Primary orbital sarcoma in adults: a case series with emphasis on post-irradiation sarcoma

References

• Bonavolontà G, Strianese D, Grassi P, Comune C, Tranfa F, Uccello G, et al. An analysis of 2,480 space-occupying lesions of the orbit from 1976 to 2011. Ophthalmic Plast Reconstr Surg. 2013;29(2):79–86. doi:10.1097/IOP.0b013e31827a7622.
   PubMed Web of Science ®Google Scholar
• Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 montgomery lecture, part 1. Ophthalmology. 2004;111(5):997–1008. doi:10.1016/j.ophtha.2003.01.002.
   PubMed Web of Science ®Google Scholar
• Murray EM, Werner D, Greeff EA, Taylor DA. Postradiation sarcomas: 20 cases and a literature review. Int J Radiat Oncol Biol Phys. 1999;45(4):951–961. doi:10.1016/s0360-3016(99)00279-5.
   PubMed Web of Science ®Google Scholar
• Smith SC, Gooding WE, Elkins M, Patel RM, Harms PW, McDaniel AS, et al. Solitary fibrous tumors of the head and neck: a multi-institutional clinicopathologic study. Am J Surg Pathol. 2017;41(12):1642–1656. doi:10.1097/PAS.0000000000000940.
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Hayashi Y, Sakaki H, Murakami I. Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma. Mol Clin Oncol. 2021;15(4):1–6. doi:10.3892/mco.2021.2361.
   Web of Science ®Google Scholar
• Kazazian K, Demicco EG, de Perrot M, Strauss D, Swallow CJ. Toward better understanding and management of solitary fibrous tumor. Surg Oncol Clin N Am. 2022;31(3):459–483. doi:10.1016/j.soc.2022.03.009.
   PubMed Web of Science ®Google Scholar
• Yang BT, Wang YZ, Dong JY, Wang XY, Wang ZC. MRI study of solitary fibrous tumor in the orbit. AJR Am J Roentgenol. 2012;199(4):W506–511. doi:10.2214/AJR.11.8477.
   PubMed Web of Science ®Google Scholar
• Blessing NW, Bermudez-Magner JA, Fernandez MP, Rosenberg AE, Dubovy SR, Johnson TE. Solitary fibrous tumor of the orbit: a case series with clinicopathologic correlation and evaluation of STAT6 as a diagnostic marker. Ophthalmic Plast Reconstr Surg. 2020;36(2):164–171. doi:10.1097/IOP.0000000000001504.
   PubMed Web of Science ®Google Scholar
• The WHO Classification of Tumours Editorial Board. WHO Classification of Tumours. Soft Tissue and Bone Tumours. 5th ed. Lyon: IARC Press ; 2020.
   Google Scholar
• van Houdt WJ, Westerveld CMA, Vrijenhoek JEP, van Gorp J, van Coevorden F, Verhoef C, et al. Prognosis of solitary fibrous tumors: a multicenter study. Ann Surg Oncol. 2013;20(13):4090–4095. doi:10.1245/s10434-013-3242-9.
   PubMed Web of Science ®Google Scholar
• Demicco EG, Wagner MJ, Maki RG, Gupta V, Iofin I, Lazar AJ, et al. Risk assessment in solitary fibrous tumors: validation and refinement of a risk stratification model. Mod Pathol. 2017;30(10):1433–1442. doi:10.1038/modpathol.2017.54.
   PubMed Web of Science ®Google Scholar
• Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, et al. Clinicopathologic correlates of solitary fibrous tumors. Cancer. 2002;94(4):1057–1068. doi:10.1002/cncr.10328.
   PubMed Web of Science ®Google Scholar
• Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ. Clinical outcomes of extra-thoracic solitary fibrous tumours. Eur J Surg Oncol. 2009;35(9):994–998. doi:10.1016/j.ejso.2009.02.015.
   PubMed Web of Science ®Google Scholar
• Rice CD, Kersten RC, Mrak RE. An orbital hemangiopericytoma recurrent after 33 years. Arch Ophthalmol. 1989;107(4):552–556. doi:10.1001/archopht.1989.01070010566033.
   PubMedGoogle Scholar
• Dorfman DM, To K, Dickersin GR, Rosenberg AE, Pilch BZ. Solitary fibrous tumor of the orbit. Am J Surg Pathol. 1994;18(3):281–287. doi:10.1097/00000478-199403000-00008.
