References
- Lowy , DR and Willumsen , BM . 1993 . Function and regulation of Ras . Annu Rev Biochem , 62 : 851 – 891 .
- Katz , ME and McCormick , F . 1997 . Signal transduction from multiple Ras effectors . Curr Opin Genet Dev , 7 : 75 – 79 .
- Trahey , M and McCormick , F . 1987 . A cytoplasmic protein stimulates normal N‐ras p21 GTPase, but does not affect oncogenic mutants . Science , 238 : 542 – 545 .
- von Deimling , A , Krone , W and Menon , GA . 1995 . Neurofibromatosis type 1: pathology, clinical features and molecular genetics . Brain Pathol , 5 : 153 – 162 .
- Boguski , MS and McCormick , F . 1993 . Proteins regulating Ras and its relatives . Nature , 366 : 643 – 653 .
- Bos , JL . 1989 . Ras oncogenes in human cancer: a review . Cancer Res , 49 : 4682 – 4689 .
- Chang , EH , Furth , ME , Scolnic , EM and Lowy , DR . 1982 . Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus . Nature , 297 : 479 – 481 .
- Stahle‐Backdhal , M , Inoue , M , Zedenius , J , Sandstedt , B Demarco , L . 1995 . Decreased expression of Ras GTPase activating protein in human trophoblastic tumors . Am J Pathol , 146 : 1073 – 1078 .
- Sundaram , V , Lee , J , Harwalkar , J , Roudebush , M Stein , DJ . 1997 . Reduced expression of neurofibromin in human meningiomas . Br J Cancer , 76 : 747 – 756 .
- Friedman , E , Gejman , PV , Martin , GA and McCormick , F . 1993 . Nonsense mutations in the C‐terminal SH2 region of the GTPase activation protein (GAP) gene in human tumours . Nature Genet , 5 : 242 – 247 .
- Golubic , M , Tanaka , K , Dobrowolski , S , Wood , D Tsai , MH . 1991 . The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid . EMBO J , 10 : 2897 – 2903 .
- Tsai , M‐H , Yu , C‐L , Wei , S‐F and Stacey , DW . 1989 . The effects of GTPase activating protein upon ras is inhibited by mitogenically responsive lipids . Science , 243 : 522 – 526 .
- Han , J‐W , McCormick , F and Macara , I . 1991 . Regulation of Ras‐GAP and the neurofibromatosis‐1 gene product by eicosanoids . Science , 252 : 576 – 579 .
- Bollag , G and McCormick , F . 1991 . Differential regulation of rasGAP and neurofibromatosis gene product activities . Nature , 351 : 576 – 579 .
- Golubic , M , Roudebush , M , Dobrowolski , S , Wolfman , A and Stacey , DW . 1992 . Catalytic properties, tissue and intracellular distribution of neurofibromin . Oncogene , 7 : 2151 – 2159 .
- Field , JK and Spandidos , DA . 1990 . The role of ras and myc oncogenes in human solid tumors and their relevance in diagnosis and prognosis (review) . Anticancer Res , 10 : 1 – 22 .
- Watson , DMA , Elton , RA , Jack , WJL , Dixon , JM Chetty , U . 1990 . The H‐ras oncogene product p21 and prognosis in human breast cancer . Breast Cancer Res Treat , 17 : 161 – 169 .
- Gumerlock , PH , Poonamallee , UR , Meyers , FJ and White , RW . 1991 . Activated ras alíeles in human carcinoma of prostate are rare . Cancer Res , 51 : 1632 – 1637 .
- Sun , X‐F , Hatschek , T , Wingren , S , Stal , O Carstensen , JM . 1991 . Ras p21 expression in relation to histopathological variables and prognosis in colorectal adenocarcinoma . Acta Oncol , 30 : 933 – 939 .
- Forrester , K , Almoguera , C , Han , K , Grizzlw , WE and Perucho , M . 1987 . Detection of high incidence of K‐ras oncogenes during human colon tumorigenesis . Nature , 327 : 298 – 303 .
