References
- Ryan JJ, Huston J, Kutty S, Hatton ND, Bowman L, Tian L, et al. Right ventricular adaptation and failure in pulmonary arterial hypertension. Can J Cardiol. 2015;31: 391–406.
- Bhargava A, Kumar A, Yuan N, Gewitz MH, Mathew R. Monocrotaline induces interleukin-6 mRNA expression in rat lungs, Heart Dis. 1999;1:126–132.
- Stevens T, Janssen PL, Tucker A. Acute and long-term TNF-alpha administration increases pulmonary vascular reactivity in isolated rat lungs. J Appl Physiol (1985). 1992;73:708–712.
- Fujita M, Shannon JM, Irvin CG, Fagan KA, Cool C, Augustin A, et al. Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2001; 280:L39–L49.
- Groth A, Vrugt B, Brock M, Speich R, Ulrich S, Huber LC. Inflammatory cytokines in pulmonary hypertension. Respir Res. 2014;15:47.
- Rabinovitch M, Guignabert C, Humbert M, Nicolls MR. Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension. Circ Res. 2014;115:165–175.
- Tominaga M, Julius D. Capsaicin receptor in the pain pathway. Jpn J Pharmacol. 2000;83:20–24.
- Zholos AV. TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli. Curr Neuropharmacol. 2015;13:279–291.
- Gibbons CH, Wang N, Freeman R. Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Ann Neurol. 2010;68:888–898.
- Datar P, Srivastava S, Coutinho E, Govil G. Substance P: structure, function, and therapeutics. Curr Top Med Chem. 2004;4:75–103.
- Mashaghi A, Marmalidou A, Tehrani M, Grace PM, Pothoulakis C, Dana R. Neuropeptide substance P and the immune response. Cell Mol Life Sci. 2016;73:4249–4264.
- de Avila ED, de Molon RS, de Godoi Gonçalves DA, Camparis CM. Relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain: a literature review. J Investig Clin Dent. 2014;5:91–97.
- Munoz M, Covenas R, Esteban F, Redondo M. The substance P/NK-1 receptor system: NK-1 receptor antagonists as anti-cancer drugs, J Biosci. 2015;40:441–463.
- Severini C, Petrella C, Calissano P. Substance P and Alzheimer's disease: emerging novel roles. Curr Alzheimer Res. 2016;13:964–972.
- Muñoz M, Coveñas R. Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer:a new approach. Saudi J Gastroenterol. 2016;22:260–268.
- Mistrova E, Kruzliak P, Chottova DM. Role of substance P in the cardiovascular system. Neuropeptides. 2016;58:41–51.
- Sun J, Bhatia M. Substance P at the neuro-immune crosstalk in the modulation of inflammation, asthma and antimicrobial host defense. Inflamm Allergy Drug Targets. 2014;13:112–120.
- Chen KH, Lai YL, Chen MJ. Oxygen radicals and substance P in perinatal hypoxia-exaggerated, monocrotaline-induced pulmonary hypertension. Chin J Physiol. 2012;55:82–90.
- Jessell TM. Substance P in nociceptive sensory neurons. Ciba Found Symp. 1982;91:225–248.
- Chen MJ, Chiang LY, Lai YL. Reactive oxygen species and substance P in monocrotaline-induced pulmonary hypertension. Toxicol Appl Pharmacol. 2001;171:165–173.
- Church AC, Martin DH, Wadsworth R, Bryson G, Fisher AJ, Welsh DJ. The reversal of pulmonary vascular remodeling through inhibition of p38 MAPK-alpha: a potential novel anti-inflammatory strategy in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015;309:L333–L347.
- Tokuda M, Miyamoto R, Sakuta T, Nagaoka S, Torii M. Substance P activates p38 mitogen-activated protein kinase to promote IL-6 induction in human dental pulp fibroblasts. Connect Tissue Res. 2005;46:153–158.
- Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JY, et al. Peroxisome proliferator-activated receptor-gamma ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor.Hypertension. 2012;60:1471–1478.
- Zhu J, Qu C, Lu X, Zhang S. Activation of microglia by histamine and substance P. Cell Physiol Biochem. 2014;34:768–780.
- Voelkel NF, Tuder RM, Bridges J, Arend WP. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am J Respir Cell Mol Biol. 1994;11:664–675.
- Price LC, Shao D, Meng C, Perros F, Garfield BE, Zhu J, et al. Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells. Respir Res. 2015;16:114.
- Katzman NJ, Lai YL. Capsaicin pre-and post-treatment on rat monocrotaline pneumotoxicity.Chin J Physiol. 2000;43:171–178.
- O'Connor TM, O'Connell J, O'Brien DI, Goode T, Bredin CP, Shanahan F. The role of substance P in inflammatory disease. J Cell Physiol. 2004;201:167–180.
- Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 2007;1773:1358–1375.
- Brand A, Smith ES, Lewin GR, Park TJ. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat. PLoS One. 2010;5:e15162.