References
- Zhang F, Hang J, Zheng B, et al. The changing epidemiology of asthma in Shanghai, China. J Asthma. 2015;52:465–470. doi:10.3109/02770903.2014.982762. PMID:25387151.
- Akinbami LJ, Moorman JE, Liu X. Asthma prevalence, health care use, and mortality: United States, 2005–2009. Natl Health Stat Report. 2011;32:1--14. Hyattsville, MD: National Center for Health Statistics.
- Schatz M, Rosenwasser L. The allergic asthma phenotype. J Allergy Clin Immunol Pract. 2014;2:645–648. quiz 649. doi:10.1016/j.jaip.2014.09.004. PMID:25439351.
- Rubin BK, Priftis KN, Schmidt HJ, et al. Secretory hyperresponsiveness and pulmonary mucus hypersecretion. Chest. 2014;146:496–507. doi:10.1378/chest.13-2609. PMID:25091755.
- Lacunza E, Ferretti V, Barbeito C, et al. Immunohistochemical evidence of Muc1 expression during rat embryonic development. Eur J Histochem. 2010;54:e49. doi:10.4081/ejh.2010.e49. PMID:21263748.
- Koga T, Kuwahara I, Lillehoj EP, et al. TNF-alpha induces MUC1 gene transcription in lung epithelial cells: its signaling pathway and biological implication. Am J Physiol Lung Cell Mol Physiol. 2007;293:L693–701. doi:10.1152/ajplung.00491.2006. PMID:17575006.
- Hattrup CL, Gendler SJ. Structure and function of the cell surface (tethered) mucins. Annu Rev Physiol. 2008;70:431–457. doi:10.1146/annurev.physiol.70.113006.100659. PMID:17850209.
- Kim KC, Lillehoj EP. MUC1 mucin: a peacemaker in the lung. Am J Respir Cell Mol Biol. 2008;39:644–647. doi:10.1165/rcmb.2008-0169TR. PMID:18617677.
- Choi S, Park YS, Koga T, et al. TNF-alpha is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol. 2011;44:255–260. doi:10.1165/rcmb.2009-0323OC. PMID:20448050.
- Li Y, Dinwiddie DL, Harrod KS, et al. Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2010;298:L558–563. doi:10.1152/ajplung.00225.2009. PMID:20081068.
- Ueno K, Koga T, Kato K, et al. MUC1 mucin is a negative regulator of toll-like receptor signaling. Am J Respir Cell Mol Biol. 2008;38:263–268. doi:10.1165/rcmb.2007-0336RC. PMID:18079492.
- Hamid Q, Tulic MK. New insights into the pathophysiology of the small airways in asthma. Ann Thorac Med. 2007;2:28–33. doi:10.4103/1817-1737.30361. PMID:19724673.
- Wang Y, Bai C, Li K, et al. Role of airway epithelial cells in development of asthma and allergic rhinitis. Respir Med. 2008;102:949–955. doi:10.1016/j.rmed.2008.01.017. PMID:18339528.
- Kato A, Favoreto S, Avila PC, et al. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol. 2007;179:1080–1087. doi:10.4049/jimmunol.179.2.1080. PMID:17617600.
- Imai T, Takase M, Takeda S, et al. Serum KL-6 levels in pediatric patients: reference values for children and levels in pneumonia, asthma, and measles patients. Pediatr Pulmonol. 2002;33:135–141. doi:10.1002/ppul.10044. PMID:11802251.
- Vanacker NJ, Palmans E, Kips JC, et al. Fluticasone inhibits but does not reverse allergen-induced structural airway changes. Am J Respir Crit Care Med. 2001;163:674–679. doi:10.1164/ajrccm.163.3.2004160. PMID:11254522.
- Souma T. The distribution and surface ultrastructure of airway epithelial cells in the rat lung: a scanning electron microscopic study. Arch Histol Jpn. 1987;50:419–436. doi:10.1679/aohc.50.419. PMID:3439845.
