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Reviews

Optic Nerve Head Drusen: An Update

, ORCID Icon, &
Pages 367-384 | Received 09 Jan 2018, Accepted 20 Feb 2018, Published online: 25 Apr 2018

References

  • Müller H. Beitrage zur Ophthalmologie. Albrecht Von Graefes Arch Klin Ophthalmol. 1858;4:1–40. doi:10.1007/BF02720734.
  • Traber GL, Weber KP, Sabah M, Keane PA, Plant GT. Enhanced depth imaging optical coherence tomography of optic nerve head drusen: a comparison of cases with and without visual field loss. Ophthalmology. 2017;124(1):66–73. doi:10.1016/j.ophtha.2016.09.022.
  • Lam BL, Morais CG Jr., Pasol J. Drusen of the optic disc. Curr Neurol Neurosci Rep. 2008;8(5):404–408. doi:10.1007/s11910-008-0062-6.
  • Wilkins JM, Pomeranz HD. Visual manifestations of visible and buried optic disc drusen. J Neuroophthalmol. 2004;24(2):125–129. doi:10.1097/00041327-200406000-00006.
  • Flores-Rodriguez P, Gili P, Martin-Rios MD. Ophthalmic features of optic disc drusen. Ophthalmologica. 2012;228(1):59–66. doi:10.1159/000337842.
  • Park KH, Woo SJ, Hwang JM. Optic nerve head drusen mimicking optic nerve tumor. Korean J Ophthalmol. 2015;29(3):207–208. doi:10.3341/kjo.2015.29.3.207.
  • Aumiller MS. Optic disc drusen: complications and management. Optometry. 2007;78(1):10–16. doi:10.1016/j.optm.2006.07.009.
  • Granger RH, Bonnelame T, Daubenton J, Dreyer M, McCartney P. Optic nerve head drusen and idiopathic intracranial hypertension in a 14-year-old girl. J Pediatr Ophthalmol Strabismus. 2009;46(4):238–240. doi:10.3928/01913913-20090706-13.
  • Komur M, Sari A, Okuyaz C. Simultaneous papilledema and optic disc drusen in a child. Pediatr Neurol. 2012;46(3):187–188. doi:10.1016/j.pediatrneurol.2011.12.002.
  • Rossiter JD, Lockwood AJ, Evans AR. Coexistence of optic disc drusen and idiopathic intracranial hypertension in a child. Eye (Lond). 2005;19(2):234–235. doi:10.1038/sj.eye.6701430.
  • Distelmaier F, Sengler U, Messing-Juenger M, Assmann B, Mayatepek E, Rosenbaum T. Pseudotumor cerebri as an important differential diagnosis of papilledema in children. Brain Dev. 2006;28(3):190–195. doi:10.1016/j.braindev.2005.07.003.
  • Rott D, Leibowitz D. Optic nerve head drusen mimicking papilledema and malignant hypertension. Eur J Intern Med. 2009;20(5):e112–3. doi:10.1016/j.ejim.2008.09.019.
  • Antcliff RJ, Spalton DJ. Are optic disc drusen inherited?. Ophthalmology. 1999;106(7):1278–1281. doi:10.1016/S0161-6420(99)00708-3.
  • Pilat AV, Proudlock FA, McLean RJ, Lawden MC, Gottlob I. Morphology of retinal vessels in patients with optic nerve head drusen and optic disc edema. Invest Ophthalmol Vis Sci. 2014;55(6):3484–3490. doi:10.1167/iovs.14-13903.
  • Donders FC. Beitrage zur pathologischen Anatomie des Auges. Graefe’s Archive Ophthalmol. 1855;1:106–118. doi:10.1007/BF02720791.
  • Iwanhoff A. Ueber Neuritis optica. Klin Monatsbl Augenheilkd. 1868;6:421–427.
  • Liebreich R. Contribution to discussion on: iwanhoff, A.: Ueber Neuritis optica. Klin Monatsbl Augenheilkd. 1868;6:426–427.
  • Lorentzen SE. Drusen of the optic disk. A clinical and genetic study. Acta Ophthalmol (Copenh). 1966;Suppl 90:1–180.
  • Tso MO. Pathology and pathogenesis of drusen of the optic nervehead. Ophthalmology. 1981;88(10):1066–1080. doi:10.1016/S0161-6420(81)80038-3.
  • Friedman AH, Gartner S, Modi SS. Drusen of the optic disc. A retrospective study in cadaver eyes. Br J Ophthalmol. 1975;59(8):413–421. doi:10.1136/bjo.59.8.413.
  • Grover S, Fishman GA, Brown J Jr. Frequency of optic disc or parapapillary nerve fiber layer drusen in retinitis pigmentosa. Ophthalmology. 1997;104(2):295–298. doi:10.1016/S0161-6420(97)30321-2.
