Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide

References

• Parker , SL , Tong , T , Bolden , S and Wingo , PA . 1997 . “Cancer statistics, 1997” . CA Cancer J Clin , 47 : 5 – 27 .
   PubMed Web of Science ®Google Scholar
• Gallagher , RP , Ma , B , McLean , DI , Yang , CP Ho , V . 1990 . “Trends in basal cell carcinoma, squamous cell carcinoma, and melanoma of the skin from 1973 through 1987” . J Am Acad Dermatol , 23 : 413 – 421 .
   PubMed Web of Science ®Google Scholar
• Fears , TR and Scotto , J . 1983 . “Estimating increases in skin cancer morbidity due to increases in ultraviolet radiation exposure” . Cancer Invest , 1 : 119 – 126 .
   PubMed Web of Science ®Google Scholar
• Kanjilal , S , Pierceall , WE , Cummings , KK , Kripke , ML and Anan‐thaswamy , HN . 1993 . “High frequency of p53 mutations in ultraviolet radiation‐induced murine skin tumors: evidence for strand bias and tumor heterogeneity” . Cancer Res , 53 : 2961 – 2964 .
   PubMed Web of Science ®Google Scholar
• Kripke , ML . 1990 . “Effects of UV radiation on tumor immunity” . JNCI , 82 : 1392 – 1396 .
   PubMed Web of Science ®Google Scholar
• Fisher , MS and Kripke , ML . 1982 . “Suppressor T lymphocytes control the development of primary skin cancers in UV‐irradiated mice” . Science , 216 : 1133 – 1134 .
   PubMed Web of Science ®Google Scholar
• Stevens , SR , Shibaki , A , Meunier , L and Cooper , KD . 1995 . “Suppressor T cell‐activating macrophages in ultraviolet‐irradiated human skin induce a novel, TGF‐β‐dependent form of T cell activation characterized by deficient IL‐2rα expression” . J Immunol , 155 : 5601 – 5607 .
   PubMed Web of Science ®Google Scholar
• Cooper , KD , Oberhelman , L , Hamilton , TA , Baadsgaard , O Terhyne , M . 1992 . “UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CDla‐DR+ epidermal macrophage induction, and Langerhans cell depletion” . Proc Nati Acad Sci USA , 89 : 8497 – 8501 .
   PubMed Web of Science ®Google Scholar
• Ludwig , A , Dietel , M , Schäfer , G , Müller , K and Hilz , H . 1990 . “Nicotin‐amide and nicotinamide analogues as antitumor promoters in mouse skin” . Cancer Res , 50 : 2470 – 2475 .
   PubMed Web of Science ®Google Scholar
• Gensler , HL and Magdaleno , M . 1991 . “Topical vitamin E inhibition of immunosuppression and tumorigenesis induced by ultraviolet irradiation” . Nutr Cancer , 15 : 97 – 106 .
   PubMed Web of Science ®Google Scholar
• Miller , RG . 1980 . Survival Analysis , New York : Wiley .
   Google Scholar
• Weisberg , S . 1980 . Applied Linear Regression , New York : Wiley .
   Google Scholar
• Letvin , NL , Fox , IJ , Greene , MI , Benacerraf , B and Germain , RN . 1980 . “Immunologic effects of whole body ultraviolet (UV) irradiation. II. Defect in splenic adherent cell antigen presentation for stimulation of T cell proliferation” . J Immunol , 125 : 1402 – 1404 .
   PubMed Web of Science ®Google Scholar
• Letvin , NL , Nepoom , JT , Greene , MI , Benacerraf , B and Germain , RN . 1980 . “Loss of la‐bearing splenic adherent cells after whole body ultraviolet irradiation” . J Immunol , 125 : 2550 – 2554 .
   PubMed Web of Science ®Google Scholar
• Yagi , H , Tokura , Y , Wakita , H , Furukawa , F and Takigawa , M . 1996 . “TCRVb7+ Th2 cells mediate UVB‐induced suppression of murine contact photosensitivity by releasing 1L‐10” . J Immunol , 156 : 1824 – 1831 .
   PubMed Web of Science ®Google Scholar
• Ullrich , S . 1995 . “The role of epidermal cytokines in the generation of cutaneous immune reactions and ultraviolet radiation‐induced immune suppression” . Photochem Photobiol , 62 : 389 – 401 .
   PubMed Web of Science ®Google Scholar
• Mosmann , TR and Moore , KW . 1991 . “The role of IL‐10 in crossregulation of Th1 and Th2 responses” . Immunol Today , 12 : A49 – A53 .
   PubMedGoogle Scholar
• Gensler , HL , Gerrish , KE , Williams , T , Rao , G and Kittelson , J . 1994 . “Prevention of photocarcinogenesis and UV‐induced immunosuppression in mice by topical tannic acid” . Nutr Cancer , 22 : 121 – 130 .