   PubMed Web of Science ®Google Scholar
• Karcioglu ZA, Nasr AM, Haik BG. Orbital hemangiopericytoma: clinical and morphologic features. Am J Ophthalmol. 1997;124(5):661–672. doi:10.1016/s0002-9394(14)70904-3.
   PubMed Web of Science ®Google Scholar
• Ing EB, Kennerdell JS, Olson PR, Ogino S, Rothfus WE. Solitary fibrous tumor of the orbit. Ophthalmic Plast Reconstr Surg. 1998;14(1):57–61. doi:10.1097/00002341-199801000-00012.
   PubMed Web of Science ®Google Scholar
• de Saint Aubain Somerhausen N, Rubin BP, Fletcher CD. Myxoid solitary fibrous tumor: a study of seven cases with emphasis on differential diagnosis. Mod Pathol. 1999;12:463–471.
   PubMed Web of Science ®Google Scholar
• Woo KI, Suh YL, Kim YD. Solitary fibrous tumor of the lacrimal sac. Ophthalmic Plast Reconstr Surg. 1999;15(6):450–453. doi:10.1097/00002341-199911000-00018.
   PubMed Web of Science ®Google Scholar
• Alexandrakis G, Johnson TE. Recurrent orbital solitary fibrous tumor in a 14-year-old girl. Am J Ophthalmol. 2000;130(3):373–376. doi:10.1016/s0002-9394(00)00545-6.
   PubMed Web of Science ®Google Scholar
• Hayashi S, Kurihara H, Hirato J, Sasaki T. Solitary fibrous tumor of the orbit with extraorbital extension: case report. Neurosurgery. 2001;49(5):1241–1245. doi:10.1227/00006123-200111000-00042.
   PubMed Web of Science ®Google Scholar
• Polito E, Tosi GM, Toti P, Schürfeld K, Caporossi A. Orbital solitary fibrous tumor with aggressive behavior. Three cases and review of the literature. Graefes Arch Clin Exp Ophthalmol. 2002;240(7):570–574. doi:10.1007/s00417-002-0486-7.
   PubMed Web of Science ®Google Scholar
• Krishnakumar S, Subramanian N, Mohan ER, Mahesh L, Biswas J, Rao NA. Solitary fibrous tumor of the orbit: a clinicopathologic study of six cases with review of the literature. Surv Ophthalmol. 2003;48(5):544–554. doi:10.1016/s0039-6257(03)00087-0.
   PubMed Web of Science ®Google Scholar
• Bernardini FP, de Conciliis C, Schneider S, Kersten RC, Kulwin DR. Solitary fibrous tumor of the orbit: is it rare? Report of a case series and review of the literature. Ophthalmology. 2003;110(7):1442–1448. doi:10.1016/S0161-6420(03)00459-7.
   PubMed Web of Science ®Google Scholar
• Romer M, Bode B, Schuknecht B, Schmid S, Holzmann D. Solitary fibrous tumor of the orbit–two cases and a review of the literature. Eur Arch Otorhinolaryngol. 2005;262(2):81–88. doi:10.1007/s00405-003-0731-7.
   PubMed Web of Science ®Google Scholar
• Ness GO, Lybaek H, Arnes J, Rødahl E. Chromosomal imbalances in a recurrent solitary fibrous tumor of the orbit. Cancer Genet Cytogenet. 2005;162(1):38–44. doi:10.1016/j.cancergencyto.2005.01.014.
   PubMedGoogle Scholar
• Tam ES, Chen EC, Nijhawan N, Harvey JT, Howarth D, Oestreicher JH. Solitary fibrous tumor of the orbit: a case series. Orbit. 2008;27(6):426–431. doi:10.1080/01676830802344508.
   PubMedGoogle Scholar
• Carrera M, Prat J, Quintana M. Malignant solitary fibrous tumour of the orbit: report of a case with 8 years follow-up. Eye (Lond). 2001;15(Pt 1):102–104. doi:10.1038/eye.2001.24.
   PubMedGoogle Scholar
• Manousaridis K, Stropahl G, Guthoff RF. Recurrent malignant solitary fibrous tumor of the orbit. Ophthalmologe. 2011;108(3):260–264. doi:10.1007/s00347-010-2277-6.
