194
Views
24
CrossRef citations to date
0
Altmetric
Original Article

Kaempferol attenuates acute lung injury in caecal ligation and puncture model of sepsis in mice

, , , , , , , & show all
Pages 63-78 | Received 20 May 2017, Accepted 18 Dec 2017, Published online: 02 Feb 2018

References

  • Gill SE, Rohan M, Mehta S. Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo. Respir Res. 2015;16:109. doi:10.1186/s12931-015-0266-7.
  • Acosta-Herrera M, Lorenzo-Diaz F, Pino-Yanes M, Corrales A, Valladares F, Klassert TE, et al. Lung transcriptomics during protective ventilatory support in sepsis-induced acute lung injury. PLoS One. 2015;10:e0132296. doi:10.1371/journal.pone.0132296.
  • Villar J, Blanco J, Anon JM, Santos-Bouza A, Blanch L, Ambros A, et al. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med. 2011;37:1932–1941. doi:10.1007/s00134-011-2380-4.
  • Raghavendran K, Pryhuber GS, Chess PR, Davidson BA, Knight PR, Notter RH. Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem. 2008;15:1911–1924. doi:10.2174/092986708785132942.
  • Choudhury S, Kandasamy K, Maruti BS, Addison MP, Kasa JK, Darzi SA, et al. Atorvastatin along with imipenem attenuates acute lung injury in sepsis through decrease in inflammatory mediators and bacterial load. Eur J Pharmacol. 2015;765:447–456. doi:10.1016/j.ejphar.2015.09.009.
  • Calderón-Montaño JM, Burgos-Morón E, Pérez-Guerrero C, López-Lázaro M. A review on the dietary flavonoid kaempferol. Mini Rev Med Chem. 2011;11:298–344. doi:10.2174/138955711795305335.
  • Devi KP, Malar DS, Nabavi SF, Sureda A, Xiao J, Nabavi SM, et al. Kaempferol and inflammation: From chemistry to medicine. Pharmacol Res. 2015;99:1–10. doi:10.1016/j.phrs.2015.05.002.
  • Olszewska M. Separation of quercetin, sexangularetin, kaempferol and isorhamnetin for simultaneous HPLC determination of flavonoid aglycones in inflorescences, leaves and fruits of three Sorbus species. J Pharm Biomed Anal. 2008;48:629–635. doi:10.1016/j.jpba.2008.06.004.
  • Shakya G, Manjini S, Hoda M, Rajagopalan R. Hepatoprotective role of kaempferol during alcohol- and ΔPUFA-induced oxidative stress. J Basic Clin Physiol Pharmacol. 2014;25:73–79. doi:10.1515/jbcpp-2013-0051.
  • Wang M, Sun J, Jiang Z, Xie W, Zhang X. Hepatoprotective effect of kaempferol against alcoholic liver injury in mice. Am J Chin Med. 2015;43:241–254. doi:10.1142/S0192415X15500160.
  • Xiao J, Sun GB, Sun B, Wu Y, He L, Wang X, et al. Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. Toxicology. 2012;292:53–62. doi:10.1016/j.tox.2011.11.018.
  • Suchal K, Malik S, Gamad N, Malhotra RK, Goyal SN, Chaudhary U, et al. Kaempferol attenuates myocardial ischemic injury via inhibition of MAPK signaling pathway in experimental model of myocardial ischemia-reperfusion injury. Oxid Med Cell Longev. 2016;2016:7580731. doi:10.1155/2016/7580731.
  • Kim SH, Park JG, Lee J, Yang WS, Park GW, Kim HG, et al. The dietary flavonoid kaempferol mediates anti-inflammatory responses via the src, syk, IRAK1, and IRAK4 molecular targets. Mediators Inflamm. 2015;2015:904141. doi:10.1155/2015/904142.
  • Yang QS, He LP, Zhou XL, Zhao Y, Shen J, Xu P, et al. Kaempferol pretreatment modulates systemic inflammation and oxidative stress following hemorrhagic shock in mice. Chin Med. 2015;10:6. doi:10.1186/s13020-015-0035-z.
