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Special Feature: Stem cell research: current uses and future challenges

Canine mesenchymal stem cells: state of the art, perspectives as therapy for dogs and as a model for man

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Pages 225-233 | Received 05 Nov 2013, Accepted 07 Dec 2013, Published online: 10 Jan 2014

References

  • Alberton P, Popov C, Pragert M, Kohler J, Shukunami C, Schieker M, Docheva D. 2012. Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis. Stem Cells Dev. Apr 10;21:846–858.
  • Alves AG, Stewart AA, Dudhia J, Kasashima Y, Goodship AE, Smith RK. 2011. Cell-based therapies for tendon and ligament injuries. Vet Clin North Am Equine Pract. Aug;27:315–333.
  • Barry FP, Murphy JM. 2004. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. Apr;36:568–584.
  • Black LL, Gaynor J, Adams C, Dhupa S, Sams AE, Taylor R, Harman S, Gingerich DA, Harman R. 2008. Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther. 9:192–200.
  • Black LL, Gaynor J, Gahring D, Adams C, Aron D, Harman S, Gingerich DA, Harman R. 2007. Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther. 8:272–284.
  • Borjesson DL, Peroni JF. 2011. The regenerative medicine laboratory: facilitating stem cell therapy for equine disease. Clin Lab Med. Mar;31:109–123.
  • Bruder SP, Kraus KH, Goldberg VM, Kadiyala S. 1998. The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am. Jul;80:985–996.
  • Chanda D, Kumar S, Ponnazhagan S. 2010. Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton. J Cell Biochem. Oct 1;111:249–257.
  • Chu CR, Szczodry M, Bruno S. 2010. Animal models for cartilage regeneration and repair. Tissue Eng Part B Rev. Feb;16:105–115.
  • Clegg PD, Pinchbeck GL. 2011. Evidence-based medicine and stem cell therapy: how do we know such technologies are safe and efficacious? Vet Clin North Am Equine Pract. 27:373–382.
  • Corr SA, Draffan D, Kulendra E, Carmichael S, Brodbelt D. 2010. Retrospective study of Achilles mechanism disruption in 45 dogs. Vet Rec. Sep 11;167:407–411.
  • Crovace A, Favia A, Lacitignola L, Di Comite MS, Staffieri F, Francioso E. 2008. Use of autologous bone marrow mononuclear cells and cultured bone marrow stromal cells in dogs with orthopaedic lesions. Vet Res Commun. Sep;32:S39–S44.
  • Csaki C, Matis U, Mobasheri A, Ye H, Shakibaei M. 2007. Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and ultrastructural study. Histochem Cell Biol. Dec;128:507–520.
  • de Bakker E, Gielen I, Saunders JH, Polis I, Vermeire S, Peremans K, Dewulf J, van Bree H, Van Ryssen B. 2013. Primary and concomitant flexor enthesopathy of the canine elbow. Vet Comp Orthop Traumatol. Nov 12;26:425–434. doi:10.3415/VCOT-12-02-0025
  • De Schauwer C, Meyer E, Van de Walle GR, Van Soom A. 2011. Markers of stemness in equine mesenchymal stem cells: a plea for uniformity. Theriogenology. 75:1431–1443.
  • De Schauwer C, Piepers S, Van de Walle GR, Demeyere K, Hoogewijs MK, Govaere JL, Braeckmans K, Van Soom A, Meyer E. 2012. In search for cross-reactivity to immunophenotype equine mesenchymal stromal cells by multicolor flow cytometry. Cytom part A. 81A:312–323.
  • De Schauwer C, Van de Walle GR, Van Soom A, Meyer E. 2013. Mesenchymal stem cell therapy in horses: useful beyond orthopedic injuries? Vet Q. May 22. doi:10.1080/01652176.2013.800250
  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E. 2006. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 8:315–317.
  • Fortier LA. 2005. Stem cells: classifications, controversies, and clinical applications. Vet Surg. Sep–Oct;34:415–423.
