An explorative study comparing skin surface lipids in the West Highland white terrier dog with and without atopic dermatitis

References

• Angelbeck-Schulze M, Mischke R, Rohn K, Hewicker-Trautwein M, Naim HY, Bäumer W. 2014. Canine epidermal lipid sampling by skin scrub revealed variations between different body sites and normal and atopic dogs. BMC Vet Res. 10:152.
   PubMed Web of Science ®Google Scholar
• Chermprapai S, Broere F, Gooris G, Schlotter YM, Rutten VPMG, Bouwstra JA. 2018. Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis. Biochim Biophys Acta Biomembr. 1860(2):526–533.
   PubMed Web of Science ®Google Scholar
• Dahlhoff M, Camera E, Schäfer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR. 2016. Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. Development. 143(10):1823–1831.
   PubMed Web of Science ®Google Scholar
• Favrot C, Steffan J, Seewald W, Picco F. 2010. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol. 21(1):23–31.
   PubMed Web of Science ®Google Scholar
• Favrot C, Fischer N, Olivry T, Zwickl L, Audergon S, Rostaher A. 2020. Atopic dermatitis in West Highland white terriers - part I: natural history of atopic dermatitis in the first three years of life. Vet Dermatol. 31(2):106–110.
   PubMed Web of Science ®Google Scholar
• Fluhr JW, Mao-Qiang M, Brown BE, Wertz PW, Crumrine D, Sundberg JP, Feingold KR, Elias PM. 2003. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. J Invest Dermatol. 120(5):728–737.
   PubMed Web of Science ®Google Scholar
• Folch J, Lees M, Sloane-Stanley GH. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 226(1):497–509.
   PubMed Web of Science ®Google Scholar
• Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM. 1995. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in human and a senescent murine model. J Clin Invest. 95(5):2281–2290.
   PubMed Web of Science ®Google Scholar
• Hill PB, Lau P, Rybnicek J. 2007. Development of an owner-assessed scale to measure the severity of pruritus in dogs. Vet Dermatol. 18(5):301–308.
   PubMed Web of Science ®Google Scholar
• Inman AO, Olivry T, Dunston SM, Monteiro-Riviere NA, Gatto H. 2001. Electron microscopic observations of stratum corneum intercellular lipids in normal and atopic dogs. Vet Pathol. 38(6):720–723.
   PubMed Web of Science ®Google Scholar
• Jaeger K, Linek M, Power HT, Bettenay SV, Zabel S, Rosychuk RA, Mueller RS. 2010. Breed and site predispositions of dogs with atopic dermatitis: a comparison of five locations in three continents. Vet Dermatol. 21(1):118–122.
   PubMed Web of Science ®Google Scholar
• Kligman AM. 1963. The uses of sebum. Br J Dermatol. 75:307–319.
   PubMed Web of Science ®Google Scholar
• Lovászi M, Szegedi A, Zouboulis CC, Törőcsik D. 2017. Sebaceous-immunobiology is orchestrated by sebum lipids. Dermatoendocrinol. 9(1):e1375636.
   PubMed Web of Science ®Google Scholar
• Ludovici M, Kozul N, Materazzi S, Risoluti R, Picardo M, Camera E. 2018. Influence of the sebaceous gland density on the stratum corneum lipidome. Sci Rep. 8(1):11500.
   PubMed Web of Science ®Google Scholar
• Marsella R. 2014. The aberrant immune system in atopic dermatitis. In: Noli C, Foster A, Rosenkrantz W, editors. Veterinary allergy. 1st ed. Singapore: Wiley Blackwell. p. 16–23.
   Google Scholar
• Mattii M, Lovászi M, Garzorz N, Atenhan A, Quaranta M, Lauffer F, Konstantinow A, Kupper M, Zouboulis C, Kemeny L, et al. 2018. Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells. Br J Dermatol. 178(3):722–730.
   PubMed Web of Science ®Google Scholar
• Miller WH, Griffin CE, Campbell KL. 2013. Structure and function of the skin in: Muller and Kirk’s small animal dermatology. 7th ed. Philadelphia: WB Saunders. p. 1–56.
   Google Scholar
• Nishifuji K. 2014. Skin barrier and its role in the pathophysiology of atopic dermatitis. In: Noli C, Foster A, Rosenkrantz W, editors. Veterinary allergy. 1st ed. Singapore: Wiley Blackwell. p. 42–50.
