Metformin alleviates lung ischemia–reperfusion injury in a rat lung transplantation model

References

• Yusen RD, Edwards LB, Dipchand AI, International Society for Heart and Lung Transplantation, et al. The registry of the international society for heart and lung transplantation: thirty-third adult lung and heart-lung transplant report-2016; Focus Theme: primary diagnostic indications for transplant. J Heart Lung Transplant. 2016;35(10):1170–1184. doi:10.1016/j.healun.2016.09.001.
   PubMed Web of Science ®Google Scholar
• Altun GT, Arslantaş MK, Cinel İ. Primary graft dysfunction after lung transplantation. Turk J Anaesthesiol Reanim. 2015;43(6):418–423. doi:10.5152/TJAR.2015.16443.
   PubMedGoogle Scholar
• Christie JD, Kotloff RM, Ahya VN, et al. The effect of primary graft dysfunction on survival after lung transplantation. Am J Respir Crit Care Med. 2005;171(11):1312–1316. doi:10.1164/rccm.200409-1243OC.
   PubMed Web of Science ®Google Scholar
• Fiser SM, Tribble CG, Long SM, et al. Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome. Ann Thorac Surg. 2002;73(4):1041–1048. doi:10.1016/s0003-4975(01)03606-2.
   PubMed Web of Science ®Google Scholar
• Huang HJ, Yusen RD, Meyers BF, et al. Late primary graft dysfunction after lung transplantation and bronchiolitis obliterans syndrome. Am J Transplant. 2008;8(11):2454–2462. doi:10.1111/j.1600-6143.2008.02389.x.
   PubMed Web of Science ®Google Scholar
• Piwkowska A, Rogacka D, Jankowski M, et al. Metformin induces suppression of NAD(P)H oxidase activity in podocytes. Biochem Biophys Res Commun. 2010;393(2):268–273. doi:10.1016/j.bbrc.2010.01.119.
   PubMed Web of Science ®Google Scholar
• Wu K, Tian R, Huang J, et al. Metformin alleviated endotoxemia-induced acute lung injury via restoring AMP Kdependent suppression of mTOR. Chem Biol Interact. 2018;291:1–6. doi:10.1016/j.cbi.2018.05.018.
   PubMed Web of Science ®Google Scholar
• Zhang X, Shang F, Hui L, et al. The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism. Saudi Pharm J. 2017;25(4):666–670. doi:10.1016/j.jsps.2017.05.001.
   PubMed Web of Science ®Google Scholar
• Huang KY, Que JQ, Hu ZS, et al. Metformin suppresses inflammation and apoptosis of myocardiocytes by inhibiting autophagy in a model of ischemia-reperfusion injury. Int J Biol Sci. 2020;16(14):2559–2579. doi:10.7150/ijbs.40823.
   PubMed Web of Science ®Google Scholar
• Leech T, Chattipakorn N, Chattipakorn SC. The beneficial roles of metformin on the brain with cerebral ischaemia/reperfusion injury. Pharmacol Res. 2019;146:104261. doi:10.1016/j.phrs.2019.104261.
   PubMed Web of Science ®Google Scholar
• Westerkamp AC, Fujiyoshi M, Ottens PJ, et al. Metformin preconditioning improves hepatobiliary function and reduces injury in a rat model of normothermic machine perfusion and orthotopic transplantation. Transplantation. 2020;104(9):e271–e280. doi:10.1097/TP.0000000000003216.
   PubMed Web of Science ®Google Scholar
• Chen-Yoshikawa TF. Ischemia-reperfusion injury in lung transplantation. Cells. 2021;10(6):1333. doi:10.3390/cells10061333.
   PubMed Web of Science ®Google Scholar
• Laubach VE, Sharma AK. Mechanisms of lung ischemia-reperfusion injury. Curr Opin Organ Transplant. 2016;21(3):246–252.
   PubMed Web of Science ®Google Scholar
• Eltzschig HK, Eckle T. Ischemia and reperfusion—from mechanism to translation. Nat Med. 2011;17(11):1391–1401. doi:10.1097/MOT.0000000000000304.