  • Fortier LA, Nixon AJ, Williams J, Cable CS. 1998. Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells. Am J Vet Res. Sep;59:1182–1187.
  • Fortier LA, Travis AJ. 2011. Stem cells in veterinary medicine. Stem Cell Res Ther. 2:9. doi:10.1186/scrt50
  • Ginis I, Luo Y, Miura T, Thies S, Brandenberger R, Gerecht-Nir S, Amit M, Hoke A, Carpenter MK, Itskovitz-Eldor J, Rao MS. 2004. Differences between human and mouse embryonic stem cells. Dev Biol. May 15;269:360–380.
  • Godwin EE, Young NJ, Dudhia J, Beamish IC, Smith RK. 2012. Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon. Equine Vet J. Jan;44:25–32.
  • Guercio A, Di Marco P, Casella S, Cannella V, Russotto L, Purpari G, Di Bella S, Piccione G. 2012. Production of canine mesenchymal stem cells from adipose tissue and their application in dogs with chronic osteoarthritis of the humeroradial joints. Cell Biol Int. Feb;36:189–194.
  • Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, Tamura F, Sakai D. 2008. Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res. May;26:589–600.
  • Hodgkiss-Geere HM, Argyle DJ, Corcoran BM, Whitelaw B, Milne E, Bennett D, Argyle SA. 2012a. Characterisation and cardiac directed differentiation of canine adult cardiac stem cells. Vet J. Feb;191:176–182.
  • Hodgkiss-Geere HM, Argyle DJ, Corcoran BM, Whitelaw B, Milne E, Bennett D, Argyle SA. 2012b. Characterisation and differentiation potential of bone marrow derived canine mesenchymal stem cells. Vet J. Dec;194:361–368.
  • Jiang Y, Vaessen B, Lenvik T, Blackstad M, Reyes M, Verfaillie CM. 2002. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol. Aug;30:896–904.
  • Jung DI, Ha J, Kang BT, Kim JW, Quan FS, Lee JH, Woo EJ, Park HM. 2009. A comparison of autologous and allogenic bone marrow-derived mesenchymal stem cell transplantation in canine spinal cord injury. J Neurol Sci. Oct 15;285:67–77.
  • Kamishina H, Deng J, Oji T, Cheeseman JA, Clemmons RM. 2006. Expression of neural markers on bone marrow-derived canine mesenchymal stem cells. Am J Vet Res. Nov;67:1921–1928.
  • Kang BJ, Ryu HH, Park SS, Koyama Y, Kikuchi M, Woo HM, Kim WH, Kweon OK. 2012. Comparing the osteogenic potential of canine mesenchymal stem cells derived from adipose tissues, bone marrow, umbilical cord blood, and Wharton's jelly for treating bone defects. J Vet Sci. Sep;13:299–310.
  • Kisiel AH, McDuffee LA, Masaoud E, Bailey TR, Esparza Gonzalez BP, Nino-Fong R. 2012. Isolation, characterization, and in vitro proliferation of canine mesenchymal stem cells derived from bone marrow, adipose tissue, muscle, and periosteum. Am J Vet Res. Aug;73:1305–1317.
  • Little CB, Smith MM. 2008. Animal models of osteoarthritis. Curr Rheumatol Rev.4:1–8.
  • Martinello T, Bronzini I, Maccatrozzo L, Mollo A, Sampaolesi M, Mascarello F, Decaminada M, Patruno M. 2011. Canine adipose-derived-mesenchymal stem cells do not lose stem features after a long-term cryopreservation. Res Vet Sci. Aug;91:18–24.
  • Memon IA, Sawa Y, Miyagawa S, Taketani S, Matsuda H. 2005. Combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells in canine hearts for ischemic cardiomyopathy. J Thorac Cardiovasc Surg. Sep;130:646–653.
  • Mokbel A, El-Tookhy O, Shamaa AA, Sabry D, Rashed L, Mostafa A. 2011. Homing and efficacy of intra-articular injection of autologous mesenchymal stem cells in experimental chondral defects in dogs. Clin Exp Rheumatol. 29:275–284.
  • Neupane M, Chang CC, Kiupel M, Yuzbasiyan-Gurkan V. 2008. Isolation and characterization of canine adipose-derived mesenchymal stem cells. Tissue Eng Part A. Jun;14:1007–1015.
