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Experimental Lung Research Volume 42, 2016 - Issue 4
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Original Articles

The effects of the 5-HT2A receptor antagonist sarpogrelate hydrochloride on chronic hypoxic pulmonary hypertension in rats

Jie GengDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
,
Fen-ling FanDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
,
Sai HeDepartment of Breast Cancer, Shaanxi Provincial Tumor Hospital, Xi'an, Shaanxi, China
,
Ya LiuDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
,
Yan MengDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
,
Hua TianDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
,
Dan ZhangDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
,
Qiang MaDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
,
Jun-bo ZhangDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
&
Hong-yan TianDepartment of Peripheral Vascular Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaCorrespondence[email protected]
 show all
Pages 190-198 | Received 13 Oct 2015, Accepted 30 Mar 2016, Published online: 18 May 2016

References

  • Rabinovitch M. Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest. 2012;122(12):4306–4313.
  • McLaughlin VV, Davis M, Cornwell W. Pulmonary arterial hypertension. Curr Probl Cardiol. 2011 Dec;36(12):461–517.
  • Tuder RM, Yun JH, Bhunia A, Fijalkowska I. Hypoxia and chronic lung disease. J Mol Med (Berlin, Germany). 2007;85(12):1317–1324.
  • Howell K, Preston RJ, McLoughlin P. Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol. 2003;547(Pt 1):133–145.
  • Meyrick B, Reid L. The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study. Lab Invest J Tech Method Pathol. 1978;38(2):188–200.
  • Postolow F, Fediuk J, Nolette N, Hinton M, Dakshinamurti S. Hypoxia and nitric oxide exposure promote apoptotic signaling in contractile pulmonary arterial smooth muscle but not in pulmonary epithelium. Pediatr Pulmonol. 2011;46(12):1194–1208.
  • Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, et al. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension[J]. Amer J Physiol Lung Cell Mol Physiol. 2006;290(3):L450–L458.
  • Sumou IK, Du JB, Wei B, Zhang CY, Qi JG, Tang CS. Effect of L-arginine on pulmonary artery smooth muscle cell apoptosis in rats with hypoxic pulmonary vascular structural remodeling. Acta Biochim Biophys Sin. 2006;38(1):15–21.
  • Gurbanov E, Shiliang X. The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension. Eur J Cardiothorac Surg. 2006 Sep;30(3):499–507.
  • Lambert CM, Roy M, Robitaille GA, Richard DE, Bonnet S. HIF-1 inhibition decreases systemic vascular remodelling diseases bypromoting apoptosis through a hexokinase 2-dependent mechanism. Cardiovasc Res. 2010;88(1):196–204.
  • Liu Y, Tian H, Yan X, Fan F, Wang W, Han J. Serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-HT2A receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension. Exp Lung Res. 2013;39(2):70–79.
  • Igarashi M, Okuda T, Oh-i T, Koga M. Changes in plasma serotonin concentration and acceleration plethysmograms in patients with Raynaud's phenomenon after long-term treatment with a 5-HT2 receptor antagonist. J Dermatol. 2000;27(10):643–650.
  • Miyazaki M, Higashi Y, Goto C, Chayama K, Yoshizumi M, Sanada H, et al. Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease. J Cardiovasc Pharmacol. 2007;49(4):221–227.
  • Kato S, Kishiro I, Machida M, Fuse D, Yoshida T, Kaneko N. Suppressive effect of sarpogrelate hydrochloride on respiratory failure and right ventricular failure with pulmonary hypertension in patients with systemic sclerosis. J Int Med Res. 2000;28(6):258–268.
  • Zhang E, Maruyama J, Yokochi A, Mitani Y, Sawada H, Nishikawa M, et al. Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats. J Anesth. 2015;29(5):715–723.
  • Miyata M, Ito M, Sasajima T, Ohira H, Sato Y, Kasukawa R. Development of monocrotaline-induced pulmonary hypertension is attenuated by a serotonin receptor antagonist. Lung 2000;178(2):63–73.
  • Hironaka E, Hongo M, Sakai A, Mawatari E, Terasawa F, Okumura N, Yamazaki A, Ushiyama Y, Yazaki Y, Kinoshita O. Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Cardiovasc Res. 2003 Dec 1;60(3):692–699.
  • Guibert C, Savineau JP, Crevel H, Marthan R, Rousseau E. Effect of short-term organoid culture on the pharmaco-mechanical properties of rat extra- and intrapulmonaryarteries. Br J Pharmacol. 2005 Nov;146(5):692–701.
  • Rabinovitch M, Gamble W, Nadas AS, Miettinen OS, Reid L. Rat pulmonary circulation after chronic hypoxia: Hemodynamic and structural features. Am J Physiol. 1979 Jun;236(6):H818–H827.
  • Hislop A, Reid L. Arterial changes in Crotalaria spectabilis-induced pulmonary hypertension in rats. Br J Exp Pathol. 1974 Apr;55(2):153–163.
  • Hislop A, Reid L. New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol. 1976 Oct;57(5):542–554.

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