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Review Articles

Canine idiopathic immune-mediated haemolytic anaemia: a review with recommendations for future research

Pages 129-141 | Received 09 Jun 2011, Accepted 30 Jul 2011, Published online: 02 Aug 2011

References

  • Angles , JM , Kennedy , LJ and Pedersen , NC . 2005 . Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American Kennel Club breeds . Tissue Antigens , 66 ( 3 ) : 173 – 184 .
  • Astrup , J , Wyse , C , Elliott , J and Wood , JLN . 1998. Canine autoimmune haemolytic anaemia and immunemediated thrombocytopenia: what are the riskfactors? Proceedings British Small Animal Veterinarian Association, 41st BSAVA Congress in Birmingham. p. 246
  • Balch , A and Mackin , A . 2007 . Canine immune-mediated hemolytic anemia: pathophysiology, clinical signs, and diagnosis . Compend Contin Educ Vet , 29 ( 4 ) : 217 – 225 .
  • Bloom , JC , Thiem , PA , Sellers , TS , Deldar , A and Lewis , HB . 1988 . Cephalosporin-induced immune cytopenia in the dog: demonstration of erythrocyte-, neutrophil-, and platelet-associated IgG following treatment with cefazedone . Am J Hematol , 28 ( 2 ) : 71 – 78 .
  • Botsch , V , Kuchenhoff , H , Hartmann , K and Hirschberger , J . 2009 . Retrospective study of 871 dogs with thrombocytopenia . Vet Rec , 164 ( 21 ) : 647 – 651 .
  • Breuhl , EL , Moore , G , Brooks , MB and Scott-Moncrieff , JC . 2009 . A prospective study of unfractionated heparin therapy in dogs with primary immune-mediated hemolytic anemia . J Am Anim Hosp Assoc , 45 ( 3 ) : 125 – 133 .
  • Bundza , A , Lumsden , JH , McSherry , BJ , Valli , VE and Jazen , EA . 1976 . Haemobartonellosis in a dog in association with Coombs’ positive anemia . Can Vet J , 17 ( 10 ) : 267 – 270 .
  • Burgess , K , Moore , A , Rand , W and Cotter , SM . 2000 . Treatment of immune-mediated hemolytic anemia in dogs with cyclophosphamide . J Vet Intern Med , 14 ( 4 ) : 456 – 462 .
  • Cain , SM . 1977 . Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia . J Appl Physiol , 42 ( 2 ) : 228 – 234 .
  • Cain , SM and Chapler , CK . 1978 . O2 extraction by hind limb versus whole dog during anemic hypoxia . J Appl Physiol , 45 ( 6 ) : 966 – 970 .
  • Campbell , KL , George , JW and Greene , CE . 1984 . Application of the enzyme-linked immunosorbent assay for the detection of platelet antibodies in dogs . Am J Vet Res , 45 ( 12 ) : 2561 – 2564 .
  • Carr , AP , Panciera , DL and Kidd , L . 2002 . Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs . J Vet Intern Med , 16 ( 5 ) : 504 – 509 .
  • Corato , A , Shen , CR , Mazza , G , Barker , RN and Day , MJ . 1997 . Proliferative responses of peripheral blood mononuclear cells from normal dogs and dogs with autoimmune haemolytic anaemia to red blood cell antigens . Vet Immunol Immunopathol , 59 ( 3–4 ) : 191 – 204 .
  • Couto , CG . 2009 . “ Anemia ” . In Small animal internal medicine , Edited by: Nelson , RW . 1215 St. Louis, MO : Mosby Elsevier .
  • Day , MJ . 1996 . Inheritance of serum autoantibody, reduced serum IgA and autoimmune disease in a canine breeding colony . Vet Immunol Immunopathol , 53 ( 3–4 ) : 207 – 219 .
  • Day , MJ . 1999 . Antigen specificity in canine autoimmune haemolytic anaemia . Vet Immunol Immunopathol , 69 ( 2–4 ) : 215 – 224 .
