PULMONARY VASCULAR REMODELING DISTAL TO PULMONARY ARTERY LIGATION IS ACCOMPANIED BY UPREGULATION OF ENDOTHELIN RECEPTORS AND NITRIC OXIDE SYNTHASE

References

• Liebow AA, Hales MR, Bloom er WE, Harrison W, Lindskog GE: Studies on the lung after ligation of the pulmona ry artery. II. Anatomical changes. Am J Pathol. 1950;26:177–195.
   Google Scholar
• Weibel ER: Early stages in the developm ent of collateral circulation to the lung in the rat. Circ Res. 1960;8:353–376.
   Google Scholar
• Michel RP, Hakim TS, Petsikas D: Segm ental vascular resistance in postobstructive pulm onary vasculopathy. J Appl Physiol. 1990;69:1022–1032.
   Google Scholar
• Michel RP, Hakim TS: Increased resistance in postobstructive pulmona ry vasculop athy: structure - function relationships. J Appl Physiol. 1991;71:601–610.
   Google Scholar
• Shi W, Cernacek P, Hu Fu, Michel RP: Endothelin reactivity and receptor pro file of pulm onary vessels in postobstructive pulmona ry vasculopathy. Am J Physiol. 1997;273:H2558–H 2564.
   Google Scholar
• Yanagisawa M, Kurihar a H, Kimura S, Tom obe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411–415.
   Google Scholar
• Tamirasa P, Frishm an WH, Kum ar A: Endothelin and endothelin antagonism: roles in cardio- vascular health and disease. Am Heart J. 1994;130:601–610.
   Google Scholar
• Ferro CJ, Webb DJ: The clinical potential of endothelin receptor antagonists in cardiovascular medicine. Drugs. 1996;51:12–27.
   Google Scholar
• Arai H, Hori H, Aram ori I, Ohkubo H, Nakanishi S: Cloning and expression of a cDN A encoding an endothelin receptor. Nature. 1990;348:730–732.
   Google Scholar
• Sakurai T, Yanagisawa M, Takuw a Y, Miyazaki H, Kimura S, Goto K, Masaki T: Cloning of a cDN A encoding a non isopeptide selective subtype of the endothelin receptor. Nature. 1990;348:732– 735.
   Google Scholar
• Schiffrin EL, Intengan HD, Thibault G, Touyz RM: Clinical significance of endothelin in cardio- vascular disease. Curr Opin Cardiol. 1997;12:354–367.
   Google Scholar
• Tjen-A-Looi S, Ekman R, Osborn J, Keith I: Pulm onary vascular pressure effects of endothelin-1 in normoxia and chronic hypoxia: a longitudinal study. Am J Physiol. 1996;271:H 2246–H2253.
   Google Scholar
• Nava E, Luscher TF: Endothelium-derived vasoactive factors in hyperten sion: nitric oxide and endo- thelin. J Hypertension. 1995;13:S39–S48.
   Google Scholar
• Stewart DJ: Endothelial dysfunction in pulm onary vascular disorders . Arzneimittel Forschun g. 1994;44:451–454.
   Google Scholar
• Mansoor AM, Honda M, Saida K, Ishinaga Y, Kuramochi T, Maeda A, Takabatake T, Mitsui Y: Endothelin induced collagen remodeling in experime ntal pulmona ry hyperten sion. Biochem Biophys Res Commun . 1995;215:981–986.
   Google Scholar
• Giaid A, Stewart DJ, Michel RP: Endothelin-1-like imm unoreactivity in postobstructive pulm onary vasculopathy. JV asc Res. 1993;30:333–338.
   Google Scholar
• Forsterm ann U, Kleinert H: Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn Schmied ebergs Arch Pharmacol. 1995;352:351–364.
   Google Scholar
• Shaul PW, North AJ, Brannon TS, Ujiie K, Wells LB, Nisen PA, Lowenstein CJ, Snyder SH, Star RA: Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adults rat lung. Am J Respir Cell Mol Biol. 1995;13:167–174.
   Google Scholar
• Shaul PW: Ontogeny of nitric oxide in the pulmona ry vasculature. Semin Perinatol. 1997;21:381– 392.
