Modulatory influence of alcoholic extract of Ocimum leaves on carcinogen‐metabolizing enzyme activities and reduced glutathione levels in mouse

References

• Morse , MA and Stoner , GD . 1993 . “Cancer Chemoprevention: Principles and Prospects” . Carcinogenesis , 14 : 1737 – 1746 .
   PubMed Web of Science ®Google Scholar
• Talalay , P , De Long , MJ and Prochaska , HJ . 1987 . “Molecular Mechanisms in Protection Against Carcinogenesis” . In Cancer Biology and Therapeutics , Edited by: Cory , JG and Szentivani , A . 197 – 216 . New York : Plenum .
   Google Scholar
• Wattenberg , LW . 1985 . “Chemoprevention of Cancer” . Cancer Res , 45 : 1 – 8 .
   PubMed Web of Science ®Google Scholar
• Yang , CS , Smith , TJ and Hong , JY . 1994 . “Cytochrome P450 Enzymes as Targets for Chemoprevention Against Chemical Carcinogenesis and Toxicity: Opportunity and Limitations” . Cancer Res , 54 ( Suppl ) : 1982s – 1986s .
   PubMedGoogle Scholar
• Miller , EC . 1988 . “Some Current Perspectives on Chemical Carcinogenesis in Human and Experimental Animals” . Cancer Res , 38 : 1479 – 1496 .
   Google Scholar
• Miller , EC and Miller , JA . 1981 . “Mechanisms of Chemical Carcinogenesis” . Cancer , 47 : 1055 – 1063 .
   PubMed Web of Science ®Google Scholar
• Block , G , Patterson , B and Subar , A . 1992 . “Fruits, Vegetables and Cancer Prevention: a Review of the Epidemiologic Evidence” . Nutr Cancer , 18 : 1 – 29 .
   PubMed Web of Science ®Google Scholar
• Coldin , GA , Branch , LG , Lipnick , RJ , Willett , WC Rosner , B . 1985 . “Increased Green and Yellow Vegetable Intake and Lowered Cancer Death in Elderly Population” . Am J Clin Nutr , 41 : 32 – 36 .
   PubMed Web of Science ®Google Scholar
• Koshimizu , K , Ohigashi , H , Tokuda , H , Kondo , A and Yamaguchi , K . 1988 . “Screening of Edible Plants Against Possible Antitumor Promoting Activity” . Cancer Lett , 39 : 247 – 257 .
   PubMed Web of Science ®Google Scholar
• Hayatsu , H , Arimoto , S and Negishi , T . 1988 . “Dietary Inhibitors of Mutagenesis and Carcinogenesis” . Mutat Res , 202 : 429 – 446 .
   PubMed Web of Science ®Google Scholar
• Bidlack , WR , Brown , RC and Mohan , C . 1986 . “Nutritional Parameters That Alter Hepatic Drug Metabolism, Conjugation and Toxicity” . Fed Proc , 45 : 142 – 148 .
   PubMedGoogle Scholar
• Bradfield , CA and Bjeldanes , LF . 1984 . “Effect of Dietary Indole‐3 Carbinol on Intestinal and Hepatic Monooxygenase, Glutathione S‐Transferase and Epoxide Hydrolase Activities in the Rat” . Food Chem Toxicol , 22 : 977 – 982 .
   PubMed Web of Science ®Google Scholar
• Pantuck , EJ , Pantuck , CB , Anderson , KE , Wattenberg , LW Conney , AH . 1984 . “Effect of Brussels Sprouts and Cabbage on Drug Conjugation” . Clin Pharmacol Ther , 35 : 161 – 169 .
   PubMed Web of Science ®Google Scholar
• Zhang , Y and Talalay , P . 1984 . “Anticarcinogenic Activities of Organic Isothiocyanates: Chemistry and Metabolism” . Cancer Res , 54 ( Suppl ) : 1976 – 1981 .