  • Day , MJ . 2008 . Immune-mediated haematological disease , Clinical immunology of the dog and the cat. . Day MJ, editor. London: Manson Publishing Ltd. p. 94–120
  • Day , MJ and Penhale , WJ . 1992 . Immune-mediated disease in the old English sheepdog . Res Vet Sci , 53 ( 1 ) : 87 – 92 .
  • Dodds , WJ . 1977 . Autoimmune hemolytic disease and other causes of immune-mediated anaemia: an overview . J Am Anim Hosp Assoc , 13 : 437 – 441 .
  • Duffy , AL , Olea-Popelka , FJ , Eucher , J , Rice , DM and Dow , SW . 2010 . Serum concentrations of monocyte chemoattractant protein-1 in healthy and critically ill dogs . Vet Clin Pathol , 39 ( 3 ) : 302 – 305 .
  • Duval , D and Giger , U . 1996 . Vaccine-associated immune-mediated hemolytic anemia in the dog . J Vet Intern Med , 10 ( 5 ) : 290 – 295 .
  • Ekstrom Smedby , K , Vajdic , CM , Falster , M , Engels , EA , Martinez-Maza , O , Turner , J , Hjalgrim , H , Vineis , P , Seniori Costantini , A Bracci , PM . 2008 . Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium . Blood , 111 ( 8 ) : 4029 – 4038 .
  • Evans , RS and Duane , RT . 1949 . Acquired hemolytic anemia. I: the relation of erythrocyte antibody to activity of the disease. II: significance of thrombocytopenia and leukopenia . Blood , 4 : 1196 – 1213 .
  • Evans , RS , Takahashi , K , Duane , RT , Payne , R and Liu , C . 1951 . Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology . AMA Arch Intern Med , 87 ( 1 ) : 48 – 65 .
  • Feldman , BF , Handagama , P and Lubberink , AA . 1985 . Splenectomy as adjunctive therapy for immune-mediated thrombocytopenia and hemolytic anemia in the dog . J Am Vet Med Assoc , 187 ( 6 ) : 617 – 619 .
  • Fenty , RK , Delaforcade , AM , Shaw , SE and O’Toole , TE . 2011 . Identification of hypercoagulability in dogs with primary immune-mediated hemolytic anemia by means of thromboelastography . J Am Vet Med Assoc , 238 ( 4 ) : 463 – 467 .
  • Frank , JR and Breitschwerdt , EB . 1999 . A retrospective study of ehrlichiosis in 62 dogs from North Carolina and Virginia . J Vet Intern Med , 13 ( 3 ) : 194 – 201 .
  • Gerber , B , Steger , A , Hassig , M and Glaus , TM . 2002 . [Use of human intravenous immunoglobulin in dogs with primary immune mediated hemolytic anemia] . Schweiz Arch Tierheilkd , 144 ( 4 ) : 180 – 185 .
  • Giger , U . 2005 . “ Regenerative anemia caused by blood loss or hemolysis ” . In Textbook of veterinary internal medicine , Edited by: Ettinger , JE and Feldman , EC . 1886 – 1907 . St. Louis, MO : Elsevier Saunders .
  • Goggs , R , Boag , AK and Chan , DL . 2008 . Concurrent immune-mediated haemolytic anaemia and severe thrombocytopenia in 21 dogs . Vet Rec , 163 ( 11 ) : 323 – 327 .
  • Griebsch , C , Arndt , G and Kohn , B . 2010 . [Evaluation of different prognostic markers in dogs with primary immune-mediated hemolytic anemia] . Berl Munch Tierarztl Wochenschr , 123 ( 3–4 ) : 160 – 168 .
  • Griebsch , C , Arndt , G , Raila , J , Schweigert , FJ and Kohn , B . 2009 . C-reactive protein concentration in dogs with primary immune-mediated hemolytic anemia . Vet Clin Pathol , 38 ( 4 ) : 421 – 425 .
  • Grundy , SA and Barton , C . 2001 . Influence of drug treatment on survival of dogs with immune-mediated hemolytic anemia:88 cases (1989–1999) . J Am Vet Med Assoc , 218 ( 4 ) : 543 – 546 .