  • Edwards A, Grover S, Fishman GA. Frequency of photographically apparent optic disc and parapapillary nerve fiber layer drusen in Usher syndrome. Retina. 1996;16(5):388–392. doi:10.1097/00006982-199616050-00004.
  • Friedman AH, Beckerman B, Gold DH, Walsh JB, Gartner S. Drusen of the optic disc. Surv Ophthalmol. 1977;21(5):373–390. doi:10.1016/0039-6257(77)90041-8.
  • Auw-Haedrich C, Staubach F, Witschel H. Optic disk drusen. Surv Ophthalmol. 2002;47(6):515–532. doi:10.1016/S0039-6257(02)00357-0.
  • Spencer WH. XXXIV Edward Jackson Memorial Lecture: drusen of the optic disc and aberrant axoplasmic transport. Ophthalmology. 1978;85(1):21–38. doi:10.1016/S0161-6420(78)35696-7.
  • Kapur R, Pulido JS, Abraham JL, Sharma M, Buerk B, Edward DP. Histologic findings after surgical excision of optic nerve head drusen. Retina. 2008;28(1):143–146. doi:10.1097/IAE.0b013e31815e98d8.
  • McLeod D, Marshall J, Kohner EM, Bird AC. The role of axoplasmic transport in the pathogenesis of retinal cotton-wool spots. Br J Ophthalmol. 1977;61(3):177–191. doi:10.1136/bjo.61.3.177.
  • McLeod D. Why cotton wool spots should not be regarded as retinal nerve fibre layer infarcts. Br J Ophthalmol. 2005;89(2):229–237. doi:10.1136/bjo.2004.058347.
  • Noval S, Visa J, Contreras I. Visual field defects due to optic disk drusen in children. Graefes Arch Clin Exp Ophthalmol. 2013;251(10):2445–2450. doi:10.1007/s00417-013-2384-6.
  • Chang MY, Pineles SL. Optic disk drusen in children. Surv Ophthalmol. 2016;61(6):745–758. doi:10.1016/j.survophthal.2016.03.007.
  • Erkkila H. Optic disc drusen in children. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1973;189(1):1–7. doi:10.1007/BF00411120.
  • Lorentzen SE. Optic disc drusen. Acta Ophthalmol (Copenh). 1983;61(2):335–336. doi:10.1111/j.1755-3768.1983.tb01429.x.
  • Malmqvist L, Li XQ, Eckmann CL, et al. Optic disc drusen in children: the Copenhagen Child Cohort 2000 Eye Study. J Neuroophthalmol. 2017; doi:10.1097/WNO.0000000000000567.
  • Kurz-Levin MM, Landau K. A comparison of imaging techniques for diagnosing drusen of the optic nerve head. Arch Ophthalmol. 1999;117(8):1045–1049. doi:10.1001/archopht.117.8.1045.
  • De La Hoz Polo M, Torramilans Lluis A, Pozuelo Segura O, Anguera Bosque A, Esmerado Appiani C, Caminal Mitjana JM. Ocular ultrasonography focused on the posterior eye segment: what radiologists should know. Insights Imaging. 2016;7(3):351–364. doi:10.1007/s13244-016-0471-z.
  • Pineles SL, Arnold AC. Fluorescein angiographic identification of optic disc drusen with and without optic disc edema. J Neuroophthalmol. 2012;32(1):17–22. doi:10.1097/WNO.0b013e31823010b8.
  • Boldt HC, Byrne SF, DiBernardo C. Echographic evaluation of optic disc drusen. J Clin Neuroophthalmol. 1991;11(2):85–91.
  • Zaouali S, Abroug N, Khochtali S, et al. Optic nerve head drusen: a comparative study of 10 MHz and 20 MHz ultrasound probes. Int Ophthalmol. 2015;35(2):229–232. doi:10.1007/s10792-014-9939-3.
  • Almog Y, Nemet A, Nemet AY. Optic disc drusen demonstrate a hyperechogenic artifact in B mode ultrasound. J Clin Neurosci. 2016;23:111–119. doi:10.1016/j.jocn.2015.08.005.
  • Moosajee M, Restori M, Acheson J, Dahlmann-Noor A. The cost-effectiveness of different strategies to evaluate optic disk drusen in children. J Aapos. 2015;19(4):392–393. doi:10.1016/j.jaapos.2015.02.014.
  • Leon M, Hutchinson AK, Lenhart PD, Lambert SR. The cost-effectiveness of different strategies to evaluate optic disk drusen in children. J Aapos. 2014;18(5):449–452. doi:10.1016/j.jaapos.2014.06.006.
