References
- Lederer DJ, Martinez FJ. Idiopathic pulmonary fibrosis. N Engl J Med. 2018;378(19):1811–1823. doi:https://doi.org/10.1056/NEJMra1705751.
- Barratt S, Creamer A, Hayton C, Chaudhuri N. Idiopathic pulmonary fibrosis (IPF): An overview. JCM. 2018;7(8):201. doi:https://doi.org/10.3390/jcm7080201.
- Phan THG, Paliogiannis P, Nasrallah GK, et al. Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis. Cell Mol Life Sci. 2021;78(5):2031–2057. doi:https://doi.org/10.1007/S00018-020-03693-7.
- Sakai N, Tager AM. Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis. Biochim Biophys Acta. 2013;1832(7):911–921. doi:https://doi.org/10.1016/j.bbadis.2013.03.001.
- Xu X, Zheng L, Yuan Q, et al. Transforming growth factor-β in stem cells and tissue homeostasis. Bone Res. 2018;6(1):2–31. doi:https://doi.org/10.1038/s41413-017-0005-4.
- Frangogiannis NG. Transforming growth factor–ß in tissue fibrosis. J Exp Med. 2020;217(3):e20190103. doi:https://doi.org/10.1084/jem.20190103.
- Herrera J, Henke CA, Bitterman PB. Extracellular matrix as a driver of progressive fibrosis. J Clin Invest. 2018;128(1):45–53. doi:https://doi.org/10.1172/JCI93557.
- Gabasa M, Duch P, Jorba I, et al. Epithelial contribution to the profibrotic stiff microenvironment and myofibroblast population in lung fibrosis. Mol Biol Cell. 2017;28(26):3741–3755. doi:https://doi.org/10.1091/mbc.E17-01-0026.
- Giménez A, Duch P, Puig M, Gabasa M, Xaubet A, Alcaraz J. Dysregulated collagen homeostasis by matrix stiffening and TGF-β1 in fibroblasts from idiopathic pulmonary fibrosis patients: Role of FAK/Akt. IJMS. 2017;18(11):2431. doi:https://doi.org/10.3390/ijms18112431.
- Vicens-Zygmunt V, Estany S, Colom A, et al. Fibroblast viability and phenotypic changes within glycated stiffened three-dimensional collagen matrices. Respir Res. 2015;16(1):82. doi:https://doi.org/10.1186/s12931-015-0237-z.
- Carrington R, Jordan S, Pitchford SC, Page CP. Use of animal models in IPF research. Pulm Pharmacol Ther. 2018;51:73–78. doi:https://doi.org/10.1016/j.pupt.2018.07.002.
- Sundarakrishnan A, Chen Y, Black LD, Aldridge BB, Kaplan DL. Engineered cell and tissue models of pulmonary fibrosis. Adv Drug Deliv Rev. 2018;129:78–94. doi:https://doi.org/10.1016/j.addr.2017.12.013.
- Rhee S. Fibroblasts in three dimensional matrices: Cell migration and matrix remodeling. Exp Mol Med. 2009;41(12):858–865. doi:https://doi.org/10.3858/emm.2009.41.12.096.
- Knight E, Przyborski S. Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro. J Anat. 2015;227(6):746–756. doi:https://doi.org/10.1111/joa.12257.
- Langhans SA. Three-dimensional in vitro cell culture models in drug discovery and drug repositioning. Front Pharmacol. 2018;9(JAN):6. doi:https://doi.org/10.3389/fphar.2018.00006.
- Raghu G, Collard HR, Egan JJ, ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183(6):788–824. doi:https://doi.org/10.1164/rccm.2009-040GL.
- Heidebrecht F, Schulz I, Keller M, Behrens S-E, Bader A. Improved protocols for protein and RNA isolation from three-dimensional collagen sandwich cultures of primary hepatocytes. Anal Biochem. 2009;393(1):141–144. doi:https://doi.org/10.1016/j.ab.2009.06.017.