  • Helmond , SE , Polzin , DJ , Armstrong , PJ , Finke , M and Smith , SA . 2010 . Treatment of immune-mediated hemolytic anemia with individually adjusted heparin dosing in dogs . J Vet Intern Med , 24 ( 3 ) : 597 – 605 .
  • Holahan , ML , Brown , AJ and Drobatz , KJ . 2010 . The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases (2003–2006) . J Vet Emerg Crit Care. (San Antonio) , 20 ( 4 ) : 413 – 420 .
  • Horgan , JE , Roberts , BK and Schermerhorn , T . 2009 . Splenectomy as an adjunctive treatment for dogs with immune-mediated hemolytic anemia: ten cases (2003-2006) . J Vet Emerg Crit Care. (San Antonio) , 19 ( 3 ) : 254 – 261 .
  • Horton , R , Wilming , L , Rand , V , Lovering , RC , Bruford , EA , Khodiyar , VK , Lush , MJ , Povey , S , Talbot , CC Jr Wright , MW . 2004 . Gene map of the extended human MHC . Nat Rev Genet , 5 ( 12 ) : 889 – 899 .
  • Ishihara , M , Fujino , Y , Setoguchi , A , Takahashi , M , Nakashima , K , Ohno , K and Tsujimoto , H . 2010 . Evaluation of prognostic factors and establishment of a prognostic scoring system for canine primary immune-mediated hemolytic anemia . J Vet Med Sci , 72 ( 4 ) : 465 – 470 .
  • Jackson , ML and Kruth , SA . 1985 . Immune-mediated hemolytic anemia and thrombocytopenia in the dog: a retrospective study of 55 cases diagnosed from 1969 through 1983 at the western college of veterinary medicine . Can Vet J Res , 26 ( 8 ) : 245 – 250 .
  • Jacobs , RM , Murtaugh , RJ and Crocker , DB . 1984 . Use of a microtiter Coombs’ test for study of age, gender, and breed distributions in immunohemolytic anemia of the dog . J Am Vet Med Assoc , 185 ( 1 ) : 66 – 69 .
  • Jonas , LD , Thrall , MA and Weiser , MG . 1987 . Nonregenerative form of immune-mediated hemolytic anemia in dogs . JAAHA , 23 : 201 – 204 .
  • Jones , DR . 1993 . Canine systemic lupus erythematosus: new insights and their implications . J Comp Pathol , 108 ( 3 ) : 215 – 228 .
  • Jones , DR , Gruffydd-Jones , TJ , Stokes , CR and Bourne , FJ . 1990 . Investigation into factors influencing performance of the canine antiglobulin test . Res Vet Sci , 48 ( 1 ) : 53 – 58 .
  • Jones , DR , Stokes , CR , Gruffydd-Jones , TJ and Bourne , FJ . 1987 . An enzyme-linked antiglobulin test for the detection of erythrocyte-bound antibodies in canine autoimmune haemolytic anaemia . Vet Immunol Immunopathol , 16 ( 1–2 ) : 11 – 21 .
  • Keller , ET . 1992 . Immune-mediated disease as a risk factor for canine lymphoma . Cancer , 70 ( 9 ) : 2334 – 2337 .
  • Kellerman , D and Bruyette , D . 1997 . Intravenous human immunoglobulin for the treatment of immune-mediated hemolytic anemia in 13 dogs . J Vet Intern Med , 11 ( 6 ) : 327 – 332 .
  • Kennedy , LJ , Barnes , A , Ollier , WE and Day , MJ . 2006 . Association of a common dog leucocyte antigen class II haplotype with canine primary immune-mediated haemolytic anaemia . Tissue Antigens , 68 ( 6 ) : 502 – 508 .
  • Kennedy , LJ , Barnes , A , Short , A , Brown , JJ , Lester , S , Seddon , J , Fleeman , L , Francino , O , Brkljacic , M Knyazev , S . 2007a . Canine DLA diversity: 1. New alleles and haplotypes . Tissue Antigens , 69 ( Suppl. 1 ) : 272 – 288 .
