Progression of Anterograde Trans-Synaptic Degeneration in the Human Retina Is Modulated by Axonal Convergence and Divergence

References

• Coleman MP, Freeman MR. Wallerian degeneration, WldS, and Nmnat. Annu Rev Neurosci. 2010;33(1):245–267. doi:10.1146/annurev-neuro-060909-153248.
   PubMed Web of Science ®Google Scholar
• Beatty RM, Sadun AA, Smith LEH, Vonsattel JP, Richardson EP. Direct demonstration of transsynaptic degeneration in the human visual system: A comparison of retrograde and anterograde changes. J Neurol Neurosurg Psychiatry. 1982;45(2):143–146. doi:10.1136/jnnp.45.2.143.
   PubMed Web of Science ®Google Scholar
• Van BJM. Trans-synaptic retrograde degeneration in the visual system of primates. J Neurol Neurosurg Psychiatry. 1963;26(5):402–409. doi:10.1136/jnnp.26.5.402.
   PubMed Web of Science ®Google Scholar
• Balk LJ, Twisk JWR, Steenwijk MD, et al. A dam for retrograde axonal degeneration in multiple sclerosis? J Neurol Neurosurg Psychiatry. 2014;85(7):782–789. doi:10.1136/jnnp-2013-306902.
   PubMed Web of Science ®Google Scholar
• Eliasieh K, Liets LC, Chalupa LM. Cellular reorganization in the human retina during normal aging. Investig Ophthalmol Vis Sci. 2007;48(6):2824–2830. doi:10.1167/iovs.06-1228.
   PubMed Web of Science ®Google Scholar
• Gabilondo I, Martínez-Lapiscina EH, Martínez-Heras E, et al. Brain atrophy and longitudinal_Trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis. Ann Neurol. 2014;75(1):98–107. doi:10.1002/ana.24030.
   PubMed Web of Science ®Google Scholar
• Balk LJ, Steenwijk MD, Tewarie P, et al. Bidirectional trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2015;86(4):419–424. doi:10.1136/jnnp-2014-308189.
   PubMed Web of Science ®Google Scholar
• Fujiwara T, Imamura Y, Giovinazzo VJ, Spaide RF. Fundus autofluorescence and optical coherence tomographic findings in acute zonal occult outer retinopathy. Retina. 2010;30(8):1206–1216. doi:10.1097/IAE.0b013e3181e097f0.
   PubMed Web of Science ®Google Scholar
• Shields CL, Perez B, Materin MA, Mehta S, Shields JA. Optical coherence tomography of choroidal osteoma in 22 cases. Evidence for photoreceptor atrophy over the decalcified portion of the tumor. Ophthalmology. 2007;114(12):53–58. doi:10.1016/j.ophtha.2007.07.037.
   Google Scholar
• Huang D, Swanson E, Lin C, et al. Optical coherence tomography. Science (80-). 1991;254(5035):1178–1181. doi:10.1126/science.1957169.
   PubMed Web of Science ®Google Scholar
• Oberwahrenbrock T, Traber GL, Lukas S, et al. Multicenter reliability of semiautomatic retinal layer segmentation using OCT. Neurol - Neuroimmunol Neuroinflammation. 2018;5(3):e449. doi:10.1212/NXI.0000000000000449.
   PubMed Web of Science ®Google Scholar
• Westeneng-Van Haaften SC, Boon CJF, Cremers FPM, Hoefsloot LH, Den Hollander AI, Hoyng CB. Clinical and genetic characteristics of late-onset Stargardt’s disease. Ophthalmology. 2012;119(6):1199–1210. doi:10.1016/j.ophtha.2012.01.005.
   PubMed Web of Science ®Google Scholar
• Eagle RC, Lucier AC, Bernardino VB, Yanoff M. Retinal pigment epithelial abnormalities in fundus flavimaculatus: a light and electron microscopic study. Ophthalmology. 1980;87(12):1189–1200. http://www.ncbi.nlm.nih.gov/pubmed/6165950.
   PubMed Web of Science ®Google Scholar
• Maugeri A, Klevering BJ, Rohrschneider K, et al. Report mutations in the ABCA4 (ABCR) Gene are the major cause of autosomal recessive cone-rod dystrophy. Am J Hum Genet. 2000;67(4):960–966. doi:10.1086/303079.
   PubMed Web of Science ®Google Scholar
• Holz FG, Strauss EC, Schmitz-Valckenberg S. Van Lookeren Campagne M. Geographic atrophy: clinical features and potential therapeutic approaches. Ophthalmology. 2014;121(5):1079–1091. doi:10.1016/j.ophtha.2013.11.023.
   PubMed Web of Science ®Google Scholar
• Holz FG, Bellman C, Staudt S, Schütt F, Völcker HE. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Investig Ophthalmol Vis Sci. 2001;42(5):1051–1056. doi:10.1016/S0002-9394(01)01394-0.