   PubMed Web of Science ®Google Scholar
• Gensler , HL . 1991 . “Prevention by α‐difluoromethylornithine of skin car‐cinogenesis and immunosuppression induced by ultraviolet irradiation” . J Cancer Res Clin Oncol , 117 : 345 – 350 .
   PubMed Web of Science ®Google Scholar
• Gensler , HL , Aickin , M , Peng , YM and Xu , M . 1996 . “Importance of the form of topical vitamin E for prevention of photocarcinogenesis” . Nutr Cancer , 26 : 183 – 191 .
   PubMed Web of Science ®Google Scholar
• Ullrich , SE . 1994 . “Mechanism involved in the systemic suppression of antigen‐presenting cell function by UV irradiation: keratinocyte‐derived IL‐10 modulates antigen‐presenting cell function of splenic adherent cells” . J Immunol , 152 : 3410 – 3416 .
   PubMed Web of Science ®Google Scholar
• Seder , RA , Gazzinelli , R , Sher , A and Paul , WE . 1993 . “IL‐12 acts directly on CD4+ T cells to enhance priming for IFNγ production and diminishes IL‐4 inhibition of such priming” . Proc Nati Acad Sci USA , 90 : 10188 – 10192 .
   PubMed Web of Science ®Google Scholar
• Schmitt , E , Hoehn , P , Huels , C , Goedert , S Palm , N . 1994 . “T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β” . Eur J Immunol , 24 : 793 – 797 .
   PubMed Web of Science ®Google Scholar
• Bradley , LM , Yoshimoto , K and Swain , SL . 1995 . “The cytokines IL‐4, IFN‐γ, and IL‐12 regulate the development of subsets of memory effector helper T cells in vitro” . J Immunol , 155 : 1713 – 1724 .
   PubMed Web of Science ®Google Scholar
• McKnight , AJ , Zimmer , GJ , Fogellman , I , Wolf , SF and Abbas , AK . 1994 . “Effects of IL‐2 on helper ? cell‐dependent immune responses in vivo” . J Immunol , 152 : 2172 – 2177 .
   PubMed Web of Science ®Google Scholar
• Schmitt , DA , Owen‐Schaub , L and Ullrich , SE . 1995 . “Effect of IL‐12 on immune suppression and suppressor cell induction by ultraviolet radiation” . J Immunol , 154 : 5114 – 5120 .
   PubMed Web of Science ®Google Scholar
• Manetti , R , Gerosa , F , Giudizi , MG , Biagiotti , R Parronchi , P . 1994 . “Interleukin‐12 induces stable priming for interferon‐γ (IFN‐γ) production during differentiation of human ? helper (Th) cells and transient IFN‐γ production in established Th2 cell clones” . J Exp Med , 179 : 1273 – 1283 .
   PubMed Web of Science ®Google Scholar
• Scharton‐Kersten , T , Afonso , LC , Wysocka , M , Trinchieri , G and Scott , P . 1995 . “IL‐12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis” . J Immunol , 154 : 5320 – 5330 .
   PubMed Web of Science ®Google Scholar
• Novelli , F , Giovarelli , M , Reber‐Liske , R , Virgallita , G Garotte , G . 1991 . “Blockade of physiologically secreted IFN‐γ inhibits human T lymphocyte and natural killer cell activation” . J Immunol , 147 : 1445 – 1452 .
   PubMed Web of Science ®Google Scholar
• Pace , JL , Russel , SW , Torres , BA , Johnson , HM and Gray , PW . 1983 . “Recombinant mouse γ Interferon induces the prime step in macrophage activation for tumor cell killing” . J Immunol , 130 : 2011 – 2013 .
   PubMed Web of Science ®Google Scholar
• Gensler , HL , Simpson , J , Gerrish , K and Gilmore , J . 1995 . “Reduction of interferon‐γ as a critical mechanism by which ultraviolet radiation prevents tumor rejection” . Photochem Photobiol , 62 : 862 – 868 .
   PubMed Web of Science ®Google Scholar
• D'Andrea , A , Aste‐Amezaga , M , Vallante , NM , Ma , X Kubin , M . 1993 . “Interleukin 10 (IL‐10) inhibits human lymphocyte interferon‐γ production by suppressing natural killer cell stimulatory factor/IL‐12 synthesis in accessory cells” . J Exp Med , 178 : 1041 – 1048 .
   PubMed Web of Science ®Google Scholar
• Rivas , JM and Ullrich , SE . 1994 . “The role of IL‐4, IL‐10 and TNF‐α in the immune suppression induced by ultraviolet radiation” . J Leukocyte Biol , 56 : 769 – 775 .
   PubMed Web of Science ®Google Scholar