   PubMed Web of Science ®Google Scholar
• Young TK, Hardy TG. Solitary fibrous tumor of the orbit with intracranial involvement. Ophthalmic Plast Reconstr Surg. 2011;27(3):e74–76. doi:10.1097/IOP.0b013e3181ed3590.
   PubMed Web of Science ®Google Scholar
• Wang X, Qian J, Bi Y, Ping B, Zhang R. Malignant transformation of orbital solitary fibrous tumor. Int Ophthalmol. 2013;33(3):299–303. doi:10.1007/s10792-012-9637-y.
   PubMed Web of Science ®Google Scholar
• Blandamura S, Alaggio R, Bettini G, Guzzardo V, Valentini E, Bedogni A. Four cases of solitary fibrous tumour of the eye and orbit: one with sarcomatous transformation after radiotherapy and one in a 5-year-old child’s eyelid. J Clin Pathol. 2014;67(3):263–267. doi:10.1136/jclinpath-2013-201820.
   PubMed Web of Science ®Google Scholar
• Griepentrog GJ, Harris GJ, Zambrano EV. Multiply recurrent solitary fibrous tumor of the orbit without malignant degeneration: a 45-year clinicopathologic case study. JAMA Ophthalmol. 2013;131(2):265–267. doi:10.1001/2013.jamaophthalmol.69.
   PubMed Web of Science ®Google Scholar
• Parrozzani R, Fusetti S, Montesco C, Favero V, Midena E. Biphasic solitary fibrous tumor of the orbit with distant metastases. Int Ophthalmol. 2013;33(6):701–705. doi:10.1007/s10792-012-9706-2.
   PubMed Web of Science ®Google Scholar
• Chakrabartty H, Singhvi S, Purohit D, Mittal RS. Malignant solitary fibrous tumour of orbit. Asian J Neurosurg. 2017;12(1):55–57. doi:10.4103/1793-5482.144180.
   PubMedGoogle Scholar
• Vu AF, Chundury RV, Blandford AD, Perry JD. Recurrent orbital solitary fibrous tumor in a 12-year-old. Ocul Oncol Pathol. 2017;3(2):83–86. doi:10.1159/000452151.
   PubMedGoogle Scholar
• Shen J, Li H, Feng S, Cui H. Orbital solitary fibrous tumor: a clinicopathologic study from a Chinese tertiary hospital with a literature review. Cancer Manage Res. 2018;10:1069–1078. doi:10.2147/CMAR.S165218.
   PubMed Web of Science ®Google Scholar
• Sagiv O, Bell D, Guo Y, Su S, Wester ST, Jiang K, et al. Pathological features and clinical course in patients with recurrent or malignant orbital solitary fibrous tumor/hemangiopericytoma. Ophthalmic Plast Reconstr Surg. 2019;35(2):148–154. doi:10.1097/IOP.0000000000001189.
   PubMed Web of Science ®Google Scholar
• Rana N, Kim E, Jaboin J, Attia A. The role of adjuvant radiation in the management of solitary fibrous tumors of the central nervous system: a national cancer database analysis of 155 patients. Cureus. 2018;10(5):e2656. doi:10.7759/cureus.2656.
   PubMed Web of Science ®Google Scholar
• Stessin AM, Sison C, Nieto J, Raifu M, Li B. The role of postoperative radiation therapy in the treatment of meningeal hemangiopericytoma-experience from the SEER database. Int J Radiat Oncol Biol Phys. 2013;85(3):784–790. doi:10.1016/j.ijrobp.2012.05.042.
   PubMed Web of Science ®Google Scholar
• Levard A, Derbel O, Méeus P, Ranchère D, Ray-Coquard I, Blay J-Y, et al. Outcome of patients with advanced solitary fibrous tumors: the Centre Léon Bérard experience. BMC Cancer. 2013;13(1):109–7. doi:10.1186/1471-2407-13-109.
   PubMedGoogle Scholar
• Park MS, Ravi V, Conley A, Patel SR, Trent JC, Lev DC, et al. The role of chemotherapy in advanced solitary fibrous tumors: a retrospective analysis. Clin Sarcoma Res. 2013;3(1):7–7. doi:10.1186/2045-3329-3-7.
   PubMedGoogle Scholar
• Machado I, Morales MGN, Cruz J, Lavernia J, Giner F, Navarro S, et al. Solitary fibrous tumor: integration of clinical, morphologic, immunohistochemical and molecular findings in risk stratification and classification may better predict patient outcome. Int J Mol Sci. 2021;22(17):9423. doi:10.3390/ijms22179423.
