Immune responses in dogs with cutaneous adverse food reactions

References

• Admyre , C , Bohle , B , Johansson , SM , Focke-Tejkl , M , Valenta , R , Scheynius , A and Gabrielsson , S . 2007 . B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines . J Allergy Clin Immunol , 120 : 1418 – 1424 .
   PubMed Web of Science ®Google Scholar
• Akdis , CA , Blesken , T , Akdis , M , Wüthrich , B and Blaser , K . 1998 . Role of interleukin 10 in specific immunotherapy . J Clin Invest , 102 : 98 – 106 .
   PubMed Web of Science ®Google Scholar
• Akdis , M , Verhagen , J , Taylor , A , Karamloo , F , Karagiannidis , C , Crameri , R , Thunberg , S , Deniz , G , Valenta , R Fiebig , H . 2004 . Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells . J Exp Med , 199 : 1567 – 1575 .
   PubMed Web of Science ®Google Scholar
• Akimzhanov , AM , Yang , ZO and Dong , C . 2007 . Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation . J Biol Chem , 282 : 5969 – 5972 .
   PubMed Web of Science ®Google Scholar
• Armitage , RJ , Macduff , BM , Spriggs , MK and Fanslow , WC . 1993 . Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines . J Immunol , 150 : 3671 – 3680 .
   PubMed Web of Science ®Google Scholar
• Avery , DT , Bryant , VL , Ma , GS , de Waal Malefyt , R and Tangye , SG . 2008 . IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4 . J Immunol , 181 : 1767 – 1779 .
   PubMed Web of Science ®Google Scholar
• Berlin , C , Berg , EL , Briskin , MJ , Andrew , DP , Kilshaw , PJ , Holzmann , B , Weissman , IL , Hamann , A and Butcher , EC . 1993 . α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1 . Cell , 74 : 185 – 195 .
   PubMed Web of Science ®Google Scholar
• Bettelli , E , Carrier , Y , Gao , W , Korn , T , Strom , TB , Oukka , M , Weiner , HL and Kuchroo , VK . 2006 . Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells . Nature , 441 : 235 – 238 .
   PubMed Web of Science ®Google Scholar
• Bevilacqua , C , Montagnac , G , Benmerah , A , Candalh , C , Brousse , N , Cerf-Bensussan , N , Perdue , MH and Heyman , M . 2004 . Food allergens are protected from degradation during CD23-mediated transepithelial transport . Int Arch Allergy Immunol , 135 : 108 – 116 .
   Web of Science ®Google Scholar
• Beyer , K , Castro , R , Birnbaum , A , Benkov , K , Pittman , N and Sampson , HA . 2002 . Human milk-specific mucosal lymphocytes of the gastrointestinal tract display a TH2 cytokine profile . J Allergy Clin Immunol , 109 : 707 – 713 .
   Web of Science ®Google Scholar
• Borghesan , F , Mistrello , G , Roncarolo , D , Amato , S , Plebani , M and Asero , R . 2008 . Respiratory allergy to lipid transfer protein . Int Arch Allergy Immunol , 147 : 161 – 165 .
   PubMed Web of Science ®Google Scholar
• Briere , F , Servet-Delprat , C , Bridon , JM , Saint-Remy , JM and Banchereau , J . 1994 . Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3 . J Exp Med , 179 : 757 – 762 .
   PubMed Web of Science ®Google Scholar
• Carlotti , DN , Remy , I and Prost , C . 1990 . Food allergy in dogs and cats. A review and report of 43 cases . Vet Dermatol , 1 : 55 – 62 .
   PubMedGoogle Scholar
• Chehade , M and Mayer , L . 2005 . Oral tolerance and its relation to food hypersensitivities . J Allergy Clin Immunol , 115 : 3 – 12 .
   PubMed Web of Science ®Google Scholar
• Chen , W , Jin , W , Hardegen , N , Lei , KJ , Li , L , Marinos , N , McGrady , G and Wahl , SM . 2003 . Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3 . J Exp Med , 198 : 1875 – 1886 .
   PubMed Web of Science ®Google Scholar
• Chen , ML , Yan , BS , Bando , Y , Kuchroo , VK and Weiner , HL . 2008 . Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFβ-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis . J Immunol , 180 : 7327 – 7337 .
   PubMed Web of Science ®Google Scholar
• Chervet , L , Galichet , A , McLean , WH , Chen , H , Suter , MM , Roosje , PJ and Müller , EJ . 2010 . Missing C-terminal filaggrin expression, NFkappaB activation and hyperproliferation identify the dog as a putative model to study epidermal dysfunction in atopic dermatitis . Exp Dermatol , 19 : 343 – 346 .
   PubMed Web of Science ®Google Scholar
• Chesney , CJ . 2002 . Food hypersensitivity in the dog: a quantitative study . J Small Anim Pract , 43 : 203 – 207 .