  • Kennedy , LJ , Barnes , A , Short , A , Brown , JJ , Lester , S , Seddon , J , Happ , GM and Ollier , WE . 2007b . Canine DLA diversity: 2. Family studies . Tissue Antigens , 69 ( Suppl. 1 ) : 289 – 291 .
  • Kennedy , LJ , Barnes , A , Short , A , Brown , JJ , Seddon , J , Fleeman , L , Brkljacic , M , Happ , GM , Catchpole , B and Ollier , WE . 2007c . Canine DLA diversity: 3. Disease studies . Tissue Antigens , 69 ( Suppl. 1 ) : 292 – 296 .
  • Kenny , MJ , Shaw , SE , Beugnet , F and Tasker , S . 2004 . Demonstration of two distinct hemotropic mycoplasmas in French dogs . J Clin Microbiol , 42 ( 11 ) : 5397 – 5399 .
  • Klag , AR , Giger , U and Shofer , FS . 1993 . Idiopathic immune-mediated hemolytic anemia in dogs: 42 cases (1986–1990) . J Am Vet Med Assoc , 202 ( 5 ) : 783 – 788 .
  • Klein , MK , Dow , SW and Rosychuk , RA . 1989 . Pulmonary thromboembolism associated with immune-mediated hemolytic anemia in dogs: ten cases (1982–1987) . J Am Vet Med Assoc , 195 ( 2 ) : 246 – 250 .
  • Kol , A and Borjesson , DL . 2010 . Application of thrombelastography/thromboelastometry to veterinary medicine . Vet Clin Pathol , 39 ( 4 ) : 405 – 416 .
  • Kristensen , AT , Weiss , DJ , Klausner , JS , Laber , J and Christie , DJ . 1994a . Comparison of microscopic and flow cytometric detection of platelet antibody in dogs suspected of having immune-mediated thrombocytopenia . Am J Vet Res , 55 ( 8 ) : 1111 – 1114 .
  • Kristensen , AT , Weiss , DJ , Klausner , JS , Laber , J and Christie , DJ . 1994b . Detection of antiplatelet antibody with a platelet immunofluorescence assay . J Vet Intern Med , 8 ( 1 ) : 36 – 39 .
  • Lapierre , Y , Rigal , D , Adam , J , Josef , D , Meyer , F , Greber , S and Drot , C . 1990 . The gel test: a new way to detect red cell antigen-antibody reactions . Transfusion. (Paris) , 30 ( 2 ) : 109 – 113 .
  • Lavergne , SN , Danhof , RS , Volkman , EM and Trepanier , LA . 2006 . Association of drug-serum protein adducts and anti-drug antibodies in dogs with sulphonamide hypersensitivity: a naturally occurring model of idiosyncratic drug toxicity . Clin Exp Allergy , 36 ( 7 ) : 907 – 915 .
  • Lewis , M , Schwartz , RS and Gilmore , CE . 1965 . Autoimmune diseases in domestic animals . Ann N Y Acad Sci , 124 ( 1 ) : 178 – 200 .
  • Mason , N , Duval , D , Shofer , FS and Giger , U . 2003 . Cyclophosphamide exerts no beneficial effect over prednisone alone in the initial treatment of acute immune-mediated hemolytic anemia in dogs: a randomized controlled clinical trial . J Vet Intern Med , 17 ( 2 ) : 206 – 212 .
  • Mathes , M , Jordan , M and Dow , S . 2006 . Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs . Exp Hematol , 34 ( 10 ) : 1393 – 1402 .
  • McAlees , TJ . 2010 . Immune-mediated haemolytic anaemia in 110 dogs in Victoria, Australia . Aust Vet J , 88 ( 1–2 ) : 25 – 28 .
  • McDevitt , HO . 2000 . Discovering the role of the major histocompatibility complex in the immune response . Annu Rev Immunol , 18 : 1 – 17 .
