RME and Henderson , PT . 1981 . “Detection of Human Exposure to Electrophilic Compounds by Assay of Thioether Detoxication Products in Urine” . Ann Occup Hyg , 24 : 77 – 92 .
   PubMedGoogle Scholar
• Van Doom , R , Bos , RP , Leijdekkers , CM , Wagenaas‐Zegers , MAP , Theuws , JLG and Henderson , PT . 1979 . “Thioether Concentration and Mutagenicity of Urine From Cigarette Smokers” . Int Arch Occup Environ Health , 43 : 159 – 166 .
   PubMedGoogle Scholar
• Conn , EE , ed. 1981 . The Biochemistry of Plants—a Comprehensive Treatise. Vol. 7. Secondary Plant Products , Vol. 7 , 269 – 316 . 403 – 478 . New York : Academic Press, Inc. .
   Google Scholar
• Wood , AW , Huang , MT , Chang , RL , Newmark , HL , Lehr , RE , Yagi , H , Sayer , JM , Jerina , DM and Conney , AH . 1982 . “Inhibition of the Mutagenicity of Bay‐Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Naturally Occurring Plant Phenols: Exceptional Activity of Ellagic Acid” . Proc Natl Acad Sci USA , 79 : 5513 – 5517 .
   PubMed Web of Science ®Google Scholar
• Wattenberg , LW , Coccia , JB and Lam , LKT . 1980 . “Inhibitory Effects of Phenolic Compounds on Benzo(α )pyrene‐Induced Neoplasia” . Cancer Res , 40 : 2820 – 2823 .
   PubMed Web of Science ®Google Scholar
• Sayer , JM , Yagi , H , Wood , AW , Conney , AH and Jerina , DM . 1982 . “Extremely Facile Reaction Between the Ultimate Carcinogen Benzo(a )pyrene‐7,8‐diol 9,10‐epoxide and Ellagic Acid” . J Am Chem Soc , 104 : 5562 – 5563 .
   Web of Science ®Google Scholar
• Wood , AW , Sayer , JM , Newmark , HL , Yagi , H , Michaud , DP , Jerina , DM and Conney , AH . 1982 . “Mechanism of the Inhibition of Mutagenicity of a Benzo(a )pyrene‐7,8‐diol 9,10‐epoxide by Riboflavin 5'‐phosphate” . Proc Natl Acad Sci USA , 79 : 5122 – 5126 .
   PubMed Web of Science ®Google Scholar
• Huang , MT , Wood , AW , Chang , RL , Newmark , HL , Lehr , RE , Sayer , JM , Yagi , H , Jerina , DM and Conney , AH . 1983 . “Inhibition of the Mutagenicity of Bay‐Region Diol‐epoxides of Polycyclic Aromatic Hydrocarbons by Naturally Occurring Plant Phenols and Related Compounds” . Proc Am Soc Cancer Res , 24 : 88
   Google Scholar
• Raj , AS , Stuart , E , Heddle , JA , Newmark , HL and Katz , M . 1982 . “Caffeic Acid as an Inhibitor of DMBA Induced Chromosomal Breakage in the Bone Marrow Micronucleus Test” . Meeting abstr., Genetics Society of Canada Annual Meeting . 1982 . Mutat Res in press
   Google Scholar
• Hirono , I , Hosaka , S , Uchida , E , Takanashi , H , Haga , M , Sakata , M , Mori , H , Taneka , T and Hikino , H . 1980 . “Safety Examination of Some Edible or Medicinal Plants and Plant Constituents, Part 3” . J Food Safety , 4 : 205 – 211 .
   Google Scholar
• Raj, AS, Heddle, JA, Newmark, HL: Unpublished data, 1983.
   Google Scholar
• Wood, AW: Personal communication.
   Google Scholar
• Weiss , LC . 1957 . “Report on Chlorogenic Acid in Coffee” . J Assoc Off Anal Chem , 40 : 350 – 354 .
   Google Scholar
• McMichael , CE and Bailey , AE . 1951 . “Oils, Fats and Related Products” . In The Chemistry and Technology of Food and Food Products, , 2nd ed. , Edited by: Jacobs , MB . Vol. 3 , 2317 – 2345 . New York : Interscience Publishers .
   Google Scholar
• Pamukcu , AM , Yalciner , S , Hatcher , JF and Bryan , GT . 1980 . “Quercetin, A Rat Intestinal and Bladder Carcinogen Present in Bracken Fern (Pteridium aquilinum)” . Cancer Res , 40 : 3468 – 3472 .
   PubMed Web of Science ®Google Scholar
• Morino , K , Matsukura , N , Kawachi , T , Ohgaki , H , Sugimura , T and Hirono , I . 1982 . “Carcinogenicity Test of Quercetin and Rutin in Golden Hamsters by Oral Administration” . Carcinogenesis , 3 : 93 – 97 .