  • Silverman AL, Tatham AJ, Medeiros FA, Weinreb RN. Assessment of optic nerve head drusen using enhanced depth imaging and swept source optical coherence tomography. J Neuroophthalmol. 2014;34(2):198–205. doi:10.1097/WNO.0000000000000115.
  • Chang MY, Federico GV, Demer JL, et al. Accuracy of diagnostic imaging modalities for classifying pediatric eyes as papilledema versus pseudopapilledema. Ophthalmology. 2017;124:1839–1848. doi:10.1016/j.ophtha.2017.06.016.
  • Rajesh B, Hussain R, Autofluorescence GA. Infrared fundus imaging for detection of retinal emboli and unmasking undiagnosed systemic abnormalities. J Ophthalmic Vis Res. 2016;11(4):449–451. doi:10.4103/2008-322X.194149.
  • Erol MK, Coban DT, Ceran BB, Bulut M. Enhanced depth imaging optical coherence tomography and fundus autofluorescence findings in bilateral choroidal osteoma: a case report. Arq Bras Oftalmol. 2013;76(3):189–191. doi:10.1590/S0004-27492013000300012.
  • Sato T, Mrejen S, Spaide RF. Multimodal imaging of optic disc drusen. Am J Ophthalmol. 2013;156(2):275–82 e1. doi:10.1016/j.ajo.2013.03.039.
  • Gili P, Flores-Rodriguez P, Yanguela J, Orduna-Azcona J, Martin-Rios MD. Sensitivity and specificity of monochromatic photography of the ocular fundus in differentiating optic nerve head drusen and optic disc oedema: optic disc drusen and oedema. Graefes Arch Clin Exp Ophthalmol. 2013;251(3):923–928. doi:10.1007/s00417-012-2223-1.
  • Caramoy A, Engel L, Koch KR, Kirchhof B, Cursiefen C, Heindl LM. Multiple imaging modalities for the detection of optic nerve head drusen: is echography still mandatory?. Acta Ophthalmologica. 2017;95(3):320–323. doi:10.1111/aos.2017.95.issue-3.
  • Merchant KY, Su D, Park SC, et al. Enhanced depth imaging optical coherence tomography of optic nerve head drusen. Ophthalmology. 2013;120(7):1409–1414. doi:10.1016/j.ophtha.2012.12.035.
  • Malmqvist L, Bursztyn L, Costello F, et al. The optic disc drusen studies consortium recommendations for diagnosis of optic disc drusen using optical coherence tomography. J Neuroophthalmol. 2017; doi:10.1097/WNO.0000000000000585.
  • Lee KM, Woo SJ, Hwang JM. Differentiation of optic nerve head drusen and optic disc edema with spectral-domain optical coherence tomography. Ophthalmology. 2011;118(5):971–977. doi:10.1016/j.ophtha.2010.09.006.
  • Kulkarni KM, Pasol J, Rosa PR, Lam BL. Differentiating mild papilledema and buried optic nerve head drusen using spectral domain optical coherence tomography. Ophthalmology. 2014;121(4):959–963. doi:10.1016/j.ophtha.2013.10.036.
  • Bassi ST, Mohana KP. Optical coherence tomography in papilledema and pseudopapilledema with and without optic nerve head drusen. Indian J Ophthalmol. 2014;62(12):1146–1151. doi:10.4103/0301-4738.149136.
  • Patel NN, Shulman JP, Chin KJ, Finger PT. Optical coherence tomography/scanning laser ophthalmoscopy imaging of optic nerve head drusen. Ophthalmic Surg Lasers Imaging. 2010;41(6):614–621. doi:10.3928/15428877-20100929-07.
  • Murthy RK, Storm L, Grover S, Brar VS, Chalam KV. In-vivo high resolution imaging of optic nerve head drusen using spectral-domain optical coherence tomography. BMC Med Imaging. 2010;10:11. doi:10.1186/1471-2342-10-11.
  • Ghassibi MP, Chien JL, Abumasmah RK, Liebmann JM, Ritch R, Park SC. Optic nerve head drusen prevalence and associated factors in clinically normal subjects measured using optical coherence tomography. Ophthalmology. 2017;124(3):320–325. doi:10.1016/j.ophtha.2016.10.035.
  • Yi K, Mujat M, Sun W, et al. Imaging of optic nerve head drusen: improvements with spectral domain optical coherence tomography. J Glaucoma. 2009;18(5):373–378. doi:10.1097/IJG.0b013e31818624a4.
  • Wester ST, Fantes FE, Lam BL, Anderson DR, McSoley JJ, Knighton RW. Characteristics of optic nerve head drusen on optical coherence tomography images. Ophthalmic Surg Lasers Imaging. 2010;41(1):83–90. doi:10.3928/15428877-20091230-15.
