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Ultrastructural Pathology Volume 25, 2001 - Issue 2
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Research Article

Electron Microscopic Detection of Copper in the Liver of Two Patients with Morbus Wilson by EELS and EDX

Ludwig Jonas Electron Microscopic Centre, Medical Faculty of the University of Rostock, Rostock, Germany
,
Gerhard Fulda Electron Microscopic Centre, Medical Faculty of the University of Rostock, Rostock, Germany
,
Touhama Salameh Department of Pathology, Medical Faculty of the University of Rostock, Rostock, Germany
,
Wolfgang Schmidt Department of Pathology, Medical Faculty of the University of Rostock, Rostock, Germany
,
Geofred Kröning Department of Pharmacology and Toxicology, Medical Faculty of the University of Rostock, Rostock, Germany
,
Ulrich T. Hopt Department of Surgery, Medical Faculty of the University of Rostock, Rostock, Germany
&
Horst Nizze Department of Pathology, Medical Faculty of the University of Rostock, Rostock, Germany
 show all
Pages 111-118 | Published online: 10 Jul 2009

References

  • Harris ED. Copper transport and metabolism: an update. J Trace Elements Exp Med. 1998; 11: 163–176.
  • Kim EK, Yoo OJ, Song KY, et al. Identifcation of three novel mutations and a high frequency of the Arg 778 leu mutation in korean patients with Wilson´s disease. Hum. Mutat. 1998; 11: 275–278.
  • Loudianos G, Dessi V, Lovicu M, et al. Molecular characterization of Wilson´s disease in the sardinian population: evidence of a founder effect. Hum Mutat. 1999; 14: 294–303.
  • Loudianos G, Dessi V, Lovicu M, et al. Mutation analysis in patents of Mediterranean descent with Wilson´s disease: identifcation of 19 novel mutations. J Med Genet. 1999; 36: 833–836.
  • Tsai CH, Tsai FJ, Wu JY, Chang JG, Lee CC, Lin SP. Mutation analysis of Wilson´s disease in Taiwan and description of six new mutations. Hum Mutat. 1998; 12: 370–376.
  • Sternlieb I. Perspectives on Wilson´s disease. Hepatology. 1990; 12: 1234–1239.
  • Cox DW, Thomas GR, Flynin JBA, Nanji MS. Wilson´s disease: mutations and their consequences. Am J Hum Genet. 1995;57:A8.
  • Brewer GJ, Dick RD, Johnson VD, Brunberg JA, Kluin KJ, Fink JK. Treatment of Wilson´s disease with zinc: XV long -term follow -up studies. J Lab Clin Med. 1998; 134: 264–278.
  • Uzman LL. Histochemical localization of copper with rubeanic acid. Lab Invest. 1958;5:299–305.
  • Lindquist RR. Studies on the pathogenesis of hepatolenticular degeneration. Arch Pathol. 1969; 87: 370–379.
  • Merkord J, Weber H, KrÎ ning G, Hennighausen G. An antidotal effect of 2,3 -dimercapto -propane-1 -sulfonic acid (DMPS) and meso-2,3-dimercapto -succinic acid (DMSA) on the organotoxicity of di -butyltinn -dichloride (DBTC) in rats. Hum Exp Toxicol. 2000; 19: 132–137.
  • Brewer G, Yuzbasiyan -Gurkan V. Wilson´s disease. Medicine. 1992;3:139–164.
  • Cartwright GE, Wintrobe MM. Copper metabolism in normal subjects. Am J Clin Nutr. 1964; 14: 224–232.
  • Farrer LA, Bowcock AM, Hebert JM, et al. Predictive testing for Wilson´s disease using tightly linked and flanking DANN markers. Neurology. 1991; 41: 992–999.
  • Danks DM. Disorders of copper transport. In: Sciver CR, Beandet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Basis of Inherited Disease, ed 7. New York: McGraw-Hill; 1995:2211–2224.
  • Prasad R, Kaur G, Walia BNS. A critical evaluation of copper metabolism in indian Wilson´s disease children with special reference to their phenotypes and relatives. Biol Trace Elem Res. 1998; 65: 153–165.
  • Stremmel W, Meyerrose KW, Niederau C, Hefter C, Kreuzpainter P, Strohmeyer G. Wilson´s disease: clinical presentation, treatment, and survival. Ann Intern Med. 1991; 115: 720–726.
  • Treble RG, Thompson TS, Lynch HR. Determination of copper, manganese and zinc in human liver. Bio Metals. 1998;11:49–53.
  • Bush VJ, Moyer TP, Batts KP, Parisi JE. Essential and toxic element concentrations in fresh and formalin -fxed human autopsy tissue. Clin Chem. 1995; 41: 284–294.
  • Faa G, Nurchi V, Demelia L. Uneven hepatic copper distribution in Wilson´s disease. J Hepatol. 1995; 22: 303–308.
  • Faa G. The role of the pathologist in the diagnosis and monitoring of Wilson´s disease. Pathologia. 1996; 88: 102–110.
  • Lembowicz K, Kryczka W, Walewska -Zielecka B, Kubicka J. Wilson´s disease coexisting with viral hepatitis type C: a case report with histological and ultrastructural studies of the liver. Ultrastruct Pathol. 1999;23:39–44.
  • Phillips MJ, Ackerley CA, Superina RA, Roberts EA, Filler RM, Levy GA. Excess zinc associated with severe progressive cholestasis in Cree and Ojibwa-Cree children. Lancet. 1996; 347: 866–868.
  • Sternlieb I, Feldmann G. Effects of anticopper therapy on hepatocellular mitochondria in patients with Wilson´s disease. Gastroenterology. 1976; 71: 457–461.
  • Sternlieb I. Fraternal concordance of types of abnormal hepatocellular mitochondria in Wilson´s disease. Hepatology. 1992; 16: 728–732.
  • Dickersin GR. Diagnostic Electron Microscopy: A Text/ Atlas. New York: Springer;2000:747–756.
  • Yarze JC, Martin P, Munoz SJ, Friedman LS. Wilson´s disease: current status. Am J Med. 1992;12:11–13.

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