63
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Ultrastructure of the Ewing's Sarcoma Family of Tumors

, , &
Pages 67-76 | Published online: 10 Jul 2009

  • Ewing's J. Diffuse endothelioma of bone. Proc NY Pathol Soc. 1921;21:17-24.
  • Ginsberg J, Woo SY, Johnson M, Hicks MJ, Horowtiz ME. Ewing's sarcoma family of tumors: Ewing's sarcoma of bone and soft tissue and the peripheral primitive neurectodermal tumors. In: Principles and Practice of Pediatric Oncology, ed 4. Pizzo PA, Poplack DG, eds. Philadelphia: Lippincott-Raven; 2002:973-1016.
  • Joshi W, Balarezo F, Hicks MJ, Mierau GW, Tsongalis GJ. Approach to small round cell tumors of childhood. Pathol Case Rev. 2000;5:26-41.
  • De Alva E, Gerald WL Molecular biology of the Ewing's's sarcoma/primitive neuroectodermal tumor family. J Clin Oncol. 2000;18:204-213.
  • Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29:577-580.
  • Hedley Da Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem. 1983;32:1333-1335.
  • Auer G, Caspersson T, Wallgren A. DNA content and survival in mammary carcinoma. Anal Quant Cytol. 1980;2:161-165.
  • Guter GE, Gamboni MM, Zakowski MF. The cytology of extraskeletal Ewing's sarcoma. Cancer 1999;87:141-148.
  • Swanson PE. Clear cell tumors of bone. Semin Diagn Pathol. 1997;14:281-291.
  • Navarro S, Cavazzana AO, Llombart-Bosch A, Triche TJ. Comparison of Ewing's's sarcoma of bone and peripheral neuroepithelioma: an immunocytochemical and ultrastructural analysis of two primitive neuroectodermal neoplasms. Arch Pathol Lab Med. 1994;118:608-615.
  • Llombart-Bosch A, Contesso G, Peydro-Olaya A. Histology, immunohistochemistry, and electron microscopy of small round cell tumors of bone. Semin Diagn Pathol. 1996;13:153-170.
  • Renshaw AA, Perez-Atayde AR, Fletcher JA, Granter SR. Cytology of typical and atypical Ewing's's sarcoma/PNET. Am J Clin Pathol. 1996;106:561-564.
  • Oda Y, Tsuneyoshi M. A comparative study of nuclear morphometry and proliferating activity in neuroectodermal tumors of bone and Ewing's's sarcoma of bone. Gen Diagn Pathol. 1995;141:121-129.
  • Schmidt D, Mackay B, Ayala AG. Ewing's's sarcoma with neuroblastoma-like features. Ultrastruct Pathol. 1982;3:143-151.
  • Llombart-Bosch A, Lacombe MJ, Contesso G, PeydroOlaya A. Small round blue cell sarcoma of bone mimicking atypical Ewing's's sarcoma with neuroectodermal features: an analysis of five cases with immunohistochemical and electron microscopic support. Cancer. 1987;60:1570-1582.
  • Mackay B, Ordonez NG. Adult neuroblastoma of bone: a case report. UHrastruct Pathol. 1987;11:455-464.
  • Parham DM, Hijazi Y, Steinberg SM, et al. Neuroectodermal differentiation in Ewing's's sarcoma family of tumors does not predict tumor behavior. Hum Pathol. 1999;30:911-918.
  • Park SH, Kim I. Small cell osteogenic sarcoma of the ribs: cytological, immunohistochemical, and ultrastructural study with literature review. UHrastruct Pathol. 1999;23:133-140.
  • Schlossman SF, Boumsell L, Gilks W, et al. CD antigens 1993. J lmmunol. 1994;152:1-2.
  • Dracopoli NC, Rettig WJ, Albino AP, et al. Genes controlling gp25/30 cell-surface molecules map to chromosomes X and Y and escape X-inactivation. Am J Hum Genet. 1985;37:199-207.
  • Hamilton G, Fellinger EJ, Schratter I, Fritsch A. Characterization of a human endocrine tissue and tumor-associated Ewing's's sarcoma antigen. Cancer Res. 1988;48:6127-6131.
  • Halliday BE, Siegel DD, Elsheikh TE, Silverman JF. Diagnostic utility of MIC-2 immunocytochemical staining in the differential diagnosis of small blue cell tumors. Diagn Cytopathol. 1998;19:410-416.
  • Fellinger EJ, Garin-Chesa P, Classer DB, Huvos AI, Rettig WJ. Comparison of cell surface antigen HBA71 (p30/32), neuron-specific enolase, and vimentin in the immunohistochemical analysis of Ewing's Is sarcoma of bone. Am J Surg Pathol. 1992;16:746-755.
  • Devaney K, Vinh TN, Sweet DE. Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. Hum Pathol. 1993;24:1211-1225.
  • Ramani P, Rampling D, Link M. Immunocytochemical study of 12E7 in small round-cell tumours of childhood: an assessment of its sensitivity and specificity. Histopathology. 1993;23:557-561.
  • Pappo AS, Douglass EC, Meyer WH, Marina N, Parham DM. Use of HBA71 and anti-B-microglobulin to distinguish peripheral neuroepithelioma from neuroblastoma. Hum Pathol. 1993;24:880-885.
  • Riopel M, Dickman PS, Link MP, Perlman EJ. MIC2 analysis in pediatric lymphomas and leukemias. Hum Pathol. 1994;25:396-399.
  • Weidner N, Tjoe J. lmmunohistochemical profile of monoclonal antibody 013: antibody that recognizes glycoprotein p30/32 and is useful in diagnosing Ewing's's sarcoma and peripheral neuroepithelioma. Am J Surg Pathol. 1994;18:486-494.
