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Reports

Mammary gland carcinogenicity of 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Sprague‐Dawley rats on high‐ and low‐fat diets

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Pages 160-167 | Received 24 Mar 1998, Accepted 04 Jun 1998, Published online: 04 Aug 2009

References

  • Kelsey , JL and Horn‐Ross , PL . 1993 . Breast cancer: magnitude of the problem and descriptive epidemiology . Epidemiol Rev , 15 : 7 – 17 .
  • Greenwald , P , Sherwood , K and McDonald , SS . 1997 . Fat, caloric intake, and obesity: lifestyle risk factors for breast cancer . J Am Diet Assoc , 97 ( Suppl ) : S24 – S30 .
  • Wynder , EL , Cohen , LA , Muscat , JE , Winters , B Dwyer , JT . 1997 . Breast cancer: weighing the evidence for a promoting role of dietary fat . JNCI , 89 : 766 – 775 .
  • Adlercreutz , H , Mousavi , Y and Höckerstedt , K . 1992 . Diet and breast cancer . Acta Oncol , 31 : 175 – 181 .
  • Greenwald , P , Clifford , C , Pilch , S , Heimendinger , J and Kelloff , G . 1995 . “ New directions in dietary studies in cancer: The National Cancer Institute ” . In Nutrition and Biotechnology in Heart Disease and Cancer , Edited by: Longenecker , JB , Kritchevsky , D. and Drezner , M. K. 229 – 239 . New York : Plenum .
  • Hunter , KJ and Willett , WC . 1994 . Diet, body build, and breast cancer . Annu Rev Nutr , 14 : 393 – 418 .
  • Carroll , KK , Braden , LM , Bell , JA and Kalamegham , R . 1986 . Fat and cancer . Cancer , 58 : 1818 – 1825 .
  • Knekt , P , Steineck , G , Järvinen , R , Hakulinen , T and Aromaa , A . 1994 . Intake of fried meat and risk of cancer, a follow‐up study in Finland . Int J Cancer , 59 : 756 – 760 .
  • Ronco , A , De Stefani , E , Mendilaharsu , M and Deneo‐Pellegrini , H . 1996 . Meat, fat and risk of breast cancer: a case‐control study from Uruguay . Int J Cancer , 65 : 328 – 331 .
  • De Stefani , E , Ronco , A , Mendilaharsu , M , Guidobono , M and Deneo‐Pellegrini , H . 1997 . Meat intake, heterocyclic amines, and risk of breast cancer: a case‐control study in Uruguay . Cancer Epidemiol Biomarkers Prev , 6 : 573 – 581 .
  • Weisburger , JH , Rivenson , A , Kingston , DGI , Wilkins , TD Van‐Tassell , RL . 1995 . “ Dietary modulation of the carcinogenicity of the heterocyclic amines ” . In Heterocyclic Amines in Cooked Foods: Possible Human Carcinogens , Edited by: Adamson , RH , Gustafsson , J‐A , Ito , N , Nagao , M Sugimura , T . 240 – 250 . Princeton, NJ : Princeton Scientific .
  • Snyderwine , EG . 1994 . Some perspectives of the nutritional aspects of breast cancer research . Cancer , 74 : 1070 – 1077 .
  • Hunter , DJ and Willett , WC . 1996 . Nutrition and breast cancer . Cancer Causes Control , 7 : 56 – 68 .
  • Sugimura , T . 1982 . Mutagens, carcinogens, and tumor promoters in our daily food . Cancer , 49 : 1970 – 1984 .
  • Sugimura , T . 1985 . Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process . Mutat Res , 150 : 33 – 41 .
  • Felton , JS , Knize , MG , Shen , NH , Andresen , BD Bjeldanes , LF . 1986 . Identification of the mutagens in cooked beef . Environ Health Perspect , 67 : 17 – 24 .
  • Wakabayashi , K , Ushiyama , H , Makoto , T , Nukaya , H Kim , S‐B . 1993 . Exposure to heterocyclic amines . Environ Health Perspect , 99 : 129 – 133 .
  • Felton , JS and Knize , MG . 1990 . “ Heterocyclic‐amine mutagens/carcinogens in foods ” . In Handbook of Experimental Pharmacology , Edited by: Cooper , CS and Grover , PL . vol 94/1 , 471 – 502 . Berlin : Springer‐Verlag .
