Schisandrin B inhibits TGF-β1-induced epithelial-mesenchymal transition in human A549 cells through epigenetic silencing of ZEB1

References

• Wendt MK, Allington TM, Schiemann WP. Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future Oncology. 2009;5(8):1145. doi:10.2217/fon.09.90.
   PubMed Web of Science ®Google Scholar
• Bremnes RM, Veve R, Hirsch FR, Franklin WA. The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis. Lung Cancer. 2002;36(2):115.
   PubMed Web of Science ®Google Scholar
• Phan SH. Biology of fibroblasts and myofibroblasts. Proc Am Thoracic Soc. 2008;5(3):334. doi:10.1513/pats.200708-146DR.
   PubMedGoogle Scholar
• Yoshida J, Horiuchi A, Kikuchi N, et al. Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression. Med Mol Morphol. 2009;42(2):82. doi:10.1007/s00795-008-0436-5.
   PubMed Web of Science ®Google Scholar
• Puisieux A, Brabletz T, Caramel J. Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol. 2014;16(6):488. doi:10.1038/ncb2976.
   PubMed Web of Science ®Google Scholar
• Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer. 2007;7(6):415. doi:10.1038/nrc2131.
   PubMed Web of Science ®Google Scholar
• Melhem A, Stern M, Shibolet O, et al. Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial. J. Clin. Gastroenterol. 2005;39(8):737. doi:10.1097/01.mcg.0000174023.73472.29.
   PubMed Web of Science ®Google Scholar
• Yasukawa K, Ikeya Y, Mitsuhashi H, et al. Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 1992;49(1):68. doi:10.1159/000227014.
   PubMed Web of Science ®Google Scholar
• Min HY, Park EJ, Hong JY, et al. Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. Bioorganic & Med Chem Lett. 2008;18(2):523. doi:10.1016/j.bmcl.2007.11.082.
   PubMed Web of Science ®Google Scholar
• Chiu PY, Ko KM. Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats. Mol Cell Biochem. 2004;266(1/2):139. doi:10.1023/B:MCBI.0000049151.79238.30.
   PubMed Web of Science ®Google Scholar
• Kim EY, Baek IH, Rhyu MR. Cardioprotective effects of aqueous Schizandra chinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: effects on serum lipid profiles and blood pressure. J. Ethnopharmacol. 2011;134(3):668. doi:10.1016/j.jep.2011.01.019.
   PubMed Web of Science ®Google Scholar
• Chien CF, Wu YT, Tsai TH. Biological analysis of herbal medicines used for the treatment of liver diseases. Biomed. Chromatogr 2011;25(1–2):21.
   PubMed Web of Science ®Google Scholar
• Amaryan G, Astvatsatryan V, Gabrielyan E, Panossian A, Panosyan V, Wikman G. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard–a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Phytomed: Int J Phytother Phytopharmacol. 2003;10(4):271. doi:10.1078/094471103322004767.
   PubMed Web of Science ®Google Scholar
• Oh BG, Lee H, Kim Y, et al. Inhibitory effects of Schizandrae Fructus on eotaxin secretion in A549 human epithelial cells and eosinophil migration. Phytomed: Int J Phytother Phytopharmacol. 2009;16(9):814.
   PubMed Web of Science ®Google Scholar
• Lv XJ, Zhao LJ, Hao YQ, et al. Schisandrin B inhibits the proliferation of human lung adenocarcinoma A549 cells by inducing cycle arrest and apoptosis. Int J Clin Exp Med 2015;8(5):6926.
   PubMed Web of Science ®Google Scholar
• Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. TGF-beta1 induces human alveolar epithelial to Mesenchymal Cell Transition (EMT). Resp Res. 2005;6:56.
   PubMed Web of Science ®Google Scholar
• Gao Y, Zhao Y, Zhang J, et al. The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Scientific Rep. 2016;6:19874.
   PubMed Web of Science ®Google Scholar
• Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139(5):871. doi:10.1016/j.cell.2009.11.007.
   PubMed Web of Science ®Google Scholar
• Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420. doi:10.1172/JCI39104.