  • McManus , PM and Craig , LE . 2001 . Correlation between leukocytosis and necropsy findings in dogs with immune-mediated hemolytic anemia: 34 cases (1994-1999) . J Am Vet Med Assoc , 218 ( 8 ) : 1308 – 1313 .
  • McVey , DS and Shuman , WS . 1989 . Detection of antiplatelet immunoglobulin in thrombocytopenic dogs . Vet Immunol Immunopathol , 22 ( 2 ) : 101 – 111 .
  • Mellett , AM , Nakamura , RK and Bianco , D . 2010 . A prospective study of clopidogrel therapy in dogs with primary immune-mediated hemolytic anemia . J Vet Intern Med , 25 ( 1 ) : 71 – 75 .
  • Mellor , PJ , Roulois , AJ , Day , MJ , Blacklaws , BA , Knivett , SJ and Herrtage , ME . 2005 . Neutrophilic dermatitis and immune-mediated haematological disorders in a dog: suspected adverse reaction to carprofen . J Small Anim Pract , 46 ( 5 ) : 237 – 242 .
  • Miller , SA , Hohenhaus , AE and Hale , AS . 2004 . Case-control study of blood type, breed, sex, and bacteremia in dogs with immune-mediated hemolytic anemia . J Am Vet Med Assoc , 224 ( 2 ) : 232 – 235 .
  • Mischke , R and Grebe , S . 2000 . The correlation between plasma anti-factor Xa activity and haemostatic tests in healthy dogs, following the administration of a low molecular weight heparin . Res Vet Sci , 69 ( 3 ) : 241 – 247 .
  • Mischke , R , Grebe , S , Jacobs , C and Kietzmann , M . 2001 . Amidolytic heparin activity and values for several hemostatic variables after repeated subcutaneous administration of high doses of a low molecular weight heparin in healthy dogs . Am J Vet Res , 62 ( 4 ) : 595 – 598 .
  • Mischke , R and Jacobs , C . 2001 . The monitoring of heparin administration by screening tests in experimental dogs . Res Vet Sci , 70 ( 2 ) : 101 – 108 .
  • Mitchell , KD , Kruth , SA , Wood , RD and Jefferson , B . 2009 . Serum acute phase protein concentrations in dogs with autoimmune hemolytic anemia . J Vet Intern Med , 23 ( 3 ) : 585 – 591 .
  • Morita , T , Saeki , H , Imai , S and Ishii , T . 1995 . Reactivity of anti-erythrocyte antibody induced by Babesia gibsoni infection against aged erythrocytes . Vet Parasitol , 58 ( 4 ) : 291 – 299 .
  • Morley , P , Mathes , M , Guth , A and Dow , S . 2008 . Anti-erythrocyte antibodies and disease associations in anemic and nonanemic dogs . J Vet Intern Med , 22 ( 4 ) : 886 – 892 .
  • Murata , H , Shimada , N and Yoshioka , M . 2004 . Current research on acute phase proteins in veterinary diagnosis: an overview . Vet J , 168 ( 1 ) : 28 – 40 .
  • Orcutt , ES , Lee , JA and Bianco , D . 2010 . Immune-mediated hemolytic anemia and severe thrombocytopenia in dogs: 12 cases (2001-2008) . J Vet Emerg Crit Care. (San Antonio) , 20 ( 3 ) : 338 – 345 .
  • Overmann , JA , Sharkey , LC , Weiss , DJ and Borjesson , DL . 2007 . Performance of 2 microtiter canine Coombs’ tests . Vet Clin Pathol , 36 ( 2 ) : 179 – 183 .
  • Piek , CJ , Junius , G , Dekker , A , Schrauwen , E , Slappendel , RJ and Teske , E . 2008 . Idiopathic immune-mediated hemolytic anemia: treatment outcome and prognostic factors in 149 dogs . J Vet Intern Med , 22 ( 2 ) : 366 – 373 .
