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Original Article

CB2R agonist prevents nicotine induced lung fibrosis

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Pages 344-351 | Received 28 Jun 2018, Accepted 29 Oct 2018, Published online: 24 Jan 2019

References

  • Gamaleddin I, Wertheim C, Zhu AZ, et al. Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking. Addict Biol. 2012 Jan;17(1):47–61. doi:10.1111/j.1369-1600.2011.00314.x.
  • Castañé A, Berrendero F, Maldonado R. The role of the cannabinoid system in nicotine addiction. Pharmacol Biochem Behav. 2005;81(2):381–386.
  • Balerio GN, Aso E, Maldonado R. Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology (Berl). 2006;184(3-4):504–513.
  • Ignatowska-Jankowska BM, Muldoon PP, Lichtman AH, Damaj MI. The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. Psychopharmacology (Berl). 2013 Oct;229(4):591–601. doi:10.1007/s00213-013-3117-6.
  • Navarrete F, Rodríguez-Arias M, Martín-García E, et al. Role of CB2 cannabinoid receptors in the rewarding, reinforcing and physical effects of nicotine. Neuropsychopharmacology. 2013 Nov;38(12):2515– 2524. doi:10.1038/npp.2013.157.
  • Croxford JL, Yamamura T. Cannabinoids and the immune system: potential for the treatment of inflammatory diseases? J Neuroimmunol. 2005;166(1-2):3–18.
  • Frei RB, Luschnig P, Parzmair GP, et al. Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice. Allergy. 2016;71(7):944–956. doi:10.1111/all.12858.
  • Cinar R, Gochuico BR, Iyer MR, et al. Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis. ReJCI Insight. 2017;2(8):e92281. doi:10.1172/jci.insight.92281
  • Tam J, Liu J, Mukhopadhyay B, Cinar R, Godlewski G, Kunos G. Endocannabinoids in liver disease. Hepatology. 2011;53(1):346–355.doi:10.1002/hep.24077.
  • Xu H, Cheng CL, Chen M, et al. Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. J Leukoc Biol. 2007;82(3):532–541.
  • Servettaz A, Kavian N, Nicco C, et al. Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis. Am J Pathol. 2010;177(1):187–196. doi:10.2353/ajpath.2010.090763.
  • Schweitzer KS, Chen SX, Law S, et al. Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L175–L187. doi:10.1152/ajplung.00411.2014.
  • Vicary GW, Ritzenthaler JD, Panchabhai TS, Torres-González E, Roman J. Nicotine stimulates collagen type I expression in lung via α7 nicotinic acetylcholine receptors. Respir Res. 2017;18(1):115. doi:10.1186/s12931-017-0596-8.
  • Marriott KS, Huffman JW. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Curr Top Med Chem.2008;8(3):187–204.
  • Kruk-Slomka M, Banaszkiewicz I, Biala G. The Impact of CB2 Receptor Ligands on the MK-801-Induced Hyperactivity in Mice. Neurotox Res. 2017;31(3):410–420. doi:10.1007/s12640-017-9702-4.
  • Jenkin KA, O'Keefe L, Simcocks AC, et al. Renal effects of chronic pharmacological manipulation of CB2 receptors in rats with diet‐induced obesity. British Jou rnal of Pharmacology 2016;173:1128–1142.
  • Varghese F, Bukhari AB, Malhotra R, De A. IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples. PLoS One. 2014;9(5):e96801. doi:10.1371/journal.pone.0096801.
  • Hernández-Morera P, Castaño-González I, Travieso-González CM, Mompeó-Corredera B, Ortega-Santana F. Quantification and Statistical Analysis Methods for Vessel Wall Components from Stained Images with Masson's Trichrome. PLoS One. 2016;11(1): e0146954. doi:10.1371/journal.pone.0146954.
  • Seyed Jafari SM, Hunger RE. IHC Optical Density Score: A New Practical Method for Quantitative Immunohistochemistry Image Analysis. Appl Immunohistochem Mol Morphol. 2017;25(1):e12–e13.
  • Hübner RH, Gitter W, El Mokhtari NE, et al. Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques. 2008;44(4):507–11, 514-7. doi:10.2144/000112729.