  • Malmqvist L, Lindberg AW, Dahl VA, Jorgensen TM, Hamann S. Quantitatively measured anatomic location and volume of optic disc drusen: an enhanced depth imaging optical coherence tomography study. Invest Ophthalmol Vis Sci. 2017;58(5):2491–2497. doi:10.1167/iovs.17-21608.
  • Malmqvist L, Fraser C, Fraser JA, et al. Enhanced depth imaging optical coherence tomography of optic nerve head drusen: a comparison of cases with and without visual field loss. Ophthalmology. 2017;124(6):e55–e6. doi:10.1016/j.ophtha.2017.01.007.
  • Johnson LN, Diehl ML, Hamm CW, Sommerville DN, Petroski GF. Differentiating optic disc edema from optic nerve head drusen on optical coherence tomography. Arch Ophthalmol. 2009;127(1):45–49. doi:10.1001/archophthalmol.2008.524.
  • Lee KM, Woo SJ, Hwang JM. Morphologic characteristics of optic nerve head drusen on spectral-domain optical coherence tomography. Am J Ophthalmol. 2013;155(6):1139–47 e1. doi:10.1016/j.ajo.2013.01.024.
  • Flores-Rodriguez P, Gili P, Martin-Rios MD. Sensitivity and specificity of time-domain and spectral-domain optical coherence tomography in differentiating optic nerve head drusen and optic disc oedema. Ophthalmic Physiol Opt. 2012;32(3):213–221. doi:10.1111/j.1475-1313.2012.00902.x.
  • Sarac O, Tasci YY, Gurdal C, Can I. Differentiation of optic disc edema from optic nerve head drusen with spectral-domain optical coherence tomography. J Neuroophthalmol. 2012;32(3):207–211. doi:10.1097/WNO.0b013e318252561b.
  • Scott CJ, Kardon RH, Lee AG, Frisen L, Wall M. Diagnosis and grading of papilledema in patients with raised intracranial pressure using optical coherence tomography vs clinical expert assessment using a clinical staging scale. Arch Ophthalmol. 2010;128(6):705–711. doi:10.1001/archophthalmol.2010.94.
  • Duncan JE, Freedman SF, El-Dairi MA. The incidence of neovascular membranes and visual field defects from optic nerve head drusen in children. J Aapos. 2016;20(1):44–48. doi:10.1016/j.jaapos.2015.10.013.
  • Savini G, Bellusci C, Carbonelli M, et al. Detection and quantification of retinal nerve fiber layer thickness in optic disc edema using stratus OCT. Arch Ophthalmol. 2006;124(8):1111–1117. doi:10.1001/archopht.124.8.1111.
  • Lee AG, Zimmerman MB. The rate of visual field loss in optic nerve head drusen. Am J Ophthalmol. 2005;139(6):1062–1066. doi:10.1016/j.ajo.2005.01.020.
  • Malmqvist L, Kyhnel A, Hamann S. Substantial visual field loss associated with giant optic disc drusen. JAMA Ophthalmol. 2017;135(12):e174778. doi:10.1001/jamaophthalmol.2017.4778.
  • Khan MA, Forman AR. Legal blindness from severe optic nerve head drusen. JAMA Ophthalmol. 2016;134(2):e153660. doi:10.1001/jamaophthalmol.2015.3660.
  • Grippo TM, Shihadeh WA, Schargus M, et al. Optic nerve head drusen and visual field loss in normotensive and hypertensive eyes. J Glaucoma. 2008;17(2):100–104. doi:10.1097/IJG.0b013e31814b995a.
  • Savino PJ, Glaser JS, Rosenberg MA. A clinical analysis of pseudopapilledema. II. Visual field defects. Arch Ophthalmol. 1979;97(1):71–75. doi:10.1001/archopht.1979.01020010011002.
  • Katz BJ, Pomeranz HD. Visual field defects and retinal nerve fiber layer defects in eyes with buried optic nerve drusen. Am J Ophthalmol. 2006;141(2):248–253. doi:10.1016/j.ajo.2005.09.029.
  • Casado A, Rebolleda G, Guerrero L, et al. Measurement of retinal nerve fiber layer and macular ganglion cell-inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen. Graefes Arch Clin Exp Ophthalmol. 2014;252(10):1653–1660. doi:10.1007/s00417-014-2773-5.
  • Krill AE, Klien BA, Archer DB. Precursors of angioid streaks. Am J Ophthalmol. 1973;76(6):875–879. doi:10.1016/0002-9394(73)90076-7.
  • Malmqvist L, Hamann S. Photographic documentation of optic disc drusen over more than 50 years. JAMA Ophthalmol. 2017;135(3):e165470. doi:10.1001/jamaophthalmol.2016.5470.