  • Nixon AJ, Dahlgren LA, Haupt JL, Yeager AE, Ward DL. 2008. Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis. Am J Vet Res. Jul;69:928–937.
  • Pacini S, Spinabella S, Trombi L, Fazzi R, Galimberti S, Dini F, Carlucci F, Petrini M. 2007. Suspension of bone marrow-derived undifferentiated mesenchymal stromal cells for repair of superficial digital flexor tendon in race horses. Tissue Eng. Dec;13:2949–2955.
  • Park A, Hogan MV, Kesturu GS, James R, Balian G, Chhabra AB. 2010. Adipose-derived mesenchymal stem cells treated with growth differentiation factor-5 express tendon-specific markers. Tissue Eng Part A. Sep;16:2941–2951.
  • Phinney DG, Prockop DJ. 2007. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair–current views. Stem Cells. Nov;25:2896–2902.
  • Ralphs SC, Whitney WO. 2002. Arthroscopic evaluation of menisci in dogs with cranial cruciate ligament injuries: 100 cases (1999-2000). J Am Vet Med Assoc. Dec 1;221:1601–1604.
  • Richardson LE, Dudhia J, Clegg PD, Smith R. 2007. Stem cells in veterinary medicine - attempts at regenerating equine tendon after injury. Trends Biotechnol. 25:409–416.
  • Sampaolesi M, Blot S, D’Antona G, Granger N, Tonlorenzi R, Innocenzi A, Mognol P, Thibaud JL, Galvez BG, Barthelemy I, et al. 2006. Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs. Nature. Nov 30;444:574–579.
  • Seo MS, Jeong YH, Park JR, Park SB, Rho KH, Kim HS, Yu KR, Lee SH, Jung JW, Lee YS, Kang KS. 2009. Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells. J Vet Sci. Sep;10:181–187.
  • Smith RK. 2008. Mesenchymal stem cell therapy for equine tendinopathy. Disabil Rehabil. 30:1752–1758.
  • Smith RK, Korda M, Blunn GW, Goodship AE. 2003. Isolation and implantation of autologous equine mesenchymal stem cells from bone marrow into the superficial digital flexor tendon as a potential novel treatment. Equine Vet J. Jan;35:99–102.
  • Smolders LA, Meij BP, Onis D, Riemers FM, Bergknut N, Wubbolts R, Grinwis GCM, Houweling M, Groot Koerkamp MJA, van Leenen D, et al. 2013. Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Res Ther. Jan;15:R23.
  • Smolders LA, Meij, BP, Riemers FM, Licht R, Wubbolts R, Heuvel D, Grinwis GCM, Vernooij HCM, Hazewinkel HAW, Penning LC, Tryfonidou MA. 2012. Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration. J Orthop Res. Jun;30:950–957.
  • Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, Schumichen C, Nienaber CA, Freund M, Steinhoff G. 2003. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet. Jan 4;361:45–46.
  • Stewart MC, Stewart AA. 2011. Mesenchymal stem cells: characteristics, sources, and mechanisms of action. Vet Clin North Am Equine Pract. Aug;27:243–261.
  • Takemitsu H, Zhao D, Yamamoto I, Harada Y, Michishita M, Arai T. 2012. Comparison of bone marrow and adipose tissue-derived canine mesenchymal stem cells. BMC Vet Res. 8:150.
  • Vieira NM, Brandalise V, Zucconi E, Secco M, Strauss BE, Zatz M. 2010. Isolation, characterization, and differentiation potential of canine adipose-derived stem cells. Cell Transplant. 19:279–289.
  • Vilar JM, Morales M, Santana A, Spinella G, Rubio M, Cuervo B, Cugat R, Carrillo JM. 2013. Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs. BMC Vet Res. 9:131.
  • Violini S, Ramelli P, Pisani LF, Gorni C, Mariani P. 2009. Horse bone marrow mesenchymal stem cells express embryo stem cell markers and show the ability for tenogenic differentiation by in vitro exposure to BMP-12. BMC Cell Biol. 10:29.
  • Wagner J, Kean T, Young R, Dennis JE, Caplan AI. 2009. Optimizing mesenchymal stem cell-based therapeutics. Curr Opin Biotechnol. Oct;20:531–536.

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