   PubMed Web of Science ®Google Scholar
• Clarke , L and McQueen , J . 1996 . The dietary management of food allergy and food intolerance in children and adults . Aust J Nutr Diet , 53 : 89 – 98 .
   Google Scholar
• Constant , S and Bottomly , K . 1997 . Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches . Ann Rev Immunol , 15 : 297 – 322 .
   PubMed Web of Science ®Google Scholar
• Cork , MJ , Robinson , DA , Vasilopoulos , Y , Ferguson , A , Moustafa , M , MacGowan , A , Duff , GW , Ward , SJ and Tazi-Ahnini , R . 2006 . New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene–environment interactions . J Allergy Clin Immunol , 118 : 3 – 21 .
   PubMed Web of Science ®Google Scholar
• Das , J , Chen , CH , Yang , L , Cohn , L , Ray , P and Ray , A . 2001 . A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation . Nat Immunol , 2 : 45 – 50 .
   PubMed Web of Science ®Google Scholar
• de Jong , E , , Suddason , T and Lord , GM . 2009 . Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells . Clin Exp Immunol , 159 : 148 – 158 .
   Web of Science ®Google Scholar
• Defrance , T , Vanbervliet , B , Briere , F , Durand , I , Rousset , F and Banchereau , J . 1992 . Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A . J Exp Med , 175 : 671 – 682 .
   PubMed Web of Science ®Google Scholar
• Elser , B , Lohoff , M , Kock , S , Giaisi , M , Kirchhoff , S , Krammer , PH and Li-Weber , M . 2002 . IFN-γ represses IL-4 expression via IRF-1 and IRF-2 . Immunity , 1 : 703 – 712 .
   Web of Science ®Google Scholar
• Frossard , CP , Tropia , L , Hauser , C and Eigenmann , PA . 2004 . Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy . J Allergy Clin Immunol , 113 : 958 – 964 .
   PubMed Web of Science ®Google Scholar
• Fujieda , S , Zhang , K and Saxon , A . 1995 . IL-4 plus CD40 monoclonal antibody induces human B cells gamma subclass-specific isotype switch: switching to gamma 1, gamma 3, and gamma 4, but not gamma 2 . J Immunol , 155 : 2318 – 2328 .
   PubMed Web of Science ®Google Scholar
• Fuhlbrigge , RC , Kieffer , JD , Armerding , D and Kupper , TS . 1997 . Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed in skin-homing T cells . Nature , 389 : 978 – 981 .
   PubMed Web of Science ®Google Scholar
• Gascan , H , Gauchat , JF , Aversa , G , Van Vlasselaer , P and de Vries , JE . 1991 . Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways . J Immunol , 147 : 8 – 13 .
   PubMed Web of Science ®Google Scholar
• Geha , RS , Jabara , HH and Brodeur , SR . 2003 . The regulation of immunoglobulin E class-switch recombination . Nat Rev Immunol , 3 : 721 – 732 .
   PubMed Web of Science ®Google Scholar
• German , AJ , Hall , EJ and Day , MJ . 1999 . Analysis of leucocyte subsets in the canine intestine . J Comp Pathol , 120 : 129 – 145 .
   PubMed Web of Science ®Google Scholar
• German , AJ , Hall , EJ , Moore , PJ , Ringler , DJ , Newman , W and Day , MJ . 1999 . The distribution of lymphocytes expressing αβ and γδ T-cell receptors, and the expression of mucosal address in cell adhesion molecule-1 in the canine intestine . J Comp Pathol , 121 : 249 – 263 .
   PubMed Web of Science ®Google Scholar
• Hamid , Q , Boguniewicz , M and Leung , DY . 1994 . Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis . J Clin Invest , 94 : 870 – 876 .
   PubMed Web of Science ®Google Scholar
• Hammad , H , Smits , HH , Ratajczak , C , Nithiananthan , A , Wierenga , EA , Stewart , GA , Jacquet , A , Tonnel , AB and Pestel , J . 2003 . Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22 . Eur Cytokine Netw , 14 : 219 – 228 .
   PubMed Web of Science ®Google Scholar
• Harrington , LE , Hatton , RD , Mangan , PR , Turner , H , Murphy , TL , Murphy , KM and Weaver , CT . 2005 . Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages . Nat Immunol , 6 : 1123 – 1132 .
   PubMed Web of Science ®Google Scholar
• Homey , B , Alenius , H , Müller , A , Soto , H , Bowman , EP , Yuan , W , McEvoy , L , Lauerma , AI , Assmann , T Bünemann , E . 2002 . CCL27–CCR10 interactions regulate T cell-mediated skin inflammation . Nat Med , 8 : 157 – 165 .
   PubMed Web of Science ®Google Scholar
• Hosken , NA , Shibuya , K , Heath , AW , Murphy , KM and O'Garra , A . 1995 . The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model . J Exp Med , 182 : 1579 – 1584 .
