STAT1 participates in the induction of substance P expression in airway epithelial cells by respiratory syncytial virus

References

• Nelson DA, Bost KL. Non-neuronal mammalian tachykinin expression. Front Biosci. 2004;9:2166–2176. doi:10.2741/1372.
   PubMed Web of Science ®Google Scholar
• Bracci-Laudiero L, Aloe L, Caroleo MC, et al. Endogenous NGF regulates CGRP expression in human monocytes, and affects HLA-DR and CD86 expression and IL-10 production. Blood. 2005;106(10):3507–3514. doi:10.1182/blood-2004-10-4055.
   PubMed Web of Science ®Google Scholar
• Stewart JP, Kipar A, Cox H, Payne C, Vasiliou S, Quinn JP. Induction of tachykinin production in airway epithelia in response to viral infection. PLoS One. 2008;3(3):e1673 doi:10.1371/journal.pone.0001673.
   PubMed Web of Science ®Google Scholar
• Dakhama A, Park J, Taube C, et al. Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2005;288(4):L761–L770. doi:10.1152/ajplung.00143.2004.
   PubMed Web of Science ®Google Scholar
• Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW. Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev. 2014;94(1):265–301. doi:10.1152/physrev.00031.2013.
   PubMed Web of Science ®Google Scholar
• Hökfelt T, Pernow B, Wahren J. Substance P: a pioneer amongst neuropeptides. J Intern Med. 2001;249(1):27–40. doi:10.1046/j.0954-6820.2000.00773.x.
   PubMed Web of Science ®Google Scholar
• Devane CL. Substance P: a new era, a new role. Pharmacotherapy. 2001;21(9):1061–1069. doi:10.1592/phco.21.13.1061.34612.
   PubMed Web of Science ®Google Scholar
• Yang L, Di G, Qi X, et al. Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor. Diabetes. 2014;63(12):4262–4274. doi:10.2337/db14-0163.
   PubMed Web of Science ®Google Scholar
• Luo Y, Li P, Zhang C, et al. Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure. Inflamm Res. 2013;62(12):1053–1061. doi:10.1007/s00011-013-0664-6.
   PubMed Web of Science ®Google Scholar
• Samarasinghe AE, Hoselton SA, Schuh JM. Spatio-temporal localization of vasoactive intestinal peptide and neutral endopeptidase in allergic murine lungs. Regul Pept. 2010;164(2-3):151–157. doi:10.1016/j.regpep.2010.05.017.
   PubMedGoogle Scholar
• Larsson O, Tengroth L, Xu Y, Uddman R, Kumlien Georén S, Cardell L. Substance P represents a novel first-line defense mechanism in the nose. J Allergy Clin Immunol. 2018;141(1):128–136. doi:10.1016/j.jaci.2017.01.021.
   PubMed Web of Science ®Google Scholar
• Kowalska K, Carr DB, Lipkowski AW. Direct antimicrobial properties of substance P. Life Sci. 2002;71(7):747–750. doi:10.1016/s0024-3205(02)01740-x.
   PubMed Web of Science ®Google Scholar
• Stein RT, Bont LJ, Zar H, et al. Respiratory syncytial virus hospitalization and mortality: Systematic review and meta-analysis. Pediatr Pulmonol. 2017;52(4):556–569. doi:10.1002/ppul.23570.
   PubMed Web of Science ®Google Scholar
• Huang H, Deng L, Xiao F, et al. Clinical analysis of children with pertussis and significance of respiratory virus detection in the combined diagnosis. Zhonghua er ke za zhi [Chinese Journal of Pediatrics]. 2017;55(8):580. doi:10.3760/cma.j.issn.0578-1310.2017.08.007.
   PubMedGoogle Scholar
• Sundaram ME, Meece JK, Sifakis F, Gasser RA, Belongia EA. Medically attended respiratory syncytial virus infections in adults aged ≥ 50 years: clinical characteristics and outcomes. Clin Infect Dis. 2014;58(3):342–349. doi:10.1093/cid/cit767.
   PubMed Web of Science ®Google Scholar
• Tripp RA, Moore D, Winter J, Anderson LJ. Respiratory syncytial virus infection and g and/or sh protein expression contribute to substance P, which mediates inflammation and enhanced pulmonary disease in BALB/c mice. J Virol. 2000;74(4):1614–1622. doi:10.1128/JVI.74.4.1614-1622.2000.
   PubMed Web of Science ®Google Scholar
• Haynes LM, Jones LP, Barskey A, Anderson LJ, Tripp RA. Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to g glycoprotein CX3C-CX3CR1 interaction and expression of substance P. J Virol. 2003;77(18):9831–9844. doi:10.1128/JVI.77.18.9831-9844.2003.