- Kromhout , D . 1990 . The importance of n‐6 and n‐3 fatty acids in carcino‐genesis . Med Oncol Tumors Pharmacother , 7 : 173 – 176 .
- Birt , DF . 1990 . The influence of dietary fat on carcinogenesis: lessons from experimental models . Nutr Rev , 48 : 1 – 5 .
- Rose , DP , Connolly , JM , Raybum , J and Coleman , M . 1995 . Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice . JNCI , 87 : 587 – 592 .
- Wang , Y , Corr , JG , Thaler , HT , Tao , Y Fair , WR . 1995 . Decreased growth of established human prostate LNCaP tumors in nude mice fed a low‐fat diet . JNCI , 87 : 1456 – 1466 .
- Henderson , M . 1992 . International differences in diet and cancer incidence . Nati Cancer Inst Monogr , 12 : 59 – 63 .
- Cohen , LA . 1992 . Lipids and cancer: an introduction . Lipids , 27 : 791 – 792 .
- Giovannucci , EJ , Rimm , EB , Colditz , GA , Stampfer , MJ Ascherio , A . 1993 . A prospective study of dietary fat and risk of prostate cancer . JNCI , 85 : 1571 – 1579 .
- Sumida , C , Graber , R and Nunez , E . 1993 . Role of fatty acids in signal transduction: modulators and messengers . Prostaglandins Leukot Es‐sent Fatty Acids , 48 : 117 – 122 .
- Holian , O and Nelson , R . 1992 . Action of long‐chain fatty acids on protein kinase C activity: comparison of ω‐6 and ω‐3 fatty acids . Anticancer Res , 12 : 975 – 980 .
- DeWille , JW , Waddell , K , Steinmeyer , C and Farmer , SJ . 1993 . Dietary fat promotes mammary tumorigenesis in MMTV/v‐Ha‐ras transgenic mice . Cancer Lett , 69 : 59 – 66 .
- Karmali , RA , Chao , C‐C , Basu , A and Modak , M . 1989 . Effect of n‐3 and n‐6 fatty acids on mammary H‐ras expression and PGE2 levels in DMBA‐treated rats . Anticancer Res , 9 : 1169 – 1174 .
- Singh , J , Hamid , R and Reddy , BR . 1997 . Dietary fat and colon cancer: modulating effect of types and amount of dietary fat on ras‐p21 function during promotion and progression stages of colon cancer . Cancer Res , 57 : 253 – 258 .
- Yoder‐Hill , J , Golubic , M and Stacey , DW . 1995 . A conserved region of c‐Ha‐Ras is required for efficient GTPase stimulation by GTPase activating protein but not neurofibromin . J Biol Chem , 270 : 27615 – 27621 .
- Bryant , SS , Mitchell , AL , Collins , F , Miao , W Marshall , M . 1996 . N‐terminal sequences contained in the src homology 2 and 3 domains of p120 GTPase‐activating protein are required for full catalytic activity toward Ras . J Biol Chem , 271 : 5195 – 5199 .
- Rose , DP , Connolly , JM and Liu , X‐H . 1994 . Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro . Cancer Res , 54 : 6557 – 6562 .
- Cave , WT . 1991 . Dietary n‐3 (ω‐3) polyunsarurated fatty acid effects on animal tumorigenesis . FASEB J , 5 : 2160 – 2166 .
- Gonzalez , MJ , Schemmel , RA , Dugan , L , Gray , JI and Welsch , CW . 1993 . Dietary fish oil inhibits human breast carcinoma growth: a function of increased lipid peroxidation . Lipids , 28 : 827 – 832 .
- Hitomi , M , Shu , J , Strom , D , Hiebert , SW Harter , ML . 1996 . Pros‐taglandin A2 blocks the activation of G1 phase cyclin‐dependent kinase without altering mitogen‐activated protein kinase stimulation . J Biol Chem , 271 : 9376 – 9383 .
