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Reports

Absence of PhIP adducts, p53 and Apc mutations, in rats fed a cooked beef diet containing a high level of heterocyclic amines

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Pages 227-231 | Received 20 Oct 1997, Accepted 26 Feb 1998, Published online: 04 Aug 2009

References

  • Gerhardsson de Verdier , M , Hangman , U , Peters , RK , Steineck , G and Overvik , K . 1991 . Meat cooking methods and colorectal cancer: a case‐referent study in Stockholm . Int J Cancer , 49 : 520 – 525 .
  • Sugimura , T , Nagao , M and Wakabayashi , K . 1994 . Heterocyclic amines in cooked foods: candidates for causation of common cancers . JNCI , 86 : 2 – 4 .
  • Ward , MH , Sinha , R , Heineman , EF , Rothman , N Markin , RS . 1996 . Increased risk of stomach cancer with the level of meat doneness (abstr) . Proc Am Assoc Cancer Res , 37 : 282
  • Ito , N , Hasegawa , R , Sano , M , Tamano , S Esumi , H . 1991 . A new colon and mammary carcinogen in cooked food, 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) . Carcinogenesis , 12 : 1503 – 1506 .
  • Schut , HAJ and Herzog , CR . 1992 . Formation of DNA adducts of 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) in male Fischer‐344 rats . Cancer Lett , 67 : 117 – 124 .
  • Hollstein , M , Sidransky , D , Vogelstein , B and Harris , CC . 1991 . p53 mutations in human cancer . Science , 253 : 49 – 53 .
  • Nigro , JM , Baker , SJ , Preisinger , AC , Jessup , JM Hostetter , R . 1989 . Mutations in the p53 gene occur in diverse human tumor types . Nature , 342 : 705 – 708 .
  • Makino , H , Ushijima , T , Kakiuchi , H , Onda , M Ito , N . 1994 . Absence of p53 mutations in rat colon tumors induced by 2‐amino‐6‐methyl‐dipyrido[ 1,2‐a:3’,2'‐d]imidazole, 2‐amino‐3‐methylimidazo[4,5‐f]quinoline or 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine . Jpn J Cancer Res , 85 : 510 – 514 .
  • Suzui , M , Yoshimi , N , Ushijima , T , Hirose , Y Makita , H . 1995 . No involvement of Ki‐ras or p53 gene mutations in colitis‐associated rat colon tumors induced by 1‐hydroxyanthraquinone and methylazoxy‐methanol acetate . Mol Carcinog , 12 : 193 – 197 .
  • Powell , SM , Zilz , N , Beazer‐Barclay , Y , Bryan , TM Hamilton , SR . 1992 . Apc mutations occur early during colorectal tumorigenesis . Nature , 359 : 235 – 237 .
  • Kakiuchi , H , Watanabe , M , Ushijima , T , Toyota , M Imai , K . 1995 . Specific 5'‐GGGA‐3’ ? 5'‐GGA‐3’ mutation of the Apc gene in rat colon tumors induced by 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine . Proc Natl Acad Sci USA , 92 : 910 – 914 .
  • Pence , BC , Landers , M , Dunn , DM , Shen , C‐L and Miller , MF . 1998 . Feeding of a well‐cooked beef diet containing a high heterocyclic amine content enhances colon and stomach carcinogenesis in 1,2‐dimethyl‐hydrazine‐treated rats . Nutr Cancer , 30 : 220 – 226 .
  • Gupta , RC . 1984 . Non‐random binding of the carcinogen N‐hydroxy‐2‐acetylaminofluroence to repetitive sequences of rat liver DNA in vivo . Proc Natl Acad Sci USA , 81 : 6943 – 6947 .
  • Randerath , E , Agrawal , HP , Weaver , JA , Bordelon , CB and Randerath , K . 1985 . 32P‐postabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12‐dimethylbenz[a]anthracene . Carcinogenesis , 6 : 1117 – 1126 .
  • Lu , JJ , Disher , RM , Reddy , MV and Randerath , K . 1986 . 32P‐postlabeling assay in mice of transplacental DNA damage induced by the environmental carcinogens safrolen 4‐aminobiphenyl and benzo(a)pyrene . Cancer Res , 46 : 3046 – 3054 .
  • Chozick , BS , Eva Weicker , M , Pezzullo , JC , Jackson , CL Finkelstein , SD . 1994 . Pattern of mutant p53 expression in human astrocytomas suggests the existence of alternate pathways of tumorigenesis . Cancer , 73 : 406 – 415 .
  • Weghorst , CM and Dragner , KH . 1994 . Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat renal mesenchymal tumors . Cancer Res , 54 : 215 – 219 .
  • Hecker , KH and Roux , KH . 1996 . High and low annealing temperatures increase both specificity and yield in touchdown and stepdown PCR . Biotechniques , 20 : 478 – 485 .
  • Friesen , MD , Cummings , DA , Garren , L , Butler , R Bartsch , H . 1996 . Validation in rats of two biomarkers of exposure to the food‐borne carcinogen 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP): PhIP‐DNA adducts and urinary PhIP . Carcinogenesis , 17 : 67 – 72 .
  • Takayama , K , Yamashita , K , Wakabayashi , K , Sugimura , T and Nagao , M . 1989 . DNA modification by 2‐amino‐l‐methyl‐6‐phenylimi‐dazo[4,5‐b]pyridine in rats . Jpn J Cancer Res , 80 : 1145 – 1148 .
  • Ouhtit , A , Ueda , M , Nakazawa , H , Ichisashi , M Dumaz , N . 1997 . Quantitative detection of ultraviolet‐specific p53 mutations in normal skin from Japanese patients . Cancer Epidemiol Biomarkers Prev , 6 : 433 – 438 .
  • Kakiuchi , H , Ushijima , T , Ochiai , M , Imai , K Ito , N . 1993 . Rare frequency of activation of the Ki‐ras gene in colon tumors induced by heterocyclic amines: possible alternative mechanisms of human colon carcinogenesis . Mol Carcinog , 8 : 44 – 48 .

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