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Ultrastructural Pathology Volume 26, 2002 - Issue 2
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Research Article

Ultrastructural Abnormalities in Cultured Exostosis Chondrocytes

Pauline Jackie Duke The University of Texas Health Science Center at Houston, Dental Branch, Department of Orthodontics, Houston, Texas, USA
,
Dina Montufar-Solis The University of Texas Health Science Center at Houston, Dental Branch, Department of Orthodontics, Houston, Texas, USA
,
Richard Haynes Shriners Hospital for Children - Houston, Houston, Texas, USA
&
Jacqueline T. Hecht The University of Texas Health Science Center at Houston, Medical School, Department of Pediatrics, Houston, Texas, USA; and Shriners Hospital for Children - Houston, Houston, Texas, USA
Pages 99-106 | Published online: 10 Jul 2009

  • Schajowicz F. Tumors and Tumorlike Lesions of Bone: Pathology, Radiology, and Treatment. New York: Springer; 1994.
  • Solomon L Hereditary multiple exostosis. Bone Joint Surg. 1963;45B:292-304.
  • Porter DE, Simpson AHRW. The neoplastic pathogenesis of solitary and multiple osteochondromas. J Palhol. 1999;188:119-125.
  • Wicklund CL, Pauli RM, Johnston D, Hecht JT. Natural history study of hereditary multiple exostoses. Am J Med Gene. 1995;55:43-46.
  • Hecht JT, Hogue D, Strong LC, Hansen MF, Blanton SH, Wagner M. Hereditary multiple exostosis and chondrosarcoma: linkage to chromosome 11 and loss of heterozygosity for EXT-linked markers on chromosomes 11 and 8. Am J Hum Genet. 1995;56:1125-1131.
  • Stickers D, Clines G, Burbee D, et al. The EXT2 multiple exostoses gene defines a family of putative tumour suppresor genes. Nat Genet. 1996:14:25-32.
  • McCormick C, Leduc Y, Martindale D, et al. The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate. Nat Genet. 1998;19:158-161.
  • Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K. The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate. J Biol Chem. 1998;273:26265-26268.
  • McCormick C, Duncan G, Goutsos KT, Tufaro F. The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. Proc Natl Acad Sci USA. 2000;97:668-673.
  • Kobayashi S, Morimoto K, Shimuzu T, Takahashi M, Kurosawa H, Shirasawa T. Association of EXT1 and EXT2, hereditary multiple exostoses (HME) gene products, in Golgi apparatus. Biochem Biophys Res Commun. 2000;268:860-867.
  • Bernard MA, Hogue DA, Cole WG, et al. Cytoskeletalabnormalities in chondrocytes with EXT1 or EXT2 mutations. J Bone Miner Res. 2000;15:442-486.
  • McCormick C, Duncan G, Tufaro F. New perspectives on the molecular basis of hereditary bone tumours. MoI Med Today. 1999;5:481-486.
  • Duke PJ, Montufar-Solis D, Hecht JT. Use of rotating bioreactor to study skeletal mutations: hereditary multiple exostosis. Grav Space Biol. 2000:14:26.
  • Hewitt AT, Elmer WA. Reactivity of normal and brachypod mouse limb mesenchymal cells with con A. Nature. 1976;264:177-178.
  • Duke J, Elmer WA. Effect of the brachypod mutation on early stages of chondrogenesis in mouse embryonic hind limbs: an ultrastructural analysis. Teratology. 1979;19:367-376.
  • Duke J, Elmer WA. Effect of the brachypod mutation on cell adhesion and chondrogenesis in aggregates of mouse limb mesenchyme. J Embryol Exp Morphol. 1977;42:209-217.
  • Duke J, Elmer WA. Cell adhesion and chondrogenesis in brachypod mouse limb mesenchyme: fragment fusion studies. J Embryol Exp Morphol. 1978;48:161-168.
  • Hewitt AT, Elmer WA. Developmental modulation oflectin-binding sites on the surface membranes of normal and brachypod mouse limb mesenchymal cells. Differentiation. 1978;10:31-38.
  • Perrimon N, Bernfield M. Specificities of heparan sulphate proteoglycans in developmental processes. Nature. 2000;404:725-728.
  • San Antonio J, Winston B, Tuan R. Regulation ofchondrogenesis by heparan sulfate and structurally related glycosaminoglycans. Dev Biol. 1987;123:17-24.
  • Shimazu A, Nah HD, Kirsch T, et al. Syndecan-3 and the control of chondrocyte proliferation during endochondral ossification. Exp Cell Res. 1996;229:126-136.
  • Looser RF. Chondroycyte integrin expression and function. Biorheology 2000;37:109-116.
  • Mallein-Gerin F, Garrone R, van der Rest M. Proteoglycan and collagen synthesis are correlated with actin organization in dedifrerentiating chondrocytes. Eur J Cell Biol. 1991;56:364-373.
  • Kiehne K, Herzig KH, Folsch UR. Regulation of the actin cytosketeton by p125 focal adhesion kinase in rat pancreatic acinar cells. Digestion. 1999;60:153-160.
  • Melegh B, Trombitas K. Valproate treatment induces lipid globule accumulation with ultrastructural abnormalities of mitochondria in skeletal muscle. Neumpediatrics. 1997;28:257-261.
  • Hunziker EB, Schenk RK. Physiological mechanisms adopted by chondrocytes in regulating longitudinal bone growth in rats. J Physiol. 1989;414:55-71.
  • Kember NF. Cell kinetics of cartilage. In: Hall BK, ed. Cartilage: StiuctuK. Function, and Biochemistry, VoI I. New York: Academic; 1983;149-180.
  • Bernard MA, Hall CE, Hogue DA, et al. Diminished levels of putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes. Cell Motil Cytoskeleton. 2001;48:149-162.
  • Duke PJ, Daane E, Montufar-Solis D. Studies ofchondrogenesis in rotating systems. J Cell Biochem. 1993;51: 274-282.
  • Duke PJ, Montufar-Solis D, Williams N, Hecht JT. Culture of human costochondral chondrocytes in a three-dimensional system. J Dent Res. 2001;80:697.

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