   PubMed Web of Science ®Google Scholar
• Howell , MD , Kim , BE , Gao , P , Grant , AV , Boquniewicz , M , Debenedetto , A , Schneider , L , Beck , LA , Barnes , KC and Leung , DY . 2007 . Cytokine modulation of atopic dermatitis filaggrin skin expression . J Allergy Clin Immunol , 120 : 150 – 155 .
   PubMed Web of Science ®Google Scholar
• Hsieh , KY , Tsai , CC , Wu , CH and Lin , RH . 2003 . Epicutaneous exposure to protein antigen and food allergy . Clin Exp Allergy , 33 : 1067 – 1075 .
   PubMed Web of Science ®Google Scholar
• Hunt , J , Beavil , RL , Calvert , RA , Gould , HJ , Sutton , BJ and Beavil , AJ . 2005 . Disulfide linkage controls the affinity and stoichiometry of IgE Fcepsilon3-4 binding to FcepsilonRI . J Biol Chem , 280 : 16808 – 16814 .
   Web of Science ®Google Scholar
• Hussain , R , Kifayet , A , Dojki , M and Dockrell , HM . 1999 . Selective correlation of interferon-gamma, tumour necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor with immunoglobulin G1 and immunoglobulin G3 subclass antibody in leprosy . Immunology , 98 : 238 – 243 .
   Web of Science ®Google Scholar
• Hwang , ES , Szabo , SJ , Schwartzberg , PL and Glimcher , LH . 2005 . T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3 . Science , 307 : 430 – 433 .
   PubMed Web of Science ®Google Scholar
• Imai , T , Nagira , M , Takagi , S , Kakizaki , M , Nishimura , M , Wang , J , Gray , PW , Matsushima , K and Yoshie , O . 1999 . Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine . Int Immunity , 11 : 81 – 88 .
   PubMed Web of Science ®Google Scholar
• Jackson , HA , Jackson , MW , Coblentz , L and Hammerberg , B . 2003 . Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy . Vet Dermatol , 14 : 181 – 187 .
   PubMed Web of Science ®Google Scholar
• James , SP . 1993 . The gastrointestinal mucosal immune system . Dig Dis Sci , 11 : 146 – 156 .
   Web of Science ®Google Scholar
• Jeannin , P , Lecoanet , S , Delneste , Y , Gauchat , JF and Bonnefoy , JY . 1998 . IgE versus IgG4 production can be differentially regulated by IL-10 . J Immunol , 160 : 3555 – 3561 .
   PubMed Web of Science ®Google Scholar
• Jeffers , JG , Meyer , EK and Sosis , EJ . 1996 . Responses of dogs with food allergies to single-ingredient dietary provocation . J Am Vet Med Assoc , 209 : 608 – 611 .
   PubMed Web of Science ®Google Scholar
• Johansson-Lindbom , B and Agace , WW . 2007 . Generation of gut-homing T cells and their localization to the small intestinal mucosa . Immunol Rev , 215 : 226 – 242 .
   PubMed Web of Science ®Google Scholar
• Jump , RL and Levine , AD . 2004 . Mechanisms of natural tolerance in the intestine. Implications for inflammatory bowel disease . Inflamm Bowel Dis , 10 : 462 – 478 .
   PubMed Web of Science ®Google Scholar
• Kanari , H , Kagami , S , Kashiwakuma , D , Oya , Y , Furuta , S , Ikeda , K , Suto , A , Suzuki , K , Hirose , K Watanabe , N . 2010 . Role of Th2 cells in IgG4-related lacrimal gland enlargement . Int Arch Allergy Immunol , 152 ( Suppl 1 ) : 47 – 53 .
   PubMed Web of Science ®Google Scholar
• Kaplan , MH , Schindler , U , Smiley , ST and Grusby , MJ . 1996 . Stat6 is required for mediating responses to IL-4 and for development of Th2 cells . Immunity , 4 : 313 – 319 .
   PubMed Web of Science ®Google Scholar
• Kawano , Y , Noma , T , Kou , K , Yoshizawa , I and Yata , J . 1995 . Regulation of human IgG subclass production by cytokines: human IgG subclass production enhanced differentially by interleukin-6 . Immunology , 84 : 278 – 284 .
   PubMed Web of Science ®Google Scholar
• Kim , J , Ho , IC , Grusby , M and Glimcher , LH . 1999 . The transcription factor c-maf controls the production of IL-4 but not other Th2 cytokines . Immunity , 10 : 745 – 751 .
   PubMed Web of Science ®Google Scholar
• King , CL and Nutman , TB . 1993 . IgE and IgG subclass regulation by IL4 and IFN gamma in human helminth infections . J Immunol , 150 : 458 – 465 .
