References
- Anonymous . 1998 . Editorial . Drug Discovery Today , 3 : 296
- Barnes , P and Adcock , IM . 1997 . NF‐κB: a pivotal role in asthma and a new target for therapy . TiPS , 18 : 46 – 50 .
- Beutler , B and Kruys , V . 1995 . Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself . J Cardiovasc Pharmacol , 25 (supl 2) : S1 – S8 .
- Blake Marriott , J , Westby , M and Dalgleish , AG . 1997 . Therapeutic potential of TNF‐α inhibitors old and new . Drug Discovery Today , 2 : 273 – 82 .
- Buckle , DR and Hedgecock , CJR . 1997 . Drug targets in inflammation and immunomodulation . Drug Discovery Today , 2 : 325 – 32 .
- Curfs , JHAJ , Meis , JFGM and Hoogkamp‐Korstanje , JAA . 1997 . A primer on cytokines: sources, receptors, effects and inducers . Clin Microbiol Rev , 10 : 742 – 80 .
- Ghosh , S , May , MJ and Kopp , EB . 1998 . NF‐κB and Rel proteins : evolutionary conserved mediators of immune responses . Ann Rev Immunol , 16 : 225 – 60 .
- Hughes , B , Owens , R , Perry , M , Warrellow , G and Allen , R . 1997 . PDE IV inhibitors: the use of molecular cloning in the design and development of novel drugs . Drug Discovery Today , 2 : 89 – 101 .
- Izebound , CA , Monshouwer , M , Witkamp , RF and Miert , ASJPAM van . 2000 . Suppression of the acute inflammatory response of porcine alveolar and liver macrophages . Vet Quart , 22 : 26 – 30 .
- Kirschning , CJ , Wesche , H , Merrill Ayres , T and Rothe , M . 1998 . Human toll‐like receptor 2 confers responsiveness to bacterial lipopolysaccharide . J Exp Med , 188 : 2091 – 7 .
- Miert , ASJPAM van . 1995 . Pro‐inflammatory cytokines in a ruminant model: pathophysiological, pharmacological and therapeutic aspects . Vet Quart , 17 : 41 – 50 .
- Sweet , MJ and Hume , DA . 1996 . Endotoxin signal transduction in macrophages . J Leukocyte Biol , 60 : 8 – 26 .
- Wells , TNC , Power , CS and Proudfoot , AEI . 1998 . Definition, function and pathophysiological significance of chemokine receptors . TiPS , 19 : 376 – 80 .
- Yang , RB , Mark , MR , Gray , A , Huang , A , Xie , MH , Zhang , M , Goddard , A , Wood , WI , Gurney , AL and Godowski , PJ . 1998 . Toll‐like receptor‐2 mediates lipopolysaccharide‐induced cellular signalling . Nature , 95 (6699) : 284 – 8 .
- Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80152, 3508 TD Utrecht, the Netherlands.
- Department of Pharmacology, TNO Pharma, Zeist, the Netherlands.
- Present adress : Department of Metabolism and Pharmacokinetics, Pharmacia & Upjohn, Viale Pasteur 10, 200014 Nerviano (MI), Italy.