  • Mishra A, Chaturvedi P, Datta S, Sinukumar S, Joshi P, Garg A. Harmful effects of nicotine. Indian J Med Paediatr Oncol. 2015;36(1):24–31. doi:10.4103/0971-5851.151771.
  • Flower M, Nandakumar L, Singh M, Wyld D, Windsor M, Fielding D. Respiratory bronchiolitis-associated interstitial lung disease secondary to electronic nicotine delivery system use confirmed with open lung biopsy. Respirol Case Rep. 2017;3;5(3):e00230. doi:10.1002/rcr2.230.
  • Moussad EE, Brigstock DR. Connective tissue growth factor: what's in a name? Mol Genet Metab. 2000;71(1–2):276–292.
  • Zhang YP, Li WB, Wang WL, et al. siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats. Acta Pharmacol Sin. 2012; 33(7):897–908. doi:10.1038/aps.2012.39.
  • Blaauboer ME, Boeijen FR, Emson CL, et al. Extracellular matrix proteins: a positive feedback loop in lung fibrosis? Matrix Biol. 2014;34:170–178. doi:10.1016/j.matbio.2013.11.002.
  • Krebs M, Sakurai R, Torday JS, Rehan VK. Evidence for in vivo nicotine-induced alveolar interstitial fibroblast-to-myofibroblast transdifferentiation. Exp Lung Res. 2010;36(7):390–398. doi:10.3109/01902141003714023.
  • Hinz B. Mechanical aspects of lung fibrosis: a spotlight on the myofibroblast. Proc Am Thorac Soc. 2012;9(3):137–147. doi:10.1513/pats.201202-017AW.
  • Ponticos M, Holmes AM, Shi-wen X, et al. Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum. 2009 Jul;60(7):2142–2155. doi:10.1002/art.24620.
  • Pandey R, Mousawy K, Nagarkatti M, Nagarkatti P. Endocannabinoids and immune regulation. Pharmacol Res. 2009;60(2):85–92. doi:10.1016/j.phrs.2009.03.019.
  • Jia J, Peng J, Li Z, et al. Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to β Amyloid via Protein Kinase C. Mediators Inflamm. 2016;4854378. doi:10.1155/2016/4854378
  • Balistreri E, Garcia-Gonzalez E, Selvi E, et al. The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model. Ann Rheum Dis. 2011 Apr;70(4):695–699. doi:10.1136/ard.2010.137539.
  • Lowin T, Pongratz G, Straub RH. The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets. J Inflamm (Lond). 2016;13:15.doi:10.1186/s12950-016-0114-7
  • Fu Q, Zheng Y, Dong X, Wang L, Jiang CG. Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice. Oncotarget. 2017;8(61):103486–103498. doi:10.18632/oncotarget.21975.
  • Rokicki W, Rokicki M, Wojtacha J, Dżeljijli A. The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases. Kardiochir Torakochirurgia Pol. 2016;13(1):26–30. doi:10.5114/kitp.2016.58961.
  • Lenssen J, Stolk J. Pulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema. Int J Chron Obstruct Pulmon Dis. 2007;2(2):131–139.
  • Burstein SH. Ajulemic acid: potential treatment for chronic inflammation. Pharmacol Res Perspect. 2018;6(2):e00394. doi:10.1002/prp2.394.
  • Tam J, Hinden L, Drori A, Udi S, Azar S, Baraghithy S. The therapeutic potential of targeting the peripheral endocannabinoid/CB1 receptor system. Eur J Intern Med. 2018;49:23–29. doi:10.1016/j.ejim.2018.01.009.
  • Ma H, Zhang G, Mou C, Fu X, Chen Y. Peripheral CB1 Receptor Neutral Antagonist, AM6545, Ameliorates Hypometabolic Obesity and Improves Adipokine Secretion in Monosodium Glutamate Induced Obese Mice. Front Pharmacol. 2018, 20;9:156. doi:10.3389/fphar.2018.00156.
  • Al-Obaidi S, Mathew TC, Dean E. Exercise may offset nicotine-induced injury in lung tissue: a preliminary histological study based on a rat model. Exp Lung Res. 2012;38(4):211–221. doi:10.3109/01902148.2012.666331.
  • Gonzalez EG, Selvi E, Balistreri E, et al. Synthetic cannabinoid ajulemic acid exerts potent antifibrotic effects in experimental models of systemic sclerosis. Ann Rheum Dis. 2012;71(9):1545–1551.doi:10.1136/annrheumdis-2011-200314.
  • Lucattelli M, Fineschi S, Selvi E, et al. Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung. Respir Res. 2016;17(1):49. doi:10.1186/s12931-016-0373-0.

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