Diagnosing Optic Disc Drusen in the Modern Imaging Era: A Practical Approach

References

• Hamann S, Malmqvist L, Costello F. Optic disc drusen: understanding an old problem from a new perspective. Acta Ophthalmol. 2018;96(7):673–684. doi:10.1111/aos.13748.
   PubMed Web of Science ®Google Scholar
• Lorentzen SE. Drusen of the optic disk. A clinical and genetic study. Acta Ophthalmol (Copenh). 1966;Suppl 90:91–180.
   Google Scholar
• Fraser JA, Bursztyn LLCD. Optical coherence tomography in optic disc drusen. Annal Eye Sci. 2020;5:5. doi:10.21037/aes.2019.12.03.
   Google Scholar
• Chang MY, Pineles SL. Optic disk drusen in children. Surv Ophthalmol. 2016;61(6):745–758. doi:10.1016/j.survophthal.2016.03.007.
   PubMed Web of Science ®Google Scholar
• Duncan JE, Freedman SF, El-Dairi MA. The incidence of neovascular membranes and visual field defects from optic nerve head drusen in children. J Aapos. 2016;20(1):44–48. doi:10.1016/j.jaapos.2015.10.013.
   PubMed Web of Science ®Google Scholar
• Fraser JA, Rueløkke LL, Malmqvist L, Hamann S. Prevalence of optic disc drusen in young patients with nonarteritic anterior ischemic optic neuropathy: A 10-year retrospective study. J Neuroophthalmol. (2020). Advanced online publication. doi: 10.1097/WNO.0000000000000974.
   Google Scholar
• Hamann S, Malmqvist L, Wegener M, Biousse V, Bursztyn L, Citirak G, Costello F, Crum AV, Digre K, Fraser JA, Huna-Baron R, Katz B, Lawlor M, Newman NJ, Peragallo JH, Petzold A, Sibony PA, Subramanian PS, Warner JEA, Wong SH, Fraser CL, on behalf of the Optic Dis Drusen Studies Consortium. Young adults with anterior ischemic optic neuropathy: a multicenter optic disc drusen study. Am J Ophthalmol. 2020;217:174–181. doi:10.1016/j.ajo.2020.03.052.
   PubMed Web of Science ®Google Scholar
• de Carvalho ER, Maloca PM. Overview of optical coherence tomography in neuro-ophthalmology. Annal Eye Sci. 2020;5:14. doi:10.21037/aes.2019.12.08.
   Google Scholar
• Johnson LN, Diehl ML, Hamm CW, Sommerville DN, Petroski GF. Differentiating optic disc edema from optic nerve head drusen on optical coherence tomography. Arch Ophthalmol. 2009;127(45–49):45. doi:10.1001/archophthalmol.2008.524.
   PubMedGoogle Scholar
• Sarac O, Tasci YY, Gurdal C, Can I. Differentiation of optic disc edema from optic nerve head drusen with spectral-domain optical coherence tomography. J Neuroophthalmol. 2012;32(3):207–211. doi:10.1097/WNO.0b013e318252561b.
   PubMed Web of Science ®Google Scholar
• Malmqvist L, Bursztyn L, Costello F, Digre K, Fraser JA, Fraser C, Katz B, Lawlor MF, Petzold A, Sibony P, Warner J, Wegener M, Wong S, Hamann S.. The optic disc drusen studies consortium recommendations for diagnosis of optic disc drusen using optical coherence tomography. J Neuroophthalmol. 2018;38(3):299–307. doi:10.1097/WNO.0000000000000585.
   PubMed Web of Science ®Google Scholar
• Malmqvist L, Li XQ, Hansen MH, Thomsen AK, Skovgaard AM, Olsen EM, Larsen M, Munch IC, Hamann S. Progression over 5 years of prelaminar hyperreflective lines to optic disc drusen in the copenhagen child cohort 2000 eye study. J Neuroophthalmol. 2020;40(3):315–321. doi:10.1097/WNO.0000000000000911.
   PubMed Web of Science ®Google Scholar
• Traber GL, Weber KP, Sabah M, Keane PA, Plant GT. Enhanced depth imaging optical coherence tomography of optic nerve head drusen: a comparison of cases with and without visual field loss. Ophthalmology. 2017;124(1):66–73. doi:10.1016/j.ophtha.2016.09.022.
   PubMed Web of Science ®Google Scholar
• Malmqvist L, Lindberg AW, Dahl VA, Jorgensen TM, Hamann S. Quantitatively measured anatomic location and volume of optic disc drusen: an enhanced depth imaging optical coherence tomography study. Invest Ophthalmol Vis Sci. 2017;58(5):2491–2497. doi:10.1167/iovs.17-21608.