  • Scotlandi K, Serra M, Manara MC, et al. lmmunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's's sarcoma and peripheral neuroectodermal tumor. Hum Pathol. 1996;27:408-416.
  • Collins BT, Cramer HM, Frain BE, Davis MM. Fine-needle aspiration biopsy of met astatic Ewing's's sarcoma with MIC2 (CD99) immunocytochemistry. Diagn Cytopathol. 1998;19:382-384.
  • Fellinger EJ, Garin-Chesa P, Triche TJ, Huvos AG, Rettig WJ. lmmunohistochemical analysis of Ewing's's sarcoma cell surface antigen p30/32. Am J Pathol. 1991;139:317-325.
  • Fellinger EJ, Garin-Chesa P, Su SL, et al. Biochemical and genetic characterization of the HBA71 Ewing's's sarcoma cell surface antigen. Cancer Res. 1991; 51:336-340.
  • Stevenson AJ, Chatten J, Bertoni F, Miettinen M. CD99(p30/32MIC2) neuroectodermal/Ewing's's sarcoma antigen as an immunohistochemical marker: review of more than 600 tumors and the literature experience. Appl lmmunohistochem. 1994;2:231-240.
  • Ordonez NG. Desmoplastic small round cell tumor, II: anultrastructural and immunocytochemical study with emphasis on new immunohistochemical markers. Am J Surg Pathol. 1998;22:1314-1327.
  • Granter SR, Renshaw AA, Fletcher CD, Bhan AK, Rosenberg AE. CD99 reactivity in mesenchymal chondrosarcoma. Hum Pathol. 1996;27:1273-1276.
  • Lucas DR, BentleyG, Dan ME, Tabaczka P, Poulik JM, Mott MP. Ewing's sarcoma vs lymphoblastic lymphoma: a comparative immunohistochemical study. Am J Clin Pathol. 2001;115:11-17.
  • Gu M, Antonescu CR, Gutter G, Huvos AG, Ladanyi M, Zakowski MF. Cytokeratin immunoreactivity in Ewing's's sarcoma: prevalence in 50 cases confirmed by molecular diagnostic studies. Am J Surg Pathol. 2000;24:410-416.
  • Collini P, Sampietro G, Bertulli R, et al. Cytokeratinimmunoreactivity in 41 cases of Ewing's's sarcoma/PN ET confirmed by molecular diagnostic studies. Am J Surg Pathol. 2001;25:273-274.
  • Teitell MA, Thompson AD, Sorensen PH B, Shimada H, Triche TJ, Denny CT. EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts. Lab Invest 1999;79:1535-1552.
  • Moll R, Lee I, Gould VE, Berndt R, Roessner A, Franke WW. Immunocytochemical analysis of Ewing's's sarcomas: patterns of expression of intermediate filaments and desmosomal proteins indicate cell type heterogeneity and pluripotential differentiation. Am J Pathol. 1987;127:288-304.
  • Ushigome S, Shimoda T, Takaki K, et al. Immunocytochemical and ultrastructural studies of the histogenesis of Ewing's's sarcoma and putatively related tumors. Cancer 1989;64:52-62.
  • Molenaar WM, Muntinghe FL Expression of neural cell adhesion molecules and neurofilament protein isoforms in Ewing's's sarcoma of bone and soft tissue sarcomas other than rhabdomyosarcoma. Hum Path. 1999;30:1207-1212.
  • Franchi A, Pasquinelli G, Cenacchi D, et al.Immunohisto-chemical and ultrastructural investigation of neural differentiation in Ewing's Sarcoma/PNET of bone and soft tissue. UIfastruct Pathol. 2001;25:219-226.
  • Kullendorff CM, Mertens F, Donner M, Wiebe T, Akerman M, Mandahl N. Cytogenetic aberrations in Ewing's sarcoma: are secondary changes associated with clinical outcome? Med Pediatr Oncol. 1999;32:79-83.
  • Adams V, Many MA, Schmid M, Hassam S, Briner J, Niggli FK. Detection of t(11;22)(q24; q13) translocation breakpoint in paraffin-embedded tissue of the Ewing's's sarcoma family by nested reverse transcription-polymerase chain reaction. Diagn Mol Palhol. 1996;5:107-113.
  • Knezevich SR, Hendson G, Mathers JA, et al. Absence of detectable EWS/FLI1 expression after therapy-induced neural differentiation in Ewmg'ssarcoma.HumPathol. 1998;29:289-294.
  • Grier HE. The Ewing's family of tumors: Ewing's's sarcoma and primitive neuroectodermal tumors. Pediatr Clin NA. 1997;44:991-1004.
  • Luksch R, Sampietro G, Collini P, et al. Prognostic value of clinicopathologic characteristics including neuroectodermal differentiation in osseous Ewing's's sarcoma family of tumors in children. Tumori. 1999;85:101-107.
  • Dierick AM, Langlis M, Van Oosteveldt P, Roels H. The prognostic significance of the DNA content in Ewing's's sarcoma: a retrospective cytophotometric and flow cytometric study. Histopathology, 1993;22:333-339.
  • Perotti D, Corletto V, Giardini R, Parafioriti A, Fossati-Bellani F, Luksch R. Retrospective analysis of ploidy in primary osseous and extraosseous Ewing's family tumors in children. Tumori. 1998;84:493-498.
  • LaSaIIe DL James Ewing's, MD: contemporary oncologist exemplar. Arch Surg. 1987;122:1240-1243.
  • Ewing's J. Further report on endothelial myeloma of bone. Proc NY Pathol Soc. 1924;24:93-101.
  • Maeda G, Masui F, Yokoyama R, et al. Ganglion cells in Ewing's's sarcoma following chemotherapy: a case report. Pathol Int. 1998;48:475-480.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.