   PubMed Web of Science ®Google Scholar
• Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye. 1988;2(5):552–577. doi:10.1038/eye.1988.106.
   PubMed Web of Science ®Google Scholar
• Boon CJF, Klevering BJ, Cremers FPM, et al. Central areolar choroidal dystrophy. Ophthalmology. 2009;116(4):771–82, 782.e1. doi:10.1016/j.ophtha.2008.12.019.
   PubMed Web of Science ®Google Scholar
• Ashton N. Central Areolar Choroidal Sclerosis *. Br J Ophthalmol. 1953;37(3):140–147. doi:10.1136/bjo.37.3.140.
   PubMed Web of Science ®Google Scholar
• Marmorstein AD, Marmorstein LY, Rayborn M, Wang X, Hollyfield JG, Petrukhin K. Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2000;97(23):12758–12763. doi:10.1073/pnas.220402097.
   PubMed Web of Science ®Google Scholar
• Weingeist TA, Kobrin JL, Watzke RC. Histopathology of best’s macular dystrophy. Arch Ophthalmol. 1982;100(7):1108–1114. doi:10.1001/archopht.1982.01030040086016.
   PubMedGoogle Scholar
• Gass JD. Are acute zonal occult outer retinopathy and the white spot syndromes (AZOOR complex) specific autoimmune diseases? Am J Ophthalmol. 2003;135(3):380–381. doi:10.1016/S0002-9394(03)00030-8.
   PubMed Web of Science ®Google Scholar
• Michaelides M, Gaillard MC, Escher P, et al. The PROM1 mutation p.R373C causes an autosomal dominant bull’s eye maculopathy associated with rod, rod-cone, and macular dystrophy. Investig Ophthalmol Vis Sci. 2010;51(9):4771–4780. doi:10.1167/iovs.09-4561.
   PubMed Web of Science ®Google Scholar
• Cella W, Greenstein VC, Zernant-Rajang J, et al. G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull’s eye maculopathy. Exp Eye Res. 2009;89(1):16–24. doi:10.1016/j.exer.2009.02.001.
   PubMed Web of Science ®Google Scholar
• Tewarie P, Balk L, Costello F, et al. The OSCAR-IB consensus criteria for retinal OCT quality assessment. PLoS One. 2012;7(4):e34823. doi:10.1371/journal.pone.0034823.
   PubMed Web of Science ®Google Scholar
• Glynn RJ, Rosner B. Regression methods when the eye is the unit of analysis. Ophthalmic Epidemiol. 2012;19(3):159–165. doi:10.3109/09286586.2012.674614.
   PubMed Web of Science ®Google Scholar
• Balcer LJ, Galetta SL OCT and NMO: are there methods to our madness? J Neuro Ophthalmol. 2013;33(3):209–212. doi:10.1097/WNO.0b013e3182a1e6aa.
   PubMed Web of Science ®Google Scholar
• Da Cruz L, Fynes K, Georgiadis O, et al. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018;36(4):1–10. doi:10.1038/nbt.4114.
   PubMed Web of Science ®Google Scholar
• Lim JI, Tan O, Fawzi AA, Hopkins JJ, Gil-Flamer JH, Huang D. A pilot study of fourier-domain optical coherence tomography of retinal dystrophy patients. Am J Ophthalmol. 2008;146(3):417–426. doi:10.1016/j.ajo.2008.05.018.
   PubMed Web of Science ®Google Scholar
• Ohta K, Sato A, Fukui E. Spectral domain optical coherence tomographic findings at convalescent stage of acute zonal occult outer retinopathy. Clin Ophthalmol. 2009;3(1):423–428. doi:10.2147/OPTH.S6108.
   PubMedGoogle Scholar
• Petzold A, Balcer LJ, Calabresi PA, et al. Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol. 2017;16(10):797–812. doi:10.1016/S1474-4422(17)30278-8.
   PubMed Web of Science ®Google Scholar
• Zhang L, Sonka M, Folk JC, Russell SR, Abràmoff MD. Quantifying disrupted outer retinal-subretinal layer in SD-OCT images in choroidal neovascularization. Investig Ophthalmol Vis Sci. 2014;55(4):2329–2335. doi:10.1167/iovs.13-13048.
   PubMed Web of Science ®Google Scholar
• Wu Z, Weng DSD, Thenappan A, Ritch R, Hood DC. Evaluation of a region-of-interest approach for detecting progressive glaucomatous macular damage on optical coherence tomography. Transl Vis Sci Technol. 2018;7(2):14. doi:10.1167/tvst.7.2.14.
   PubMed Web of Science ®Google Scholar
• Masland RH. The neuronal organization of the retina. Neuron. 2012;76(2):266–280. doi:10.1016/j.neuron.2012.10.002.
   PubMed Web of Science ®Google Scholar