Antitumor effect of an oral administration of canthaxanthin on BALB/c mice bearing thymoma cells

References

• Mayne , ST . 1996 . “Beta‐carotene, carotenoids, and disease prevention in humans” . FASEB J , 10 : 690 – 701 .
   PubMed Web of Science ®Google Scholar
• Van Poppel , G and Goldbohm , RA . 1995 . “Epidemiological evidence for β‐carotene and cancer prevention” . Am J Clin Nutr , 62 ( Suppl ) : 1393S – 1402S .
   PubMedGoogle Scholar
• Alpha‐Tocopherol, Beta Carotene Cancer Prevention Study Group . 1994 . “The effect of vitamin E and β‐carotene on the incidence of lung cancer and other cancers in male smokers” . N Engl J Med , 330 : 1029 – 1035 .
   PubMed Web of Science ®Google Scholar
• Omenn , GS , Goodman , GE , Thornquist , MD , Balmes , J Cullen , MR . 1996 . “Effects of a combination of β‐carotene and vitamin A on lung cancer and cardiovascular disease” . N Engl J Med , 334 : 1150 – 1155 .
   PubMed Web of Science ®Google Scholar
• Hennekens , CH , Buring , JE , Manson , JE , Stampfer , M Rosner , B . 1996 . “Lack of effect of long‐term supplementation with β‐carotene on the incidence of malignant neoplasms and cardiovascular disease” . N Engl J Med , 334 : 1145 – 1149 .
   PubMed Web of Science ®Google Scholar
• Greenberg , ER , Baron , JA , Karagas , MR , Stukel , TA Nierenberg , DW . 1996 . “Mortality associated with low plasma concentration of β‐carotene and the effect of oral supplementation” . JAMA , 275 : 699 – 703 .
   Web of Science ®Google Scholar
• Krinsky , NI . 1989 . “Carotenoids and cancer in animal models” . J Nutr , 119 : 123 – 126 .
   PubMed Web of Science ®Google Scholar
• Gerster , H . 1995 . “P‐Carotene, vitamin E and vitamin C in different stages of experimental carcinogenesis” . Eur J Clin Nutr , 49 : 155 – 168 .
   PubMed Web of Science ®Google Scholar
• Mathews‐Roth , MM . 1982 . “Antitumor activity of β‐carotene, canthaxanthin and phytoene” . Oncology , 39 : 33 – 37 .
   PubMed Web of Science ®Google Scholar
• Shklar , G and Schwartz , J . 1988 . “Tumor necrosis factor in experimental cancer regression with α‐tocopherol, β‐carotene, canthaxanthin and algae extracts” . Eur J Cancer Clin Oncol , 24 : 839 – 850 .
   PubMedGoogle Scholar
• Santamaria , L , Bianchi , A , Ravetto , C , Arnaboldi , A Santagati , G . 1987 . “Prevention of gastric cancer induced by N‐methyl‐N´‐nitro‐N‐nitrosoguanidine in rats fed supplemental carotenoids” . J Nutr Growth Cancer , 4 : 175 – 181 .
   Google Scholar
• Schwartz , J and Shklar , G . 1988 . “Regression of experimental oral carcinomas by local injection of β‐carotene and canthaxanthin” . Nutr Cancer , 11 : 35 – 40 .
   PubMed Web of Science ®Google Scholar
• Grubbs , CJ , Eto , I , Juliana , MM and Whitaker , LM . 1991 . “Effect of canthaxanthin on chemically induced mammary carcinogenesis” . Oncology , 48 : 239 – 245 .
   PubMed Web of Science ®Google Scholar
• Tanaka , T , Morishita , Y , Suzui , M , Kojima , T Okumura , A . 1994 . “Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin” . Carcinogenesis , 15 : 15 – 19 .
   PubMed Web of Science ®Google Scholar
• Tanaka , T , Kawamori , T , Ohnishi , M , Makita , H Mori , H . 1995 . “Suppression of azoxymethane‐induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase” . Carcinogenesis , 16 : 2957 – 2963 .
   PubMed Web of Science ®Google Scholar
• Katsumura , N , Okuno , M , Onogi , N , Moriwaki , H Muto , Y . 1996 . “Suppression of mouse skin papilloma by canthaxanthin and β‐carotene in vivo: possibility of the regression of tumorigenesis by carotenoids without conversion to retinoic acid” . Nutr Cancer , 26 : 203 – 208 .