  • Yang EJ, Kim GS, Jun M, Song KS. Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells. Food Funct. 2014;5:1395–1402. doi:10.1039/c4fo00068d.
  • Liao W, Chen L, Ma X, Jiao R, Li X, Wang Y. Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells. Eur J Med Chem. 2016;114:24–32.
  • Chen X, Yang X, Liu T, Guan M, Feng X, Dong W, et al. Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice. Int Immunopharmacol. 2012;14:209–216. doi:10.1016/j.intimp.2012.07.007.
  • Gong JH, Shin D, Han SY, Park SH, Kang MK, Kim JL, et al. Blockade of airway inflammation by kaempferol via disturbing Tyk-STAT signaling in airway epithelial cells and in asthmatic mice. Evid Based Complement Alternat Med. 2013;250725.
  • Zhou YJ, Wang H, Li L, Sui HH, Huang JJ. Inhibitory effect of kaempferol on inflammatory response of lipopolysaccharide-stimulated human mast cells. Yao Xue Xue Bao. 2015;50:702–707.
  • Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock-a review of laboratory models and a proposal. J Surg Res. 1980;29:189–201. doi:10.1016/0022-4804(80)90037-2.
  • Fernanda BAP, Cibele MCPG, Patricia PA. Protective action of a hexane crude extract of Pterodon emarginatus fruits against oxidative and nitrosative stress induced by acute exercise in rats. BMC Complementary Altern Med. 2005;5:17–21. doi:10.1186/1472-6882-5-17.
  • Sedlak J, Lindsay RH. Estimation of total, protein bound and non protein SH groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192–194. doi:10.1016/0003-2697(68)90092-4.
  • Madesh M, Balasubramanium KA. Microtitre plate assay for SOD using MTT reduction by superoxide. Indian J Biochem Biophy. 1998;35:184–188.
  • Aebi M. Catalase, In H.U. Bergmeyer, ed. Methods of enzymatic analysis, second edition, New York: Chemic Academic Press. 1983;673–676.
  • Giustarini D, Rossi R, Milzani A. Nitrite and nitrate measurement by griess reagent in human plasma: evaluation of interferences and standardization. Methods Enzymol. 2008;440:361–380. doi:10.1016/S0076-6879(07)00823-3.
  • Frazier WJ, Wang X, Wancket LM. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice. J Immunol. 2009;183:7411–7419. doi:10.4049/jimmunol.0804343.
  • Luna LG. Manual of histologic staining methods, Armed Forces Institute of Pathology, New York, USA: McGraw Hill Pub. 1968;94–95.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–408. doi:10.1006/meth.2001.1262.
  • Buras JA, Holzmann B, Sitkovsky M. Animal models of sepsis: setting the stage. Nat Rev Drug Discovery 2005;4:854–865. doi:10.1038/nrd1854.
  • Matute-Bello G, Frevert GW, Martin TR. Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008;295:L379–L399. doi:10.1152/ajplung.00010.2008.
  • Xiao H, Remick DG. Correction of perioperative hypothermia decreases experimental sepsis mortality by modulating the inflammatory response. Crit Care Med. 2005;33:161–167. doi:10.1097/01.CCM.0000151049.19253.54.
  • Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol. 2004;202:145–156. doi:10.1002/path.1491.
  • Cao R, Fu K, Lv X. Protective effects of kaempferol on lipopolysaccharide-induced mastitis in mice. Inflammation. 2014;37:1453–1458. doi:10.1007/s10753-014-9870-9.
  • Bobe G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Colburn NH, et al. Interleukin-6 as a potential indicator for prevention of high risk adenoma recurrence by dietary flavonols in the polyp prevention trial. Cancer Prev. Res. 2010;3:764–775. doi:10.1158/1940-6207.CAPR-09-0161.
  • Garcia JJ, Reiter RJ, Guerrero JM. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett. 1997;408:297–300. doi:10.1016/S0014-5793(97)00447-X.