   Google Scholar
• Kitts , D , Yuan , Y , Joneja , J , Scott , F , Szilagyi , A , Amiot , J and Zarkadas , M . 1997 . Adverse reactions to food constituents: allergy, intolerance, and autoimmunity . Can J Physiol Pharmacol , 75 : 241 – 254 .
   PubMed Web of Science ®Google Scholar
• Leser , C , Hartmann , AL , Prami , G and Wuthrich , B . 2001 . The ‘egg-egg’ syndrome: occupational respiratory allergy to airborne egg proteins with consecutive ingestive egg allergy in the bakery and confectionery industry . J Invest Allergol Clin Immunol , 11 : 89 – 93 .
   Web of Science ®Google Scholar
• Leung , DY , Boguniewicz , M , Howell , MD , Nomura , I and Hamid , QA . 2004 . New insights into atopic dermatitis . J Clin Invest , 113 : 651 – 657 .
   PubMed Web of Science ®Google Scholar
• Leung , DYM . 2009 . Our evolving understanding of the functional role of filaggrin in atopic dermatitis . J Allergy Clin Immunol , 124 : 494 – 495 .
   Web of Science ®Google Scholar
• Li , H , Nowak-Wegrzyn , A , Charlop-Powers , Z , Shreffler , W , Chehade , M , Thomas , S , Roda , G , Dahan , S , Sperber , K and Berlin , MC . 2006 . Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy . Gastroenterology , 131 : 47 – 58 .
   Web of Science ®Google Scholar
• Liang , SC , Long , AJ , Bennett , F , Whitters , MJ , Karim , R , Collins , M , Goldman , SJ , Dunussi-Joannopoulos , K , Williams , CM , Wright , JF and Fouser , LA . 2007 . An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment . J Immunol , 179 : 7791 – 7799 .
   PubMed Web of Science ®Google Scholar
• Lighvani , AA , Frucht , DM , Jankovic , D , Yamane , H , Aliberti , J , Hissong , BD , Nguyen , BV , Gadina , M , Sher , A , Paul , WE and O'Shea , JJ . 2001 . T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells . Proc Natl Acad Sci. USA , 98 : 15137 – 15142 .
   PubMed Web of Science ®Google Scholar
• Lin , XP , Almqvist , N and Telemo , E . 2005 . Human small intestinal epithelial cells constitutively express the key elements for antigen processing and the production of exosomes . Blood Cells Mol Dis , 35 : 122 – 128 .
   PubMed Web of Science ®Google Scholar
• Lundqvist , C , Baranov , V , Hammarström , S , Athlin , L and Hammarström , ML . 1995 . Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium . Int Immunol , 7 : 1473 – 1487 .
   Web of Science ®Google Scholar
• Maeda , S , Fujiwara , S , Omori , K , Kawano , K , Kurata , K , Masuda , K , Ohno , K and Tsujimoto , H . 2002 . Lesional expression of thymus and activation-regulated chemokine in canine atopic dermatitis . Vet Immunol Immunopathol , 88 : 79 – 87 .
   Web of Science ®Google Scholar
• Maeda , S , Ohmori , K , Yasuda , N , Kurata , K , Sakaguchi , M , Masuda , K , Ohno , K and Tsujimoto , H . 2004 . Increase of CC chemokine receptor 4-positive cells in the peripheral CD4 cells in dogs with atopic dermatitis or experimentally sensitized to Japanese cedar pollen . Clin Exp Allergy , 34 : 1467 – 1473 .
   Web of Science ®Google Scholar
• Maeda , S , Tsukui , T , Saze , K , Masuda , K , Ohno , K , Tsujimoto , H and Iwabuchi , S . 2005 . Production of a monoclonal antibody to canine thymus and activation regulated chemokine (TARC) and detection of TARC in lesional skin from dogs with atopic dermatitis . Vet Immunol Immunopathol , 103 : 83 – 92 .
   Web of Science ®Google Scholar
• Maeda , S , Tsuchida , H , Shibata , S , Kawakami , T , Tsukui , T , Ohba , Y , Fukata , T and Kitagawa , H . 2008 . Expression analysis of CCL27 and CCL28 mRNA in lesional and non-lesional skin of dogs with atopic dermatitis . J Vet Med Sci , 70 : 51 – 55 .
   Web of Science ®Google Scholar
• Marsella , R , Olivry , T and Maeda , S . 2006 . Cellular and cytokine kinetics after epicutaneous allergen challenge (atopy patch testing) with house dust mites in high-IgE beagles . Vet Dermatol , 17 : 111 – 120 .
   Web of Science ®Google Scholar
• Marsella , R , Olivry , T , Carlotti , DN and International Task Force on Canine Atopic Dermatitis . 2011 . Current evidence of skin barrier dysfunction in human and canine atopic dermatitis . Vet Dermatol , 22 : 239 – 248 .