  • Malmqvist L, Lund-Andersen H, Hamann S. Long-term evolution of superficial optic disc drusen. Acta Ophthalmologica. 2017;95(4):352–356. doi:10.1111/aos.2017.95.issue-4.
  • Spencer TS, Katz BJ, Weber SW, Digre KB. Progression from anomalous optic discs to visible optic disc drusen. J Neuroophthalmol. 2004;24(4):297–298. doi:10.1097/00041327-200412000-00006.
  • Seo Du R, Park SH. Case of rapidly progressing buried optic nerve head drusen. JAMA Ophthalmol. 2015;133(2):e143467. doi:10.1001/jamaophthalmol.2014.3467.
  • Frisen L. Evolution of drusen of the optic nerve head over 23 years. Acta Ophthalmologica. 2008;86(1):111–112. doi:10.1111/j.1600-0420.2007.00986.x.
  • Semela L, Yang EB, Hedges TR, Vuong L, Odel JG, Hood DC. Multifocal visual-evoked potential in unilateral compressive optic neuropathy. Br J Ophthalmol. 2007;91(4):445–448. doi:10.1136/bjo.2006.097980.
  • Scholl GB, Song HS, Winkler DE, Wray SH. The pattern visual evoked potential and pattern electroretinogram in drusen-associated optic neuropathy. Arch Ophthalmol. 1992;110(1):75–81. doi:10.1001/archopht.1992.01080130077029.
  • Mustonen E, Sulg I, Kallanranta T. Electroretinogram (ERG) and visual evoked response (VER) studies in patients with optic disc drusen. Acta Ophthalmol (Copenh). 1980;58(4):539–549. doi:10.1111/j.1755-3768.1980.tb08295.x.
  • Grippo TM, Ezon I, Kanadani FN, et al. The effects of optic disc drusen on the latency of the pattern-reversal checkerboard and multifocal visual evoked potentials. Invest Ophthalmol Vis Sci. 2009;50(9):4199–4204. doi:10.1167/iovs.08-2887.
  • Malmqvist L, De Santiago L, Boquete L, Hamann S. Multifocal visual evoked potentials for quantifying optic nerve dysfunction in patients with optic disc drusen. Acta Ophthalmologica. 2017;95(4):357–362. doi:10.1111/aos.2017.95.issue-4.
  • Medeiros FA, Lisboa R, Weinreb RN, Girkin CA, Liebmann JM, Zangwill LM. A combined index of structure and function for staging glaucomatous damage. Arch Ophthalmol. 2012;130(9):1107–1116. doi:10.1001/archophthalmol.2012.827.
  • Danesh-Meyer HV, Papchenko T, Savino PJ, Law A, Evans J, Gamble GD. In vivo retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after surgery for parachiasmal tumors. Invest Ophthalmol Vis Sci. 2008;49(5):1879–1885. doi:10.1167/iovs.07-1127.
  • Malmqvist L, Wegener M, Sander BA, Hamann S. Peripapillary retinal nerve fiber layer thickness corresponds to drusen location and extent of visual field defects in superficial and buried optic disc drusen. J Neuroophthalmol. 2016;36(1):41–45. doi:10.1097/WNO.0000000000000325.
  • Tsikata E, Verticchio Vercellin AC, Falkenstein I, et al. Volumetric measurement of optic nerve head drusen using swept-source optical coherence tomography. J Glaucoma. 2017;26(9):798–804. doi:10.1097/IJG.0000000000000707.
  • Skaat A, Muylaert S, Mogil RS, et al. Relationship between optic nerve head drusen volume and structural and functional optic nerve damage. J Glaucoma. 2017;26(12):1095–1100.
  • Mwanza JC, Budenz DL, Godfrey DG, et al. Diagnostic performance of optical coherence tomography ganglion cell–inner plexiform layer thickness measurements in early glaucoma. Ophthalmology. 2014;121(4):849–854. doi:10.1016/j.ophtha.2013.10.044.
  • Roh S, Noecker RJ, Schuman JS. Evaluation of coexisting optic nerve head drusen and glaucoma with optical coherence tomography. Ophthalmology. 1997;104(7):1138–1144. doi:10.1016/S0161-6420(97)30171-7.
  • Piccone MR, Piltz-Seymour JR, Shin D. Coexisting optic nerve head drusen and glaucoma. Ophthalmology. 1998;105(5):761–762. doi:10.1016/S0161-6420(98)95007-2.
  • Tatlipinar S, Kadayifcilar S, Bozkurt B, et al. Polarimetric nerve fiber analysis in patients with visible optic nerve head drusen. J Neuroophthalmol. 2001;21(4):245–249. doi:10.1097/00041327-200112000-00003.