  • Maurya H, Mangal V, Gandhi S, Prabhu K, Ponnudurai K. Prophylactic antioxidant potential of gallic acid in murine model of sepsis. Int J Inflammation. 2014;580320.
  • Gutteridge JMC. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem. 1995;1819–1828.
  • Malmezat T, Breuillé D, Capitan P, Mirand PP, Obled C. Glutathione turnover is increased during the acute phase of sepsis in rats. J Nutr. 2000;130:1239–1246.
  • Birben E, Sahiner UM, Sackesen C. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5:9–19. doi:10.1097/WOX.0b013e3182439613.
  • Rajendran P, Rengarajan T, Nandakumar N, Palaniswami R, Nishigaki Y, Nishigaki I. Kaempferol, a potential cytostatic and cure for inflammatory disorders. Eur J Med Chem. 2014;86:103–112. doi:10.1016/j.ejmech.2014.08.011.
  • Sahu SC, Gray GC. Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nuclei. Cancer Lett. 1996;104:193–6. doi:10.1016/0304-3835(96)04251-6.
  • Galati G, Sabzevari O, Wilson JX, O'Brien PJ. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology. 2002;177:91–104. doi:10.1016/S0300-483X(02)00198-1.
  • Hasan Z, Palani K, Rahman M, Thorlacius H. Targeting CD44 expressed on neutrophils inhibits lung damage in abdominal sepsis. Shock. 2011;35:567–572. doi:10.1097/SHK.0b013e3182144935.
  • Hildebrand F, Pape HC, Harwood P, Muller K, Hoevel P, Putz C, et al. Role of adhesion molecule ICAM in the pathogenesis of polymicrobial sepsis. Exp Toxicol Pathol. 2005;56:281–290. doi:10.1016/j.etp.2004.09.004.
  • Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986;137:245–254.
  • Chen CC, Chow MP, Huang WC, Lin YC, Chang YJ. Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. Mol Pharmacol. 2004;66:683–693.
  • Parida S, Singh TU, Thangamalai R, Narasimha Reddy ChE, Panigrahi M, Kandasamy K, et al. Daidzein pretreatment improves survival in mouse model of sepsis. J Surg Res. 2015;197:363–373. doi:10.1016/j.jss.2015.03.059.
  • Pacher P, Beckman SJ, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007;87:315–424. doi:10.1152/physrev.00029.2006.
  • Choi IS, Choi EY, Jin JY, Park HR, Choi JI, Kim SJ. Kaempferol inhibits P. intermedia lipopolysaccharide-induced production of nitric oxide through translational regulation in murine macrophages: critical role of heme oxygenase-1-mediated ROS reduction. J Periodontol. 2013;84:545–555. doi:10.1902/jop.2012.120180.
  • Park SE, Sapkota K, Kim S, Kim H, Kim SJ. Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells. Br J Pharmacol. 2011;164:1008–1025. doi:10.1111/j.1476-5381.2011.01389.x.
  • Yuan H, Kim JT, Kim SH, Chung SH. Ginseng and Diabetes: The evidences from in vitro, animal and human studies. J Ginseng Res. 2012;36:27–39. doi:10.5142/jgr.2012.36.1.27.
  • Kataoka M, Hirata K, Kunikata T, Ushio S, Iwaki K, Ohashi K, et al. Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against helicobacter pylori-infected Mongolian gerbils. J Gastroenterol. 2001;36:5–9. doi:10.1007/s005350170147.
  • Habbu PV, Mahadevan KM, Shastry RA, Manjunatha H. Antimicrobial activity of flavanoid sulphates and other fractions of Argyreia speciosa (Burm.f) Boj. Indian J Exp Biol. 2009;47:121–128.
  • Gong JH, Shin D, Han SY, Kim JL, Kang YH. Kaempferol suppresses eosinophil infiltration and airway inflammation in airway epithelial cells and in mice with allergic asthma. J Nutr. 2012;142:47–56. doi:10.3945/jn.111.150748.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.