   PubMed Web of Science ®Google Scholar
• Shook D, Keller R. Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Devel. 2003;120(11):1351. doi:10.1016/j.mod.2003.06.005.
   PubMed Web of Science ®Google Scholar
• Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003;112(12):1776. doi:10.1172/JCI200320530.
   PubMed Web of Science ®Google Scholar
• Grunert S, Jechlinger M, Beug H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol. 2003;4(8):657. doi:10.1038/nrm1175.
   PubMed Web of Science ®Google Scholar
• Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Developmental Cell. 2008;14(6):818. doi:10.1016/j.devcel.2008.05.009.
   PubMed Web of Science ®Google Scholar
• Bouyssou JM, Manier S, Huynh D, Issa S, Roccaro AM, Ghobrial IM. Regulation of microRNAs in cancer metastasis. Biochim et Biophys Acta. 2014;1845(2):255. doi:10.1016/j.bbcan.2014.02.002.
   PubMed Web of Science ®Google Scholar
• Perez RE, Navarro A, Rezaiekhaligh MH, Mabry SM, Ekekezie II. TRIP-1 regulates TGF-beta1-induced epithelial-mesenchymal transition of human lung epithelial cell line A549. Am J Physiol. Lung Cellular Mol Physiol. 2011;300(5):L799. doi:10.1152/ajplung.00350.2010.
   PubMed Web of Science ®Google Scholar
• Panossian A, Hamm R, Kadioglu O, Wikman G, Efferth T. Synergy and antagonism of active constituents of ADAPT-232 on transcriptional level of metabolic regulation of isolated neuroglial cells. Front Neurosci, 2013;7:16.
   PubMed Web of Science ®Google Scholar
• Park JH, Yoon J. Schizandrin inhibits fibrosis and epithelial-mesenchymal transition in transforming growth factor-beta1-stimulated AML12 cells. Int Immunopharmacol. 2015;25(2):276. doi:10.1016/j.intimp.2015.02.014.
   PubMed Web of Science ®Google Scholar
• Zhang D, Liu B, Cao B, et al. Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-beta1/Smad2 pathways and overexpression of NOX4. Int Immunopharmacol. 2017;48:67. doi:10.1016/j.intimp.2017.04.024.
   PubMed Web of Science ®Google Scholar
• Chun JN, Park S, Lee S, et al. Schisandrol B and schisandrin B inhibit TGFbeta1-mediated NF-kappaB activation via a Smad-independent mechanism. Oncotarget 2018;9(3):3121.
   PubMedGoogle Scholar
• Radisky DC. Epithelial-mesenchymal transition. J Cell Sci. 2005;118(19):4325. doi:10.1242/jcs.02552.
   PubMed Web of Science ®Google Scholar
• Ohira T, Gemmill RM, Ferguson K, et al. WNT7a induces E-cadherin in lung cancer cells. Proc Nat Acad Sci USA. 2003;100(18):10429. doi:10.1073/pnas.1734137100.
   PubMed Web of Science ®Google Scholar
• Takeyama Y, Sato M, Horio M, et al. Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Cancer Lett. 2010;296(2):216. doi:10.1016/j.canlet.2010.04.008.
   PubMed Web of Science ®Google Scholar
• Chinnadurai G. Transcriptional regulation by C-terminal binding proteins. Int J Biochem Cell Biol. 2007;39(9):1593. doi:10.1016/j.biocel.2007.01.025.
   PubMed Web of Science ®Google Scholar
• Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349(21):2042. doi:10.1056/NEJMra023075.
   PubMed Web of Science ®Google Scholar
• Sanders YY, Pardo A, Selman M, et al. Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2008;39(5):610. doi:10.1165/rcmb.2007-0322OC.
   PubMed Web of Science ®Google Scholar
• Coward WR, Watts K, Feghali-Bostwick CA, Knox A, Pang L. Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. Mol Cell Biol. 2009;29(15):4325. doi:10.1128/MCB.01776-08.
   PubMed Web of Science ®Google Scholar
• Voigt P, Tee WW, Reinberg D. A double take on bivalent promoters. Genes Dev. 2013;27(12):1318. doi:10.1101/gad.219626.113.
   PubMed Web of Science ®Google Scholar