   Google Scholar
• Bhargava , KP and Singh , N . 1981 . “Antistress Activity of Ocimum sanctum Linn” . Indian J Med Res , 73 : 443 – 451 .
   PubMed Web of Science ®Google Scholar
• Singh , N , Misra , N , Srivastava , AK , Dixit , AK and Gupta , GP . 1991 . “Effect of Antistress Plants on Biochemical Changes During Stress Reaction” . Indian J Pharmacol , 23 : 137 – 147 .
   Google Scholar
• Mediratta , PK , Dewan , V , Bhattacharaya , SK , Gupta , VS Maiti , PC . 1988 . “Effect of Ocimum sanctum Linn on Humoral Immune Responses” . Indian J Med Res , 87 : 384 – 386 .
   Google Scholar
• Singh , S and Agrawal , SS . 1991 . “Anti‐Asthamatic and Anti‐Inflammatory Activity of Ocimum sanctum” . Int J Pharmacognosy , 29 : 306 – 310 .
   Google Scholar
• Prashar , R , Kumar , A , Banerjee , S and Rao , AR . 1994 . “Chemopreventive Action by an Extract From Ocimum sanctum on Mouse Skin Papillomagenesis and Its Enhancement of Skin Glutathione S‐Transferase Activity and Acid Soluble Sulfhydryl Level” . Anti‐Cancer Drugs , 5 : 567 – 572 .
   PubMed Web of Science ®Google Scholar
• Omura , T and Sato , R . 1964 . “The Carbon‐Monoxide Binding Pigment of Liver” . J Biol Chem , 239 : 2370 – 2378 .
   PubMed Web of Science ®Google Scholar
• Nebert , DW and Gelboin , HV . 1968 . “Substrate Inducible Microsomal Aryl Hydrocarbon Hydroxylase in Mammalian Cell Culture” . J Biol Chem , 243 : 6242 – 6249 .
   PubMed Web of Science ®Google Scholar
• Yang , CS , Stickhart , FS and Kicha , LP . 1978 . “Analysis of Aryl Hydrocarbon Hydroxylase Assay” . Biochem Pharmacol , 27 : 2321 – 2326 .
   PubMed Web of Science ®Google Scholar
• Habig , WH , Pabst , MJ and Jakoby , WB . 1974 . “Glutathione S‐Transferases: the First Enzymatic Step in Mercapturic Acid Formation” . J Biol Chem , 249 : 7130 – 7139 .
   PubMed Web of Science ®Google Scholar
• Bradford , MM . 1976 . “A Rapid and Sensitive Method for the Quantification of Microgram Quantities of Protein Utilizing the Principle of Protein‐Dye Binding” . Anal Biochem , 72 : 248 – 254 .
   PubMed Web of Science ®Google Scholar
• Moron , MA , Depierre , JW and Mannervick , B . 1979 . “Levels of Glutathione, Glutathione Reductase, and Glutathione S‐Transferase Activities in Rat Lung and Liver” . Biochim Biophys Acta , 582 : 67 – 78 .
   PubMed Web of Science ®Google Scholar
• Wattenberg , LW . 1983 . “Inhibition of Neoplasia by Minor Dietary Constituents” . Cancer Res , 43 ( Suppl ) : 2448 – 245 .
   Google Scholar
• Prestera , T , Zhang , Y , Spencer , SR , Wilczak , C and Talalay , P . 1993 . “The Electrophilic Counterattack Response: Protection Against Neoplasia and Toxicity” . Adv Enzyme Regul , 33 : 281 – 296 .
   PubMedGoogle Scholar
• Wall , KW , Gao , W , Kopple , JM , Kwei , GY Kauffman , FC . 1991 . “The Liver Plays a Central Role in the Mechanism of Chemical Carcinogenesis Due to Polycyclic Aromatic Hydrocarbons” . Carcinogenesis , 12 : 783 – 786 .
