Small and large airways’ reactions to inhaled capsaicin in patients with chronic idiopathic cough, or asthma and in healthy control subjects

References

• Morice AH, Fontana GA, Sovijarvi AR. The diagnosis and management of chronic cough. Eur Respir J. 2004;24(3):481–492. doi:10.1183/09031936.04.00027804.
   PubMed Web of Science ®Google Scholar
• Song WJ, Chang YS, Faruqi S, et al. Defining chronic cough: A systematic review of the epidemiological literature. Allergy Asthma Immunol Res. 2016;8(2):146–155. doi:10.4168/aair.2016.8.2.146.
   PubMed Web of Science ®Google Scholar
• Haque RA, Usmani OS, Barnes PJ. Chronic idiopathic cough: a discrete clinical entity? Chest 2005;127(5):1710–1713. doi:10.1378/chest.127.5.1710.
   PubMed Web of Science ®Google Scholar
• Ternesten-Hasseus E, Larsson C, Larsson S, Millqvist E. Capsaicin sensitivity in patients with chronic cough- results from a cross-sectional study. Cough 2013;9(1):5. doi:10.1186/1745-9974-9-5.
   PubMedGoogle Scholar
• Song WJ, Chang YS, Faruqi S, et al. The global epidemiology of chronic cough in adults: a systematic review and meta-analysis. Eur Respir J. 2015;45(5):1479–1481. doi:10.1183/09031936.00218714.
   PubMed Web of Science ®Google Scholar
• Koskela H, Purokivi M. [Chronic cough: common problem, discontended patients]. Duodecim. 2014;130(18):1827–1833.
   PubMedGoogle Scholar
• Ternesten-Hasseus E, Larsson S, Millqvist E. Symptoms induced by environmental irritants and health-related quality of life in patients with chronic cough - A cross-sectional study. Cough 2011;7:6. doi:10.1186/1745-9974-7-6.
   PubMedGoogle Scholar
• French CL, Irwin RS, Curley FJ, Krikorian CJ. Impact of chronic cough on quality of life. Arch Intern Med. 1998;158(15):1657–1661.
   PubMedGoogle Scholar
• Caterina M, Schumacher M, Tominaga M, Rosen T, Levine J, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389(6653):816–823. doi:10.1038/39807.
   PubMed Web of Science ®Google Scholar
• Groneberg DA, Niimi A, Dinh QT, et al. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med. 2004;170(12):1276–1280. doi:10.1164/rccm.200402-174OC.
   PubMed Web of Science ®Google Scholar
• Mitchell JE, Campbell AP, New NE, et al. Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough. Exp. Lung Res 2005;31(3):295–306.
   PubMed Web of Science ®Google Scholar
• Niimi A, Chung KF. Evidence for neuropathic processes in chronic cough. Pulmonary Pharmacology & Therapeutics. 2015;35:100–104. doi:10.1016/j.pupt.2015.10.004.
   PubMed Web of Science ®Google Scholar
• Chung KF, McGarvey L, Mazzone SB. Chronic cough as a neuropathic disorder. Lancet Respir Med. 2013;1(5):414–422. doi:10.1016/S2213-2600(13)70043-2.
   PubMed Web of Science ®Google Scholar
• Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319–338. doi:10.1183/09031936.05.00034805.
   PubMed Web of Science ®Google Scholar
• Brashier B, Salvi S. Measuring lung function using sound waves: role of the forced oscillation technique and impulse oscillometry system. Breathe 2015;11(1):57–65. (Sheff). doi:10.1183/20734735.020514.
   Web of Science ®Google Scholar
• Dubois AB, Botelho SY, Bedell GN, Marshall R, Comroe JH. Jr. A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J Clin Invest. 1956;35(3):322–326. doi:10.1172/JCI103281.
   PubMed Web of Science ®Google Scholar
• Oostveen E, MacLeod D, Lorino H, et al. The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J. 2003;22(6):1026–1041. doi:10.1183/09031936.03.00089403.
   PubMed Web of Science ®Google Scholar
• Aronsson D, Tufvesson E, Bjermer L. Comparison of central and peripheral airway involvement before and during methacholine, mannitol and eucapnic hyperventilation challenges in mild asthmatics. Clin Respir J. 2011;5(1):10–18. doi:10.1111/j.1752-699X.2009.00183.x.
   PubMed Web of Science ®Google Scholar
• van der Wiel E, Postma DS, van der Molen T, Schiphof-Godart L, Ten Hacken NH, van den Berge M. Effects of small airway dysfunction on the clinical expression of asthma: a focus on asthma symptoms and bronchial hyper-responsiveness. Allergy 2014;69(12):1681–1688. doi:10.1111/all.12510.
   PubMed Web of Science ®Google Scholar
• Kjellberg S, Houltz BK, Zetterstrom O, Robinson PD, Gustafsson PM. Clinical characteristics of adult asthma associated with small airway dysfunction. Respir Med. 2016;117:92–102. doi:10.1016/j.rmed.2016.05.028.
   PubMed Web of Science ®Google Scholar
• Haruna A, Oga T, Muro S, et al. Relationship between peripheral airway function and patient-reported outcomes in COPD: a cross-sectional study. BMC Pulm Med 2010;10 :10. doi:10.1186/1471-2466-10-10.
   PubMedGoogle Scholar
• Guan WJ, Gao YH, Xu G, et al. Impulse oscillometry in adults with bronchiectasis. Annals Ats. 2015;12(5):657–665. doi:10.1513/AnnalsATS.201406-280OC.