   PubMed Web of Science ®Google Scholar
• Tanaka , T , Makita , H , Ohnishi , M , Mori , H Satoh , K . 1995 . “Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls astaxanthin and canthaxanthin” . Cancer Res , 55 : 4059 – 4064 .
   PubMed Web of Science ®Google Scholar
• Tomita , Y . 1989 . “Studies on the role of nutrition and diet in prevention of cancer” . Bull Phys Fitness Res Inst , 72 : 116 – 120 .
   Google Scholar
• Foote , CS and Denny , RW . 1968 . “Chemistry of singlet oxygen. VIII. Quenching by β‐carotene” . J Am Chem Soc , 90 : 6233 – 6235 .
   Web of Science ®Google Scholar
• Burton , GW and Ingold , KU . 1984 . “β‐Carotene: an unusual type of lipid antioxidant” . Science , 224 : 569 – 573 .
   PubMed Web of Science ®Google Scholar
• Palozza , P and Krinsky , NI . 1992 . “Antioxidant effects of carotenoids in vivo and in vitro: an overview” . Methods Enzymol , 213 : 403 – 420 .
   PubMed Web of Science ®Google Scholar
• Krinsky , NI . 1993 . “Actions of carotenoids in biological systems” . Annu Rev Nutr , 13 : 561 – 587 .
   PubMed Web of Science ®Google Scholar
• Sies , H and Stahl , W . 1995 . “Vitamins E and C, β‐carotene, and other carotenoids as antioxidants” . Am J Clin Nutr , 62 ( Suppl ) : 1315S – 1321S .
   PubMedGoogle Scholar
• Huang , DS , Odeleye , OE and Watson , RR . 1992 . “Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells” . Cancer Lett , 65 : 209 – 213 .
   PubMed Web of Science ®Google Scholar
• Levy , J , Bosin , E , Feldman , B , Giat , Y Miinster , A . 1995 . “Lycopene is a more potent inhibitor of human cancer cell proliferation than either α‐carotene or β‐carotene” . Nutr Cancer , 24 : 257 – 266 .
   PubMed Web of Science ®Google Scholar
• Zhang , L‐X , Cooney , KW and Bertram , JS . 1992 . “Carotenoids upregulate connexin 43 gene expression independent of their provitamin A or antioxidant properties” . Cancer Res , 52 : 5707 – 5712 .
   PubMed Web of Science ®Google Scholar
• Bendich , A and Shapiro , SS . 1986 . “Effect of β‐carotene and canthaxanthin on the immune responses of the rat” . J Nutr , 116 : 2254 – 2262 .
   PubMed Web of Science ®Google Scholar
• Nikawa , T , Schulz , WA , van den Brink , CE , Hanusch , M van der Saag , P . 1995 . “Efficacy of all‐wara‐β‐carotene, canthaxanthin, and all‐trans‐ 9‐cis‐ and 4‐oxoretinoic acids in inducing differentiation of an F9 embryonal carcinoma RAR‐IacZ reporter cell line” . Arch Biochem Biophys , 316 : 665 – 672 .
   PubMed Web of Science ®Google Scholar
• Hanusch , M , Stahl , W , Schulz , WA and Sies , H . 1995 . “Induction of gap junctional communication by 4‐oxoretinoic acid generated from its precursor canthaxanthin” . Arch Biochem Biophys , 317 : 423 – 428 .
   PubMed Web of Science ®Google Scholar
• Pijnappel , WWM , Hendriks , HFJ , Folkers , GE , van den Brink , CE Dekker , EJ . 1993 . “The retinoid ligand 4‐oxo‐retinoic acid is a highly active modulator of positional specification” . Nature , 366 : 340 – 344 .
   PubMed Web of Science ®Google Scholar
• Palozza , P and Krinsky , NI . 1992 . “Astaxanthin and canthaxanthin are potent antioxidants in a membrane model” . Arch Biochem Biophys , 297 : 291 – 295 .
   PubMed Web of Science ®Google Scholar
• Palozza , P , Luberto , C , Ricci , P , Sgarlata , E Calviello , G . 1996 . “Effect of β‐carotene and canthaxanthin on tert‐butyl hydroperoxide‐induced lipid peroxidation in murine normal and tumor thymocytes” . Arch Biochem Biophys , 325 : 145 – 151 .
   PubMed Web of Science ®Google Scholar
• Shapiro , SS , Mott , DJ and Machlin , LJ . 1984 . “Kinetic characteristics of β‐carotene uptake and depletion in rat tissue” . 3 Nutr , 114 : 1924 – 1933 .
