41
Views
19
CrossRef citations to date
0
Altmetric
Research Article

K-Ras p21 EXPRESSION AND ACTIVITY IN LUNG AND LUNG TUMORS

, , , , , & show all
Pages 659-671 | Published online: 02 Jul 2009

References

  • Lowy DR, Willumsen BM:Function and regulation of ras. Ann Rev Biochem. 1993;62:851-891.
  • Bos JL:ras oncogenes in human cancer:A review. Cancer Res. 1989;49:4682-4689.
  • Enomoto T, Inoue M, Perantoni AO, Terakawa N, Tanizawa O, Rice JM:K-ras activation in neoplasms of the hu man female reproductive tract. Cancer Res. 1990;50:6139-6145.
  • Enomoto T, Weghorst CM, Inoue M, Tanizawa O, Rice JM:K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in oth er common epithelial tumors of the human ovary. Am J Pathol. 1991;139:777-785.
  • Konishi N, Enomoto T, Buzard G, Ohshima M, Ward JM, Rice JM:K-ras activation and ras p21 expression in latent prostatic carcinoma in Japanese men. Cancer. 1992;69:2293-2299.
  • Mills NE, Fishman CL, Rom WN, Dubin N, Jacobson DR:Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma. Cancer Res. 1995;55:1444-1447.
  • McCormick F:Ras oncogenes. In:Weinberg RA, ed. Oncogenes and the Molecular Origin of Cancer. Cold Spring Harbor, NY:Cold Spring Harbor Laboratory; 1989:125-145.
  • Yamamoto T, Taya A, Kaibuchi K:Ras-induced transformation and signaling pathway. J Biochem. 1999;126:799-803.
  • Shields JM, Pruitt K, McFall A, Shaub A, Der CJ:Understanding ras:‘it ain’t over ‘til it’s over’. Trends Cell Biol. 2000;4:1-7.
  • Frame S, Balmain A:Integration of positive and negative growth signals during ras pathway activation in viv o. Curr Opin Genet Develop. 2000;10:106-113.
  • Slamon DJ, deKernion JB, Verma IM, Cline MJ:Expression of cellular oncogenes in human malignancies. Science. 1984;224:256-262.
  • Slebos RJC, Habets GGM, Evers SG, Mooi WJ, Rodenhuis S:Allele-specific detection of K-ra soncogene expression in hu man non-small-cell lung carcinomas. Int J Cancer. 1991;48:51-56.
  • Capon DJ, Seeburg PH, McGrath JP, Hayfiick JS, Edman U, Levinson AD, Goeddel DV:Activation of Ki-ras2 gene in hu man colon and lung carcinomas by two different point mutations. Nature. 1983;304:507-513.
  • Leon J, Guerrero I, Pellicer A:Differential expression of the ras gene family in mice. Mol Cell Biol. 1987;7:1535-1540.
  • Pan YHL, Nuzum EO, Hanson LA, Beer DG:Ki-ras activation and expression in transformed mou se lung cell lines. Mol Carcinog. 1990;3:279-286.
  • Li J, Beer DG:Ki-ras mRNA regulation in untransformed mouse lung cells. Mol Carcinog. 1993;8:193-201.
  • Hanson LA, Nuzum EO, Jones BC, Malkinson AM, Beer DG:Expression of the glucocorticoid receptor and K-ras genes in urethan-induced mouse lung tu mors and transformed cell lines. Exp Lung Res. 1991;17:371-387.
  • Nuzum EO, Malkinson AM, Beer DG:Specific Ki-ras codon 61 mutations may dete rmine the development of urethan-induced mou se lung adenomas or adenocarcinomas. Mol Carcinog. 1990;3:287-295.
  • You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds SH, Anderson M:Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids. Proc Natl Acad Sci US A. 1992;89:5804-5808.
  • Chen B, You L, Wang Y, Stoner GD, You M:Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens. Carcinogenesis. 1994;15:2031-2035.
  • Matzinger SA, Chen B, Wang Y, Crist KA, Stoner GD, Kelloff GJ, Lubet RA, You M:Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice. Gene. 1997;188:261-269.
