SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia

References

• Turrens JF, Freeman BA, Levitt JG, Crapo JD. The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch Biochem Biophys. 1982;217:401–410.
   PubMed Web of Science ®Google Scholar
• Berkelhamer SK, Kim GA, Radder JE, Wedgwood S, Czech L, Steinhorn RH, Schumacker PT. Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung. Free Radic Biol Med. 2013;61:51–60.
   PubMed Web of Science ®Google Scholar
• Resseguie EA, Staversky RJ, Brookes PS, O'Reilly MA. Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction. Redox Biol. 2015;5:176–185.
   PubMed Web of Science ®Google Scholar
• Gardner PR, Nguyen DD, White CW. Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc Natl Acad Sci U.S.A. 1994;91:12248–12252.
   PubMed Web of Science ®Google Scholar
• Panayiotidis MI, Rancourt RC, Allen CB, Riddle SR, Schneider BK, Ahmad S, White CW. Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells. Antioxid Redox Signal. 2004;6:129–136.
   PubMed Web of Science ®Google Scholar
• Kannan S, Pang H, Foster DC, Rao Z, Wu M. Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity. Cell Death Differ. 2006;13:311–323.
   PubMed Web of Science ®Google Scholar
• Barja G. Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxid Redox Signal. 2013;19:1420–1445.
   PubMed Web of Science ®Google Scholar
• Vousden KH, Prives C. Blinded by the light: the growing complexity of p53. Cell. 2009;137:413–431.
   PubMed Web of Science ®Google Scholar
• el-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 1994;54:1169–1174.
   PubMed Web of Science ®Google Scholar
• Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA. p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol. 2006;168:1838–1847.
   PubMed Web of Science ®Google Scholar
• Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, et al. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell. 2004;14:585–598.
   PubMed Web of Science ®Google Scholar
• Gehen SC, Staversky RJ, Bambara RA, Keng PC, O'Reilly MA. hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress. Oncogene. 2008;27:4065–4074.
   PubMed Web of Science ®Google Scholar
• Gewandter JS, Bambara RA, O'Reilly MA. The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA. Cell Cycle. 2011;10:2561–2567.
   PubMed Web of Science ®Google Scholar
• Shiloh Y, Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol. 2013;14:197–210.
   Web of Science ®Google Scholar
• Goodwin JF, Knudsen KE. Beyond DNA repair: DNA-PK function in cancer. Cancer Discov. 2014;4:1126–1139.
   PubMed Web of Science ®Google Scholar
• Schoenberg DR, Maquat LE. Regulation of cytoplasmic mRNA decay. Nat Rev Genet. 2012;13:246–259.
   PubMed Web of Science ®Google Scholar
• Kalifa L, Gewandter JS, Staversky RJ, Sia EA, Brookes PS, O'Reilly MA. DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells. Free Radic Biol Med. 2014;75:30–39.
   PubMed Web of Science ®Google Scholar
• Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP. Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem. 2001;276:22709–22714.
   PubMed Web of Science ®Google Scholar
• Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S. Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev. 2001;15:2215–2228.
   PubMed Web of Science ®Google Scholar
• Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, et al. Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev. 2006;20:355–367.
   PubMed Web of Science ®Google Scholar
• Chen RQ, Yang QK, Chen YL, Oliveira VA, Dalton WS, Fearns C, Lee JD. Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia. J Biol Chem. 2009;284:16752–16758.
   PubMed Web of Science ®Google Scholar
• Oliveira V, Romanow WJ, Geisen C, Otterness DM, Mercurio F, Wang HG, et al. A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2008;283:13174–13184.
   PubMed Web of Science ®Google Scholar
• Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Sci (New York, NY). 2007;318:798–801.
   Google Scholar
• Masse I, Molin L, Mouchiroud L, Vanhems P, Palladino F, Billaud M, Solari F. A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. PloS one. 2008;3:e3354.
   PubMed Web of Science ®Google Scholar
• Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, et al. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol. 2011;31:4417–4429.
   PubMed Web of Science ®Google Scholar
• Yepiskoposyan H, Aeschimann F, Nilsson D, Okoniewski M, Muhlemann O. Autoregulation of the nonsense-mediated mRNA decay pathway in human cells. RNA. 2011;17:2108–2118.
   PubMed Web of Science ®Google Scholar
• Zielonka J, Kalyanaraman B. Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. Free Radic Biol Med. 2010;48:983–1001.
   PubMed Web of Science ®Google Scholar
• Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, et al. A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation. Nucleic Acids Res. 2015;43:7600–7611.
   PubMed Web of Science ®Google Scholar
• Tao W, Levine AJ. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc Natl Acad Sci U.S.A. 1999;96:3077–3080.
   PubMed Web of Science ®Google Scholar
• Porras CA, Bai Y. Respiratory supercomplexes: plasticity and implications. Frontiers Biosci (Landmark Edition). 2015;20:621–634.
   PubMed Web of Science ®Google Scholar
• Ilizarov AM, Koo HC, Kazzaz JA, Mantell LL, Li Y, Bhapat R, et al. Overexpression of manganese superoxide dismutase protects lung epithelial cells against oxidant injury. Am J Respir Cell Mol Biol. 2001;24:436–441.
   PubMed Web of Science ®Google Scholar
• Frank L. Developmental aspects of experimental pulmonary oxygen toxicity. Free Radic Biol Med. 1991;11:463–494.
   PubMed Web of Science ®Google Scholar
• Li J, Gao X, Qian M, Eaton JW. Mitochondrial metabolism underlies hyperoxic cell damage. Free Radic Biol Med. 2004;36:1460–1470.
   PubMed Web of Science ®Google Scholar
• Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, Chumakov PM. The antioxidant function of the p53 tumor suppressor. Nat Med. 2005;11:1306–1313.
   PubMed Web of Science ®Google Scholar
• Gubanova E, Issaeva N, Gokturk C, Djureinovic T, Helleday T. SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways. Cell Cycle. 2013;12:3770–3780.
   PubMed Web of Science ®Google Scholar
• Davis JM, Parad RB, Michele T, Allred E, Price A, Rosenfeld W. Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase. Pediatrics. 2003;111:469–476.
   PubMed Web of Science ®Google Scholar
• Sandberg K, Fellman V, Stigson L, Thiringer K, Hjalmarson O. N-acetylcysteine administration during the first week of life does not improve lung function in extremely low birth weight infants. Biol Neonate. 2004;86:275–279.
   PubMedGoogle Scholar
• Brion LP, Bell EF, Raghuveer TS. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2003;4:CD003665.
   Google Scholar
• Rancourt RC, Hayes DD, Chess PR, Keng PC, O'Reilly MA. Growth arrest in G1 protects against oxygen-induced DNA damage and cell death. J Cell Physiol. 2002;193:26–36.
   PubMed Web of Science ®Google Scholar