BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling

References

• Cevhertas L, Ogulur I, Maurer DJ, et al. Advances and recent developments in asthma in 2020. Allergy. 2020;75(12):3124–3146. doi:10.1111/all.14607.
   PubMed Web of Science ®Google Scholar
• Trikamjee T, Comberiati P, Peter J. Pediatric asthma in developing countries: challenges and future directions. Curr Opin Allergy Clin Immunol. 2022;22(2):80–85. doi:10.1097/ACI.0000000000000806.
   PubMed Web of Science ®Google Scholar
• Papadopoulos NG, Miligkos M, Xepapadaki P. A current perspective of allergic asthma: from mechanisms to management. Handb Exp Pharmacol. 2022;268:69–93. doi:10.1007/164_2021_483.
   PubMedGoogle Scholar
• Camoretti-Mercado B, Lockey RF. Airway smooth muscle pathophysiology in asthma. J Allergy Clin Immunol. 2021;147(6):1983–1995. doi:10.1016/j.jaci.2021.03.035.
   PubMed Web of Science ®Google Scholar
• Kardas G, Daszyńska-Kardas A, Marynowski M, Brząkalska O, Kuna P, Panek M. Role of platelet-derived growth factor (PDGF) in asthma as an immunoregulatory factor mediating airway remodeling and possible pharmacological target. Front Pharmacol. 2020;11(47):47.
   PubMed Web of Science ®Google Scholar
• Hough KP, Curtiss ML, Blain TJ. Airway remodeling in asthma. Front Med (Lausanne). 2020;7:191.
   PubMed Web of Science ®Google Scholar
• Ojiaku CA, Yoo EJ, Panettieri RA.Jr. Transforming growth factor beta1 function in airway remodeling and hyperresponsiveness. the missing link? Am J Respir Cell Mol Biol. 2017;56(4):432–442. doi:10.1165/rcmb.2016-0307TR.
   PubMed Web of Science ®Google Scholar
• Arteaga-Badillo DA, Portillo-Reyes J, Vargas-Mendoza N, et al. Asthma: new integrative treatment strategies for the next decades. Medicina (Kaunas). 2020;56(9):438. doi:10.3390/medicina56090438.
   PubMed Web of Science ®Google Scholar
• Wang KCW, Donovan GM, James AL, Noble PB. Asthma: Pharmacological degradation of the airway smooth muscle layer. Int J Biochem Cell Biol. 2020;126:105818. doi:10.1016/j.biocel.2020.105818.
   PubMed Web of Science ®Google Scholar
• Yu X, Li Z, Shen J. BRD7: a novel tumor suppressor gene in different cancers. Am J Transl Res. 2016;8(2):742–748.
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhao R, Wei Y, et al. BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141. J Exp Clin Cancer Res. 2018;37(1):64. doi:10.1186/s13046-018-0734-2.
   PubMed Web of Science ®Google Scholar
• Fujisawa T, Filippakopoulos P. Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Nat Rev Mol Cell Biol. 2017;18(4):246–262. doi:10.1038/nrm.2016.143.
   PubMed Web of Science ®Google Scholar
• Kaeser MD, Aslanian A, Dong MQ, Yates JR, 3rd, Emerson BM. BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J Biol Chem. 2008;283(47):32254–32263. doi:10.1074/jbc.M806061200.
   PubMed Web of Science ®Google Scholar
• Mantovani F, Drost J, Voorhoeve PM, Del Sal G, Agami R. Gene regulation and tumor suppression by the bromodomain-containing protein BRD7. Cell Cycle. 2010;9(14):2777–2781. doi:10.4161/cc.9.14.12309.
   PubMed Web of Science ®Google Scholar
• Wang H, Xie Y. BRD7-mediated miR-3148 inhibits progression of cervical cancer by targeting Wnt3a/beta-catenin pathway. Reprod Sci. 2020;27(3):877–887. doi:10.1007/s43032-019-00091-8.
   PubMed Web of Science ®Google Scholar
• Lee JM, Liu R, Park SW. The regulatory subunits of PI3K, p85alpha and p85beta, differentially affect BRD7-mediated regulation of insulin signaling. J Mol Cell Biol. 2022;13(12):889–901. doi:10.1093/jmcb/mjab073.
   PubMed Web of Science ®Google Scholar
• Park SW, Lee JM. Emerging roles of BRD7 in pathophysiology. IJMS. 2020;21(19):7127. doi:10.3390/ijms21197127.
   Web of Science ®Google Scholar
• Lee JM, Kim Y, Salazar Hernández MA, Han Y, Liu R, Park SW. BRD7 deficiency leads to the development of obesity and hyperglycemia. Sci Rep. 2019;9(1):5327. doi:10.1038/s41598-019-41713-0.
   PubMed Web of Science ®Google Scholar
• Chen C-L, Mo H-Q, Jiang Y-H, et al. BRD7 inhibits tumor progression by positively regulating the p53 pathway in hepatocellular carcinoma. J Cancer. 2021;12(5):1507–1519. doi:10.7150/jca.50293.
   PubMed Web of Science ®Google Scholar
• Niu W, Luo Y, Zhou Y, et al. BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition. J Exp Clin Cancer Res. 2020;39(1):30. doi:10.1186/s13046-019-1493-4.
   PubMed Web of Science ®Google Scholar
• Yu X, Jiang N, Li J, Li X, He S. Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3beta-dependent manner. Tissue Cell. 2022;76:101813. doi:10.1016/j.tice.2022.101813.