   PubMed Web of Science ®Google Scholar
• Knight SWE, Knight TE, Santiago T, Murphy AJ, Abdelhafeez AH. Malignant peripheral nerve sheath tumors-a comprehensive review of pathophysiology, diagnosis, and multidisciplinary management. Children (Basel). 2022;9(1):38. doi:10.3390/children9010038.
   PubMed Web of Science ®Google Scholar
• Chikkannaiah P, Boovalli MM, Nathiyal V, Venkataramappa S. Morphological spectrum of peripheral nerve sheath tumors: an insight into World Health Organization 2013 classification. J Neurosci Rural Pract. 2019;07(3):346–354. doi:10.4103/0976-3147.182768.
   Google Scholar
• Goldblum JR, Weiss SW, Folpe AL. Enzinger and Weiss’s Soft Tissue Tumors. 7 th ed. Philadelphia, PA : Elsevier; 2019.
   Google Scholar
• Dutton JJ, Tawfik HA, DeBacker CM, Lipham WJ, Gayre GS, Klintworth GK. Multiple recurrences in malignant peripheral nerve sheath tumor of the orbit: a case report and a review of the literature. Ophthalmic Plast Reconstr Surg. 2001;17(4):293–299. doi:10.1097/00002341-200107000-00010.
   PubMed Web of Science ®Google Scholar
• Gündüz K. Peripheral nerve tumours. In: Karcioglu Z, ed. Orbital Tumors. 2nd ed. New York: Springer; 2015: 209–216.
   Google Scholar
• Jones KE, Patel A, Kunesh MG, Thuro BA. Malignant peripheral nerve sheath tumor of the orbit: a case report and review of the literature. Orbit. 2021 April;41:1–5. doi:10.1080/01676830.2021.1918178.
   Google Scholar
• Prescott DK, Racz MM, Ng JD. Epithelioid malignant peripheral nerve sheath tumor in the infraorbital nerve. Ophthalmic Plast Reconstr Surg. 2006;22(2):150–151. doi:10.1097/01.iop.0000200899.47766.80.
   PubMed Web of Science ®Google Scholar
• Barh A, Mukherjee B, Koka K, Krishnakumar S. Triton tumor of the orbit. Orbit. 2020;39(6):418–421. doi:10.1080/01676830.2019.1692873.
   PubMed Web of Science ®Google Scholar
• Sweeney AR, Gupta D, Keene CD, Cimino PJ, Chambers CB, Chang S-H, et al. Orbital peripheral nerve sheath tumors. Surv Ophthalmol. 2017;62(1):43–57. doi:10.1016/j.survophthal.2016.08.002.
   PubMed Web of Science ®Google Scholar
• Lyons CJ, McNab AA, Garner A, Wright JE. Orbital malignant peripheral nerve sheath tumours. Br J Ophthalmol. 1989;73(9):731–738. doi:10.1136/bjo.73.9.731.
   PubMed Web of Science ®Google Scholar
• Cleven AH, Sannaa Al GA, Briaire-de Bruijn I, Ingram DR, van de Rijn M, Rubin BP, et al. Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. Mod Pathol. 2016;29(9):1113–1113. doi:10.1038/modpathol.2016.103.
   PubMed Web of Science ®Google Scholar
• Wang Y, Katagiri H, Murata H, Wasa J, Miyagi M, Kakuda Y, et al. Metastatic malignant peripheral nerve sheath tumor with NF1 successfully treated with ‘gradual subtraction’ ICE chemotherapy. Anticancer Res. 2020;40(3):1619–1624. doi:10.21873/anticanres.14110.
   PubMed Web of Science ®Google Scholar
• Lane CM, Wright JE, Garner A. Primary myxoid liposarcoma of the orbit. Br J Ophthalmol. 1988;72(12):912–917. doi:10.1136/bjo.72.12.912.
   PubMed Web of Science ®Google Scholar
• Jakobiec FA, Rini F, Char D, Orcutt J, Rootman J, Baylis H, et al. Primary liposarcoma of the orbit. Problems in the diagnosis and management of five cases. Ophthalmology. 1989;96(2):180–191. doi:10.1016/s0161-6420(89)32916-2.