  • Piek , CJ , van Spil , WE , Junius , G and Dekker , A . 2011 . Lack of evidence of a beneficial effect of azathioprine in dogs treated with prednisolone for idiopathic immune-mediated haemolytic anaemia: a retrospective cohort study . BMC Vet Res , 7 : 15
  • Ramacciotti , E , Hawley , AE , Farris , DM , Ballard , NE , Wrobleski , SK , Myers , DD Jr , Henke , PK and Wakefield , TW . 2009 . Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis . Thromb Haemost , 101 ( 4 ) : 748 – 754 .
  • Reimer , ME , Troy , GC and Warnick , LD . 1999 . Immune-mediated hemolytic anemia: 70 cases (1988-1996) . J Am Anim Hosp Assoc , 35 ( 5 ) : 384 – 391 .
  • Ridyard , AE , Shaw , DJ and Milne , EM . 2010 . Evaluation of platelet activation in canine immune-mediated haemolytic anaemia . J Small Anim Pract , 51 ( 6 ) : 296 – 304 .
  • Rozanski , EA , Callan , MB , Hughes , D , Sanders , N and Giger , U . 2002 . Comparison of platelet count recovery with use of vincristine and prednisone or prednisone alone for treatment for severe immune-mediated thrombocytopenia in dogs . J Am Vet Med Assoc , 220 ( 4 ) : 477 – 481 .
  • Scott-Moncrieff , C . 2001 . Immune-mediated hemolytic anemia: 70 cases (1988–1996) . J Am Anim Hosp Assoc , 37 ( 1 ) : 11
  • Scott-Moncrieff , JC , Treadwell , NG , McCullough , SM and Brooks , MB . 2001 . Hemostatic abnormalities in dogs with primary immune-mediated hemolytic anemia . J Am Anim Hosp Assoc , 37 ( 3 ) : 220 – 227 .
  • Shaw , SE , Day , MJ , Birtles , RJ and Breitschwerdt , EB . 2001 . Tick-borne infectious diseases of dogs . Trends Parasitol , 17 ( 2 ) : 74 – 80 .
  • Sinnott , VB and Otto , CM . 2009 . Use of thromboelastography in dogs with immune-mediated hemolytic anemia: 39 cases (2000-2008) . J Vet Emerg Crit Care. (San Antonio) , 19 ( 5 ) : 484 – 488 .
  • Slappendel , RJ . 1979 . The diagnostic significance of the direct antiglobulin test (DAT) in anemic dogs . Vet Immunol Immunopathol , 1 ( 1 ) : 49 – 59 .
  • Slappendel , RJ , van Zwieten , R , van Leeuwen , M and Schneijdenberg , CT . 2005 . Hereditary spectrin deficiency in Golden Retriever dogs . J Vet Intern Med , 19 ( 2 ) : 187 – 192 .
  • Sokol , RJ , Booker , DJ and Stamps , R . 1992 . The pathology of autoimmune haemolytic anaemia . J Clin Pathol , 45 ( 12 ) : 1047 – 1052 .
  • Sokol , RJ , Booker , DJ and Stamps , R . 1994 . Erythrocyte autoantibodies, autoimmune haemolysis, and carcinoma . J Clin Pathol , 47 ( 4 ) : 340 – 343 .
  • Stokol , T , Blue , JT and French , TW . 2000 . Idiopathic pure red cell aplasia and nonregenerative immune-mediated anemia in dogs: 43 cases (1988-1999) . J Am Vet Med Assoc , 216 ( 9 ) : 1429 – 1436 .
  • Tecles , F , Spiranelli , E , Bonfanti , U , Ceron , JJ and Paltrinieri , S . 2005 . Preliminary studies of serum acute-phase protein concentrations in hematologic and neoplastic diseases of the dog . J Vet Intern Med , 19 ( 6 ) : 865 – 870 .
  • Thompson , MF , Scott-Moncrieff , JC and Brooks , MB . 2004 . Effect of a single plasma transfusion on thromboembolism in 13 dogs with primary immune-mediated hemolytic anemia . J Am Anim Hosp Assoc , 40 ( 6 ) : 446 – 454 .