  • Abegao Pinto L, Vandewalle E, Marques-Neves C, Stalmans I. Visual field loss in optic disc drusen patients correlates with central retinal artery blood velocity patterns. Acta Ophthalmologica. 2014;92(4):e286–91. doi:10.1111/aos.12314.
  • Thurtell MJ, Biousse V, Bruce BB, Newman NJ. Optic nerve head drusen in black patients. J Neuroophthalmol. 2012;32(1):13–16. doi:10.1097/WNO.0b013e3182268655.
  • Rosenberg MA, Savino PJ, Glaser JS. A clinical analysis of pseudopapilledema. I. Population, laterality, acuity, refractive error, ophthalmoscopic characteristics, and coincident disease. Arch Ophthalmol. 1979;97(1):65–70. doi:10.1001/archopht.1979.01020010005001.
  • You QS, Xu L, Wang YX, Jonas JB. Prevalence of optic disc drusen in an adult Chinese population: the Beijing Eye Study. Acta Ophthalmologica. 2009;87(2):227–228. doi:10.1111/aos.2009.87.issue-2.
  • Mansour AM, Hamed LM. Racial variation of optic nerve diseases. Neuro-Ophthalmology. 1991;11(6):319–325. doi:10.3109/01658109109036975.
  • Mansour AM. Racial variation of optic disc size. Ophthalmic Res. 1991;23(2):67–72. doi:10.1159/000267091.
  • Dohadwala AA, Damji KF. Familial occurrence of artefactual ocular hypertension from thick corneas and of primary open angle glaucoma in a French Canadian kindred. Ophthalmic Genet. 2000;21(1):1–7. doi:10.1076/1381-6810(200003)2111-IFT001.
  • Samples JR, Van Buskirk M, Shults WT, Van Dyk HJ. Optic nerve head drusen and glaucoma. Arch Ophthalmol. 1985;103(11):1678–1680. doi:10.1001/archopht.1985.01050110072028.
  • Viestenz A, Langenbucher A, Mardin CY. [Bilateral visual field defects with optic disc drusen and secondary open angle glaucoma with PEX–clinical correlation with the HRA]. Klin Monbl Augenheilkd. 2004;221(4):280–284.
  • Spalding JM. Visual-field loss with optic nerve drusen and ocular hypertension: a case report. Optometry. 2002;73(1):24–32.
  • Moussalli MA, Sanseau A, Ebner R. Papillary drusen and ocular hypertension. Int Ophthalmol. 2001;23(4–6):275–278. doi:10.1023/A:1014469608213.
  • Samuels B. Drusen of the optic papilla: a clinical and pathologic study. Arch Ophthalmol. 1941;25:412–423. doi:10.1001/archopht.1941.00870090036003.
  • Nolan KW, Lee MS, Jalalizadeh RA, Firl KC, Van Stavern GP, McClelland CM. Optic nerve head drusen: the relationship between intraocular pressure and optic nerve structure and function. J Neuroophthalmol. 2017; doi:10.1097/WNO.0000000000000587.
  • Downs JC, Girkin CA. Lamina cribrosa in glaucoma. Curr Opin Ophthalmol. 2017;28(2):113–119.
  • Katz B, Van Patten P, Rothrock JF, Katzman R. Optic nerve head drusen and pseudotumor cerebri. Arch Neurol. 1988;45(1):45–47. doi:10.1001/archneur.1988.00520250051020.
  • Krasnitz I, Beiran I, Mezer E, Miller B. Coexistence of optic nerve head drusen and pseudotumor cerebri: a clinical dilemma. Eur J Ophthalmol. 1997;7(4):383–386.
  • Reifler DM, Kaufman DI. Optic disk drusen and pseudotumor cerebri. Am J Ophthalmol. 1988;106(1):95–96. doi:10.1016/S0002-9394(14)76397-4.
  • Jacome DE. Headaches, idiopathic intracranial hypertension, and pseudopapilledema. Am J Med Sci. 1998;316(6):408–410.
  • Stiefel JW, Smith JL. Hyaline bodies (drusen) of the optic nerve and intracranial tumour. Arch Ophthalmol. 1961;65(6):814–816. doi:10.1001/archopht.1961.01840020816013.
  • Mustonen E. Optic disc drusen and tumours of the chiasmal region. Acta Ophthalmol (Copenh). 1977;55(2):191–200. doi:10.1111/j.1755-3768.1977.tb01300.x.
  • Mustonen E, Kallanranta T, Toivakka E. Neurological findings in patients with pseudopapilloedema with and without verified optic disc drusen. Acta Neurol Scand. 1983;68(4):218–230. doi:10.1111/j.1600-0404.1983.tb04830.x.
  • Gospe SM 3rd, Bhatti MT, El-Dairi MA. Anatomic and visual function outcomes in paediatric idiopathic intracranial hypertension. Br J Ophthalmol. 2016;100(4):505–509. doi:10.1136/bjophthalmol-2015-307043.