   PubMed Web of Science ®Google Scholar
• McNab AA, Moseley I. Primary orbital liposarcoma: clinical and computed tomographic features. Br J Ophthalmol. 1990;74(7):437–439. doi:10.1136/bjo.74.7.437.
   PubMed Web of Science ®Google Scholar
• Cai YC, McMenamin ME, Rose G, Sandy CJ, Cree IA, Fletcher CD. Primary liposarcoma of the orbit: a clinicopathologic study of seven cases. Ann Diagn Pathol. 2001;5(5):255–266. doi:10.1053/adpa.2001.27911.
   PubMedGoogle Scholar
• Garrity JA, Henderson JW, Cameron JD. Henderson’s tumors of primitive mesoderm, striated muscle, adipose tissue and smooth muscle. In: Garrity J, Henderson J, and Cameron J, eds. Henderson’s orbital tumors. 4th ed. Philadelphia: Lippincott Williams and Wilkins; 2007: 123–141.
   Google Scholar
• Mridha AR, Sharma MC, Sarkar C, Suri V, Garg A, Suri A. Primary liposarcoma of the orbit: a report of two cases. Can J Ophthalmol. 2007;42(3):481–483. doi:10.3129/i07-072.
   PubMed Web of Science ®Google Scholar
• Madge SN, Tumuluri K, Strianese D, Bonavolonta P, Wilcsek G, Dodd TJ, et al. Primary orbital liposarcoma. Ophthalmology. 2010;117(3):606–614. doi:10.1016/j.ophtha.2009.08.017.
   PubMed Web of Science ®Google Scholar
• Al-Qahtani AA, Al-Hussain H, Chaudhry I, El-Khamary S, Alkatan HM. Primary orbital liposarcoma: histopathologic report of two cases. Middle East Afr J Ophthalmol. 2011;18(4):314–316. doi:10.4103/0974-9233.90135.
   PubMedGoogle Scholar
• Khurana S, Gupta AK, Sen S, Kashyap S. Primary liposarcoma of the orbit. Indian J Pathol Microbiol. 2014;57(4):617–619. doi:10.4103/0377-4929.142700.
   PubMed Web of Science ®Google Scholar
• Kang JY, Kim HJ, Wojno TH, Yeung AM, Mendoza PR, Grossniklaus HE. Atypical lipomatous tumor/well-differentiated liposarcoma of the orbit: three cases and review of the literature. Ophthalmic Plast Reconstr Surg. 2021;37(3S):S134–140. doi:10.1097/IOP.0000000000001804.
   PubMed Web of Science ®Google Scholar
• Doyle M, Odashiro AN, Pereira PR, Odashiro M, Kobayashi F, Shinzato I, et al. Primary pleomorphic liposarcoma of the orbit: a case report. Orbit. 2012;31(3):168–170. doi:10.3109/01676830.2011.648806.
   PubMedGoogle Scholar
• Wang L, Ren W, Zhou X, Sheng W, Wang J. Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic study of 32 additional cases. Pathol Int. 2013;63(11):523–531. doi:10.1111/pin.12104.
   PubMed Web of Science ®Google Scholar
• Andrea T, Giulio G, Giuliana L, Sandro P. Primary dedifferentiated liposarcoma of the orbit, a rare entity: case report and review of literature. Saudi J Ophthalmol. 2019;33(3):312–315. doi:10.1016/j.sjopt.2019.01.003.
   PubMed Web of Science ®Google Scholar
• Daniel CS, Beaconsfield M, Rose GE, Luthert PJ, Heathcote JG, Clark BJ. Pleomorphic lipoma of the orbit: a case series and review of literature. Ophthalmology. 2003;110(1):101–105. doi:10.1016/s0161-6420(02)01450-1.
   PubMed Web of Science ®Google Scholar
• Tripathy D, Mittal R. Spindle cell lipoma of the orbit. Ophthalmic Plast Reconstr Surg. 2015;31(3):e53–55. doi:10.1097/IOP.0000000000000068.
   PubMed Web of Science ®Google Scholar
• Weaver J, Rao P, Goldblum JR, Joyce MJ, Turner SL, Lazar AJF, et al. Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Mod Pathol. 2010;23(10):1301–1306. doi:10.1038/modpathol.2010.106.
   PubMed Web of Science ®Google Scholar
• Crago AM, Dickson MA. Liposarcoma: multimodality management and future targeted therapies. Surg Oncol Clin N Am. 2016;25(4):761–773. doi:10.1016/j.soc.2016.05.007.