  • Trepanier , LA . 2004 . Idiosyncratic toxicity associated with potentiated sulfonamides in the dog . J Vet Pharmacol Ther , 27 ( 3 ) : 129 – 138 .
  • Trepanier , LA , Danhof , R , Toll , J and Watrous , D . 2003 . Clinical findings in 40 dogs with hypersensitivity associated with administration of potentiated sulfonamides . J Vet Intern Med , 17 ( 5 ) : 647 – 652 .
  • Wakefield , TW , Myers , DD and Henke , PK . 2009 . Role of selectins and fibrinolysis in VTE . Thromb Res , 123 ( Suppl. 4 ) : S35 – S40 .
  • Wardrop , KJ . 2005 . The Coombs’ test in veterinary medicine: past, present, future . Vet Clin Pathol , 34 ( 4 ) : 325 – 334 .
  • Warman , SM , Helps , CR , Barker , EN , Day , S , Sturgess , K , Day , MJ and Tasker , S . 2010 . Haemoplasma infection is not a common cause of canine immune-mediated haemolytic anaemia in the UK . J Small Anim Pract , 51 ( 10 ) : 534 – 539 .
  • Warman , SM , Murray , JK , Ridyard , A , Eastwood , J , Silva , S and Day , MJ . 2008 . Pattern of Coombs’ test reactivity has diagnostic significance in dogs with immune-mediated haemolytic anaemia . J Small Anim Pract , 49 ( 10 ) : 525 – 530 .
  • Weinkle , TK , Center , SA , Randolph , JF , Warner , KL , Barr , SC and Erb , HN . 2005 . Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs: 151 cases (1993-2002) . J Am Vet Med Assoc , 226 ( 11 ) : 1869 – 1880 .
  • Weiss , DJ . 1984 . Uniform evaluation and semiquantitative reporting of hematologic data in veterinary laboratories . Vet Clin Pathol , 13 ( 2 ) : 27 – 31 .
  • Weiss , DJ . 1986 . Antibody-mediated suppression of erythropoiesis in dogs with red blood cell aplasia . Am J Vet Res , 47 ( 12 ) : 2646 – 2648 .
  • Weiss , DJ . 2002 . Primary pure red cell aplasia in dogs: 13 cases (1996–2000) . J Am Vet Med Assoc , 221 ( 1 ) : 93 – 95 .
  • Weiss , DJ . 2008 . Bone marrow pathology in dogs and cats with non-regenerative immune-mediated haemolytic anaemia and pure red cell aplasia . J Comp Pathol , 138 ( 1 ) : 46 – 53 .
  • Weiss , DJ and Brazzell , JL . 2006 . Detection of activated platelets in dogs with primary immune-mediated hemolytic anemia . J Vet Intern Med , 20 ( 3 ) : 682 – 686 .
  • Whelan , MF , O’Toole , TE , Chan , DL , Rozanski , EA , DeLaforcade , AM , Crawford , SL and Cotter , SM . 2009 . Use of human immunoglobulin in addition to glucocorticoids for the initial treatment of dogs with immune-mediated hemolytic anemia . J Vet Emerg Crit Care. (San Antonio) , 19 ( 2 ) : 158 – 164 .
  • Whitley , NT and Day , MJ . 2011 . Immunomodulatory drugs and their application to the management of canine immune-mediated disease . J Small Anim Pract , 52 ( 2 ) : 70 – 85 .
  • Wilbe , M , Jokinen , P , Truve , K , Seppala , EH , Karlsson , EK , Biagi , T , Hughes , A , Bannasch , D , Andersson , G Hansson-Hamlin , H . 2010 . Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex . Nat Genet , 42 ( 3 ) : 250 – 254 .
  • Yuki , M , Itoh , H and Takase , K . 2010 . Serum alpha-1-acid glycoprotein concentration in clinically healthy puppies and adult dogs and in dogs with various diseases . Vet Clin Pathol , 39 ( 1 ) : 65 – 71 .

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