  • Jones-Bolin SE, Johansson E, Palmisano WA, Anderson MW, Wiest JS, Belinsky SA:Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression. Carcinogenesis. 1998;19:1503-1508.
  • Thrane EV, Becher R, Lag M, Refsnes M, Huitfeldt HS, Schwarze PE:Differential distribution and increased levels of ras proteins during lung development. Exp Lung Res. 1997;23:35-49.
  • Sithanandam G, Ramakrishna G, Diwan BA, Anderson LM:Selective mutation of Ki-ras by N-ethylnitrosourea shifts from codon 12 to codon 61 during fetal mouse lung maturation. Oncogene. 1998;17:493-502.
  • Ramakrishna G, Bialkowska A, Perella C, Birely L, Fornwald LW, Diwan BA, Shiao Y, Anderson LM:Ki-Ras and the characteristics of mouse lung tumors. Mol. Carcinog. 2000;28:1-12.
  • Heusch WL, Maneckjee R:Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis. 1998;19:551-556.
  • Oliver BL, Garat C, Pytela R, Matthay MA:Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix. Am J Resp Cell Mol Biol. 1997;16:613-620.
  • Massey TE, Devereux TR, Maronpot RR, Foley JF, Anderson MW:High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tu mors of relatively resistant B6C3 F1 (C57BL/6JxBALB/c) mice. Carcinogenesis 1995;16:1065-1069.
  • McKenna IM, Ramakrishna G, Diwan BA, Kang Y, Shiao Y, Wakefield LM, Anderson LM, Jakowlew SB:Heterozygous inactivation of TGF-1 increases the susceptibility to chemically induced mouse lung tu morigenesis independently of mutational activation of K-ra s. Submitted.
  • Slebos RJC, Kibbelaar RE, Dalesio O, Kooistra A, Stam J, Meijer CJLM, Wagenaar SS, Vanderschueren RGJRA,van Zandwijk N, Mooi WJ, Bos JL, Rodenhuis S:K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. NEngl J Me d. 1990;323:561-565.
  • Hwang MC, Sung YJ, Hwang YW:The differential effects of the Gly-60 to Ala mutation on the interaction of H-ras p21 with different downstream targets. J Biol Ch em. 1996;271:8196-8202.
  • Al-Mulla F, Milner-White EF, Going JJ, Birnie GD:Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression. J Pathol. 1999;187:433-438.
  • Rice PL, Porter SE, Koski KM, Ramakrishna G, Chen A, Schrump D, Kazlauskas A, Malkinson AM:Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells. Mol Carcinog. 1999;25:285-294.
  • Mulder KM:Role of Ras and Mapks in TGF signaling. Cytokine Growth Fact Rev. 2000;11:23-35.
  • Tang B, Bottinger EP, Jakowlew SB, Bagnall KM, Mariano J, Anver MR, Letterio JJ, Wakefield LM:Transforming growth factor-betal is a new form of tu mor suppressor with true haploid insuffi ciency. Nat Me d. 1998;4:802-807.
  • Mouhieddine OB, Cazals V, Maitre B, Le Bouc Y, Chadelat K, Clement A:Insulin-like growth factor-II (IGF-II), type 2 IGF receptor, and IGF-binding protein-2 gene expression in rat lung alveolar epithelial cells:relation to proliferation. Endocrinology. 1994;135:83-91.
  • Malumbres M, Pellicer A:Ras pathways to cell cycle control and cell transformation. Front Bioscience 1998;3:887-912.
  • Rebollo A, Martinez C:Ras proteins:recent advances and new functions. Blood. 1999;94:2971-2980.
  • Ramakrishna G, Anderson LM:Levels and membrane localization of c-Ki-ras p21 protein in lungs of mice of different genetic strains and effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254. Carcinogenesis. 1998;19:463-470.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.