   PubMed Web of Science ®Google Scholar
• Martin , A , Sierra , MP , Gonzales , JL and Arevalo , MA . 2004 . Identification of allergens responsible for canine cutaneous adverse food reactions to lamb, beef and cow's milk . Vet Dermatol , 15 : 349 – 356 .
   Web of Science ®Google Scholar
• Mowat , AM . 2003 . Anatomical basis of tolerance and immunity to intestinal antigens . Nat Rev Immunol , 3 : 331 – 341 .
   PubMed Web of Science ®Google Scholar
• Molenaar , R , Greuter , M , van der Marel , AP , Roozendaal , R , Martin , SF , Edele , F , Huehn , J , Förster , R , O'Toole , T Jansen , W . 2009 . Lymph node stromal cells support dendritic cell-induced gut-homing of T cells . J Immunol , 183 : 6395 – 6402 .
   PubMed Web of Science ®Google Scholar
• Moser , M and Murphy , KM . 2000 . Dendritic cell regulation of TH1-TH2 development . Nat Immunol , 1 : 199 – 205 .
   PubMed Web of Science ®Google Scholar
• Mullen , AC , Hutchins , AS , High , FA , Lee , HW , Sykes , KJ , Chodosh , LA and Reiner , SL . 2002 . Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction . Nat Immunol , 3 : 652 – 658 .
   PubMed Web of Science ®Google Scholar
• Murphy , K , Travers , P , Walport , M , Ehrenstein , M and Mauri , C . 2008 . Janeway's immunobiology , 7th , New York : Garland Sciences .
   Google Scholar
• Nakahira , M , Ahn , HJ , Park , WR , Gao , P , Tomura , M , Park , CS , Hamaoka , T , Ohta , T , Kurimoto , M and Fujiwara , H . 2002 . Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1 . J Immunol , 168 : 1146 – 1153 .
   PubMed Web of Science ®Google Scholar
• Nakamura , K , Kitani , A and Strober , W . 2001 . Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor β . J Exp Med , 194 : 629 – 644 .
   PubMed Web of Science ®Google Scholar
• van , Niel G , Raposo , G , Candalh , C , Boussac , M , Hershberg , R , Cerf-Bensussan , N and Heyman , M . 2001 . Intestinal epithelial cells secrete exosome-like vesicles . Gastroenterol , 121 : 337 – 349 .
   Web of Science ®Google Scholar
• Novak , N , Kraft , S and Bieber , T . 2003 . Unraveling the mission of FceRI on antigen-presenting cells . J Allergy Clin Immunol , 111 : 38 – 44 .
   PubMed Web of Science ®Google Scholar
• Nuttall , TJ , Knight , PA , McAleese , SM , Lamb , JR and Hill , PB . 2002 . Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis . Clin Exp Allergy , 32 : 789 – 795 .
   Web of Science ®Google Scholar
• Oida , T , Zhang , X , Goto , M , Hachimura , S , Totsuka , M , Kaminogawa , S and Weiner , HL . 2003 . CD4+CD25– T cells that express latency-associated peptide on the surface suppress CD4+CD45RB high-induced colitis by a TGF-β-dependent mechanism . J Immunol , 170 : 2516 – 2522 .
   PubMed Web of Science ®Google Scholar
• Olivry , T , Moore , PF , Affolter , VK and Naydan , DK . 1996 . Langerhans cell hyperplasia and IgE expression in canine atopic dermatitis . Arch Dermatol Res , 288 : 579 – 585 .
   Web of Science ®Google Scholar
• Olivry , T , Naydan , DK and Moore , PF . 1997 . Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis . Am J Dermatopathol , 19 : 477 – 486 .
   PubMed Web of Science ®Google Scholar
• Olivry , T , Dean , GA , Tompkins , MB , Dow , JL and Moore , PF . 1999 . Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs . Exp Dermatol , 8 : 204 – 211 .
   Web of Science ®Google Scholar
• Ou , LS and Huang , JL . 2007 . Cellular aspects of atopic dermatitis . Clin Rev Allergy Immunol , 33 : 191 – 198 .
   PubMed Web of Science ®Google Scholar
• Ouyang , W , Ranganath , SH , Weindel , K , Bhattacharya , D , Murphy , TL , Sha , WC and Murphy , KM . 1998 . Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism . Immunity , 9 : 745 – 755 .
   PubMed Web of Science ®Google Scholar
• Ouyang , W , Löhning , M , Gao , Z , Assenmacher , M , Ranganath , S and Murphy , KM . 2000 . Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment . Immunity , 12 : 27 – 37 .
   PubMed Web of Science ®Google Scholar
• Ouyang , W , Kolls , JK and Zheng , Y . 2008 . The biological functions of T helper 17 cell effector cytokines in inflammation . Immunity , 28 : 454 – 467 .