  • Layton , DW , Bogen , KT , Knize , MG , Hatch , FT Johnson , VM . 1995 . Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research . Carcinogenesis , 16 : 39 – 52 .
  • Sinha , R , Rothman , N , Brown , ED , Salmon , CP Knize , MG . 1995 . High concentrations of the carcinogen 2‐amino‐l‐methyl‐6‐phenylimi‐dazo[4,5‐b]pyridine (PhIP) occur in chicken but are dependent on the cooking method . Cancer Res , 55 : 4516 – 4519 .
  • Ito , N , Hasegawa , R , Sano , M , Tamano , S Esumi , H . 1991 . A new colon and mammary carcinogen in cooked food, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) . Carcinogenesis , 12 : 1503 – 1506 .
  • Hasegawa , R , Sano , M , Tamano , S , Imaida , K Shirai , T . 1993 . Dose dependence of 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) carcinogenicity in rats . Carcinogenesis , 14 : 2553 – 2557 .
  • Imaida , K , Hagiwara , A , Yada , H , Masui , T Hasegawa , R . 1996 . Dose‐dependent induction of mammary carcinomas in female Sprague‐Dawley rats with 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine . JPNJ Cancer Res , 87 : 116 – 1120 .
  • Ghoshal , A , Preisegger , K‐H , Takayama , S , Thorgeirsson , SS and Snyderwine , EG . 1994 . Induction of mammary rumors in female Sprague‐Dawley rats by the food‐derived carcinogen 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine and effect of dietary fat . Carcinogenesis , 15 : 2429 – 2433 .
  • El‐Bayoumy , K , Chae , Y‐H , Upadhyaya , P , Rivenson , A Kurtzke , C . 1995 . Comparative tumorigenicity of benzo[a]pyrene, 1‐nitropy‐rene, and 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine administered by gavage to female CD rats . Carcinogenesis , 16 : 431 – 434 .
  • Gammal , EB , Carroll , KK and Plunkett , ER . 1967 . Effects of dietary fat on mammary carcinogenesis by 7,12‐dimethylbenz[a]anthracene in rats . Cancer Res , 27 : 1737 – 1742 .
  • Carroll , KK and Khor , HT . 1970 . Effects of dietary fat and dose level of 7,12‐dimethylbenz[a]anthracene on mammary tumor incidence in rats . Cancer Res , 30 : 2260 – 2264 .
  • Carroll , KK and Khor , HT . 1971 . Effects of level and type of dietary fat on incidence of mammary tumors induced in female Sprague‐Dawley rats by 7,12‐dimethylbenz[a]anthracene . Lipids , 6 : 415 – 420 .
  • Hopkins , GJ , Kennedy , TG and Carroll , KK . 1981 . Polyunsaturated fatty acids as promoters of mammary carcinogenesis induced in Sprague‐Dawley rats by 7,12‐dimethylbenz[a]anthracene . JNCI , 66 : 517 – 522 .
  • Rogers , AE , Conner , B , Boulanger , C and Lee , S . 1986 . Mammary tu‐morigenesis in rats fed diets high in lard . Lipids , 21 : 275 – 280 .
  • Chan , P‐C , Ferguson , KA and Dao , TL . 1983 . Effects of different dietary fats on mammary carcinogenesis . Cancer Res , 43 : 1079 – 1083 .
  • Rogers , AE and Lee , SY . 1986 . “ Chemically induced mammary gland tumors in rats: modulation by dietary fat ” . In Progress in Clinical and Biological Research. Dietary Fat and Cancer , Edited by: Ip , C , Birt , DF , Rogers , AE and Mettlin , C . vol 222 , 255 – 282 . New York : Liss .
  • Ip , C , Carter , CA and Ip , MM . 1985 . Requirement of essential fatty acid for mammary tumorigenesis in the rat . Cancer Res , 45 : 1997 – 2001 .
  • Rose , DP , Connolly , JM and Liu , X‐H . 1994 . Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro . Cancer Res , 54 : 6557 – 6562 .
  • Liu , X‐H , Connolly , JM and Rose , DP . 1996 . Eicosanoids and mediators of linoleic acid‐stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line . Clin Exp Metastasis , 14 : 145 – 152 .
  • Rose , DP , Connolly , JM and Liu , X‐H . 1995 . Effects of linoleic acid and γ‐linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro . Nutr Cancer , 24 : 33 – 45 .
