Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit

References

• Swindle EJ, Davies DE. Artificial airways for the study of respiratory disease. Expert Rev Respir Med. 2011;5(6):757–765.
   PubMed Web of Science ®Google Scholar
• Fricker M, Deane A, Hansbro PM. Animal models of chronic obstructive pulmonary disease. Expert Opin Drug Discov. 2014;9(6):629–645.
   PubMed Web of Science ®Google Scholar
• Mercer PF, Abbott-Banner K, Adcock IM, Knowles RG. Translational models of lung disease. Clin Sci (Lond). 2015;128(4):235–256.
   PubMed Web of Science ®Google Scholar
• Shapiro SD. The use of transgenic mice for modeling airways disease. Pulm Pharmacol Ther. 2008;21(5):699–701.
   PubMed Web of Science ®Google Scholar
• Wenzel S, Holgate ST. The mouse trap: it still yields few answers in asthma. Am J Respir Crit Care Med. 2006;174(11):1173–1176.
   PubMed Web of Science ®Google Scholar
• Churg A, Sin DD, Wright JL. Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use? Am J Respir Cell Mol Biol. 2011;45(6):1111–1115.
   PubMed Web of Science ®Google Scholar
• Hackett TL, Ferrante SC, Hoptay CE, Engelhardt JF, Ingram JL, Zhang Y, et al. A Heterotopic Xenograft Model of human airways for investigating fibrosis in asthma. Am J Respir Cell Mol Biol. 2016; DOI:10.1165/rcmb.2016-0065MA.
   Web of Science ®Google Scholar
• Nicholas B, Staples KJ, Moese S, Meldrum E, Ward J, Dennison P, et al. A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs. J Immunol. 2015;194(12):6144–6154.
   PubMed Web of Science ®Google Scholar
• Morin JP, Baste JM, Gay A, Crochemore C, Corbiere C, Monteil C. Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies. Xenobiotica. 2013;43(1):63–72.
   PubMed Web of Science ®Google Scholar
• Xiao C, Puddicombe SM, Field S, Haywood J, Broughton-Head V, Puxeddu I, et al. Defective epithelial barrier function in asthma. J Allergy Clin Immunol. 2011;128(3):549–556.
   PubMed Web of Science ®Google Scholar
• Pierrou S, Broberg P, O'Donnell RA, Pawlowski K, Virtala R, Lindqvist E, et al. Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;175(6):577–586.
   PubMed Web of Science ®Google Scholar
• Davies DE. The role of the epithelium in airway remodeling in asthma. Proc Am Thorac Soc. 2009;6(8):678–682.
   PubMedGoogle Scholar
• Evans MJ, van Winkle LS, Fanucchi MV, Plopper CG. The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit. Am J Respir Cell Mol Biol. 2000;21(6):655–657.
   PubMed Web of Science ®Google Scholar
• Suwara MI, Green NJ, Borthwick LA, Mann J, Mayer-Barber KD, Barron L, et al. IL-1alpha released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. Mucosal Immunol. 2014;7(3):684–693.
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, et al. Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute. Am J Pathol. 2014;184(6):1643–1651.
   PubMed Web of Science ®Google Scholar
• Tschumperlin DJ. Matrix, mesenchyme, and mechanotransduction. Ann Am Thorac Soc. 2015;12(Suppl 1):S24–S29.
   PubMedGoogle Scholar
• Hurd SZ. Workshop summary and guidelines: investigative use of bronchoscopy, lavage, and bronchial biopsies in asthma and other airway diseases. J Allergy Clin Immunol. 1991;88(5):808–814.
   PubMed Web of Science ®Google Scholar
• Bucchieri F, Marino GA, Pitruzzella A, Fucarino A, Farina F, Howarth P, et al. Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors. PLoS ONE. 2015;10(3):e0120510.
   PubMed Web of Science ®Google Scholar
• Bucchieri F, Fucarino A, Marino GA, Pitruzzella A, Marciano V, Paderni C, et al. Medium-term culture of normal human oral mucosa: a novel three-dimensional model to study the effectiveness of drugs administration. Curr Pharm Des. 2012;18(34):5421–5430.
