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Nutrition and Cancer Volume 26, 1996 - Issue 2
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Glutathione inhibits experimental oral carcinogenesis, p53 expression, and angiogenesis

Joel L. Schwartz (Molecular Epidemiology and Disease Indicators Branch), Naval Dental Research, National Institute for Dental Research, Bldg. 1, 4th Floor, Rm. 4416, 8901 Wisconsin Ave., Bethesda, MD, 20892 Phone: (301) 295–1671 Fax: (301) 295–1671 E-mail: [email protected]
&
Gerald Shklar Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, MA, 02115
Pages 229-236 | Received 02 Jan 1996, Accepted 20 Mar 1996, Published online: 04 Aug 2009

References

  • Rotstein , JB and Slaga , TJ . 1988 . “Effect of Exogenous Glutathione on Tumor Progression in the Murine Skin Multistage Carcinogenesis Model” . Carcinogenesis , 9 : 1547 – 1551 .
  • Trickier , D , Shklar , G and Schwartz , JL . 1993 . “Inhibition of Oral Carcinogenesis by Glutathione” . Nutr Cancer , 20 : 139 – 144 .
  • Shklar , G , Schwartz , JL , Trickier , D and Reid‐Cheverie , S . 1993 . “The Effectiveness of a Mixture of Beta Carotene, Alpha Tocopherol, Glutathione, and Ascorbic Acid for Cancer Chemoprevention” . Nutr Cancer , 20 : 145 – 151 .
  • Shklar , G . 1982 . “Inhibition of Oral Mucosal Carcinogenesis by Vitamin E” . JNVCI , 68 : 791 – 779 .
  • Trickier , D and Shklar , G . 1987 . “Prevention by Vitamin E of Oral Carcinogenesis” . JVCI , 78 : 165 – 169 .
  • Suda , D , Schwartz , JL and Shklar , G . 1986 . “Inhibition of Experimental Oral Carcinogenesis by Topical Beta Carotene” . Carcinogenesis , 7 : 711 – 715 .
  • Schwartz , JL , Sloane , D and Shklar , G . 1989 . “Prevention and Inhibition of Oral Cancer in the Hamster Buccal Pouch Model Associated With Carotenoid Immune Enhancement” . Tumor Biol , 10 : 297 – 309 .
  • Schwartz , JL , Shklar , G and Trickier , D . 1993 . “p53 in the Anticancer Mechanism of Vitamin E” . Oral Oncol Eur J Cancer , 29B : 313 – 318 .
  • Shklar , G and Schwartz , JL . 1994 . “A Common Pathway for the Destruction of Cancer Cells: Experimental Evidence and Clinical Implications” . Int J Oncol A , : 215 – 224 .
  • Perchellet , J‐P , Abney , NL , Thomas , RM , Guislane , YL and Perchellet , EM . 1987 . “Effects of Combined Treatments With Selenium, Glutathione, and Vitamin E on Glutathione Peroxidase Activity, Ornithine Decarboxylase Induction, and Complete and Multistage Carcinogenesis in Mouse Skin” . Cancer Res , 47 : 477 – 485 .
  • Meister , A and Anderson , ME . 1983 . “Glutathione” . Annu Rev Biochem , 52 : 711 – 760 .
  • Meister , A . 1985 . “The Fall and Rise of Cellular Glutathione Levels: Enzyme Based Approaches” . Curr Top Cell Regul , 26 : 383 – 392 .
  • Somers , KD , Merrick , MA , Lopez , ME , Incognito , MS Schecter , GL . 1992 . “Frequent p53 Mutations in Head and Neck Cancer” . Cancer Res , 52 : 5997 – 6000 .
  • Greenblatt , MS , Bennett , WP , Hollstein , M and Harris , CC . 1994 . “Mutations in the p53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis” . Cancer Res , 54 : 4855 – 4878 .
  • Folkman , J . 1989 . “What Is the Evidence That Tumors Are Angiogenesis Dependent?” . JNCI , 82 : 4 – 6 .
  • Dameron , KM , Volpert , OV , Tainsky , MA and Bouck , N . 1994 . “Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin‐1” . Science , 265 : 1582 – 1584 .
  • Folkman , J , Watson , K Ingber , D . 1989 . “Induction of Angiogenesis During the Transition From Hyperplasia to Neoplasia” . Nature , 339 : 58 – 61 .
  • Schwartz , JL , Shklar , G , Flynn , E and Trickier , DP . 1990 . “The Administration of Beta Carotene to Prevent and Regress Oral Carcinoma in the Hamster Cheek Pouch and the Associated Enhancement of the Immune Response” . Adv Exp Med Biol , 262 : 77 – 93 .
  • Shklar , G , Schwartz , JL , Trickier , DP and Reid , S . 1990 . “Prevention of Experimental Cancer and Immunostimulation by Vitamin E (Immunosurveillance)” . J Oral Pathol Med , 19 : 60 – 64 .
  • Schwartz , JL . 1993 . “The Clinical Control of Tumor Cell Growth Through the Action of Carotenoids, Retinoids, and Tocopherols” . In Adjuvant Nutrition in Cancer Treatment , Edited by: Quillin , P and Williams , RM . 173 – 233 . Arlington Heights, IL : Cancer Treat Found .
  • Schwartz , JL . 1993 . “The Clinical Control of Tumor Cell Growth Through the Action of Carotenoids, Retinoids, and Tocopherols” . In Adjuvant Nutrition in Cancer Treatment , Edited by: Quillin , P and Williams , RM . 173 – 233 . Arlington Heights, IL : Cancer Treat Found .
  • Schwartz , JL . 1994 . “Molecular and Biochemical Control of Tumor Growth Following Treatments With Carotenoids or Tocopherols” . In In Nutrition and Cancer Prevention and Treatment , Edited by: Prasad , K , Santamaria , L and Williams , RM . 287 – 316 . Totowa, NJ : Humana .

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