   PubMed Web of Science ®Google Scholar
• Hocman , S . 1988 . “Prevention of Cancer: Phenolic Antioxidants (BHA and BHT)” . Int J Biochem , 7 : 639 – 651 .
   Google Scholar
• Ginsberg , G and Atherholt , TB . 1989 . “Transport of DNA‐Adducting Metabolites in Mouse Serum Following Benzo[a]pyrene Administration” . Carcinogenesis , 10 : 673 – 679 .
   PubMed Web of Science ®Google Scholar
• De Flora , S and Ramel , C . 1988 . “Mechanism of Inhibition of Mutagenesis and Carcinogenesis. Classification and Overview” . Mutat Res , 202 : 285 – 306 .
   PubMed Web of Science ®Google Scholar
• Ketterer , B . 1988 . “Protective Role of Glutathione and Glutathione Transferases in Mutagenesis and Carcinogenesis” . Mutat Res , 202 : 343 – 361 .
   PubMed Web of Science ®Google Scholar
• Mantle , TJ , Pickett , CB and Hayes , JD , eds. 1987 . Glutathione S‐Transferases and Carcinogenesis , New York : Taylor and Francis .
   Google Scholar
• Benson , AM , Batzinger , RP , Ou , SYL , Beuding , E Cha , Y . 1978 . “Elevation of Glutathione S‐Transferase Activities and Protection Against Mutagenic Metabolites of Benzo[a]pyrene by Dietary Antioxidants” . Cancer Res , 38 : 4486 – 4495 .
   PubMed Web of Science ®Google Scholar
• Cha , YN and Beuding , E . 1979 . “Effects of 2(3)‐Tert Butyl‐4‐Hydroxyanisole Administration on the Activities of Several Hepatic Microsomal and Cytoplasmic Enzymes in Mice” . Biochem Pharmacol , 28 : 1917 – 1921 .
   PubMed Web of Science ®Google Scholar
• McLellan , LI , Harrison , DJ and Hayes , JD . 1992 . “Modulation of Glutathione S‐Transferase and Glutathione Peroxidase by the Anticarcinogen Butylated Hydroxyanisole in Murine Extrahepatic Organs” . Carcinogenesis , 13 : 2255 – 2261 .
   PubMed Web of Science ®Google Scholar
• Yokota , H , Hashimoto , H , Motoya , M and Yuasia , A . 1988 . “Enhancement of UDP‐Glucuronyl Transferase, UDP‐Glucose Dehydrogenase in Rat Liver by Dietary Administration of Eugenol” . Biochem Pharmacol , 37 : 799 – 892 .
   PubMedGoogle Scholar
• 1983 . Carcinogenesis Studies of Eugenol (CAS 97–53–0) in F344IN Rats and B6C3F1 Mice (Food Studies) , 159 Research Triangle Park, NC : Natl Toxicol Prog . (Publ TR 223)
   Google Scholar
• Jenner , PM , Hagen , EC , Taylor , JM , Cook , EL and Fitzhugh , OG . 1964 . “Food Flavourings and Compounds of Related Structure. 1. Acute Oral Toxicity” . Food Cosmet Toxicol , 2 : 327 – 343 .
   Google Scholar
• Biaglow , JE , Varnes , ME , Epp , ER and Clark , EP . 1987 . “The Role of Thiols in Response to Radiation and Drugs” . In Anticarcinogenesis and Radiation Protection , Edited by: Cerutti , PA , Nygaard , OF and Simic , MD . 387 – 397 . New York : Plenum .
   Google Scholar
• Orrneius , S and Moldeus , P . 1984 . “The Multiple Roles of Glutathione in Drug Metabolism” . Trends Pharmacol Sci , 5 : 432 – 435 .
   Web of Science ®Google Scholar
• Younes , M and Siegers , CP . 1980 . “Lipid Peroxidation as a Consequence of Glutathione Depletion in Rat and Mouse Liver” . Res Commun Chem Pathol Pharmacol , 27 : 119 – 128 .
   PubMedGoogle Scholar