   PubMed Web of Science ®Google Scholar
• Blaner WS, O'Byrne SM, Wongsiriroj N, Kluwe J, D'Ambrosio DM, Jiang H, et al. Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim Biophys Acta. 2009;1791(6):467–473.
   PubMed Web of Science ®Google Scholar
• Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Lordan JL. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol. 2000;105:193–204.
   PubMed Web of Science ®Google Scholar
• Bracke KR, D'hulst AI, Maes T, Demedts IK, Moerloose KB, Kuziel WA, et al. Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice. Clin Exp Allergy. 2007;37(10):1467–1479.
   PubMed Web of Science ®Google Scholar
• Simet SM, Sisson JH, Pavlik JA, DeVasure JM, Boyer C, Liu X, et al. Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function. Am J Respir Cell Mol Biol. 2010;43(6):635–640.
   PubMed Web of Science ®Google Scholar
• Takeyama K, Jung B, Shim JJ, Burgel PR, Dao-Pick T, Ueki IF, et al. Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2001;280(1):L165–L172.
   PubMed Web of Science ®Google Scholar
• Blume C, Davies DE. In vitro and ex vivo models of human asthma. Eur J Pharm Biopharm. 2013;84(2):394–400.
   PubMed Web of Science ®Google Scholar
• Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang KJ, et al. Engineered in vitro disease models. Annu Rev Pathol. 2015;10:195–262.
   PubMed Web of Science ®Google Scholar
• Swartz MA, Tschumperlin DJ, Kamm RD, Drazen JM. Mechanical stress is communicated between different cell types to elicit matrix remodeling. Proc Natl Acad Sci U S A. 2001;98(11):6180–6185.
   PubMed Web of Science ®Google Scholar
• Sellgren KL, Butala EJ, Gilmour BP, Randell SH, Grego S. A biomimetic multicellular model of the airways using primary human cells. Lab Chip. 2014;14(17):3349–3358.
   PubMed Web of Science ®Google Scholar
• Choe MM, Sporn PH, Swartz MA. An in vitro airway wall model of remodeling. Am J Physiol Lung Cell Mol Physiol. 2003;285(2):L427–L433.
   PubMed Web of Science ®Google Scholar
• Ishikawa S, Ito S. Repeated whole cigarette smoke exposure alters cell differentiation and augments secretion of inflammatory mediators in air-liquid interface three-dimensional co-culture model of human bronchial tissue. Toxicol In Vitro. 2017;38:170–178.
   PubMed Web of Science ®Google Scholar
• Tschumperlin DJ, Shively JD, Kikuchi T, Drazen JM. Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. Am J Respir Cell Mol Biol. 2003;28(2):142–149.
   PubMed Web of Science ®Google Scholar
• Choe MM, Sporn PH, Swartz MA. Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model. Am J Respir Cell Mol Biol. 2006;35(3):306–313.
   PubMed Web of Science ®Google Scholar
• Grainge CL, Lau LC, Ward JA, Dulay V, Lahiff G, Wilson S, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med. 2011;364(21):2006–2015.
   PubMed Web of Science ®Google Scholar
• Gilley SK, Stenbit AE, Pasek RC, Sas KM, Steele SL, Amria M, et al. Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways. Am J Physiol Lung Cell Mol Physiol. 2014;306(2):L162–L169.
   PubMed Web of Science ®Google Scholar
• Cookson W. The immunogenetics of asthma and eczema: a new focus on the epithelium. Nat Rev Immunol. 2004;4(12):978–988.
   PubMed Web of Science ®Google Scholar
• Hansel NN, Pare PD, Rafaels N, Sin DD, Sandford A, Daley D, et al. Genome-wide association study identification of novel loci associated with airway responsiveness in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2015;53(2):226–234.
   PubMed Web of Science ®Google Scholar
• Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodelling in asthma - new insights. J Allergy Clin Immunol. 2003;111:215–225.
   PubMed Web of Science ®Google Scholar
• Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE. Reconstituting organ-level lung functions on a chip. Science. 2010;328(5986):1662–1668.
   PubMed Web of Science ®Google Scholar