  • Huggins , C , Grand , LC and Brillantes , FP . 1961 . Mammary cancer induced by a single feeding of polynuclear hydrocarbon and its suppression . Nature , 189 : 204 – 207 .
  • Russo , J , Russo , IH , van Zwieten , MJ , Rogers , AE and Gusterson , B . 1989 . “ Classification of neoplastic and nonneoplastic lesions of the rats mammary gland ” . In Integument and Mammary Glands , Edited by: Jones , TC and Mohr , U . 275 – 304 . New York : Springer‐Verlag .
  • Russo , J , Gusterson , BA , Robers , AE , Russo , IH Wellings , SR . 1990 . Biology of disease. Comparative study of human and rat mammary tumorigenesis . Lab Invest , 62 : 244 – 278 .
  • Sasa , M , Komaki , K , Tsuzuki , H , Kamamura , Y Mori , T . 1993 . Tumor progression accompanied by increase in proliferation rate in breast cancer: a preliminary report . J Surg Oncol , 54 : 255 – 259 .
  • Wyllie , AH . 1992 . Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview . Cancer Metastasis Rev , 11 : 95 – 103 .
  • Grasl‐Kraupp , B , Bursch , W , Ruttkay‐Nedecky , B , Wagner , A Lauer , B . 1994 . Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver . Proc Natl Acad Sci USA , 91 : 9995 – 9999 .
  • Aylsworth , CF , Cullum , ME , Zile , MH and Welsh , CW . 1986 . Influence of dietary retinyl acetate on normal rat mammary gland development and on the enhancement of 7,12‐dimethylbenz[a]anthracene‐induced rat mammary tumorigenesis by high levels of dietary fat . JNCI , 76 : 339 – 345 .
  • Kumaki , T and Noguchi , M . 1990 . Effects of high dietary fat on the total DNA and receptor content in rats with 7,12‐dimethylbenz[a]anthra‐cene‐induced mammary carcinoma . Oncology , 47 : 352 – 358 .
  • Snyderwine , EG , Davis , CD , Schut , HAJ and Roberts‐Thomson , SJ . 1998 . Proliferation, development and DNA adduct levels in the mammary gland of rats given 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐ft]pyridine (PhIP) and a high fat diet . Carcinogenesis , 19 : 1209 – 1215 .
  • Nagao , M , Ushijima , T , Wakabayashi , K , Ochiai , M Kushida , H . 1994 . Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods . Cancer , 74 : 1063 – 1069 .
  • Toyota , M , Ushijima , T , Weisburger , JH , Hosoya , Y Canzian , F . 1996 . Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2‐amino‐l‐methyl‐6‐phenylimi‐dazo[4,5‐b]pyridine . Mol Carcinog , 15 : 176 – 182 .
  • Roberts‐Thomson , SJ and Snyderwine , EG . 1997 . Effect of dietary fat on codon 12 and 13 Ha‐ras gene mutations in 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine‐induced rat mammary gland tumors . Mol Carcinog , 20 : 348 – 354 .
  • Davis , CD and Snyderwine , EG . 1995 . Analysis of EGFR, TGF‐α, Neu and c‐Myc in 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine‐induced mammary tumors using RT‐PCR . Carcinogenesis , 16 : 3087 – 3092 .
  • Welsch , CW , House , JL , Herr , BL , Eliasberg , SJ and Welsch , MA . 1990 . Enhancement of mammary carcinogenesis by high levels of dietary fat: a phenomenon dependent on ad libitum feeding . JNCI , 82 : 1615 – 1620 .
  • Hunter , DJ and Willett , WC . 1996 . Nutrition and breast cancer . Cancer Causes Control , 7 : 56 – 68 .
  • Brinton , LA and Swanson , CA . 1992 . Height and weight at various ages and risk of breast cancer . Ann Epidemiol , 2 : 597 – 609 .
  • Huang , Z , Hankinson , SE , Colditz , GA , Stampfer , MJ Hunter , DJ . 1997 . Dual effects of weight and weight gain on breast cancer risk . J Am Med Assoc , 278 : 1407 – 1411 .

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