217
Views
17
CrossRef citations to date
0
Altmetric
Original

ROLES OF RhoA AND Rac1 ON ACTIN REMODELING AND CELL ALIGNMENT AND DIFFERENTIATION IN FETAL TYPE II EPITHELIAL CELLS EXPOSED TO CYCLIC MECHANICAL STRETCH

, , , , &
Pages 663-680 | Received 11 Apr 2008, Accepted 11 Jul 2008, Published online: 02 Jul 2009

REFERENCES

  • Harding R. Fetal breathing movements. The Lung: Scientific Foundations, 2nd ed, R G Crystal, J B West, P J Banes, E R Weiber. Lippincott–Raven, Philadelphia 1997; 2093–2104
  • Kitterman J A. The effects of mechanical forces on fetal lung growth. Clin Perinatol 1996; 23: 727–740
  • Liu M, Tanswell A K, Post M. Mechanical force-induced signal transduction in lung cells. Am J Physiol 1999; 277: L667–L683
  • Sanchez-Esteban J, Cicchiello L A, Wang Y, Tsai S W, Williams L K, Torday J S, Rubin L P. Mechanical stretch promotes alveolar epithelial type II cell differentiation. J Appl Physiol 2001; 91: 589–595
  • Scarpelli E M, Condorelli S, Cosmi E V. Lamb fetal pulmonary fluid. I. Validation and significance of method for determination of volume and volume change. Pediatr Res 1975; 9: 190–195
  • Goldstein J D, Reid L M. Pulmonary hypoplasia resulting from phrenic nerve agenesis and diaphragmatic amyoplasia. J Pediatr 1980; 97: 282–287
  • Wigglesworth J S, Desai R. Effect on lung growth of cervical cord section in the rabbit fetus. Early Hum Dev 1979; 3: 51–65
  • Torday J S, Sanchez-Esteban J, Rubin L P. Paracrine mediators of mechanotransduction in lung development. Am J Med Sci 1998; 316: 205–208
  • Sanchez-Esteban J, Wang Y, Cicchiello L A, Rubin L P. Cyclic mechanical stretch inhibits cell proliferation and induces apoptosis in fetal rat lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2002; 282: L448–L456
  • Wert S E, Glasser S W, Korfhagen T R, Whitsett J A. Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice. Dev Biol 1993; 156: 426–443
  • Sanchez-Esteban J, Wang Y, Gruppuso P A, Rubin L P. Mechanical stretch induces fetal type II cell differentiation via an epidermal growth factor receptor-extracellular-regulated protein kinase signaling pathway. Am J Respir Cell Mol Biol 2004; 30: 76–83
  • Wang Y, Maciejewski B S, Lee N, Silbert O, McKnight N L, Frangos J A, Sanchez-Esteban J. Strain-induced fetal type II epithelial cell differentiation is mediated via cAMP-PKA-dependent signaling pathway. Am J Physiol Lung Cell Mol Physiol 2006; 291: L820–827
  • Torday J S, Rehan V K. Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptin. Am J Physiol Lung Cell Mol Physiol 2002; 283: L130–L135
  • Rubin L P, Kovacs C S, De Paepe M E, Tsai S W, Torday J S, Kronenberg H M. Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev Dyn 2004; 230: 278–289
  • Ingber D E. Mechanosensation through integrins: cells act locally but think globally. Proc Natl Acad Sci U S A 2003; 100: 1472–1474
  • Sanchez-Esteban J, Wang Y, Filardo E J, Rubin L P, Ingber D E. Integrins {beta}1, {alpha}6, and {alpha}3 contribute to mechanical strain–induced differentiation of fetal lung type II epithelial cells via distinct mechanisms. Am J Physiol Lung Cell Mol Physiol 2006; 290: L343–L350
  • Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420: 629–635
  • Ridley A J. Rho family proteins: coordinating cell responses. Trends Cell Biol, 11: 471–477
  • Tzima E. Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response. Circ Res 2006; 98: 176–185
  • Liu W F, Nelson C M, Tan J L, Chen C S. Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res 2007; 101: e44–e52
  • Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Zhu W, Kadowaki T, Yazaki Y. Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. Circ Res 1999; 84: 458–466
  • Dudek S M, Garcia J G. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001; 91: 1487–1500
  • Shikata Y, Rios A, Kawkitinarong K, DePaola N, Garcia J G, Birukov K G. Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells. Exp Cell Res 2005; 304: 40–49
  • Sylvester J T. The tone of pulmonary smooth muscle: ROK and Rho music?. Am J Physiol Lung Cell Mol Physiol 2004; 287: L624–L630
  • Birukov K G, Jacobson J R, Flores A A, Ye S Q, Birukova A A, Verin A D, Garcia J G. Magnitude dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch. Am J Physiol Lung Cell Mol Physiol 2003; 285: L785–L797
  • Birukova A A, Chatchavalvanich S, Rios A, Kawkitinarong K, Garcia J G, Birukov K G. Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. Am J Pathol 2006; 168: 1749–1761
  • Moore K A, Polte T, Huang S, Shi B, Alsberg E, Sunday M E, Ingber D E. Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn 2005; 232: 268–281
  • Sanchez-Esteban J, Tsai S W, Sang J, Qin J, Torday J S, Rubin L P. Effects of mechanical forces on lung–specific gene expression. Am J Med Sci 1998; 316: 200–204
  • Li S, Chen B P, Azuma N, Hu Y L, Wu S Z, Sumpio B E, Shyy J Y, Chien S. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. J Clin Invest 1999; 103: 1141–1150
  • Nobes C, Hall A. Regulation and function of the Rho subfamily of small GTPases. Curr Opin Genet Dev 1994; 4: 77–81
  • Tzima E, del Pozo M A, Shattil S J, Chien S, Schwartz M A. Activation of integrins in endothelial cells by fluid shear stress mediates Rho–dependent cytoskeletal alignment. EMBO J 2001; 20: 4639–4647
  • Tzima E, Del Pozo M A, Kiosses W B, Mohamed S A, Li S, Chien S, Schwartz M A. Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J 2002; 21: 6791–6800
  • Wojciak-Stothard B, Ridley A J. Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases. J Cell Biol 2003; 161: 429–439
  • Levesque M J, Nerem R M. The elongation and orientation of cultured endothelial cells in response to shear stress. J Biomechan Eng 1985; 107: 341–347
  • Civelekoglu-Scholey G, Orr A W, Novak I, Meister J J, Schwartz M A, Mogilner A. Model of coupled transient changes of Rac, Rho, adhesions and stress fibers alignment in endothelial cells responding to shear stress. J Theor Biol 2005; 232: 569–585
  • Bishop A L, Hall A. Rho GTPases and their effector proteins. Biochem J 2000; 348: 241–255, (Pt 2)
  • Chaturvedi L S, Marsh H M, Shang X, Zheng Y, Basson M D. Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1. J Biol Chem 2007; 282: 14–28
  • Jaffe A B, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21: 247–269
  • Shiu Y T, Li S, Yuan S, Wang Y, Nguyen P, Chien S. Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun 2003; 303: 548–555
  • Albinsson S, Nordstrom I, Hellstrand P. Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerization. J Biol Chem 2004; 279: 34849–34855
  • Ueyama T, Sakoda T, Kawashima S, Hiraoka E, Hirata K, Akita H, Yokoyama M. Activated RhoA stimulates c-fos gene expression in myocardial cells. Circ Res 1997; 81: 672–678

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.