   PubMed Web of Science ®Google Scholar
• Nagao , M , Morita , N , Yahagi , T , Shimizu , M , Kuroyanagi , M , Fukuoka , M , Yoshihira , K , Natori , S , Fujino , T and Surimura , T . 1981 . “Mutagenicities of 61 Flavonoids and Related Compounds” . Environ Mutagen , 3 : 401 – 419 .
   PubMedGoogle Scholar
• Aeschbacher , H , Meier , H and Ruch , E . 1982 . “Nonmutagenicity in Vivo of the Food Flavonol Quercetin” . Nutr Cancer , 4 : 90 – 98 .
   PubMedGoogle Scholar
• Newmark , J , Brady , RO , Grimley , PM , Gal , AE , Waller , SG and Thistlethwaite , JR . 1981 . “Amygdalin (Laetrile) and Prunasin Beta‐glucosidases Distribution in Germ Free Rat and in Human Tumor Tissue” . Proc Natl Acad Sci USA , 78 : 6513 – 6516 .
   PubMed Web of Science ®Google Scholar
• Tamura , G , Gold , C , Fenolazzi , A and Ames , BN . 1980 . “Fecalase: A Model for Activation of Dietary Glycosides to Mutagens by Intestinal Flora” . Proc Natl Acad Sci USA , 77 : 4961 – 4965 .
   PubMed Web of Science ®Google Scholar
• Jenkins , DJA , Wolever , TMS , Nineham , R , Sarson , DL , Bloom , SR , Ahern , J , Alberti , KGMM and Hockaday , TDR . 1980 . “Improved Glucose Tolerance Four Hours After Taking Guar With Glucose” . Diabetologia , 19 : 21 – 24 .
   PubMed Web of Science ®Google Scholar
• Jenkins , DJA , Reynolds , D , Slavin , B , Leeds , AR , Jenkins , A and Jepson , EM . 1980 . “Dietary Fiber and Blood Lipids: Treatment of Hypercholesterolemia With Guar Crispbread” . Am J Clin Nutr , 33 : 575 – 581 .
   PubMed Web of Science ®Google Scholar
• Jacobson , EA , Newmark , H , Baptista , J and Bruce , WR . in press . “A Preliminary Investigation of the Metabolism of Dietary Phenolics in Humans” . Nutr Rep Int ,
   Google Scholar
• Williams , RT . 1964 . “Metabolism of Phenolics in Animals” . In Biochemistry of Phenolic Compounds , Edited by: Harbone , JB . 205 – 248 . New York : Academic Press, Inc. .
   Google Scholar
• Doyle , G and Griffiths , LA . 1980 . “The Metabolism of Ellagic Acid in the Rat” . Xenobiotica , 10 : 247 – 257 .
   PubMed Web of Science ®Google Scholar
• Gugler , R , Leschik , M and Dengler , HJ . 1975 . “Disposition of Quercitin in Man After Single Oral and Intravenous Doses” . Eur J Clin Pharmacol , 9 : 229 – 234 .
   PubMed Web of Science ®Google Scholar
• Kuenzig , W , Chau , J , Norkus , E , Holowaschenko , H , Newmark , H , Mergens , WJ and Conney , AH . in press . “Caf‐feic and Ferulic Acid as Blockers of Nitrosamine Formation” . Carcinogenesis ,
   Google Scholar
• Lai , C‐N , Butler , MA and Matney , TS . 1980 . “Antimutagenic Activities of Common Vegetables and Their Chlorophyll Content” . Mutat Res , 77 : 245 – 250 .
   Web of Science ®Google Scholar
• Baxter , JH . 1968 . “Absorption of Chlorophyll Phytol in Normal Man and in Patients With Refsum's Disease” . Lipid Res , 9 : 636 – 641 .
   PubMed Web of Science ®Google Scholar
• Wood, AW: Personal communication, 1983.
   Google Scholar
• Arimoto , S , Negishi , T and Hayatsu , H . 1980 . “Inhibitory Effect of Hemin on the Mutagenic Activities of Carcinogens” . Cancer Lett , 11 : 29 – 33 .
   PubMed Web of Science ®Google Scholar
• Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences, National Research Council . 1982 . Diet, Nutrition and Cancer , Washington, DC : US Government Printing Office . Ch. 13
   Google Scholar
• Wargovich , M and Newmark , HL . 1983 . “Inability of Several Mutagen Blocking Agents to Inhibit 1,2‐Dimethylhydrazine Induced DNA‐Damaging Activity in Colonic Epithelium” . Mutat Res , 121 : 77 – 80 .
   PubMedGoogle Scholar