   Google Scholar
• Olivry T. 2011. Is the skin barrier abnormal in dogs with atopic dermatitis? Vet Immunol Immunopathol. 144(1–2):11–16.
   PubMed Web of Science ®Google Scholar
• Olivry T, Saridomichelakis M, Nuttall T, Bensignor E, Griffin CE, Hill PB, International Committe on Allergic Diseases of Animals (ICADA). 2014. International Committee on Allergic Diseases of Animals (ICADA). Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Vet Dermatol. 25(2):77–85.
   PubMed Web of Science ®Google Scholar
• Pappas A. 2009. Epidermal surface lipids. Dermatoendocrinol. 1(2):72–76.
   PubMedGoogle Scholar
• Popa I, Remoue N, Osta B, Pin D, Gatto H, Haftek M, Portoukalian J. 2012. The lipid alterations in the stratum corneum of dogs with atopic dermatitis are alleviated by topical application of a sphingolipid-containing emulsion. Clin Exp Dermatol. 37(6):665–671.
   PubMed Web of Science ®Google Scholar
• Reiter LV, Torres SM, Wertz PW. 2009. Characterization and quantification of ceramides in the nonlesional skin of canine patients with atopic dermatitis compared with controls. Vet Dermatol. 20(4):260–266.
   PubMed Web of Science ®Google Scholar
• Rogers J, Harding C, Mayo A, Banks J, Rawlings A. 1996. Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res. 288(12):765–770.
   PubMed Web of Science ®Google Scholar
• Rohart F, Gautier B, Singh A, Lê Cao K-A. 2017. MixOmics: an R package for ‘omics feature selection and multiple data integration. PLoS Comput Biol. 13(11):e1005752..
   PubMed Web of Science ®Google Scholar
• Rybnícek J, Lau-Gillard PJ, Harvey R, Hill PB. 2009. Further validation of a pruritus severity scale for use in dogs. Vet Dermatol. 20(2):115–222.
   PubMed Web of Science ®Google Scholar
• Salzmann CA, Olivry TJ, Nielsen DM, Paps JS, Harris TL, Olby NJ. 2011. Genome-wide linkage study of atopic dermatitis in West Highland White Terriers. BMC Genet. 12:37.
   PubMed Web of Science ®Google Scholar
• Shimada K, Yoon JS, Yoshihara T, Iwasaki T, Nishifuji K. 2009. Increased transepidermal water loss and decreased ceramide content in lesional and non-lesional skin of dogs with atopic dermatitis. Vet Dermatol. 20(5–6):541–546.
   PubMed Web of Science ®Google Scholar
• Stahl J, Paps J, Bäumer W, Olivry T. 2012. Dermatophagoides farinae house dust mite allergen challenges reduce stratum corneum ceramides in an experimental dog model of acute atopic dermatitis. Vet Dermatol. 23(6):497–e97.
   PubMed Web of Science ®Google Scholar
• Stetina KM, Marks SL, Griffin CE. 2015. Owner assessment of pruritus and gastrointestinal signs in apparently healthy dogs with no history of cutaneous or noncutaneous disease. Vet Dermatol. 26(4):246–e54.
   PubMed Web of Science ®Google Scholar
• Szöllősi AG, Oláh A, Bíró T, Tóth BI. 2017. Recent advances in the endocrinology of the sebaceous gland. Dermatoendocrinol. 9 (1):e1361576.
   PubMed Web of Science ®Google Scholar
• van Smeden J, Hoppel L, van der Heijden R, Hankemeier T, Vreeken RJ, Bouwstra JA. 2011. LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. J Lipid Res. 52(6):1211–1221.
   PubMed Web of Science ®Google Scholar
• Westerhuis JA, Hoefsloot HCJ, Smit S, Vis A, Smilde A, van Velzen E, van Duijnhoven J, van Dorsten F. 2008. Assessment of PLSDA cross validation. Metabolomics. 4(1):81–89.
   Web of Science ®Google Scholar
• Yoon J, Nishifuji K, Sasaki A, Ide K, Ishikawa J, Yoshihara T, Iwasaki T. 2011. Alteration of stratum corneum ceramide profiles in spontaneous canine model of atopic dermatitis. Exp Dermatol. 20(9):732–736.
   PubMed Web of Science ®Google Scholar