   PubMed Web of Science ®Google Scholar
• Haynes LM, Tonkin J, Anderson LJ, Tripp RA. Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infection. J Virol. 2002;76(14):6873–6881. doi:10.1128/jvi.76.14.6873-6881.2002.
   PubMed Web of Science ®Google Scholar
• King KA, Hu C, Rodriguez MM, Romaguera R, Jiang X, Piedimonte G. Exaggerated neurogenic inflammation and substance P receptor upregulation in RSV-infected weanling rats. Am J Respir Cell Mol Biol. 2001;24(2):101–107. doi:10.1165/ajrcmb.24.2.4264.
   PubMed Web of Science ®Google Scholar
• Semple MG, Dankert HM, Ebrahimi B, et al. Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P. PLoS One. 2007;2(10):e1038 doi:10.1371/journal.pone.0001038.
   PubMed Web of Science ®Google Scholar
• Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev. 2001;14(4):778–809. doi:10.1128/CMR.14.4.778-809.2001.
   PubMed Web of Science ®Google Scholar
• Di Domizio J, Blum A, Gallagher-Gambarelli M, Molens J, Chaperot L, Plumas J. TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN. Blood. 2009;114(9):1794–1802. doi:10.1182/blood-2009-04-216770.
   PubMed Web of Science ®Google Scholar
• Symes A, Lewis S, Corpus L, Rajan P, Hyman SE, Fink JS. STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines. Mol Endocrinol. 1994;8(12):1750–1763. doi:10.1210/mend.8.12.7708062.
   PubMedGoogle Scholar
• Servidei T, Aoki Y, Lewis SE, Symes A, Fink JS, Reeves SA. Coordinate regulation of STAT signaling and c-fos expression by the tyrosine phosphatase SHP-2. J Biol Chem. 1998;273(11):6233–6241. doi:10.1074/jbc.273.11.6233.
   PubMed Web of Science ®Google Scholar
• Ramaswamy M, Shi L, Varga SM, Barik S, Behlke MA, Look DC. Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology. 2006;344(2):328–339. doi:10.1016/j.virol.2005.09.009.
   PubMed Web of Science ®Google Scholar
• Lo MS, Brazas RM, Holtzman MJ. Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness. J Virol. 2005;79(14):9315–9319. doi:10.1128/JVI.79.14.9315-9319.2005.
   PubMed Web of Science ®Google Scholar
• Tripp RA, Dakhama A, Jones LP, Barskey A, Gelfand EW, Anderson LJ. The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P. J Virol. 2003;77(11):6580–6584. doi:10.1128/JVI.77.11.6580-6584.2003.
   PubMed Web of Science ®Google Scholar
• Li X, Fu ZF, Alvarez R, Henderson C, Tripp RA. Respiratory syncytial virus (RSV) Infects neuronal cells and processes that innervate the lung by a process involving RSV G protein. J Virol. 2006;80(1):537–540. doi:10.1128/JVI.80.1.537-540.2006.
   PubMed Web of Science ®Google Scholar
• Park Y, Lee J, Kwak J, et al. Fractalkine induces angiogenic potential in CX3CR1-expressing monocytes. J Leukoc Biol. 2018;103(1):53–66. doi:10.1189/jlb.1A0117-002RR.
   PubMed Web of Science ®Google Scholar
• Ho WZ, Lai JP, Zhu XH, Uvaydova M, Douglas SD. Human monocytes and macrophages express substance P and neurokinin-1 receptor. J Immunol. 1997;159(11):5654–5660.
   PubMed Web of Science ®Google Scholar
• Tang H, Inoue A, Iwasa M, Hide I, Nakata Y. Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin. J Neurochem. 2006;97(5):1412–1418. doi:10.1111/j.1471-4159.2006.03830.x.
   PubMed Web of Science ®Google Scholar
• Yasui K, Baba A, Iwasaki Y, et al. Neutrophil-mediated inflammation in respiratory syncytial viral bronchiolitis. Pediatr. Int. 2005;47(2):190–195. doi:10.1111/j.1442-200x.2005.02039.x.
   PubMed Web of Science ®Google Scholar
• Deng Y, Herbert JA, Smith CM, Smyth RL. An in vitro transepithelial migration assay to evaluate the role of neutrophils in respiratory syncytial virus (RSV) induced epithelial damage. Sci Rep. 2018;8(1):6777. doi:10.1038/s41598-018-25167-4.
   PubMed Web of Science ®Google Scholar