   PubMed Web of Science ®Google Scholar
• Zhou B, Lin W, Long Y, et al. Notch signaling pathway: architecture, disease, and therapeutics. Signal Transduct Target Ther. 2022;7(1):95.
   PubMed Web of Science ®Google Scholar
• Sprinzak D, Blacklow SC. Biophysics of Notch signaling. Annu Rev Biophys. 2021;50:157–189. doi:10.1146/annurev-biophys-101920-082204.
   PubMed Web of Science ®Google Scholar
• Hunter GL, Giniger E. Phosphorylation and proteolytic cleavage of Notch in canonical and noncanonical Notch signaling. Adv Exp Med Biol. 2020;1227:51–68. doi:10.1007/978-3-030-36422-9_4.
   PubMed Web of Science ®Google Scholar
• Hammad H, Lambrecht BN. Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma. Nat Immunol. 2020;21(11):1313–1314. doi:10.1038/s41590-020-0797-z.
   PubMed Web of Science ®Google Scholar
• Huang MT, Chiu CJ, Chiang BL. Multi-faceted Notch in allergic airway inflammation. IJMS. 2019;20(14):3508. doi:10.3390/ijms20143508.
   Web of Science ®Google Scholar
• Li X, Zou F, Lu Y, et al. Notch1 contributes to TNF-α-induced proliferation and migration of airway smooth muscle cells through regulation of the Hes1/PTEN axis. Int Immunopharmacol. 2020;88:106911. doi:10.1016/j.intimp.2020.106911.
   PubMed Web of Science ®Google Scholar
• Nie Y, Yang B, Hu J, Zhang L, Ma Z. Bruceine D ameliorates the balance of Th1/Th2 in a mouse model of ovalbumin-induced allergic asthma via inhibiting the NOTCH pathway. Allergol Immunopathol (Madr). 2021;49(6):73–79. doi:10.15586/aei.v49i6.499.
   PubMed Web of Science ®Google Scholar
• Wu Y, Lu Y, Zou F, et al. PTEN participates in airway remodeling of asthma by regulating CD38/Ca(2+)/CREB signaling. Aging (Albany NY). ). 2020;12(16):16326–16340. doi:10.18632/aging.103664.
   PubMedGoogle Scholar
• Li H, Yang T, Wu R, Chen T, Sun Z, Yang L. Salidroside inhibits platelet-derived growth factor-induced proliferation and migration of airway smooth muscle cells. J Cell Biochem. 2019;120(4):6642–6650. doi:10.1002/jcb.27960.
   PubMed Web of Science ®Google Scholar
• Sun J, Nie J, Hao B, et al. Ceap/BLOS2 interacts with BRD7 and selectively inhibits its transcription-suppressing effect on cellular proliferation-associated genes. Cell Signal. 2008;20(6):1151–1158. doi:10.1016/j.cellsig.2008.02.002.
   PubMed Web of Science ®Google Scholar
• Xu K, Xiong W, Zhou M, et al. Integrating ChIP-sequencing and digital gene expression profiling to identify BRD7 downstream genes and construct their regulating network. Mol Cell Biochem. 2016;411(1-2):57–71. doi:10.1007/s11010-015-2568-y.
   PubMed Web of Science ®Google Scholar
• Luo Y, Wang X, Niu W, et al. BRD7 stabilizes P53 via dephosphorylation of MDM2 to inhibit tumor growth in breast cancer harboring wild-type p53. J Cancer. 2022;13(5):1436–1448. doi:10.7150/jca.67447.
   PubMed Web of Science ®Google Scholar
• Dang X, He B, Ning Q, Liu Y, Chang Y, Chen M. Suppression of TRIM8 by microRNA-182-5p restricts tumor necrosis factor-α-induced proliferation and migration of airway smooth muscle cells through inactivation of NF-Κb. Int Immunopharmacol. 2020;83:106475. doi:10.1016/j.intimp.2020.106475.
   PubMed Web of Science ®Google Scholar
• Wei F, Hao Y. TRIP6 accelerates the proliferation and migration of fetal airway smooth muscle cells by enhancing YAP activation. Int Immunopharmacol. 2020;82:106366. doi:10.1016/j.intimp.2020.106366.
   PubMed Web of Science ®Google Scholar
• Zhou M, Cui ZL, Guo XJ, et al. Blockade of Notch signalling by γ-secretase inhibitor in lung T cells of asthmatic mice affects T cell differentiation and pulmonary inflammation. Inflammation. 2015;38(3):1281–1288. doi:10.1007/s10753-014-0098-5.
   PubMed Web of Science ®Google Scholar
• Li Q, Wu Y, Guo X, et al. Protocatechuic acid supplement alleviates allergic airway inflammation by inhibiting the IL-4Rα-STAT6 and Jagged 1/Jagged2-Notch1/Notch2 pathways in allergic asthmatic mice. Inflamm Res. 2020;69(10):1027–1037. doi:10.1007/s00011-020-01379-1.
   PubMed Web of Science ®Google Scholar
• Zeng Z, Wang L, Ma W, et al. Inhibiting the Notch signaling pathway suppresses Th17-associated airway hyperresponsiveness in obese asthmatic mice. Lab Invest. 2019;99(12):1784–1794. doi:10.1038/s41374-019-0294-x.
   PubMed Web of Science ®Google Scholar
• Hu M, Ou-Yang HF, Han XP, Ti XY, Wu CG. KyoT2 downregulates airway remodeling in asthma. Int J Clin Exp Pathol. 2015;8(11):14171–14179.
   PubMed Web of Science ®Google Scholar