   PubMed Web of Science ®Google Scholar
• Petzold A, Biousse V, Bursztyn L, Costello F, Crum A, Digre K, Fraser C, Fraser JA, Katz B, Jurkute N, Newman N, Lautrup-Battistini J, Lawlor M, Liskova P, Lorenz B, Malmqvist L, Perahallo J, Sibony P, Subramanian P, Rejdek R, Nowomiejska K, Touitou V, Warner J, Wegener M, Wong S, Yu-Wai-Man P, Hamann S.. Multirater validation of peripapillary hyperreflective ovoid mass-like structures (PHOMS). Neuro-Ophthalmol. 2020 (advanced online publication):1–2. doi:10.1080/01658107.2020.1760891.
   PubMed Web of Science ®Google Scholar
• Malmqvist L, Sibony PA, Fraser CL, Wegener M, Heegaard S, Skougaard M, Hamann S for the Optic Disc Drusen Studies Consortium. Peripapillary ovoid hyperreflectivity in optic disc edema and pseudopapilledema. Ophthalmology. 2018;125(10):1662–1664.doi:10.1016/j.ophtha.2018.04.036.
   PubMed Web of Science ®Google Scholar
• Pichi F, Romano S, Villani E, Lembo A, Gilardoni F, Morara M, Ciardella AP, Ohno-Matsui K, Nucci P. Spectral-domain optical coherence tomography findings in pediatric tilted disc syndrome. Graefes Arch Clin Exp Ophthalmol. 2014;252(10):1661–1667.doi:10.1007/s00417-014-2701-8.
   PubMed Web of Science ®Google Scholar
• Borrelli E, Barboni P, Battista M, Sacconi R, Querques L, Cascavilla ML, Bandello F, Querques G. Peripapillary hyperreflective ovoid mass-like structures (PHOMS): OCTA may reveal new findings. Eye (Lond). 2020. doi:10.1038/s41433-020-0890-4.
   Web of Science ®Google Scholar
• Skougaard M, Heegaard S, Malmqvist L, Hamann S. Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes. Acta Ophthalmol. 2020;98(2):195–200. doi:10.1111/aos.14180.
   PubMed Web of Science ®Google Scholar
• Paton L, Holmes G. The pathology of papilloedema: a histological study of sixty eyes. Brain. 1911;33(4):389–432. doi:10.1093/brain/33.4.389.
   Google Scholar
• Tso MO. Pathology and pathogenesis of drusen of the optic nervehead. Ophthalmology. 1981;88(10):1066–1080. doi:10.1016/s0161-6420(81)80038-3.
   PubMed Web of Science ®Google Scholar
• Willerslev A, Li XQ, Cordtz P, Munch IC, Larsen M. Retinal and choroidal intravascular spectral-domain optical coherence tomography. Acta Ophthalmol. 2014;92(2):126–132. doi:10.1111/aos.12048.
   PubMed Web of Science ®Google Scholar
• Friedman AH, Henkind P, Gartner S. Drusen of the optic disc. A histopathological study. Trans Ophthalmol Soc UK. 1975;95:4–9.
   PubMedGoogle Scholar
• Spaide RF. Enhanced depth imaging optical coherence tomography of retinal pigment epithelial detachment in age-related macular degeneration. Am J Ophthalmol. 2009;147(4):644–652. doi:10.1016/j.ajo.2008.10.005.
   PubMed Web of Science ®Google Scholar
• Sander B, Larsen M, Thrane L, Hougaard JL, Jorgensen TM. Enhanced optical coherence tomography imaging by multiple scan averaging. Br J Ophthalmol. 2005;89(2):207–212. doi:10.1136/bjo.2004.045989.
   PubMed Web of Science ®Google Scholar
• Waldstein SM, Faatz H, Szimacsek M, Glodan A-M, Podkowinski D, Montuoro A, Simader C, Gerendas BS, Schmidt-Erfurth U Comparison of penetration depth in choroidal imaging using swept source vs spectral domain optical coherence tomography. Eye (Lond). 2015;29(3):409–415.doi:10.1038/eye.2014.319.
   PubMed Web of Science ®Google Scholar
• Cennamo G, Tebaldi S, Amoroso F, Arvanitis D, Breve M, Cennamo G. Optical coherence tomography angiography in optic nerve drusen. Ophthalmic Res. 2018;59(2):76–80.doi:10.1159/000481889.
   PubMed Web of Science ®Google Scholar
• Engelke H, Shajari M, Riedel J, Mohr N, Priglinger SG, Mackert MJ. OCT angiography in optic disc drusen: comparison with structural and functional parameters. Br J Ophthalmol. 2019. doi:10.1136/bjophthalmol-2019-314096.
   PubMed Web of Science ®Google Scholar
• Gaier ED, Rizzo JF 3rd, Miller JB, Cestari DM. Focal capillary dropout associated with optic disc drusen using optical coherence tomographic angiography. J Neuroophthalmol. 2017;37(4):405–410. doi:10.1097/WNO.0000000000000502.