  • Birnbaum FA, Johnson GM, Johnson LN, Jun B, Machan JT. Increased prevalence of optic disc drusen after papilloedema from idiopathic intracranial hypertension: on the possible formation of optic disc drusen. Neuroophthalmology. 2016;40(4):171–180. doi:10.1080/01658107.2016.1198917.
  • Coleman K, Ross MH, Mc Cabe M, Coleman R, Mooney D. Disk drusen and angioid streaks in pseudoxanthoma elasticum. Am J Ophthalmol. 1991;112(2):166–170. doi:10.1016/S0002-9394(14)76696-6.
  • Mansour AM. Is there an association between optic disc drusen and angioid streaks?. Graefes Arch Clin Exp Ophthalmol. 1992;230(6):595–596. doi:10.1007/BF00181785.
  • Pierro L, Brancato R, Minicucci M, Pece A. Echographic diagnosis of drusen of the optic nerve head in patients with angioid streaks. Ophthalmologica. 1994;208(5):239–242. doi:10.1159/000310498.
  • Liaska A, Petrou P, Georgakopoulos CD, et al. beta-Thalassemia and ocular implications: a systematic review. BMC Ophthalmol. 2016;16:102. doi:10.1186/s12886-016-0285-2.
  • Nischal KK, Hingorani M, Bentley CR, et al. Ocular ultrasound in Alagille syndrome: a new sign. Ophthalmology. 1997;104(1):79–85. doi:10.1016/S0161-6420(97)30358-3.
  • Ayhan Z, Yaman A, Soylev Bajin M, Saatci AO. Unilateral acute anterior ischemic optic neuropathy in a patient with an already established diagnosis of bilateral optic disc drusen. Case Rep Ophthalmol Med. 2015;2015:730606.
  • Megur B, Megur D, Megur U, Reddy S. Anterior ischemic optic neuropathy in association with optic nervehead drusen. Indian J Ophthalmol. 2014;62(7):829–831. doi:10.4103/0301-4738.138636.
  • Pinxten I, Stalmans P. Radial optic neurotomy as a treatment for anterior ischemic optic neuropathy secondary to optic disc drusen. GMS Ophthalmol Cases. 2014;4:Doc05.
  • Newsom RS, Trew DR, Leonard TJ. Bilateral buried optic nerve drusen presenting with central retinal artery occlusion at high altitude. Eye (Lond). 1995;9(Pt 6):806–808. doi:10.1038/eye.1995.202.
  • Gallagher MJ, Clearkin LG. Drug or drusen? Central retinal vein occlusion in a young healthy woman with disc drusen. Eye (Lond). 2000;14(Pt 3A):401–402. doi:10.1038/eye.2000.103.
  • Romero J, Sowka J, Shechtman D. Hemorrhagic complications of optic disc drusen and available treatment options. Optometry. 2008;79(9):496–500. doi:10.1016/j.optm.2008.01.020.
  • Delas B, Almudi L, Carreras A, Asaad M. Bilateral choroidal neovascularization associated with optic nerve head drusen treated by antivascular endothelial growth factor therapy. Clin Ophthalmol. 2012;6:225–230. doi:10.2147/OPTH.S22991.
  • Saffra NA, Reinherz BJ. Peripapillary choroidal neovascularization associated with optic nerve head drusen treated with anti-VEGF agents. Case Rep Ophthalmol. 2015;6(1):51–55. doi:10.1159/000375480.
  • Mateo C, Moreno JG, Lechuga M, Adan A, Corcostegui B. Surgical removal of peripapillary choroidal neovascularization associated with optic nerve drusen. Retina. 2004;24(5):739–745. doi:10.1097/00006982-200410000-00009.
  • Chaudhry NA, Lavaque AJ, Shah A, Liggett PE. Photodynamic therapy for choroidal neovascular membrane secondary to optic nerve drusen. Ophthalmic Surg Lasers Imaging. 2005;36(1):70–72.
  • Sullu Y, Yildiz L, Erkan D. Submacular surgery for choroidal neovascularization secondary to optic nerve drusen. Am J Ophthalmol. 2003;136(2):367–370. doi:10.1016/S0002-9394(03)00187-9.
  • Lee KM, Hwang JM, Woo SJ. Hemorrhagic complications of optic nerve head drusen on spectral domain optical coherence tomography. Retina. 2014;34(6):1142–1148. doi:10.1097/IAE.0000000000000040.
  • Neffendorf JE, Mulholland C, Quinlan M, Lyons CJ. Disc drusen complicated by optic disc hemorrhage in childhood. Can J Ophthalmol. 2010;45(5):537–538. doi:10.3129/i10-015.