   PubMed Web of Science ®Google Scholar
• Jones RL, Fisher C, Al-Muderis O, Judson IR. Differential sensitivity of liposarcoma subtypes to chemotherapy. Eur J Cancer. 2005;41(18):2853–2860. doi:10.1016/j.ejca.2005.07.023.
   PubMed Web of Science ®Google Scholar
• Kleinerman RA, Schonfeld SJ, Sigel BS, Wong-Siegel JR, Gilbert ES, Abramson DH, et al. Bone and soft-tissue sarcoma risk in long-term survivors of hereditary retinoblastoma treated with radiation. J Clin Oncol. 2019;37(35):3436–3445. doi:10.1200/JCO.19.01096.
   PubMed Web of Science ®Google Scholar
• Kleinerman RA, Tucker MA, Abramson DH, Seddon JM, Tarone RE, Fraumeni JF. Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst. 2007;99(1):24–31. doi:10.1093/jnci/djk002.
   PubMedGoogle Scholar
• Kleinerman RA, Tucker MA, Tarone RE, Abramson DH, Seddon JM, Stovall M, et al. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol. 2005;23(10):2272–2279. doi:10.1200/JCO.2005.05.054.
   PubMed Web of Science ®Google Scholar
• Baker KS, Leisenring WM, Goodman PJ, Ermoian RP, Flowers ME, Schoch G, et al. Total body irradiation dose and risk of subsequent neoplasms following allogeneic hematopoietic cell transplantation. Blood. 2019;133(26):2790–2799. doi:10.1182/blood.2018874115.
   PubMed Web of Science ®Google Scholar
• Curtis RE, Rowlings PA, Deeg HJ, Shriner DA, Socíe G, Travis LB, et al. Solid cancers after bone marrow transplantation. N Engl J Med. 1997;336(13):897–904. doi:10.1056/NEJM199703273361301.
   PubMed Web of Science ®Google Scholar
• Socíe G, Curtis RE, Deeg HJ, Sobocinski KA, Filipovich AH, Travis LB, et al. New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia. J Clin Oncol. 2000;18(2):348–357. doi:10.1200/JCO.2000.18.2.348.
   PubMed Web of Science ®Google Scholar
• Harper GD, Dicks-Mireaux C, Leiper AD. Total body irradiation-induced osteochondromata. J Pediatr Orthop. 1998;18(3):356–358. doi:10.1097/01241398-199805000-00016.
   PubMed Web of Science ®Google Scholar
• Kebudi R, Ozger H, Kızılocak H, Bay SB, Bilgiç B. Osteosarcoma after hematopoietic stem cell transplantation in children and adolescents: case report and review of the literature. Pediatr Blood Cancer. 2016;63(9):1664–1666. doi:10.1002/pbc.26067.
   PubMed Web of Science ®Google Scholar
• Pierobon M, Mercolini F, Affinita MC, Tombolan L, Battisti L, Bisogno G. Secondary osteosarcoma after bone marrow transplant: an aggressive disease. J Adolesc Young Adult Oncol. 2020;9(6):672–675. doi:10.1089/jayao.2020.0054.
   PubMed Web of Science ®Google Scholar
• Scheuermann A, Phelan R, Browning M. Development of secondary osteosarcoma after TBI and allogeneic bone marrow transplant: a case series of 3 patients. J Pediatr Hematol Oncol. 2020;42(2):e100–103. doi:10.1097/MPH.0000000000001442.
   PubMed Web of Science ®Google Scholar
• Bjerkehagen B, Smeland S, Walberg L, Skjeldal S, Hall KS, Nesland JM, et al. Radiation-induced sarcoma: 25-year experience from the Norwegian Radium Hospital. Acta Oncol. 2008;47(8):1475–1482. doi:10.1080/02841860802047387.
   PubMed Web of Science ®Google Scholar
• Kauffman SL, Stout AP. Extraskeletal osteogenic sarcomas and chondrosarcomas in children. Cancer. 1963;16(4):432–439. doi:10.1002/1097-0142(196304)16:4<432:aid-cncr2820160403>3.0.co;2-e.
   PubMed Web of Science ®Google Scholar
• Jacob R, Abraham E, Jyothirmayi R, Nair MK. Extraskeletal osteosarcoma of the orbit. Sarcoma. 1998;2(2):121–124. doi:10.1080/13577149878082.