   PubMed Web of Science ®Google Scholar
• Bartoli , GM , Piccioni , E , Agostara , G , Calviello , G and Palozza , P . 1994 . “Different mechanisms of tert‐butyl hydroperoxide‐induced lethal injury in normal and tumor thymocytes” . Arch Biochem Biophys , 312 : 81 – 87 .
   PubMed Web of Science ®Google Scholar
• White , WS , Peck , KM , Bierer , TL , Gugger , ET and Herdman , JW Jr . 1993 . “Interactions of oral β‐carotene and canthaxanthin in ferrets” . J Nutr , 123 : 1405 – 1413 .
   PubMed Web of Science ®Google Scholar
• Handelman , GJ , van Kuijk , FJGM , Chatterjee , A and Krinsky , NI . 1991 . “Characterization of products formed during the autoxidation of β‐carotene” . Free Radicals Biol Med , 10 : 427 – 437 .
   PubMed Web of Science ®Google Scholar
• Ghosh , B , Mandal , A and Chatterjee , M . 1995 . “Physiological potential of β‐carotene in prolonging the survival of the host bearing transplantable murine lymphoma” . Planta Med , 61 : 317 – 320 .
   Google Scholar
• Kaplan , LA , Stein , EA , Willett , WC , Stampfer , MJ and Stryker , WS . 1987 . “Reference ranges of retinol, tocopherols, lycopene and α‐ and β‐carotene in plasma by simultaneous high‐performance liquid chromatog‐raphy” . Clin Physiol Biochem , 5 : 297 – 304 .
   PubMedGoogle Scholar
• Stryker , WS , Kaplan , LA , Stein , EA , Stampfer , MJ Sober , A . 1988 . “The relation of diet, cigarette smoking, and alcohol consumption to plasma β‐carotene and α‐tocopherol levels” . Am J Epidemiol , 127 : 283 – 296 .
   PubMed Web of Science ®Google Scholar
• Ito , Y , Shima , Y , Ochiai , J , Otani , M Sasaki , R . 1991 . “Effects of the consumption of cigarettes, alcohol and foods on serum concentrations of carotenoids, retinol and tocopherols in healthy inhabitants living in rural area of Hokkaido” . Jpn J Hyg , 46 : 874 – 881 .
   PubMedGoogle Scholar
• Maiani , G , Pappalardo , G , Ferro‐Luzzi , A , Raguzzini , A Azzini , E . 1995 . “Accumulation of β‐carotene in normal colorectal mucosa and colonic neoplastic lesions in humans” . Nutr Cancer , 24 : 23 – 31 .
   PubMed Web of Science ®Google Scholar
• Mayne , ST and Parker , RS . 1989 . “Antioxidant activity of dietary canthaxanthin” . Nutr Cancer , 12 : 225 – 236 .
   PubMed Web of Science ®Google Scholar
• Chen , H and Tappel , AL . 1995 . “Protection of vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q0, coenzyme Q10, beta‐carotene, canthaxanthin, and (+)‐catechin against oxidative damage to rat blood and tissues in vivo” . Free Radicals Biol Med , 18 : 949 – 953 .
   PubMed Web of Science ®Google Scholar
• Okuzumi , J , Nishino , H , Murakoshi , M , Iwashima , A Tanaka , Y . 1990 . “Inhibitory effects of fucoxanthin, a natural carotenoid, on N‐myc expression and cell cycle progression in human malignant tumor cells” . Cancer Lett , 55 : 75 – 81 .
   PubMed Web of Science ®Google Scholar
• Seifter , E , Rettura , G , Padawer , J and Levenson , SM . 1982 . “Moloney murine sarcoma virus tumors in CBA/J mice: chemopreventive and chemotherapeutic actions of supplemental β‐carotene” . JNCI , 68 : 835 – 840 .
   PubMedGoogle Scholar
• Kapsenberg , ML and Leene , W . 1979 . “Formation of B cell type gap junctions between PHA‐stimulated rabbit lymphocytes” . Exp Cell Res , 120 : 211 – 222 .
   PubMedGoogle Scholar
• Ghosh , B , Sardar , S , Roy , K and Chatterjee , M . 1995 . “Role of β‐carotene on the changes in activity patterns and levels of biotransforming enzymes in transplantable murine lymphoma” . Cancer Lett , 90 : 191 – 197 .
   PubMedGoogle Scholar