- Arantes-Costa FM, Lopes FD, Toledo AC, et al. Effects of residual oil fly ash (ROFA) in mice with chronic allergic pulmonary inflammation. Toxicol Pathol. 2008;36:680–686. doi:10.1177/0192623308317427. PMID:18477768.
- Thavagnanam S, Parker JC, McBrien ME, et al. Effects of IL-13 on mucociliary differentiation of pediatric asthmatic bronchial epithelial cells. Pediatr Res. 2011;69:95–100. doi:10.1203/PDR.0b013e318204edb5. PMID:21076368.
- Hayashi T, Ishii A, Nakai S, et al. Ultrastructure of goblet-cell metaplasia from Clara cell in the allergic asthmatic airway inflammation in a mouse model of asthma in vivo. Virchows Arch. 2004;444:66–73. doi:10.1007/s00428-003-0926-8. PMID:14648220.
- Pastor-Soler NM, Sutton TA, Mang HE, et al. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015;308:F1452–1462. doi:10.1152/ajprenal.00066.2015. PMID:25925251.
- Castorina A, Giunta S. Mucin 1 (MUC1) signalling contributes to increase the resistance to cell death in human bronchial epithelial cells exposed to nickel acetate. Biometals. 2014;27:1149–1158. doi:10.1007/s10534-014-9776-x. PMID:25053108.
- Lillehoj EP, Hyun SW, Kim BT, et al. Muc1 mucins on the cell surface are adhesion sites for Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol. 2001;280:L181–187. doi:10.1152/ajplung.2001.280.1.L181. PMID:11133508.
- Lillehoj EP, Kim BT, Kim KC. Identification of Pseudomonas aeruginosa flagellin as an adhesin for Muc1 mucin. Am J Physiol Lung Cell Mol Physiol. 2002;282:L751–756. doi:10.1152/ajplung.00383.2001. PMID:11880301.
- Lu W, Hisatsune A, Koga T, et al. Cutting edge: Enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. Journal of Immunology. 2006;176:3890–3894. doi:10.4049/jimmunol.176.7.3890.
- Iikura M, Hojo M, Koketsu R, et al. The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. PLoS One. 2015;10:e0123584. doi:10.1371/journal.pone.0123584. PMID:25901797.
- Palmans E, Kips JC, Pauwels RA. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am J Respir Crit Care Med. 2000;161:627–635. doi:10.1164/ajrccm.161.2.9902094. PMID: 0673209.
- Lai SK, Wang YY, Wirtz D, et al. Micro- and macrorheology of mucus. Adv Drug Deliv Rev. 2009;61:86–100. doi:10.1016/j.addr.2008.09.012. PMID:19166889.
- Turner J, Jones CE. Regulation of mucin expression in respiratory diseases. Biochem Soc Trans. 2009;37:877–881. doi:10.1042/BST0370877. PMID:19614611.
- Ishinaga H, Kitano M, Toda M, et al. Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells. Cytokine. 2017;90:60–65. doi:10.1016/j.cyto.2016.10.010. PMID:27776277.
- Bae CH., Choi YS., Song SY, et al. Effect of thymic stromal lymphopoietin on MUC5B expression in human airway epithelial cells. Biochem Biophys Res Commun. 2014; 448: 231–235. doi:10.1016/j.bbrc.2014.04.100. PMID:24792379.
- Zhang L, Lu R, Zhao G, et al. TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. Int J Biochem Cell Biol. 2011;43:1383–1391. doi:10.1016/j.biocel.2011.06.003. PMID:21684348.
- Kato K, Lillehoj EP, Park YS, et al. Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88. J Immunol. 2012;188:2014–2022. doi:10.4049/jimmunol.1102405. PMID:22250084.
- Li X, Chen Q, Chu C, et al. Ovalbumin-induced experimental allergic asthma is Toll-like receptor 2 dependent. Allergy Asthma Proc. 2014;35:e15–20. doi:10.2500/aap.2014.35.3735. PMID:24717780.