   PubMed Web of Science ®Google Scholar
• Ozdemir , O , Mete , E , Catal , F and Ozol , D . 2009 . Food intolerances and eosinophilic esophagitis in childhood . Dig Dis Sci , 54 : 8 – 14 .
   Web of Science ®Google Scholar
• Palmer , CN , Irvine , AD , Terron-Kwiatkowski , A , Zhao , Y , Liao , H , Lee , SP , Goudie , DR , Sandilands , A , Campbell , LE Smith , FJ . 2006 . Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis . Nat Genet , 38 : 441 – 446 .
   PubMed Web of Science ®Google Scholar
• Pene , J , Gauchat , JF , Lecart , S , Drouet , E , Guglielmi , P , Boulay , V , Delwail , A , Foster , D , Lecron , JC and Yssel , H . 2004 . Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells . J Immunol , 172 : 5154 – 5157 .
   PubMed Web of Science ®Google Scholar
• Pérez-Machado , MA , Ashwood , P , Thomson , MA , Latcham , F , Sim , R , WalkerSmith , JA and Murch , SH . 2003 . Reduced transforming growth factor-beta1-producing T cells in the duodenal mucosa of children with food allergy . Eur J Immunol , 33 : 2307 – 2315 .
   PubMed Web of Science ®Google Scholar
• Peters , IR , Helps , CR , Calvert , EL , Hall , EJ and Day , MJ . 2005 . Cytokine mRNA quantification in histologically normal canine duodenal mucosa by real-time RT-PCR . Vet Immunol Immunopathol , 103 : 101 – 111 .
   PubMed Web of Science ®Google Scholar
• Picco , F , Zini , E , Nett , C , Naegeli , C , Bigler , B , Rüfenacht , S , Roosje , P , Gutzwiller , ME , Wilhelm , S Pfister , J . 2008 . A prospective study on canine atopic dermatitis and food-induced allergic dermatitis in Switzerland . Vet Dermatol , 19 : 150 – 155 .
   Web of Science ®Google Scholar
• Proksch , E , Fölster-Holst , R and Jensen , JM . 2006 . Skin barrier function, epidermal proliferation and differentiation in eczema . J Dermatol Sci , 43 : 156 – 169 .
   Web of Science ®Google Scholar
• Pucheu-Haston , CM , Jackson , HA , Olivry , T , Dunston , SM and Hammerberg , B . 2008 . Epicutaneous sensitization with dermatophagoides farinae induces generalized allergic dermatitis and elevated mite-specific immunoglobulin E levels in a canine model of atopic dermatitis . Clin Exp Allergy , 38 : 667 – 679 .
   Web of Science ®Google Scholar
• Puigdemont , A , Brazis , P , Serra , M and Fondati , A . 2006 . Immunologic responses against hydrolysed soy protein in dogs with experimentally induced soy hypersensitivity . Am J Vet Res , 67 : 484 – 488 .
   Web of Science ®Google Scholar
• Punnonen , J , Aversa , G , Cocks , BG , McKenzie , AN , Menon , S , Zurawski , G , de Waal Malefyt , R and de Vries , JE . 1993 . Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells . Proc Natl Acad Sci USA , 90 : 3730 – 3734 .
   PubMed Web of Science ®Google Scholar
• Rautava , S and Isolauri , E . 2004 . Cow's milk allergy in infants with atopic eczema is associated with aberrant production of interleukin-4 during oral cow's milk challenge . J Pediatr Gastroenterol Nutr , 39 : 529 – 535 .
   Web of Science ®Google Scholar
• Reiss , Y , Proudfoot , AE , Power , CA , Campbell , JJ and Butcher , EC . 2001 . CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin . J Exp Med , 194 : 1541 – 1547 .
   PubMed Web of Science ®Google Scholar
• Rescigno , M , Urbano , M , Valzasina , B , Francolini , M , Rotta , G , Bonasio , R , Granucci , F , Kraehenbuhl , JP and Ricciardi-Castagnoli , P . 2001 . Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria . Nat Immunol , 2 : 361 – 367 .
   PubMed Web of Science ®Google Scholar
• Reynolds , DS , Boom , WH and Abbas , AK . 1987 . Inhibition of B lymphocyte activation by interferon-γ . J Immunol , 139 : 767 – 773 .
   PubMed Web of Science ®Google Scholar
• Rogler , G and Andus , T . 1998 . Cytokines in inflammatory bowel disease . World J Surg , 22 : 382 – 389 .
   PubMed Web of Science ®Google Scholar
• Rosser Jr , EJ . 1993 . Diagnosis of food allergy in dogs . J Am Vet Med Assoc , 203 : 259 – 262 .
   Web of Science ®Google Scholar
• Sanchez-Munoz , F , Dominguez-Lopez , A and Yamamoto-Furusho , JK . 2008 . Role of cytokines in inflammatory bowel disease . World J Gastroenterol , 14 : 4280 – 4288 .