   Google Scholar
• Johansson EL, Ternesten-Hasseus E, Gustafsson P, Pullerits T, Arvidsson M, Millqvist E. Small and large airway reactions to osmotic stimuli in asthma and chronic idiopathic cough. Pulm Pharmacol Ther. 2018;49:112–118. doi:10.1016/j.pupt.2018.02.001.
   PubMed Web of Science ®Google Scholar
• Dicpinigaitis PV, Alva RV. Safety of capsaicin cough challenge testing. Chest 2005;128(1):196–202. doi:10.1378/chest.128.1.196.
   PubMed Web of Science ®Google Scholar
• Ekstrand Y, Ternesten-Hasséus E, Arvidsson M, Löfdahl K, Palmqvist M, Millqvist E. Sensitivity to environmental irritants and capsaicin cough reaction in patients with a positive methacholine provocation test before and after treatment with inhaled corticosteroids. J Asthma. 2011;48(5):482–489. doi:10.3109/02770903.2011.570405.
   PubMed Web of Science ®Google Scholar
• Satia I, Tsamandouras N, Holt K, et al. Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction. J Allergy Clin Immunol. 2017;139(3):771–779. e710. doi:10.1016/j.jaci.2016.04.045.
   PubMed Web of Science ®Google Scholar
• Pullerits T, Ternesten-Hasseus E, Johansson EL, Millqvist E. Capsaicin cough threshold test in diagnostics. Respir Med. 2014;108(9):1371–1376. doi:10.1016/j.rmed.2014.07.012.
   PubMed Web of Science ®Google Scholar
• Holst H, Arendt-Nielsen L, Mosbech H, Vesterhauge S, Elberling J. The capsaicin cough reflex in patients with symptoms elicited by odorous chemicals. Int J Hyg Environ Health. 2010;213(1):66–71. doi:10.1016/j.ijheh.2009.08.005.
   PubMed Web of Science ®Google Scholar
• Crapo RO, Casaburi R, Coates AL, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med. 2000;161(1):309–329. doi:10.1164/ajrccm.161.1.ats11-99.
   PubMed Web of Science ®Google Scholar
• Johansson A, Lowhagen O, Millqvist E, Bende M. Capsaicin inhalation test for identification of sensory hyperreactivity. Respir Med. 2002;96(9):731–735.
   PubMed Web of Science ®Google Scholar
• Global initiative for asthma (GINA) [database on the Internet]. National Institutes of Health 2017 [cited 180920]. Available from: www.ginaasthma.org
   Google Scholar
• Sterk PJ, Fabbri LM, Quanjer PH, et al. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl. 1993;16:53–83.
   PubMedGoogle Scholar
• Morice AH, Faruqi S, Wright CE, Thompson R, Bland JM. Cough hypersensitivity syndrome: a distinct clinical entity. Lung 2011;189(1):73–79. doi:10.1007/s00408-010-9272-1.
   PubMed Web of Science ®Google Scholar
• Johansson EL, Ternesten HE. Reliability and Validity of the Swedish Version of the Hull Airway Reflux Questionnaire (HARQ-S). Lung 2016;194(6):997–1005. doi:10.1007/s00408-016-9937-5.
   PubMed Web of Science ®Google Scholar
• Ternesten-Hasseus E, Lowhagen O, Millqvist E. Quality of life and capsaicin sensitivity in patients with airway symptoms induced by chemicals and scents: a longitudinal study. Environ Health Perspect. 2007;115(3):425–429. doi:10.1289/ehp.9624.
   PubMed Web of Science ®Google Scholar
• Morice AH, Fontana GA, Belvisi MG, et al. ERS guidelines on the assessment of cough. Eur Respir J. 2007;29(6):1256–1276. doi:10.1183/09031936.00101006.
   PubMed Web of Science ®Google Scholar
• Dicpinigaitis PV, Rauf K. The influence of gender on cough reflex sensitivity. Chest 1998;113(5):1319–1321.
   PubMed Web of Science ®Google Scholar
• Chen RC, Lai KF, Liu CL, Luo W, Zheng JP, Ns Z. [The development and safety of cough provocation test by capsaicin inhalation]. Zhonghua Jie He He Hu Xi Za Zhi 2005;28(11):751–754.
   PubMedGoogle Scholar
• Millqvist E. Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like symptoms. Allergy 2000;55(6):546–550.
   PubMed Web of Science ®Google Scholar
• Fuller RW, Dixon CM, Barnes PJ. Bronchoconstrictor response to inhaled capsaicin in humans. J Appl Physiol.1985;58(4):1080–1084. doi:10.1152/jappl.1985.58.4.1080.
   PubMed Web of Science ®Google Scholar
• Doherty MJ, Mister R, Pearson MG, Calverley PM. Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease. Thorax 2000;55(8):643–649.
   PubMed Web of Science ®Google Scholar
• Dicpinigaitis PV. Capsaicin responsiveness in asthma and COPD. Thorax 2001;56(2):162
   PubMed Web of Science ®Google Scholar
• Hilton EC, Baverel PG, Woodcock A, Van Der Graaf PH, Smith JA. Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point. J Allergy Clin Immunol. 2013;132(4):847–855. e841-845. doi:10.1016/j.jaci.2013.04.042.
   PubMed Web of Science ®Google Scholar