Advanced search
Publication Cover
Experimental Lung Research Volume 28, 2002 - Issue 6
Submit an article Journal homepage
15
Views
1
CrossRef citations to date
0
Altmetric
Research Article

INHIBITION OF ENDOGENOUS NITRIC OXIDE DURING ENDOTOXEMIA IN AWAKE SHEEP - EFFECTS OF N ω -NITRO-L-ARGININE ON THE DISTRIBUTION OF PULMONARY VASCULAR RESISTANCE AND PROSTANOID PRODUCTS

Tomonobu Koizumi Center for Lung Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
,
David Johnston Center for Lung Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
,
Lars J. Bjertnaes Center for Lung Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
,
Meekule R. Banerjee Center for Lung Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
&
John H. Newman Center for Lung Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Pages 473-484 | Published online: 02 Jul 2009

  • Brigham KL, Meyrick B: Endotoxin and lung injury. Am Rev Respir Dis. 1986;133:913-927.
  • Nelson SH, Ehardt JS, Lingnau W, Dehring DJ, Traber L, Traber D: Differential effects of prolonged septicemia on isolated pulmonary arteries and veins from sheep. Shock. 1996;5:440-445.
  • Lorente JA, Landin L, Renes E, De Pablo R, Jorge P, Rodena E, Liste D: Role of nitric oxide in the hemodynamic changes of sepsis. Crit Care Med. 1993;21:759-767.
  • Kiboum RG, Jubran A, Gross S, Griffith OW, Levi R, Adams J, Lodato RF: Reversal of endotoxin-mediated shock by NG-methyl-Lrarginine, an inhibitor of nitric synthesis. Biochem Biophys Res Commun. 1990;172:1132-1138.
  • Petros A, Lamb G, Leone A, Moncada S, Bennett D, Vallance P: Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res. 1994;28:34-39.
  • Warren JB, Coughlan ML, Williams TJ: Endotoxin-induced vasodilation in anaesthetized rat skin involves nitric oxide and prostaglandin synthesis. Br J Pharmacol. 1992;106553-957.
  • Kubo K, Kobayashi T: Effects of OKY-046, a selective thromboxane synthetase inhibitior, on endotoxin-induced lung injury in unanesthetized sheep. Am Rev Respir Dis. 1985;132:494-499.
  • Schutte H, Mayer K, Gessler T, Ruhl M, Schlaudraff J, Burger H, Seeger W, Grimminger F: Nitric oxide biosynthesis in an exotoxin-induced septic lung model Am J Respir Care Med. 1998;157:498-504.
  • Hellyer PW, Johnson LW, Olson NC: Effect of NG-nitro-Lrarginine methyl ester on cardiopulmonary function and biosynthesis of cyclooxygenase products during porcine endotoxemia. Crit Care Med. 1997;25:1051-1058.
  • Cohen RI, Shapir Y, Chen L, Scharf SM: Right ventricular overload causes the decrease in cardiac output after nitric oxide synthesis inhibition in endotoxemia. Crit Care Med. 1998;26:738-747.
  • Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991;43:109-142.
  • Landin L, Lorente JA, Renes E, Canas P, Jorge P, Liste D: Inhibition of nitric oxide synthesis improves the vasoconstrictive effect of noradrenaline in sepsis. Chest 1994;106:250-256.
  • Koizumi T, Gupta R, Banerjee M, Newman JH: Changes in pulmonary vascular tone during exercise, effects of nitric oxide (NO) sythase inhibition, L-arginine infusion, and NO inhalation. J Clin Invest 1994;94:2275-2282.
  • Kane DW, Tesauro T, Koizumi T, Gupta R, Newman JH: Execise-induced pulmonary vasoconstriction during combined blockade of nitric oxide synthase and beta adrenergic receptors. J Clin Invest 1994;93:677-683.
  • Cremona G, Higenbottam T, Takao T, Bower EA, Hall LW: Nature and site of action of endogenous nitric oxide in vasculature of isolated pig lungs. J Appl Physiol. 1997;82:23-31.
  • Liu S, Crawley DE, Barnes PJ, Evans TW: Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am Rev Respir Dis. 1991;143:32-37.
  • Gruetter CA, Lemke SM: Bradykinin-induced endothelium dependent relaxation of bovine intrapulmonar artery and vein. Eur J Pharmacol. 1986;122:363-367.
  • Ignarro LJ, Byrns RE, Buga GM, Wood KS: Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologie and chemical properties identical to those of nitric oxide radical. Circ Res. 1987;61:866-879.
  • Gordon JB, Tod ML· Effects of N8-nitro-L-arginine on total and segmental vascular resistances in developing lamb lungs. J Appl Physiol. 1993;75:76-85.
  • Zidulka A, Hakim TS: Wedge pressure in large vs small pulmonary arteries to detect pulmonary venoconstriction. J Appl Physiol. 1985;9:1329-1332.
  • Parker RE, Brigham KL: Effects of endotoxemia on pulmonary vascular resistance in unanesthetized sheep. J Appl Physiol. 1987;63:1058-1062.
  • Doni MG, Whitde BJR, Palmer RMJ, Moncada S: Actions of nitric oxide on the release of prostacyclin from bovine endothelial cells in culture. Eur J Pharmacol. 1988;151:19-25.
  • Levin RI, Jaffe EA, Weksler BB, Gorldman K: Nitroglycerin stimulates synthesis of prostacyclin by cultured human endothelial cells. J din Invest. 1981;67:762-769.
  • Wickersham NE, Johnson JJ, Meyric BO, Giloy RJ, Loyd JE: Lung ischemia-reperfusion injury in awake sheep: protection with verapamil. J Appl Pysiol. 1991;71:1554-1562.
  • Bjertnaes LJ, Koizumi T, Newman JH: Inhaled nitric oxide reduces lung fluid nitration after endotoxin in awake sheep. Am J Respir Crit Care Med. 1998;158:1416-1423.
  • Johnson D, Hurst T, Wilson T, Murphy F, Saxema A, To T, Mayers I: NG-monomethyl-arginine does not restore loss of hypoxic pulmonary vasoconstriction induced by TNF-a. J Appl Physiol. 1993;75:618-625.
  • Radomski MW, Palmer RMJ, Moncada S: The anti-aggregating properities of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol. 1987;92:639-646.
  • Morcillio E, Reid PR, Dubin N, Ghodgaonkar R, Pitt B: Myocardial prostaglandin E release by nitroglycerin and modification by indomethacin. Am J Cardiol. 1980;45:53-59.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.