   PubMed Web of Science ®Google Scholar
• Yan Y, Zhou X, Chu Z, Stell L, Shariati MA, Wang RK, Liao YJ Vision loss in optic disc drusen correlates with increased macular vessel diameter and flux and reduced peripapillary vascular density. Am J Ophthalmol. 2020. doi:10.1016/j.ajo.2020.04.019.
   Web of Science ®Google Scholar
• Fard MA, Jalili J, Sahraiyan A, Khojasteh H, Hejazi M, Ritch R, Subramanian PS. Optical coherence tomography angiography in optic disc swelling. Am J Ophthalmol. 2018;191:116–123. doi:10.1016/j.ajo.2018.04.017.
   PubMed Web of Science ®Google Scholar
• Fard MA, Sahraiyan A, Jalili J, Hejazi M, Suwan Y, Ritch R, Subramanian PS. Optical coherence tomography angiography in papilledema compared with pseudopapilledema. Invest Ophthalmol Vis Sci. 2019;60(1):168. doi:10.1167/iovs.18-25453.
   PubMed Web of Science ®Google Scholar
• Maloca PM, Tufail A, Egan C, Zweifel S, Hasler PW, Petzold A, Emanuel Ramos de Carvalho J. Volume rendering of superficial optic disc drusen. Spektrum der Augenheilkunde. 2017;31(6):288–293. doi:10.1007/s00717-017-0359-4.
   Web of Science ®Google Scholar
• Sato T, Mrejen S, Spaide RF. Multimodal imaging of optic disc drusen. Am J Ophthalmol. 2013;156(2): 275-282e1. doi: 10.1016/j.ajo.2013.03.039.
   Google Scholar
• Flores-Rodriguez P, Gili P, Martin-Rios MD. Sensitivity and specificity of time-domain and spectral-domain optical coherence tomography in differentiating optic nerve head drusen and optic disc oedema. Ophthalmic Physiol Opt. 2012;32(3):213–221. doi:10.1111/j.1475-1313.2012.00902.x.
   PubMed Web of Science ®Google Scholar
• Carta A, Favilla S, Prato M, Bianchi-Marzoli S, Sadun AA, Mora P. Accuracy of funduscopy to identify true edema versus pseudoedema of the optic disc. Invest Ophthalmol Vis Sci. 2012;53(1–6). doi:10.1167/iovs.11-8082.
   PubMed Web of Science ®Google Scholar
• OCT Sub-Study Committee for NORDIC Idiopathic Intracranial Hypertension Study Group, Auinger P, Durbin M, Feldon S, Garvin M, Kardon R, Keltner J, Kupersmith M, Sibony P, Plumb K, Wang J-K, Werner JS. Baseline OCT measurements in the idiopathic intracranial hypertension treatment trial, part I: quality control, comparisons, and variability. Invest Ophthalmol Vis Sci. 2014;5(12):8180–8188 doi:10.1167/iovs.14-14960.
   Web of Science ®Google Scholar
• Costello F, Malmqvist L, Hamann S. The role of optical coherence tomography in differentiating optic disc drusen from optic disc edema. Asia Pac J Ophthalmol (Phila). 2018;7(271–279). doi:10.22608/APO.2018124.
   PubMed Web of Science ®Google Scholar
• Fard MA, Fakhree S, Abdi P, Hassanpoor N, Subramanian PS. Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography. Am J Ophthalmol. 2014;158(1):136–143. doi:10.1016/j.ajo.2014.03.008.
   PubMed Web of Science ®Google Scholar
• Malmqvist L, Li XQ, Eckmann CL, Skovgaard AM, Olsen EM, Larsen M, Munch IC, Hamann S. Optic disc drusen in children: the Copenhagen child cohort 2000 eye study. J Neuroophthalmol. 2018;38:140–146. doi:10.1097/WNO.0000000000000567.
   PubMed Web of Science ®Google Scholar
• Sibony PA, Kupersmith MJ, Feldon SE, Wang J-K, Garvin M, OCT Substudy Group for the NORDIC Idiopathic Intracranial Hypertension Treatment Trial. Retinal and choroidal folds in papilledema. Invest Ophthalmol Vis Sci. 2015;56(10):5670–5680.doi:10.1167/iovs.15-17459.
   PubMed Web of Science ®Google Scholar
• Sibony PA, Kupersmith MJ, OCT Substudy Group of the NORDIC Idiopathic Intracranial Hypertension Treatment Trial. “Paton’s folds” revisited: peripapillary wrinkles, folds, and creases in papilledema. Ophthalmology. 2016;123(6):1397–1399. doi:10.1016/j.ophtha.2015.12.017.
   PubMed Web of Science ®Google Scholar
• Abazari A, Sibony PA. The etiology of retinal and choroidal folds in optic disc drusen. Ophthalmology. 2020. doi:10.1016/j.ophtha.2020.05.022.
   Web of Science ®Google Scholar