   PubMed Web of Science ®Google Scholar
• Sandilands , A , Terron-Kwiatkowski , A , Hull , PR , O'Regan , GM , Clayton , TH , Watson , RM , Carrick , T , Evans , AT , Liao , H Zhao , Y . 2007 . Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in Ichthyosis vulgaris and atopic eczema . Nat Genet , 39 : 650 – 654 .
   PubMed Web of Science ®Google Scholar
• Saraiva , M and O'Garra , A . 2010 . The regulation of IL-10 production by immune cells . Nat Rev Immunol , 10 : 170 – 181 .
   PubMed Web of Science ®Google Scholar
• Schade , RP , Van Ieperen-Van Dijk , AG , Van Reijsen , FC , Versluis , C , Kimpen , JLL , Knol , EF , Bruijnzeel-Koomen , CAFM and Van Hoffen , E . 2000 . Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow's milk allergy: Relevance of TH2 cytokines . J Allergy Clin Immunol , 106 : 1155 – 1162 .
   Web of Science ®Google Scholar
• Sinke , JD , Thepen , T , Bihari , IC , Rutten , VP and Willemse , T . 1997 . Immunophenotyping of skin-infiltrating T-cell subsets in dogs with atopic dermatitis . Vet Immunol Immunopathol , 57 : 13 – 23 .
   Web of Science ®Google Scholar
• Sloan-Lancaster , J , Steinberg , TH and Allen , PM . 1997 . Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype . J Immunol , 159 : 1160 – 1168 .
   PubMed Web of Science ®Google Scholar
• Sonea , IM , Harkins , K , Wannemuehler , MJ , Jergens , AE , Merten , EA , Sacco , RE and Cunnick , JE . 1999 . Flow cytometric analysis of canine colonic mucosal lymphocytes from endoscopically obtained biopsy specimens . Am J Vet Res , 60 : 236 – 353 .
   Google Scholar
• Sonea , IM , Jergens , AE , Sacco , RE , Niyo , Y , Merten , E , Kauffman , LK and Moore , PF . 2000 . Flow cytometric analysis of colonic and small intestinal mucosal lymphocytes obtained by endoscopic biopsy in the healthy dog . Vet Immunol Immunopathol , 77 : 103 – 119 .
   PubMed Web of Science ®Google Scholar
• Szabo , SJ , Sullivan , BM , Stemmann , C , Satoskar , AR , Sleckman , BP and Glimcher , LH . 2002 . Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells . Science , 295 : 338 – 342 .
   PubMed Web of Science ®Google Scholar
• Thepen , T , Langeveld-Wildschut , EG , Bihari , IC , van Wichen , DF , van Reijsen , FC , Mudde , GC and Bruijnzeel-Koomen , CA . 1996 . Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study . J Allergy Clin Immunol , 97 : 828 – 837 .
   PubMed Web of Science ®Google Scholar
• Thornton , AM and Shevach , EM . 2000 . Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific . J Immunol , 164 : 183 – 190 .
   PubMed Web of Science ®Google Scholar
• Tiemessen , MM , Van Ieperen-Van Dijk , AG , Bruijnzeel-Koomen , CAFM , Garssen , J , Knol , EF and Van Hoffen , E . 2004 . Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: Key role for IL-10 . J Allergy Clin Immunol , 113 : 932 – 939 .
   PubMed Web of Science ®Google Scholar
• Tsuge , I , Kondo , Y , Tokuda , R , Kakami , M , Kawamura , M , Nakajima , Y , Komatsubara , R , Yamada , K and Urisu , A . 2006 . Allergen-specific helper T cell response in patients with cow's milk allergy: Simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimidyl ester dilution assay . Clin Exp Allergy , 36 : 1538 – 1545 .
   Web of Science ®Google Scholar
• Turcanu , V , Maleki , SJ and Lack , G . 2003 . Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts . J Clin Invest , 111 : 1056 – 1072 .
   Google Scholar
• Untersmayr , E and Jensen-Jarolim , E . 2008 . The role of protein digestibility and antacids on food allergy outcomes . J Allergy Clin Immunol , 121 : 1301 – 1308 .
   PubMed Web of Science ®Google Scholar
• Untersmayr , E , Bises , G , Starkl , P , Bevins , CL , Scheiner , O , Boltz-Nitulescu , G , Wrba , F and Jensen-Jarolim , E . 2010 . The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells . PloS One , 5 : e9023
   Web of Science ®Google Scholar
• Usui , T , Nishikomori , R , Kitani , A and Strober , W . 2003 . GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet . Immunity , 18 : 415 – 428 .
   PubMed Web of Science ®Google Scholar
• Usui , T , Preiss , JC , Kanno , Y , Yao , ZJ , Bream , JH , O'Shea , JJ and Strober , W . 2006 . T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription . J Exp Med , 203 : 755 – 766 .