   PubMedGoogle Scholar
• Fan JC, Lamont DL, Greenbaum AR, Ng SGJ. Primary orbital extraskeletal osteosarcoma. Orbit. 2011;30(6):297–299. doi:10.3109/01676830.2011.602170.
   PubMedGoogle Scholar
• de Maeyer VMDS, Kestelyn PAFA, Shah AD, Van Den Broecke CM, Denys HGN, Decock CE. Extraskeletal osteosarcoma of the orbit: a clinicopathologic case report and review of literature. Indian, J Ophthalmol. 2016;64(9):687–689. doi:10.4103/0301-4738.97555.
   PubMed Web of Science ®Google Scholar
• Hui J, Zhao Y, Zhang L, Lin J, Zhao H. Primary orbital extraskeletal osteosarcoma and review of literature. BMC Ophthalmol. 2020;20(1):425–425. doi:10.1186/s12886-020-01690-9.
   PubMed Web of Science ®Google Scholar
• Mark RJ, Poen J, Tran LM, Fu YS, Selch MT, Parker RG. Postirradiation sarcomas. A single-institution study and review of the literature. Cancer. 1994;73(10):2653–2662. doi:10.1002/1097-0142(19940515)73:10<2653:aid-cncr2820731030>3.0.co;2-g.
   PubMed Web of Science ®Google Scholar
• Brady MS, Gaynor JJ, Brennan MF. Radiation-associated sarcoma of bone and soft tissue. Arch Surg. 1992;127(12):1379–1385. doi:10.1001/archsurg.1992.01420120013002.
   PubMedGoogle Scholar
• Cha C, Antonescu CR, Quan ML, Maru S, Brennan MF. Long-term results with resection of radiation-induced soft tissue sarcomas. Ann Surg. 2004;239(6):903–9–discussion909–10. doi:10.1097/01.sla.0000128686.51815.8b.
   Web of Science ®Google Scholar
• Huvos AG, Woodard HQ, Cahan WG, Higinbotham NL, Stewart FW, Butler A, et al. Postradiation osteogenic sarcoma of bone and soft tissues. A clinicopathologic study of 66 patients. Cancer. 1985;55(6):1244–1255. doi:10.1002/1097-0142(19850315)55:6<1244:aid-cncr2820550617>3.0.co;2-1.
   PubMed Web of Science ®Google Scholar
• Yap J, Chuba PJ, Thomas R, Aref A, Lucas D, Severson RK, et al. Sarcoma as a second malignancy after treatment for breast cancer. Int J Radiat Oncol Biol Phys. 2002;52(5):1231–1237. doi:10.1016/s0360-3016(01)02799-7.
   PubMed Web of Science ®Google Scholar
• Cahan WG, Woodard HQ. Sarcoma arising in irradiated bone; report of 11 cases. Cancer. 1948;1(1):3–29. doi:10.1002/1097-0142(194805)1:1<3:aid-cncr2820010103>3.0.co;2-7.
   PubMed Web of Science ®Google Scholar
• Gladdy RA, Qin L-X, Moraco N, Edgar MA, Antonescu CR, Alektiar KM, et al. Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas? J Clin Oncol. 2010;28(12):2064–2069. doi:10.1200/JCO.2009.25.1728.
   PubMed Web of Science ®Google Scholar
• Robinson E, Neugut AI, Wylie P. Clinical aspects of postirradiation sarcomas. J Natl Cancer Inst. 1988;80(4):233–240. doi:10.1093/jnci/80.4.233.
   PubMedGoogle Scholar
• Wiklund TA, Blomqvist CP, Räty J, Elomaa I, Rissanen P, Miettinen M. Postirradiation sarcoma. Analysis of a nationwide cancer registry material. Cancer. 1991;68(3):524–531. doi:10.1002/1097-0142(19910801)68:3<524:aid-cncr2820680313>3.0.co;2-e.
   PubMed Web of Science ®Google Scholar
• Neuhaus SJ, Pinnock N, Giblin V, Fisher C, Thway K, Thomas JM, et al. Treatment and outcome of radiation-induced soft-tissue sarcomas at a specialist institution. Eur J Surg Oncol. 2009;35(6):654–659. doi:10.1016/j.ejso.2008.11.008.
   PubMed Web of Science ®Google Scholar