   PubMed Web of Science ®Google Scholar
• Chatterjee S, Nieman GF, Christie JD, Fisher AB. Shear stress-related mechanosignaling with lung ischemia: lessons from basic research can inform lung transplantation. Am J Physiol Lung Cell Mol Physiol. 2014;307(9):L668–80. doi:10.1152/ajplung.00198.2014.
   PubMed Web of Science ®Google Scholar
• Wang M, Liu Y, Liang Y, et al. Systematic understanding of pathophysiological mechanisms of oxidative stress-related conditions-diabetes mellitus, cardiovascular diseases, and ischemia-reperfusion injury. Front Cardiovasc Med. 2021;8:649785. doi:10.3389/fcvm.2021.649785.
   PubMed Web of Science ®Google Scholar
• Ferrari RS, Andrade CF. Oxidative stress and lung ischemia-reperfusion injury. Oxid Med Cell Longev. 2015;2015:590987–590914. doi:10.1155/2015/590987.
   PubMed Web of Science ®Google Scholar
• Liang S, Wang Y, Liu Y. Dexmedetomidine alleviates lung ischemia-reperfusion injury in rats by activating P I3K/Akt pathway. Eur Rev Med Pharmacol Sci. 2019;23(1):370–377. doi:10.26355/eurrev_201901_16785.
   PubMed Web of Science ®Google Scholar
• Vasilyev N, Williams T, Brennan ML, et al. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation. 2005;112(18):2812–2820. doi:10.1161/CIRCULATIONAHA.105.542340.
   PubMed Web of Science ®Google Scholar
• Matthijsen RA, Huugen D, Hoebers NT, et al. Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion. Am J Pathol. 2007;171(6):1743–1752. doi:10.2353/ajpath.2007.070184.
   PubMed Web of Science ®Google Scholar
• Ghasemnejad-Berenji M, Ghazi-Khansari M, Yazdani I, et al. Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats. Andrologia. 2018;50(2):e12846. doi:10.1111/and.12846.
   Web of Science ®Google Scholar
• Zeng J, Zhu L, Liu J, et al. Metformin Protects against Oxidative Stress Injury Induced by Ischemia/Reperfusion via Regulation of the lncRNA-H19/miR-148a-3p/Rock2 Axis. Oxid Med Cell Longev. 2019;2019:8768327–8768318. doi:10.1155/2019/8768327.
   PubMed Web of Science ®Google Scholar
• Cahova M, Palenickova E, Dankova H, et al. Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. Am J Physiol Gastrointest Liver Physiol. 2015;309(2):G100–11. doi:10.1152/ajpgi.00329.2014.
   PubMed Web of Science ®Google Scholar
• Wu L, Cen Y, Feng M, et al. Metformin Activates the Protective Effects of the AMP K Pathway in Acute Lung Injury Caused by Paraquat Poisoning. Oxid Med Cell Longev. 2019 ;Oct 302019:1709718–1709710. doi:10.1155/2019/1709718. P MID: 31781324.
   PubMed Web of Science ®Google Scholar
• Bertheloot D, Latz E, Franklin BS. Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Cell Mol Immunol. 2021;18(5):1106–1121. doi:10.1038/s41423-020-00630-3.
   PubMed Web of Science ®Google Scholar
• den Hengst WA, Gielis JF, Lin JY, et al. Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process. Am J Physiol Heart Circ Physiol. 2010;299(5):H1283–99. doi:10.1152/ajpheart.00251.2010.
   PubMed Web of Science ®Google Scholar
• Cartron PF, Juin P, Oliver L, et al. Impact of proapoptotic proteins Bax and Bak in tumor progression and response to treatment. Expert Rev Anticancer Ther. 2003;3(4):563–570. doi:10.1586/14737140.3.4.563.
   PubMedGoogle Scholar
• Niture SK, Jaiswal AK. Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance. Free Radic Biol Med. 2013;57:119–131. doi:10.1016/j.freeradbiomed.2012.12.014.
   PubMed Web of Science ®Google Scholar