- Woodley JP, Lambert DW, Asencio IO. Understanding Fibroblast Behaviour in 3D biomaterials. Tissue Eng Part B Rev. 2021 Aug 16. doi:https://doi.org/10.1089/ten.TEB.2021.0010.
- Jensen C, Teng Y. Is it time to start transitioning from 2D to 3D cell culture? Front Mol Biosci. 2020;7:33. doi:https://doi.org/10.3389/fmolb.2020.00033.
- Htwe SS, Cha BH, Yue K, Khademhosseini A, Knox AJ, Ghaemmaghami AM. Role of Rho-Associated coiled-coil forming kinase isoforms in regulation of stiffness-induced myofibroblast differentiation in lung fibrosis. Am J Respir Cell Mol Biol. 2017;56(6):772–783. doi:https://doi.org/10.1165/rcmb.2016-0306OC.
- Estany S, Vicens-Zygmunt V, Llatós R, et al. Lung fibrotic tenascin-C upregulation is associated with other extracellular matrix proteins and induced by TGFβ1. BMC Pulm Med. 2014;14(1):120. doi:https://doi.org/10.1186/1471-2466-14-120.
- Pardo A, Cabrera S, Maldonado M, Selman M. Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis. Respir Res. 2016;17(1):23. doi:https://doi.org/10.1186/s12931-016-0343-6.
- Mendez MG, Restle D, Janmey PA. Vimentin enhances cell elastic behavior and protects against compressive stress. Biophys J. 2014;107(2):314–323. doi:https://doi.org/10.1016/j.bpj.2014.04.050.
- Agis H, Collins A, Taut AD, et al. Cell population kinetics of collagen scaffolds in Ex Vivo oral wound repair. PLoS One. 2014;9(11):e112680. doi:https://doi.org/10.1371/journal.pone.0112680.
- Koukourakis MI, Kalamida D, Mitrakas AG, et al. Metabolic cooperation between co-cultured lung cancer cells and lung fibroblasts. Lab Invest. 2017;97(11):1321–1331. doi:https://doi.org/10.1038/labinvest.2017.79.
- Abulaiti A, Shintani Y, Funaki S, et al. Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6. Lung Cancer. 2013;82(2):204–213. doi:https://doi.org/10.1016/j.lungcan.2013.08.008.
- Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res. 2005;6(1):56. doi:https://doi.org/10.1186/1465-9921-6-56.
- Shintani Y, Abulaiti A, Kimura T, et al. Pulmonary fibroblasts induce epithelial mesenchymal transition and some characteristics of stem cells in non-small cell lung cancer. Ann Thorac Surg. 2013;96(2):425–433. doi:https://doi.org/10.1016/j.athoracsur.2013.03.092.
- Conforti F, Ridley R, Brereton C, et al. Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis. Cell Death Discov. 2020;6(1):1–11. doi:https://doi.org/10.1038/s41420-020-0289-9.
- Rogel MR, Soni PN, Troken JR, Sitikov A, Trejo HE, Ridge KM. Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells. Faseb J. 2011;25(11):3873–3883. doi:https://doi.org/10.1096/fj.10-170795.
- Kim KK, Kugler MC, Wolters PJ, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006;103(35):13180–13185. doi:https://doi.org/10.1073/pnas.0605669103.
- Tzouvelekis A, Herazo-Maya JD, Slade M, et al. Validation of the prognostic value of MMP-7 in idiopathic pulmonary fibrosis. Respirology. 2017;22(3):486–493. doi:https://doi.org/10.1111/resp.12920.
- Dancer RCA, Wood AM, Thickett DR. Metalloproteinases in idiopathic pulmonary fibrosis. Eur Respir J. 2011;38(6):1461–1467. doi:https://doi.org/10.1183/09031936.00024711.
- Correll KA, Edeen KE, Zemans RL, et al. Transitional human alveolar type II epithelial cells suppress extracellular matrix and growth factor gene expression in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019;317(2):L283–L294. doi:https://doi.org/10.1152/ajplung.00337.2018.