   PubMed Web of Science ®Google Scholar
• Vaden , SL , Hammerberg , B , Davenport , DJ , Orton , SM , Trogdon , MM , Melgarejo , LT , VanCamp , SD and Williams , DA . 2000 . Food hypersensitivity reactions in Soft Coated Wheaten Terriers with protein-losing enteropathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation, and fecal immunoglobulin E . J Vet Intern Med , 14 : 60 – 67 .
   PubMed Web of Science ®Google Scholar
• Veenhof , EZ , Rutten , VP , van Noort , R , Knol , EF and Willemse , T . 2010 . Evaluation of T-cell activation in the duodenum of dogs with cutaneous food hypersensitivity . Am J Vet Res , 71 : 441 – 446 .
   Web of Science ®Google Scholar
• Veenhof , EZ , Knol , EF , Schlotter , YM , Vernooij , JC , Rutten , VP and Willemse , T . 2011 . Characterisation of T cell phenotypes, cytokines and transcription factors in the skin of dogs with cutaneous adverse food reactions . Vet J , 187 : 320 – 324 .
   Web of Science ®Google Scholar
• Veldhoen , M , Hocking , RJ , Atkins , CJ , Locksley , RM and Stockinger , B . 2006 . TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells . Immunity , 24 : 179 – 189 .
   PubMed Web of Science ®Google Scholar
• Wang , X , Fujita , M , Prado , R , Tousson , A , Hsu , HC , Schottelius , A , Kelly , DR , Yang , PA , Wu , Q Chen , J . 2010 . Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model . Brit J Dermatol , 162 : 487 – 496 .
   Web of Science ®Google Scholar
• Weiner , HL . 2001 . Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells . Immunol Rev , 182 : 207 – 214 .
   PubMed Web of Science ®Google Scholar
• Werfel , T . 2009 . The Role of Leukocytes, Keratinocytes, and Allergen-Specific IgE in the Development of Atopic Dermatitis . J Invest Dermatol , 129 : 1878 – 1891 .
   PubMed Web of Science ®Google Scholar
• Westendorf , AM , Bruder , D , Hansen , W and Buer , J . 2006 . Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model . Ann N Y Acad Sci USA , 1072 : 401 – 406 .
   PubMed Web of Science ®Google Scholar
• White , SD . 1986 . Food hypersensitivity in 30 dogs . J Am Vet Med Assoc , 188 : 695 – 698 .
   PubMed Web of Science ®Google Scholar
• Wills , J and Harvey , R . 1994 . Diagnosis and management of food allergy and intolerance in dogs and cats . Aust Vet J , 71 : 322 – 326 .
   Web of Science ®Google Scholar
• Xu , L , Kitani , A , Fuss , I and Strober , W . 2007 . Cutting edge: regulatory T cells induce CD4+CD25−Foxp3− T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta . J Immunol , 178 : 6725 – 6729 .
   PubMed Web of Science ®Google Scholar
• Yang , XO , Panopoulos , AD , Nurieva , R , Chang , SH , Wang , D , Watowich , SS and Dong , C . 2007 . STAT3 regulates cytokine mediated generation of inflammatory helper T cells . J Biol Chem , 282 : 9358 – 9363 .
   PubMed Web of Science ®Google Scholar
• Yu , LCH , Yang , PC , Berin , MC , Di Leo , V , Conrad , DH , McKay , DM , Satoskar , AR and Perdue , MH . 2001 . Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4 . Gastroenterology , 121 : 370 – 381 .
   Web of Science ®Google Scholar
• Zan , H , Cerutti , A , Dramitinos , P , Schaffer , A and Casali , P . 1998 . CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-β: evidence for TGF-β but not IL-10-dependent direct Sμ→Sα and sequential Sμ→Sγ, Sγ→Sα DNA recombination . J Immunol , 161 : 5217 – 5225 .
   PubMed Web of Science ®Google Scholar
• Zheng , X , Nakamura , K , Furukawa , H , Nishibu , A , Takahashi , M , Tojo , M , Kaneko , F , Kakinuma , T and Tamaki , K . 2003 . Demonstration of TARC and CCR4 mRNA expression and distribution using in situ RT-PCR in the lesional skin of atopic dermatitis . J Dermatol , 30 : 26 – 32 .
   Web of Science ®Google Scholar
• Zhu , J , Min , B , Hu-Li , J , Watson , CJ , Grinberg , A , Wang , Q , Killeen , N , Urban Jr , JF , Guo , L and Paul , WE . 2004 . Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses . Nat Immunol , 5 : 1157 – 1165 .
   PubMed Web of Science ®Google Scholar
• Zhu , J , Yamane , H and Paul , WE . 2010 . Differentiation of effector CD4 T cell populations . Ann Rev Immunol , 28 : 445 – 489 .
   PubMed Web of Science ®Google Scholar