  • Welch K. The intracranial pressure in infants. J Neurosurg. 1980;52(5):693–699. doi:10.3171/jns.1980.52.5.0693.
  • Kaiser AM, Whitelaw AG. Normal cerebrospinal fluid pressure in the newborn. Neuropediatrics. 1986;17(2):100–102. doi:10.1055/s-2008-1052509.
  • Lee AG, Tarver WJ, Mader TH, Gibson CR, Hart SF, Otto CA. Neuro-ophthalmology of space flight. J Neuroophthalmol. 2016;36(1):85–91. doi:10.1097/WNO.0000000000000334.
  • Mader TH, Gibson CR, Pass AF, et al. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology. 2011;118(10):2058–2069. doi:10.1016/j.ophtha.2011.06.021.
  • Majno G, Joris I. Cells, Tissues and Disease: Principles of General Pathology. 2nd ed. New York, NY: Oxford University Press; 2004.
  • Bonucci E. Biological Calcification: Normal and Pathological Processes in the Early Stages. 1st ed. Berlin: Springer-Verlag; 2007.
  • Boonrungsiman S, Gentleman E, Carzaniga R, et al. The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation. Proc Natl Acad Sci U S A. 2012;109(35):14170–14175. doi:10.1073/pnas.1208916109.
  • Omelon S, Ariganello M, Bonucci E, Grynpas M, Nanci A. A review of phosphate mineral nucleation in biology and geobiology. Calcif Tissue Int. 2013;93(4):382–396. doi:10.1007/s00223-013-9784-9.
  • Davis CH, Kim KY, Bushong EA, et al. Transcellular degradation of axonal mitochondria. Proc Natl Acad Sci U S A. 2014;111(26):9633–9638. doi:10.1073/pnas.1404651111.
  • Hayreh SS. Ischemic optic neuropathy. Prog Retin Eye Res. 2009;28(1):34–62. doi:10.1016/j.preteyeres.2008.11.002.
  • Floyd MS, Katz BJ, Digre KB. Measurement of the scleral canal using optical coherence tomography in patients with optic nerve drusen. Am J Ophthalmol. 2005;139(4):664–669. doi:10.1016/j.ajo.2004.11.041.
  • Mullie MA, Sanders MD. Scleral canal size and optic nerve head drusen. Am J Ophthalmol. 1985;99(3):356–359. doi:10.1016/0002-9394(85)90369-1.
  • Spencer WH. Drusen of the optic disk and aberrant axoplasmic transport. The XXXIV Edward Jackson memorial lecture. Am J Ophthalmol. 1978;85(1):1–12. doi:10.1016/S0002-9394(14)76658-9.
  • Tripathy K, Chawla R, Meena S, Agarwal P. Unilateral giant peripapillary drusen and retinal drusenoid deposits in a case of X-linked retinoschisis. BMJ Case Rep. 2016:bcr2016214558.
  • Pan BX, Ross-Cisneros FN, Carelli V, et al. Mathematically modeling the involvement of axons in Leber’s hereditary optic neuropathy. Invest Ophthalmol Vis Sci. 2012;53(12):7608–7617. doi:10.1167/iovs.12-10452.
  • Archer SL. Mitochondrial dynamics–mitochondrial fission and fusion in human diseases. N Engl J Med. 2013;369(23):2236–2251. doi:10.1056/NEJMra1215233.
  • Alavi MV, Fuhrmann N. Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics. Mol Neurodegener. 2013;8:32. doi:10.1186/1750-1326-8-32.
  • Scott I, Youle RJ. Mitochondrial fission and fusion. Essays Biochem. 2010;47:85–98. doi:10.1042/bse0470085.
  • Cai Q, Sheng ZH. Mitochondrial transport and docking in axons. Exp Neurol. 2009;218(2):257–267. doi:10.1016/j.expneurol.2009.03.024.
  • Pfriem M, Hoerauf H. Unsuccessful surgical excision of optic nerve drusen. Graefes Arch Clin Exp Ophthalmol. 2011;249(10):1583–1585. doi:10.1007/s00417-011-1693-x.
  • Nentwich MM, Remy M, Haritoglou C, Kampik A. Radial optic neurotomy to treat patients with visual field defects associated with optic nerve drusen. Retina. 2011;31(3):612–615. doi:10.1097/IAE.0b013e318209b748.
  • Moreau A, Kc L, Bk F. Optic nerve sheath decompression: a surgical technique with minimal operative complications. J Neuroophthalmol. 2014;34(1):34–38. doi:10.1097/WNO.0000000000000065.
  • Garway-Heath DF, Crabb DP, Bunce C, et al. Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. Lancet. 2015;385(9975):1295–1304. doi:10.1016/S0140-6736(14)62111-5.

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