- Wolf , BA , Turk , J , Sherman , WR and McDaniel , ML . 1986 . Intracellular Ca++ mobilization by arachidonic acid . J Biol Chem , 261 : 3501 – 3511 .
- Winkler , JD , Sung , C , Hubbard , WC and Chilton , FH . 1993 . Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil . Biochem J , 291 : 825 – 831 .
- Sermon , BA , Eccleston , JF , Skinner , RH and Lowe , PN . 1996 . Mechanism of inhibition by arachidonic acid of the catalytic activity of Ras GTPase‐activating protein . J Biol Chem , 271 : 1566 – 1572 .
- Glick , J , Santoyo , G and Casey , PJ . 1996 . Arachidonate and related unsatu‐rated fatty acids selectively inactivate the guanine nucleotide‐binding regulatory protein Gz . J Biol Chem , 271 : 2949 – 2954 .
- DiBattiste , D , Golubic , M , Stacey , D and Wolfman , A . 1993 . Differences in interaction of p21c‐Ha‐ras‐GMP‐PNP with full‐length neurofibromin and GTPase‐activating protein . Oncogene , 8 : 637 – 643 .
- Downward , J . 1996 . Control of ras activation . Cancer Surv , 27 : 87 – 100 .
- Scheffzek , K , Ahmadian , MR , Kabash , W , Weismueller , L Lautwein , A . 1997 . The Ras‐RasGAP complex: structural basis for the GTPase activation and its loss in oncogenic Ras mutants . Science , 277 : 333 – 338 .
- Bandyopadhyay , GK , Imagawa , W and Nandi , S . 1995 . Role of GTP‐bind‐ing proteins in the polyunsaturated fatty acid stimulated proliferation of mouse mammary epithelial cells . Prostaglandins Leukot Essent Fatty Acids , 52 : 151 – 158 .
- Lu , J , Jiang , C , Fontaine , S and Thompson , HJ . 1995 . ras may mediate mammary cancer promotion by high fat . Nutr Cancer , 23 : 283 – 290 .
- Daston , MM , Scrable , H , Norlund , M , Sturbaum , AK Nissen , LM . 1992 . The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells and oligodendrocytes . Neuron , 8 : 415 – 428 .
- Murphy , MG . 1991 . Dietary fatty acids and membrane protein function . J Nutr Biochem , 1 : 68 – 79 .
- Clandinin , MT , Cheema , S , Field , CI , Garg , ML Venkatraman , J . 1991 . Dietary fat: exogenous determination of membrane structure and cell function . FASEB J , 5 : 2761 – 2769 .
- Lai , LTY and German , JB . 1993 . Modulation of fatty acid composition in murine brain by dietary unsaturated fats . J Nutr Biochem , 4 : 463 – 471 .
- Reddy , BS and Maeura , Y . 1984 . Tumor promotion by dietary fat in azoxymethane‐induced colon carcinogenesis in female F344 rats: influence of amount and source of dietary fat . JNCI , 72 : 745 – 750 .
- Cohen , LA , Thompson , DO , Maeura , Y , Choi , K Blank , ME . 1986 . Dietary fat and mammary cancer. I. Promoting effects of different dietary fats on N‐nitrosomethylurea‐induced rat mammary tumorigenesis . JNCI , 77 : 33 – 42 .
- Takeshita , M , Ueda , H , Shirabe , K , Higuch , Y and Yosida , S . 1997 . Lack of promotion of colon carcinogenesis by high‐oleic safflower oil . Cancer , 79 : 1487 – 1493 .
- Wynder , EL , Cohen , LA , Muscat , JE , Winters , B Dwyer , JT . 1997 . Breast cancer: weighing the evidence for a promoting role of dietary fat . JNCI , 89 : 766 – 775 .
- Bautista , D , Obrador , A , Moreno , V , Cabeza , E Canet , R . 1997 . Ki‐ras mutation modifies the protective effect of dietary monounsaturated fat and calcium on sporadic colorectal cancer . Cancer Epidemiol Biomarkers Prev , 6 : 57 – 61 .