   Google Scholar
• Adnot S, Raffestin B, Eddahibi S: NO in the lung. Respir Physiol. 1995;101:109–120.
   Google Scholar
• Tajchman UW, Tuder RM, Horan M, Parker TA, Abman SH: Persistent eNOS in lung hypoplasia caused by left pulmona ry artery ligation in the ovine fetus. Am J Physiol. 1997;272:L969–L978.
   Google Scholar
• LeCras TD, Tyler RC, Horan MP, Morris KG, Tuder RM, McM urtry IF, Johns RA, Abman SH: Effects of chronic hypoxia and altered hem odynam ics on endothelial nitric oxide synthase expression in the adult rat lung. J Clin Invest. 1998;101:795–801.
   Google Scholar
• Mathew R, Zeballos GA, Tun H, Gewitz MH: Role of nitric oxide and endothelin-1 in monocrota line-indu ced pulmonary hypertens ion in rats. Cardiovasc Res. 1995;30:739–746.
   Google Scholar
• Hislop A, Reid L: Changes in the pulmonary arteries of the rat during recovery from hypoxia-induced pulmona ry hyperten sion. Br J Exp Pathol. 1977;58:653–662.
   Google Scholar
• Davies P, Reid L, deM ello D: Methods in experimental pathology of pulm onary vasculature. In: Gill J, eds. Models of Lung D isease. New York: Marcel D ekker; 1990:843–904.
   Google Scholar
• Hislop A, Reid L: Normal structure and dimensions of the pulmonary arteries in the rat. J Anat. 1978;125:71–83.
   Google Scholar
• Fernie J, Lamb D: New method for measuring intimal component of pulm onary arteries. J Clin Pathol. 1985;38:1374–1379.
   Google Scholar
• Fernie J, Lamb D: New method for quantitating the medial component of pulmonary arteries. Arch Pathol Lab Med. 1985;109:843–848.
   Google Scholar
• Hsu S, Raine L, Fanger H: A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimm unoassay antibodies. Am J Clin P athol. 1981;75:734–738.
   Google Scholar
• Moser KM, Bloor CM: Pulmonary vascular lesions occurring in patients with chronic m ajor vessel throm boembolic pulmonary hypertens ion. Chest. 1993;103:685–692.
   Google Scholar
• Fedullo PF, Auger WR, Channick RN, Moser KM, Jamieson SW: Chronic thromboembolic pulmonary hypertension. Clin Chest Med. 1995;16:353–374.
   Google Scholar
• Hirsch AM, Moser KM, Auger WR, Channick RN, Fedullo PF: Unilateral pulmonary artery thrombotic occlusion: is distal arteriopathy a consequence? Am J Respir Critical Care Med. 1996;154:491– 496.
   Google Scholar
• Li H, Elton TS, Chen YF, Oparil S: Increased endothelin receptor gene expression in hypoxic rat lung. Am J Physiol. 1994;266:L553–L601.
   Google Scholar
• Xue C, Johns RA: Upregulation of nitric oxide synthase correlates temporally with onset of pulmonary vascular remodelling in the hypoxic rat. Hypertension. 1996;28:743–753.
   Google Scholar
• Ignarro LJ, Byrns RE, Buga GM, Wood KS: Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmac ologic and chemical properties identical to those of nitric oxide radical. Circ Res. 1987;61:866–879.
   Google Scholar
• Mraks DS, Vita JA, Folts JD, Kearney JF Jr, Welsh GN, Loscalzo J: Inhibition of neointimal proliferation in rabbits following vascular injury by a single treatment with a protein adduct of nitric oxide. J Clin Invest. 1995;96:2630–2638.
   Google Scholar
• Garg UC, Hassid A: Nitric oxide (N O) and 8-bromo-cyclic GM P inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1974–1977.
   Google Scholar
• Fukuo K, Inoue T, Morimoto S, Nakahasi T, Yasuda O, Kitanno S, Sasanda A, Ogihara T: Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. J Clin Invest. 1995;95:669–676.
   Google Scholar